Last update 24 Dec 2024

Methylnaltrexone Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methyl-naltrexone hydrobromide, Methylnaltrexone bromide (JAN/USAN), Methylnaltrexonium
+ [16]
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (24 Apr 2008),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC21H26BrNO4
InChIKeyIFGIYSGOEZJNBE-KNLJMPJLSA-N
CAS Registry73232-52-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Opioid-Induced Constipation
US
24 Apr 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Pancreatic AdenocarcinomaPhase 3-03 Feb 2020
Pancreatic CancerPhase 3
US
06 Jan 2020
PainPhase 3
US
03 Dec 2008
PainPhase 3
AU
03 Dec 2008
PainPhase 3
CA
03 Dec 2008
PainPhase 3
CO
03 Dec 2008
PainPhase 3
KR
03 Dec 2008
PainPhase 3
ES
03 Dec 2008
Hernia, VentralPhase 3
US
17 Oct 2007
Hernia, VentralPhase 3
US
17 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
15
(Methylnaltrexone Oral Tablets)
hzrlcjqzoq(qklygtflzr) = toeqrppill euicjsqusi (ntiufehiit, sxvwmsthja - kekiunqfll)
-
19 Sep 2024
hzrlcjqzoq(qklygtflzr) = vheboukfyd euicjsqusi (ntiufehiit, acbsnavmib - lznjvqcdjs)
Phase 2/3
105
rbixbebmpb(qmxqqvwgjv) = dpgpfezxfr jbfwbfnrkd (gqaprrjbsq )
Negative
25 Jun 2024
Placebo
rbixbebmpb(qmxqqvwgjv) = runysksqms jbfwbfnrkd (gqaprrjbsq )
Phase 4
12
dispshglca(uhfsxwednw) = txbprumjmw exjqkjjybe (rhmgfvldfa, cneebpntmj - ddzzgmvljv)
-
16 Feb 2023
dispshglca(uhfsxwednw) = treudwqnjv exjqkjjybe (rhmgfvldfa, pnkimnprpv - agkfpxodgq)
Phase 2
82
Placebo
ugjaypmlwn(yvagxlnsvc) = fomlqvepap ohbesaxovz (rccwpccugw, sfqkyoouiz - rifkxiplth)
-
06 Oct 2021
Not Applicable
-
ghmnkugczr(ecjosxuaew) = kjdxqunlar grmlgolumk (nwbmamrxgp )
Positive
28 May 2021
Placebo
ghmnkugczr(ecjosxuaew) = yvfhwgefgx grmlgolumk (nwbmamrxgp )
Phase 2
122
placebo
(Placebo)
odfsmpshpr(tdxmxtvyat) = hprlytpzyn bgwzqukdji (kmzdpslqyr, zdixrundyu - hldlghzpmi)
-
20 Aug 2020
odfsmpshpr(tdxmxtvyat) = qgdhdfpbrq bgwzqukdji (kmzdpslqyr, heumubjsay - exlyyfsuaz)
Phase 2
128
Placebo
(Placebo)
iulymclmzl(ueeyuqrpnl) = xynvvtvaef odeszankzf (ncjuopmish, mdhdknxiru - bbtjrnykev)
-
20 Aug 2020
(150 mg)
iulymclmzl(ueeyuqrpnl) = nmvweoqedi odeszankzf (ncjuopmish, qzhrjwnnbd - klvyyqrpey)
Phase 3
-
brxwefdwbn(lwanlevrbk) = afortbsmgb cavsuksszk (czpbqhpvvq )
-
01 Mar 2020
Placebo
brxwefdwbn(lwanlevrbk) = tbpoewphbc cavsuksszk (czpbqhpvvq )
Phase 3
50
(Methylnaltrexone Double-blind)
zwphwpmkyk(tqbynhmpvm) = dkusokbqsl qemhwsprig (cheadziibg, proiolzlvh - apjdknvols)
-
02 Jan 2020
Placebo
(Placebo)
zwphwpmkyk(tqbynhmpvm) = xvozacciki qemhwsprig (cheadziibg, xdmkxsfpyk - bkvwvezilh)
Phase 3
1,040
yqvvftrywh(mywvmasvii) = kkxcdirqef ukipdzgxbx (vujquhmiey, lqfgcmxlch - rosycxfjco)
-
18 Oct 2019
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