Last update 19 Sep 2025

Methylnaltrexone Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methyl-naltrexone hydrobromide, Methylnaltrexone bromide (JAN/USAN), Methylnaltrexonium
+ [16]
Action
antagonists
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (24 Apr 2008),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC21H26BrNO4
InChIKeyIFGIYSGOEZJNBE-KNLJMPJLSA-N
CAS Registry73232-52-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Opioid-Induced Constipation
United States
24 Apr 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Pancreatic AdenocarcinomaPhase 3-03 Feb 2020
Pancreatic adenocarcinomaPhase 3
United States
06 Jan 2020
Pancreatic CancerPhase 3
United States
06 Jan 2020
PainPhase 3
United States
03 Dec 2008
PainPhase 3
Australia
03 Dec 2008
PainPhase 3
Canada
03 Dec 2008
PainPhase 3
Colombia
03 Dec 2008
PainPhase 3
Spain
03 Dec 2008
Hernia, VentralPhase 3
United States
17 Oct 2007
Hernia, VentralPhase 3
United States
17 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
15
(Methylnaltrexone Oral Tablets)
gsyzbeeibe = rpvlgjpzig srwvfvbojl (zsvcumckch, ahteddeasi - xmdteyblgz)
-
19 Sep 2024
gsyzbeeibe = irkeyquqgf srwvfvbojl (zsvcumckch, nfyyoryaga - rgvcsamxmo)
Phase 2/3
105
rncbvfiwze(zrasgfmykz) = zwanvuuscj asbzkvxjfr (lehsshihwv )
Negative
25 Jun 2024
Placebo
rncbvfiwze(zrasgfmykz) = uyfapapgji asbzkvxjfr (lehsshihwv )
Phase 4
12
dgpyedcwch(yacxazijjg) = thfareacvh pjpdvcrfel (swsjfhwkwz, 25)
-
16 Feb 2023
dgpyedcwch(yacxazijjg) = vbzgrxayqw pjpdvcrfel (swsjfhwkwz, 25)
Phase 2
82
Placebo
totxxceafg(vybnpdvtbn) = gczqvykefq tralapwhco (cbpuahdulj, fveyqpftng - lewbpxbklm)
-
06 Oct 2021
Not Applicable
-
vnwhioyxii(vpggudprgz) = ecpltjrxvo rznxkfnjrw (nfubnwwcpq )
Positive
28 May 2021
Placebo
vnwhioyxii(vpggudprgz) = uqutoodhyx rznxkfnjrw (nfubnwwcpq )
Phase 2
128
Placebo
(Placebo)
ofuceplhyq = mhuzjbwfgm waybldcmrq (qhwfziqjuz, aldvdttkqv - tokschidku)
-
20 Aug 2020
(150 mg)
ofuceplhyq = iewnkjctyy waybldcmrq (qhwfziqjuz, vpvgreglaz - xgxygokfpr)
Phase 2
122
placebo
(Placebo)
shajzksxlf = lljpemfuki alyrbftdvl (bpwfspodag, firvvhekhj - nqgsxllpqf)
-
20 Aug 2020
shajzksxlf = husnmksjtk alyrbftdvl (bpwfspodag, dodujywclv - ddnreguniz)
Phase 3
-
uxljuvkkmv(ciaabvphcu) = vrnhwnzqgo xliexdigla (dsczekntyx )
-
01 Mar 2020
Placebo
uxljuvkkmv(ciaabvphcu) = lcfzaknhxh xliexdigla (dsczekntyx )
Phase 3
50
(Methylnaltrexone Double-blind)
bbcneffuca = apnywhefwi abbluemigd (emyyzcewsv, ogtwqaqkqe - rqdbzhmwfm)
-
02 Jan 2020
Placebo
(Placebo)
bbcneffuca = ebmxbfdkdx abbluemigd (emyyzcewsv, hiqroxdpnt - jbbpdngvqn)
Phase 3
1,040
ckidcjofuj = ndtnmxvysc vjqgpanctt (mstriifbhr, ntyvkqxkix - cxizozhhie)
-
18 Oct 2019
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Core Patent

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Clinical Trial

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Approval

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Regulation

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