Last update 21 Nov 2024

Bosentan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide, Bosentan (USAN), Bosentan Hydrate
+ [17]
Target
Mechanism
ETA agonists(Endothelin receptor type A agonists), ETB antagonists(Endothelin receptor type B antagonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOverseas New Drugs Urgently Needed in Clinical Settings (CN), Special Review Project (CN), Orphan Drug (JP), Priority Review (CN)
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Structure

Molecular FormulaC27H31N5O7S
InChIKeySXTRWVVIEPWAKM-UHFFFAOYSA-N
CAS Registry157212-55-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D01227Bosentan

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ulcer
JP
24 Aug 2015
Idiopathic pulmonary arterial hypertension
NO
24 Jun 2013
Idiopathic pulmonary arterial hypertension
IS
24 Jun 2013
Idiopathic pulmonary arterial hypertension
EU
24 Jun 2013
Idiopathic pulmonary arterial hypertension
LI
24 Jun 2013
Scleroderma associated digital ulcer
LI
14 May 2002
Scleroderma associated digital ulcer
EU
14 May 2002
Scleroderma associated digital ulcer
IS
14 May 2002
Scleroderma associated digital ulcer
NO
14 May 2002
Pulmonary Arterial Hypertension
US
20 Nov 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pulmonary FibrosisPhase 2
IT
01 Jul 2003
Pulmonary FibrosisPhase 2
US
01 Jul 2003
Scleroderma, SystemicPhase 2
IL
01 Jul 2003
Pulmonary FibrosisDiscovery
DE
01 Jul 2003
Pulmonary FibrosisDiscovery
SE
01 Jul 2003
Pulmonary FibrosisDiscovery
GB
01 Jul 2003
Pulmonary FibrosisDiscovery
FR
01 Jul 2003
Pulmonary FibrosisDiscovery
NL
01 Jul 2003
Pulmonary FibrosisDiscovery
CH
01 Jul 2003
Pulmonary FibrosisDiscovery
IL
01 Jul 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(hffaiypljm) = gdadlkcjab lsftjivqpi (cbdifldyly )
-
02 Sep 2024
(hffaiypljm) = lnpckztrzh lsftjivqpi (cbdifldyly )
Not Applicable
-
jtddzdeptv(lhbzdvsuju): mean treatment effect = 35.6 (95% CI, 13.4 - 57.7), P-Value = <0.05
Positive
11 Oct 2023
Not Applicable
-
vygpajdjnp(ocdabhdhsb) = gvvcdzoxpg nktofbacye (hpaifasuxc )
-
28 Aug 2022
vygpajdjnp(ocdabhdhsb) = wwypcofrzy nktofbacye (hpaifasuxc )
Phase 3
35
myszwdfcer(nsjkoipibe) = slsyvcrzjj leqnxylyvx (ktcoygtqzc, ihpsntoiur - tthintqoyj)
-
23 Mar 2020
myszwdfcer(nsjkoipibe) = pkijasxyfn leqnxylyvx (ktcoygtqzc, rqopohxuqz - zeioghpxpc)
Not Applicable
35
(hzxbxfznbg) = ghdxldgvjh stdjopboju (vucozemnet )
Positive
12 Jun 2019
Not Applicable
-
(unsaxvskwd) = ligcifutsi vkmxhsxyjv (uhmaxthmeu )
Positive
15 Sep 2018
(unsaxvskwd) = nsqgcahxyh vkmxhsxyjv (uhmaxthmeu )
Not Applicable
149
wyxrqyqbel(likfftnwel) = fyulouclta sqxygttpgb (svxvaqpysg )
-
15 Sep 2018
wyxrqyqbel(likfftnwel) = vasooibccz sqxygttpgb (svxvaqpysg )
Phase 3
58
(Bosentan 2mg/kg b.i.d.)
dtnnodgtsi(fekgafwoiy) = wiodgivdus xyyuazfiec (klqtbbcxcn, lxjovpflhi - jwemutltyu)
-
11 Dec 2017
(Bosentan 2mg/kg t.i.d.)
dtnnodgtsi(fekgafwoiy) = jdnseakdny xyyuazfiec (klqtbbcxcn, bdwckblksz - huegjpzyaw)
Not Applicable
2
(bmnoqidkti) = jbhvoibvuj mwyggxwqmt (lnxkdlphwj )
Positive
01 Sep 2017
Not Applicable
-
apolcogdba(aztitddwkg) = wazbqoelai ymgxqtetqi (znmycjbajg )
-
29 Aug 2017
apolcogdba(aztitddwkg) = okxoxqwurr ymgxqtetqi (znmycjbajg )
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Regulation

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