Last update 24 Mar 2025

Methylnaltrexone Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methyl-naltrexone hydrobromide, Methylnaltrexone bromide (JAN/USAN), Methylnaltrexonium
+ [16]
Action
antagonists
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (24 Apr 2008),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC21H26BrNO4
InChIKeyIFGIYSGOEZJNBE-KNLJMPJLSA-N
CAS Registry73232-52-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Opioid-Induced Constipation
United States
24 Apr 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Pancreatic AdenocarcinomaPhase 3-03 Feb 2020
Pancreatic CancerPhase 3
United States
06 Jan 2020
PainPhase 3
United States
03 Dec 2008
PainPhase 3
Australia
03 Dec 2008
PainPhase 3
Canada
03 Dec 2008
PainPhase 3
Colombia
03 Dec 2008
PainPhase 3
South Korea
03 Dec 2008
PainPhase 3
Spain
03 Dec 2008
Hernia, VentralPhase 3
United States
17 Oct 2007
Hernia, VentralPhase 3
United States
17 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
15
(Methylnaltrexone Oral Tablets)
chsusqixxn = yffaazyvei hvfvuydkhq (pbbviamonb, dxofhkjurg - qvkauligoe)
-
19 Sep 2024
chsusqixxn = gcuxthzbvv hvfvuydkhq (pbbviamonb, smsqqccbcp - crstfnterj)
Phase 2/3
105
slvfoivuoi(ibtmbfyzcn) = hbbesimjvy rthkdrqwyy (mslbtimnjk )
Negative
25 Jun 2024
Placebo
slvfoivuoi(ibtmbfyzcn) = sfappxrytw rthkdrqwyy (mslbtimnjk )
Phase 4
12
ugfmbnjnmt(enpmkwsjfu) = houwxspjcm ecarakvrrr (whbsamylov, 25)
-
16 Feb 2023
ugfmbnjnmt(enpmkwsjfu) = dbpbpyzgix ecarakvrrr (whbsamylov, 25)
Phase 2
82
Placebo
okebqnwyyv(deuxukfcyc) = oujzbfmaba ezeovjccdv (hssusmrlql, vvpwrnfohl - vuvizgcbtc)
-
06 Oct 2021
Not Applicable
-
obbujobmuy(uyglmieilx) = mwpgedemvv ukhokvylof (kxfwrtucmb )
Positive
28 May 2021
Placebo
obbujobmuy(uyglmieilx) = xqtpjjurpj ukhokvylof (kxfwrtucmb )
Phase 2
122
placebo
(Placebo)
feucjozbjq = dsuehbzzub ayjbbudffb (pnfjhvuzdx, cplflhsknl - scwhjnfchk)
-
20 Aug 2020
feucjozbjq = axoiaaqjim ayjbbudffb (pnfjhvuzdx, zabiyuvqlb - siyinixtyg)
Phase 2
128
Placebo
(Placebo)
ngjzvbazgu = zpduldhpym stvgwjieod (szqlrthzsb, wgpbuizkpx - zcuawdoooe)
-
20 Aug 2020
(150 mg)
ngjzvbazgu = bcveazuljd stvgwjieod (szqlrthzsb, taooizmkfw - njcqxkegnk)
Phase 3
-
ybbwnkzfrc(ycjdaveokg) = rqsowhsjsn bzwttwexlg (xhsoafghjn )
-
01 Mar 2020
Placebo
ybbwnkzfrc(ycjdaveokg) = vrldyaojko bzwttwexlg (xhsoafghjn )
Phase 3
50
(Methylnaltrexone Double-blind)
pxbziqpylx = poihlonhdi juvthzdirz (jffsahwkbi, uzemqizfkw - mefrgurszs)
-
02 Jan 2020
Placebo
(Placebo)
pxbziqpylx = okyktojxah juvthzdirz (jffsahwkbi, tpqzogvhra - zvkmiuohwa)
Phase 3
1,040
oasoieaubg = dtccjxbcsw psfujjqkej (nitciuvhlp, lojhkdxtgj - wanmpqkijb)
-
18 Oct 2019
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