The purpose of this study is to test whether using belladonna & opiate suppositories (B&Os) can improve patient discomfort during Onabotulinumtoxin A (BoNT) injection into the bladder for treatment of overactive bladder, neurogenic detrusor overactivity, or interstitial cystitis.

Start Date01 Nov 2015

Sponsor / Collaborator

University of Kansas

100 Clinical Results associated with Atropa belladonna extract

100 Translational Medicine associated with Atropa belladonna extract

100 Patents (Medical) associated with Atropa belladonna extract

273

Literatures (Medical) associated with Atropa belladonna extract

01 Dec 2023·Brain and nerve = Shinkei kenkyu no shinpo

[Belladonna (Atropine), in The Labours of Hercules].

Article

Author: Furuya, Hirokazu

The Labours of Hercules, written by Agatha Christie, contains twelve short stories, with 'atropine' playing a crucial role in the seventh story, The Cretan Bull (1939). Atropine easily crosses the blood-brain barrier (BBB), leading to central nervous system (CNS) side effects such as delirium, hallucinations, disorientation, memory problems, coma or stupor, and convulsive seizures when overdosed. In this episode, a concentrated form of atropine obtained from prescribed eye drops was misused to induce a hereditary incurable neurodegenerative disorder, similar to Huntington's Chorea, in the client's fiancée. However, Mr. Poirot discerned this by careful examination of his symptoms and resolved the case.

01 Oct 2023·Archives of Virology

Viral inhibitory potential of hyoscyamine in Japanese encephalitis virus–infected embryonated chicken eggs involving multiple signaling pathways

Article

Author: Bhattacharjee, Arghyadeep ; Pal, Abhishek ; Naga, Rahul ; Saha, Manish ; Roy, Souvik ; Karmakar, Srabani

Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis worldwide. The emergence of new genotypes of the virus and a high rate of mutation make it necessary to develop alternative treatment strategies against this deadly pathogen. Although the antiviral properties of Atropa belladonna and some of its active components, such as atropine and scopolamine, have been studied, the effect of another important component, hyoscyamine, against JEV infection has not yet been investigated. In this study, we investigated the antiviral effect of hyoscyamine against JEV and its immunomodulatory activity in embryonated chicken eggs. Pretreatment with hyoscyamine sulphate resulted in a significant decrease in the viral load in both chorioallantoic membrane (CAM) and brain tissues at 48 and 96 hours postinfection. In silico studies showed stable binding and interaction between hyoscyamine and non-structural protein 5 (NS5), suggesting that this could be the basis of its antiviral effect. Embryonated eggs pretreated with hyoscyamine sulphate showed upregulation of Toll-like receptor 3 (TLR3), TLR7, TLR8, interleukin 4 (IL-4), and IL-10 as well as interferons and regulatory factors. Hyoscyamine sulphate was also found to cause significant downregulation of TLR4. The potential use of hyoscyamine for controlling JEV replication and its dissemination to the brain suggest that it may be a promising therapy option against JEV in the future.

03 Jul 2023·Biotechnology and Genetic Engineering Reviews

Antiviral and anti-inflammatory activity of novel belladonna formulation against Japanese encephalitis virus via inhibition of p65 nuclear translocation and TNF-α mediated NF-kB signaling

Article

Author: Gadugu, Srinivasulu ; Saxena, Shailendra K ; Manchanda, Raj K ; Maurya, Vimal K ; Kaushik, Subhash ; Nayak, Debadatta ; Kumar, Swatantra

Japanese encephalitis (JE) is a mosquito-borne flavivirus infection, a major cause of viral encephalitis in South-East Asia with a CFR of ~30% and no specific treatment. Therefore, a novel belladonna formulation (BCT) was prepared and its antiviral and anti-inflammatory activity was elucidated during Japanese encephalitis virus (JEV) infection. Anti-JEV role of BCT was investigated aiming to prevent the infection in the peripheral immune cells. Antiviral activity of BCT was evaluated by plaque reduction assay, cell survival and apoptosis assay. BCT-mediated reduction in JEV-envelope expression was measured by indirect immunofluorescence, RT-PCR and Western blot assays. NF-κB expression and p65 nuclear translocation assays were determined to explore the mechanism of the action of BCT. TNF-α level was measured to evaluate the anti-inflammatory role of BCT during JEV infection. Consequently, molecular docking was performed with the TRAF2-TRADD complex. Our data suggested that BCT treatment reduces the JEV-plaque formation, JEV-induced cytopathic effects and increases cell survival. The antiviral effect of BCT was confirmed by reduction in the JEV-envelope protein expression. Moreover, BCT treatment and prevents the NF-κB activation via preventing the nuclear translocation of p65 and reduces the TNF-α levels. Our molecular docking analysis suggested that belladonna alkaloids interfere with the TRAF2-TRADD complex that results in inhibition of TNF-induced NF-κB signaling. For the first time, our data suggested that BCT reduces JEV expression and interferes with TNF-induced NF-κB signaling, thereby increasing cell survival via preventing the p65 nuclear translocation and may be used for the treatment and prevention of JE.Abbreviation: CFR: Case fatality rate; CAM: Complementary and alternative medicines; COX-2: Cyclooxygenase-2; IκB: Inhibitor kappa B; JE: Japanese encephalitis; JEV: Japanese encephalitis virus; NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells; ORF: Open reading frame; TNFR: Tumor necrosis factor receptor; TNF-α: Tumor necrosis factor-α; TRADD: TNFR1-associated death domain protein; TRAF2: TNF Receptor Associated Factor 2.

100 Deals associated with Atropa belladonna extract

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Duodenal Ulcer	CN	-	-
gastrointestinal colic	CN	-	-
Renal Colic	CN	-	-
Smooth muscle spasm	CN	-	-
Stomach Ulcer	CN	-	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02600715 (ROBIN, CTgov)	Phase 4	Urinary Bladder, Neurogenic \| Cystitis, Interstitial \| Bladder pain \| Urinary Incontinence, Urge \| Urinary Bladder, Overactive	26	Active B&O suppository of belladonna+belladonna+morphine (Active B&O Suppository of Belladonna)	diviukdwvp(lgwxkmcfzj) = bddeeadoht dcyimfuzoo (qjwdowdlbv, aihdyysvzr - ikcgksfvpn) View more	-	20 Sep 2018
				Onabotulinumtoxin A (BoNT) (Placebo Suppository)	diviukdwvp(lgwxkmcfzj) = vgifsfnqqr dcyimfuzoo (qjwdowdlbv, qgthprzytp - xolvalxwwm) View more

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Atropa belladonna extract

Overview

Basic Info

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation