Glycopyrrolate

With the help of AI, AstraZeneca’s three-in-one inhaler Breztri has a new furry mascot to help it stand tall over the crowded asthma drug field. Breztri, which recently scored an expanded asthma indication after taking home its first chronic obstructive pulmonary disease (COPD) nod in 2020, combines a long-acting muscarinic antagonist (LAMA) with an inhaled corticosteroid (ICS) and a long-acting beta 2 -adrenergic agonist (LABA). Playing on the LAMA drug class name, AZ’s new Breztri campaign features an AI-generated llama in an unexpected office setting to urge patients to “put a LAMA to work.” In the one-minute spot , a business-casual llama works a late night in the office with his coworkers, a goat and an oryx, as a voiceover explains the attributes of the only three-in-one asthma maintenance inhaler for those 12 years of age and older. The trio goes on to take part in typical and humorous workplace scenarios, such as the automated lights going off or one goat colleague pressing all of the elevator buttons. The clever way of transforming complex treatment terminology into an animal that shares its namesake was AstraZeneca’s way of “breaking through that noise” to provide asthma education in a way that was “really meaningful,” AZ marketing senior director Katie Pansegrau explained in an interview with Fierce Pharma Marketing. “We were going to need to do something clever,” Pansegrau recalled. Of course, putting a real-life llama in a tie and a cubicle might be a tall task. Thus, the idea “kind of led itself to AI,” Pansegrau said. Edelman, which teamed up with AZ to create the campaign, used the help of AI tools to help it through each step of its traditional production process. While it was necessary to help “make a llama walk and push an elevator button,” the technology “never changed our standards” or the education goal of the campaign, Pansegrau emphasized. “No matter what tools we use to make the work, this work had to disrupt,” Edelman SVP and group creative director Brian Wood added. “It had to break through.” Still, the campaign could stand as a “shining example of what it can mean for future work,” Wood noted, referring to AI’s creative prowess. Aside from the overt humor of the animals-in-the-office situation, the ad is full of subtle winks, such as the onyx working on “herd dynamics” slides and posters in the office displaying barnyard puns. The comedic aspect of the campaign hearkens back to AZ’s goal of breaking through the noise and helping “drive understanding” for patients, Pansegrau pointed out. “This triple therapy, we believe, is something that every patient that's eligible should know about," Wood said. "LAMA certainly helped us make that message more memorable and, frankly, more entertaining,” Wood said. AZ plans to spread the ad across connect channels and social media platforms where it can best make its audience “stop the scroll,” according to Pansegrau. The company’s marketing for the drug has long leaned on creative themes, such as an animated approach that depicts patients walking into a colorful world upon starting on Breztri or its vacation-themed promotions that sees people transported into an RV or a cruise ship thanks to the med. Last year, Breztri picked up $1.2 billion in annual sales for AZ as one of its key blockbuster products, rising 23% from 2024. The new asthma nod Breztri earned earlier this year is expected to further help the drug chip in on the company’s goal of reaching $80 billion in revenues by 2030.

Key Highlights Regulatory submissions for next-generation propellant pMDIs (pressurized metered-dose inhalers) across Chiesi’s Single Inhaler Triple Therapy (SITT; or ICS/LABA/LAMA) and fixed double ICS/LABA combination (inhaled corticosteroid with a long-acting bronchodilator) range have been validated by Regulatory Agencies in Europe . Transition to HFA‑152a , a next‑generation propellant classified as non‑PFAS* and with low global warming potential (GWP) , aims to reduce the carbon footprint of Chiesi’s pMDIs by up to 90% compared to current ones. 1-3 Designed for a seamless transition for patients and HCPs , maintaining established efficacy, safety and usability and supporting continuity of care. 4-8 The validation supports Chiesi’s ambition to reach Net Zero † across its full value chain by 2035 9 , following MHRA approval of Chiesi’s beclometasone pMDIs formulated with HFA-152a. PARMA, Italy--(BUSINESS WIRE)--Chiesi Group, an international research-focused biopharmaceutical company and certified B Corp, today announces a further step in its Carbon Minimal Inhaler (CMI) journey with the validation of regulatory submissions in Europe for its SITT and ICS/LABA pMDIs. The start of regulatory assessment in Europe marks a significant step towards Chiesi’s transition to carbon minimal pMDIs across its respiratory portfolio, combining innovation with responsibility. This supports the Company’s broader ambition to reduce the environmental impact of respiratory care, while enabling a seamless transition for patients and healthcare professionals. In July 2026, the UK Medicines and Healthcare products Regulatory Agency (MHRA) approved Chiesi’s beclometasone pMDIs formulated with HFA-152a, marking the first UK approval of this next-generation propellant in a pressurised metered-dose inhaler. Chiesi’s pMDIs are transitioning to HFA-152a, a next-generation propellant classified as non-PFAS* and with low-GWP, designed to reduce the products’ carbon footprint by up to 90% compared with current ones 1-3 , while maintaining established efficacy, safety, and usability. 4-8 ezstandalone.cmd.push(function () { ezstandalone.showAds(131); }); “Innovation in patient care and environmental responsibility are not a trade-off. Our next-generation carbon minimal pMDIs provide the same level of care , while reducing emissions of up to 90% compared to the ones in use today and at the same level of dry powder inhalers (DPI),” said Andrea Bizzi, Executive Vice President, Region Europe TOP 5 & Interim AIR Franchise. “These submissions are another step on our progression towards a full extrafine CMI portfolio across pMDIs and DPIs.” “The transition to carbon minimal pMDIs is not only a critical step in reducing the environmental impact of respiratory care,” said Sara Panigone, Senior Director, Global Project Leader AIR Franchise, “but also helps to guarantee the long-term availability of a full range of effective inhaled medicines, protecting patient lives, ensuring access and continuity of care.” Chiesi’s CMI portfolio transition is focused on reducing the carbon footprint associated with pMDIs, which remains an important option in asthma and COPD care. Transitioning our pMDIs to the next‑generation propellant HFA-152a, supports the decarbonization of respiratory care while helping to safeguard access and continuity of care over the long term. 1-8, 10-12 * PFAS: per- and polyfluoroalkyl substances, non-PFAS means also non-forever chemical ezstandalone.cmd.push(function () { ezstandalone.showAds(132); }); Notes to Editors - Regulatory procedures Single Inhaler Triple Therapy (SITT or ICS/LABA/LAMA, beclometasone dipropionate/formoterol fumarate dihydrate/glycopyrronium bromide) pMDIs have been submitted under the EU centralized procedure to the European Medicines Agency. ICS/LABA (beclometasone dipropionate/formoterol fumarate dihydrate) pMDIs are being managed through a coordinated multi-country regulatory procedure with BfArM – the German Federal Institute for Drugs and Medical Devices - acting as Reference Member State. †Net Zero Commitment Chiesi plans to be the first pharmaceutical company to achieve Net Zero greenhouse gas emissions across its entire value chain by 2035, 15 years ahead of the European Climate Neutrality target. This commitment covers all emission scopes. Chiesi’s targets were validated by the Science Based Targets initiative (SBTi) in April 2024. The Group has consolidated its greenhouse gas inventory in line with ISO 14064 and the GHG Protocol standards, with annual audits carried out by independent third parties. The transition to the next-generation propellant HFA-152a is one of the most impactful actions in Chiesi’s Net Zero roadmap, as inhaler propellants represent the single largest source of the Group’s greenhouse gas emissions. ezstandalone.cmd.push(function () { ezstandalone.showAds(133); }); About Chiesi Group Chiesi is a research-oriented international biopharmaceutical group that develops and markets innovative therapeutic solutions in respiratory health, rare diseases, and specialty care. The company’s mission is to improve people’s quality of life and act responsibly towards both the community and the environment. By adopting the legal form of Benefit Corporation in Italy, the US, France, and Colombia, Chiesi’s commitment to creating shared value for society as a whole is legally binding and central to company-wide decision-making. As a certified B Corp since 2019, Chiesi is part of a global community of businesses that meet high standards of social and environmental impact. The company aims to reach Net Zero greenhouse gases (GHG) emissions by 2035. With 90 years of experience, Chiesi is headquartered in Parma (Italy), with 31 affiliates worldwide, and counts more than 7,500 employees. The Group’s research and development center in Parma works alongside 6 other important R&D hubs in France, the US, Canada, China, the UK, and Sweden. ezstandalone.cmd.push(function () { ezstandalone.showAds(134); }); For further information please visit References: Panigone S et al 2020, BMJ Open Respiratory Research: Environmental impact of inhalers for respiratory diseases: decreasing the carbon footprint while preserving patient-tailored treatment ( ) EU ECHA Webinar: Restriction of per- and polyfluoroalkyl substances (PFAS) under REACH OECD Reconciling Terminology of the Universe of Per- and Polyfluoroalkyl Substances 2021 Rony F et al 2024, Pulmonary Pharmacology & Therapeutics: Evaluating the pharmacokinetics of beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide delivered via pressurized metered-dose inhaler using a low global warming potential propellant. ( ) Almeida M et al. Relative lung availability and total systemic exposure after inhalation of medium or high strength doses of beclometasone dipropionate/formoterol fumarate, formulated as pMDI with a next generation propellant. Thorax 2025 BTS Winter meeting Salvadori M et al 2025, Pulmonary Pharmacology & Therapeutics: The low global warming potential propellant HFA-152a does not induce bronchoconstriction or impair mucociliary clearance ( ) Singh D et al 2026, Respiratory Medicine : Safety and tolerability of the low global warming potential propellant HFA-152a in patients with asthma receiving beclometasone dipropionate/formoterol fumarate/glycopyrronium: The TRECOS study ( ) Matturro A et al 2025, An Official Journal of the American Association of Pharmaceutical Scientists: Innovative drug development approach to address the transition to low global warming potential propellant using hydrofluoroalkane‑152a, for triple combination pressurized metered‑dose inhaler products targeting small airways ( ) Chiesi’s Sustainability Report 2025 Pernigotti D et al 2021, BMJ Open Respiratory Research: Reducing carbon footprint of inhalers: analysis of climate and clinical implications of different scenarios in five European countries ( ) Attar-Zadeh D et al 2021, Journal of Health Economics and Outcomes Research: Health-care Resource Requirements and Potential Financial Consequences of an Environmentally Driven Switch in Respiratory Inhaler Use in England ( ) Usmani O et al 2022, Journal of Allergy Clinical Immunology Practice. Real-World Impact of Nonclinical Inhaler Regimen Switches on Asthma or COPD: A Systematic Review. ( ) Contacts Press info: Vera Valota Head of Global Communications, AIR & CARE Tel: +44 734 188 99 92 Email: v.valota@chiesi.com