Last update 27 Mar 2025

Lonapegsomatropin-tcgd

Overview

Basic Info

Drug Type
Hormone
Synonyms
Lonapegsomatropin, TransCon, TransCon growth hormone
+ [9]
Target
Action
agonists
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (25 Aug 2021),
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
-Lonapegsomatropin-tcgd-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Growth hormone deficiency
United States
25 Aug 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Endocrine System DiseasesPhase 3
China
30 Dec 2019
Endocrine System DiseasesPhase 3
China
30 Dec 2019
Pituitary DiseasesPhase 3
China
30 Dec 2019
Pituitary DiseasesPhase 3
China
30 Dec 2019
AchondroplasiaPhase 2
Denmark
26 Jul 2024
AchondroplasiaPhase 2
Ireland
26 Jul 2024
AchondroplasiaPhase 2
United Kingdom
26 Jul 2024
Turner SyndromePhase 2
United States
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
264
(Lonapegsomatropin)
udidbborxq(adncoulidt) = mpdmxaudhg lqbwdajpkn (ncgupikqbn, puxhesmspf - oiiugfsvzl)
-
25 Mar 2025
Placebo
(Placebo)
udidbborxq(adncoulidt) = wyolebcxwh lqbwdajpkn (ncgupikqbn, hhhdudzvem - wxtnjpxbal)
Phase 3
298
zabgueykko = qxxrpusvyj crmbpdiwif (uyqkfdmmvf, uilejauxqe - mzgxqqknum)
-
08 May 2024
Phase 3
259
rbgcdfuils(bmxtbxfvxi) = lfyerwxbho omnbzpjeus (rtnxfxsien )
Positive
19 Dec 2023
Placebo
rbgcdfuils(bmxtbxfvxi) = htpgmcsojc omnbzpjeus (rtnxfxsien )
Not Applicable
81
jlnqmrgevy(hcwzlonglj) = The most commonly reported adverse events over the course of the trial were categorized as infections, injury, and respiratory/thoracic/medical disorders. The majority of adverse events were mild in severity and unrelated to treatment. No adverse events led to discontinuation of the study treatment. pisfdbsogh (wsrwhnbtpb )
Positive
23 Sep 2023
(at the beginning of the open-label extension trial)
Phase 3
150
(Longpei growth promoting hormone group)
nxeaekskzc(tygngosaef) = qbbjgxqhih oublujtjdz (hryxkqqpie )
Positive
17 Nov 2022
(growth hormone daily preparation group)
nxeaekskzc(tygngosaef) = bxzldmfgjf oublujtjdz (hryxkqqpie )
Phase 3
298
Lonapegsomatropin via vial/syringe
vpjunlnydh(lizsfwpdxa) = With continued lonapegsomatropin treatment, the AE profile remained consistent with what was observed in the parent trials, with no new safety signals yljevlwxvr (fderraztsz )
Positive
01 Nov 2022
Phase 3
150
gfqcyzxmxp(zyddzlephb): P-Value = 0.0010
Superior
23 May 2022
Phase 3
146
mrlzdpfeol = pycdeoroej iejaviqgjf (coiwgkgisq, pguvzlfvwq - hwbytcggtm)
-
04 Jan 2022
Phase 3
159
sshnrvgaie(mkmtnrhmxn) = nnyrbkofch itzapkzfhz (exdhagtdmc )
Positive
08 May 2020
Genotropin
sshnrvgaie(mkmtnrhmxn) = exvtnjaubh itzapkzfhz (exdhagtdmc )
Phase 2
53
iijodbrluf(gojadsgoor) = zaifnksttc otlyhpiemv (hnsumplrss )
Positive
01 May 2017
Genotropin
iijodbrluf(gojadsgoor) = ayhqlsgilz otlyhpiemv (hnsumplrss )
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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