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Last update 14 Apr 2025
Chlorhexidine Gluconate/Isopropyl Alcohol
Last update 14 Apr 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms ChloraPrep, Soluprep |
Target- |
Action inhibitors |
Mechanism Cell membrane function inhibitors |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (14 Jul 2000), |
Regulation- |
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Structure/Sequence
Molecular FormulaC3H8O |
InChIKeyKFZMGEQAYNKOFK-UHFFFAOYSA-N |
CAS Registry67-63-0 |
View All Structures (2)
Related
25
Clinical Trials associated with Chlorhexidine Gluconate/Isopropyl AlcoholNCT04756154
Assessment of the Antimicrobial Efficacy of 3M™ SoluPrep™ Preoperative Skin Preparation Against Resident Human Skin Flora on the Inguinal Region
NCT04218110
Preoperative Skin Preparation Study Following ASTM E1173 Methods to Evaluate the Antimicrobial Capabilities of Four Test Substances
NCT03861780
Pilot Evaluation of Two Test Materials With a Positive Control When Used as a Patient Preoperative Skin Preparation
100 Clinical Results associated with Chlorhexidine Gluconate/Isopropyl Alcohol
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100 Translational Medicine associated with Chlorhexidine Gluconate/Isopropyl Alcohol
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100 Patents (Medical) associated with Chlorhexidine Gluconate/Isopropyl Alcohol
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10
Literatures (Medical) associated with Chlorhexidine Gluconate/Isopropyl Alcohol01 Jun 2024Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
BD Chloraprep™ (“2 % chlorhexidine with 70 % isopropyl alcohol”) versus povidone iodine plus alcohol, for prevention of blood culture contamination at children: An investigator-initiated, open-label, single centre, randomized controlled trial
Article
Author: Şahinkaya, Şahika ; Devrim, İlker ; Kaçar, Pelin ; Yaman, Yakup ; Sözen, Ceren ; Ayhan, Fahri Yüce ; Yılmaz Çelebi, Miray ; Bayram, Süleyman Nuri ; Cem, Ela
INTRODUCTION:
One of the important problems that lower the diagnostic value of blood culture is contamination with skin organisms. The povidone-iodine, alcohol, and chlorhexidine gluconate alcohol are used for disinfection prior to blood sampling for culture.
METHODS:
The investigator-initiated, open label, single centre, randomised trial compared blood culture contamination rates between two groups of patients in which using a povidone iodine skin-preparation process with the contamination rate for using "2 % chlorhexidine with 70 % isopropyl alcohol" skin-disinfection. The patients who required sampling for blood cultures were included in the study and study period was from 15 March 2023 to 15 July 2023.
RESULTS:
A total of 400 blood cultures were obtained during the study, including 133 in the study group and 267 in the control group. In the total blood cultures, 11.75 % (n = 47) had microorganism isolation. Among them 39 (9.75 %) were contaminants and 8 (2 %) of them were true pathogens. The contaminant microorganisms were as following; 34 coagulase-negative Staphylococci, 3 Micrococcus spp, and 2 Streptococci viridans. The blood culture contamination rate in the study group was 5.3 % (n = 7) and 12.0 % (n = 32) in the control group, and significantly lower in the study group (p = 0.033). There is no significant difference regarding skin related side effects between two groups.
CONCLUSIONS:
This study, showed that 2 % chlorhexidine gluconate in 70 % isopropyl alcohol is more efficacious in children than 10 % povidone-iodine preparations for disinfecting the skin prior to blood specimen collection for prevention of blood culture contamination.
01 Jun 2023International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Reduction of adverse outcomes from cesarean section by surgical‐site infection prevention care bundles in maternity
Article
Author: Rees, Jacqui ; Thomas, James ; Fluck, David ; Wright, Ria ; Williams, Lisa ; Fry, Christopher H. ; Low, Anna ; Irukulla, Shashi ; Thompson, Anna ; Hale, Joann ; George, Richard ; Dumitrescu, Alexandra ; Erritty, Matthew ; Carr, Megan ; Han, Thang S.
Abstract:
Objective:
To reduce average surgical‐site infection (SSI) rates to less than 7.5%, as well as other complications by incrementally implementing an SSI prevention care bundle in maternity: (1) ChloraPrep; (2) PICO dressings, performing elective cesarean sections in a main theater rather than a labor ward and warming blankets; (3) vaginal cleansing; and (4) Hibiscrub.
Methods:
In this prospective cohort study, the association between categorical variables was assessed by χ2 tests, temporal trends in the monthly percentage change of SSI were measured using the Joinpoint Regression Program v4.7.0.0.
Results:
In all, 1682 women (mean age 33.1 ± 5.2 years) underwent either elective (53.9%) or emergency (46.1%) cesarean section. After a small initial increase (10.0%–11.8%), SSI progressively declined to 4.4% (χ2 = 22.1, P < 0.001), as did sepsis, reoperation or readmission for SSI: from 12.5% to 0.5% (χ2 = 90.1, P < 0.001). The rates of SSI fell progressively with the cumulative introduction care bundle components. The average monthly percentage change was −14.0% (95% confidence interval −21.8% to −5.4%, P = 0.004), and the average SSI rate was kept below 7.5% for the last 12 months of the study.
Conclusion:
The maternal SSI prevention care bundle is simple and inexpensive; it effectively reduces SSI after a cesarean section and should be offered routinely to women undergoing cesarean section.
01 Oct 2022Orthopaedics & traumatology, surgery & research : OTSR
Surgical solutions for preoperative skin preparation in total hip arthroplasty: A cost-effectiveness analysis of Betadine® and Chloraprep™
Article
Author: Ollat, Didier ; Zadegan, Frédéric ; Terracher, Richard ; Rougereau, Grégoire ; Chatelain, Léonard
OBJECTIVE:
The purpose of our study was to compare the cost of surgical site skin preparation using ChloraPrep™ (2% chlorhexidine gluconate [CHG] and 70% isopropyl alcohol [IPA]) with skin cleansing using Betadine® Surgical Scrub and Betadine® 5% solution (povidone-iodine [PVI]) in total hip arthroplasty (THA).
HYPOTHESIS:
The hypothesis was that the ChloraPrep™ skin disinfection protocol reduces the cost of perioperative antisepsis.
METHODS:
A prospective database was created for all THAs performed at our university hospital between November 1st, 2020, and December 31st, 2020. Each surgeon was randomly assigned one type of antiseptic prior to the start of the study: one surgeon to the ChloraPrep™ group and one to the Betadine® group. In both groups, the enrollment stopped at the 15th patient. The costs related to consumables, waste disposal, and operating room occupancy time of each protocol were then assessed for each patient.
RESULTS:
The mean duration of the ChloraPrep™ protocol was 3.5±0.3minutes compared to 13.5±0.9minutes for the Betadine® protocol. The overall cost of a surgical site skin preparation involving all three steps was on average €46.8±4.2 for the ChloraPrep™ group compared to €155±10.9 for the Betadine® group (p<0.0001).
DISCUSSION:
Not only is the effectiveness of ChloraPrep™ already recognized but it also appears to have health economic benefits. However, further studies are needed to confirm this finding.
LEVEL OF EVIDENCE:
III, case control study.
100 Deals associated with Chlorhexidine Gluconate/Isopropyl Alcohol
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
R&D Status
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Disinfectants | Australia | 26 Feb 2007 | |
| Skin Diseases, Bacterial | United States | 14 Jul 2000 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 3 | - | 154 | (CHG/IPA Surgical Skin Preparation) | gtxlyjszkd(kaudoablwy) = ixnwbmdbfb vyokwfasuz (nwfhzuxtgh, 0.816) View more | - | 01 Aug 2023 | |
(Normal Saline) | gtxlyjszkd(kaudoablwy) = rvpwlgqmqr vyokwfasuz (nwfhzuxtgh, 0.411) View more | ||||||
Phase 2 | - | 28 | (3M CHG/IPA Prep / Center) | xxsfpjblze(eybiogmjon) = bkrjtvupfs lrwxlohbzn (anwejxvdjl, 1.31) View more | - | 27 Jun 2023 | |
(3M CHG/IPA Prep / Mid-peripheral) | nksflcqnsk = vgeeqgonfc rvmkyckrbc (rugxskfuvd, ofvfcgdyiw - fzcbgbyjif) View more | ||||||
Phase 3 | 329 | (Project X 26ml) | advqmaixpl(gwifhgkqqs) = drnfmulfba pfdekatnsa (zdsnyiragz, 1.58) View more | - | 22 Oct 2021 | ||
(Project X 10.5ml) | advqmaixpl(gwifhgkqqs) = iopboaqgun pfdekatnsa (zdsnyiragz, 1.48) View more | ||||||
Phase 3 | - | 170 | (Project X 26ml) | kxmxqsfgeq(zqzcjqnezs) = alvjtygcww pleuqxvukn (hkzdkofdls, 1.42) View more | - | 22 Oct 2021 | |
(Project X 5.1ml) | kxmxqsfgeq(zqzcjqnezs) = nuilzlppgh pleuqxvukn (hkzdkofdls, 1.56) View more | ||||||
Phase 3 | - | 152 | (Project X 26ml) | edthixougf(xsghdcppvu) = izjekpblzy rmqdiprffw (poriypnbcx, 1.4) View more | - | 22 Oct 2021 | |
(Project X 5.1ml) | edthixougf(xsghdcppvu) = imifbfcufw rmqdiprffw (poriypnbcx, 1.3) View more | ||||||
Phase 4 | - | 20 | Chlorhexidine (Chlorhexidine Group) | jaenwpgsex = rxfchnlzhl lfjdaskuin (vmqrkfbehc, hxgkbisgqh - rshariezor) View more | - | 10 Jul 2013 | |
Iodophor+Iodine+IPA (Iodine Group) | jaenwpgsex = evxhnzmngl lfjdaskuin (vmqrkfbehc, kikkapowex - qhxuswbcnm) View more |
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