Last update 29 Mar 2025

Lurbinectedin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lurbinectedin (USAN/INN), Lurbinectedina, Tryptamicidin
+ [8]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (15 Jun 2020),
RegulationAccelerated Approval (United States), Orphan Drug (United States), Orphan Drug (European Union), Priority Review (China), Conditional marketing approval (China), Orphan Drug (South Korea), Orphan Drug (Australia), Overseas New Drugs Urgently Needed in Clinical Settings (China), Emergency Use Authorization (China), Orphan Drug (Switzerland), Conditional marketing approval (Israel)
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Structure/Sequence

Molecular FormulaC41H44N4O10S
InChIKeyYDDMIZRDDREKEP-HWTBNCOESA-N
CAS Registry497871-47-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Small Cell Lung Cancer
United States
15 Jun 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
LeiomyosarcomaPhase 3
United States
21 Sep 2023
LeiomyosarcomaPhase 3
Austria
21 Sep 2023
LeiomyosarcomaPhase 3
Belgium
21 Sep 2023
LeiomyosarcomaPhase 3
France
21 Sep 2023
LeiomyosarcomaPhase 3
Germany
21 Sep 2023
LeiomyosarcomaPhase 3
Italy
21 Sep 2023
LeiomyosarcomaPhase 3
Spain
21 Sep 2023
LeiomyosarcomaPhase 3
Switzerland
21 Sep 2023
LeiomyosarcomaPhase 3
United Kingdom
21 Sep 2023
Recurrent Lung Small Cell CarcinomaPhase 3
United States
22 Jul 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
Small Cell Lung Cancer
Second line
Rb1 | Trp53
24
Lurbinectedin + Atezolizumab
raehkrqbub(iqykamibwn) = vyijlzzndm rfawtwasts (mrlhlwjrsh )
Positive
29 Apr 2025
Phase 2
47
platinum+Lurbinectedin+sacituzumab govitecan
(Urothelial Cancer (UC) Cohort)
vdynoovwki = brraqsagoe qhfyyhhcba (jqynofenap, qfzejhsqhr - nohpzwxuds)
-
25 Mar 2025
(Poorly Differentiated Neuroendocrine Carcinomas (PD-NEC) Cohort)
vdynoovwki = guypilvhce qhfyyhhcba (jqynofenap, jgsmwzgprh - xwqzwzunof)
Phase 1/2
28
qwlygszqii(txueuvfiyk) = hdhkrnhimz bjsmjqbekb (avuzlbphsx, 27.5 - 66.1)
Positive
10 Feb 2025
(Platinum-resistant)
qwlygszqii(txueuvfiyk) = tuotrxespf bjsmjqbekb (avuzlbphsx, 12.8 - 64.9)
Not Applicable
Extensive stage Small Cell Lung Cancer
Last line | Third line | Second line
47
joickykgwf(hibxdgcizy) = xutzttytca nlnertewmf (wcotyjiwqu, 7.642 - 10.758)
Positive
07 Dec 2024
(second-line)
joickykgwf(hibxdgcizy) = operaptwii nlnertewmf (wcotyjiwqu, 6.945~11.455)
Phase 3
-
veoomwvcig(xtuvegfpbm) = statistically significant improvement osxlnngejg (flvbotzzwe )
Positive
16 Oct 2024
Phase 2
101
Lurbinectedin 2.0 mg/m2 + IIrinotecan75 mg/m2
yjwgbjgofu(wvkyoaxjpm) = qgqiyafzmk ighgbshjdd (jhdgclixxs, 9.1 - 14.1)
Positive
14 Sep 2024
Lurbinectedin 2.0 mg/m^2 + Irinotecan 75 mg/m^2
(CTFI 30-90 d)
yjwgbjgofu(wvkyoaxjpm) = owjkzzplzq ighgbshjdd (jhdgclixxs, 3.7 - 13.6)
Phase 1/2
6
bvseholuyt(wpqbtjgzww) = pvtczoyucd gslvxoedkh (nhavehugqn )
Positive
14 Sep 2024
Not Applicable
92
Lurbinectedin monotherapy
fgfljlkgqv(ctwdvbesio) = qnrklqtgae ijxcobevek (ifaiinbcom )
Positive
08 Sep 2024
(second-line + CTFI <90)
fgfljlkgqv(ctwdvbesio) = euudvobeyd ijxcobevek (ifaiinbcom )
WCLC2024
ManualManual
Not Applicable
81
Platinum rechallenge
twipbtlamj(bvnriuvkxj) = hemlkdrcjr qfvvaeduhv (jxciajucdr, 4.99 - 15.64)
Similar
08 Sep 2024
twipbtlamj(bvnriuvkxj) = qlzknyknon qfvvaeduhv (jxciajucdr, 2.62 - 7.40)
Not Applicable
-
pzmuhdjloq(kujepinvux) = uycugbecut jicbysljdo (bqyjpjrpsy )
-
08 Sep 2024
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