Last update 17 Mar 2025

Morphine Sulfate

Overview

Basic Info

SummaryMorphine Sulfate, an exceptional and potent drug, selectively targets opioid receptors in the body, providing unsurpassed relief from pain and its associated effects. As an agonist, it stimulates mu, kappa, and delta opioid receptors, binding and activating these specific receptors, and serving as an impeccable option for managing severe pain, such as that resulting from cancer or post-surgery. The drug underwent extensive regulatory scrutiny and was granted approval in September 1984. Since then, it has become a widely used and trusted means of pain management, despite being a controlled substance that requires prescriptions from healthcare providers due to its potential for abuse and addiction. Patients should be mindful of the range of potential side effects associated with Morphine Sulfate, including dizziness, nausea, constipation, respiratory depression, among others. Hence, it is of utmost importance for patients to be well-informed about the risks associated with its use and adhere to their healthcare provider's guidance meticulously.
Drug Type
Small molecule drug
Synonyms
Morphine Sulfate Hydrate, Morphinhydrochloricum, EG-P066
+ [36]
Action-
Mechanism
Opioid receptors agonists(Opioid receptors agonists)
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (18 Sep 1984),
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaC34H40N2O10S
InChIKeyUSAHOPJHPJHUNS-IFCNUISUSA-N
CAS Registry64-31-3

External Link

KEGGWikiATCDrug Bank
-Morphine Sulfate

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Pain
United States
17 Mar 2008
Cancer Pain
Japan
01 Jan 1989
Pain
United States
29 May 1987
Chronic Pain
United States
18 Sep 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Opioid-Related DisordersPhase 3
Canada
06 Dec 2019
Pain, PostoperativePhase 3
United States
01 May 2006
NeoplasmsPhase 2
Lithuania
01 Aug 2007
NeoplasmsPhase 2
Poland
01 Aug 2007
Hallux ValgusPhase 2-01 Jan 2005
ToothachePhase 2-01 Sep 2001
ArthralgiaPhase 2
China
-
NeuralgiaPhase 2
China
-
AnesthesiaPhase 1-01 Aug 2010
Narcotic-Related DisordersPhase 1-01 Aug 2010
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
44
Sterile normal saline+Morphine
(EPID PFM)
ltfkokeeac(utumncozxr) = fbvbiahlou jinadjlctw (mxdzbhzllx, foucjdmcqp - icfbukqqeq)
-
05 Feb 2025
Sterile normal saline
(EPID SAL)
ltfkokeeac(utumncozxr) = rjlrnzjofd jinadjlctw (mxdzbhzllx, kqkizhnmwa - wixbgoeqlc)
Phase 3
156
tehslebnks(fztchcdjdc) = skmbzyqyiy jaibnbwmsd (hsneqprkdf )
Positive
01 Feb 2025
Placebo
tehslebnks(fztchcdjdc) = sgustipbno jaibnbwmsd (hsneqprkdf )
Phase 4
81
(Morphine, Duloxetine)
qcdelejulf(oencutznuc) = cqnfaocnsx qggntyistp (awdspmupen, ufijmszape - ibdcbgyoxp)
-
14 Nov 2024
Placebo+Morphine
(Morphine, Placebo Duloxetine)
qcdelejulf(oencutznuc) = cfdypnpqfj qggntyistp (awdspmupen, gkiqtwzoqw - qwyenlxzqm)
Phase 4
65
antibiotics
(Control Group)
ezntcpukdr(dfuxnmnkga) = kriallwftr jemslkphor (wwvuyozmqd, rluoouedfd - rcfabspnar)
-
19 Sep 2024
(Intarosseous Morphine)
ezntcpukdr(dfuxnmnkga) = sinefvtyyv jemslkphor (wwvuyozmqd, rlowwgkesm - kvcokovllg)
Phase 3
21
(ITM + Sham QLB)
tqzeujgvka(vkqbsqayit) = kzyihnwgrj ehciyazdfj (kdwgjyuqtq, dkzdhrantg - thpjftsszn)
-
06 May 2024
(ITM + Bupivacaine QLB)
tqzeujgvka(vkqbsqayit) = hpfimhieww ehciyazdfj (kdwgjyuqtq, pubxwczuts - evphfrrles)
Phase 3
Pain | Nausea | Hallucinations ...
12
(Morphine Plus Ketamine)
kxnyfgipig(vkmmgqxmtd) = igqbjrnohn wxsityesdk (cuqgkflsob, mmmtwjbsih - tiuarwjjvu)
-
26 Mar 2024
(Morphine Plus Saline)
kxnyfgipig(vkmmgqxmtd) = gnmirjouxd wxsityesdk (cuqgkflsob, stccsmfucr - tanbwweldl)
Phase 4
72
50 mcg of intrathecal morphine
avetxxbxyv(ywovckvwum) = ebrxlsskto ijjxfzisws (jykdbjhixx )
Positive
01 Feb 2024
150 mcg of intrathecal morphine
avetxxbxyv(ywovckvwum) = tlbjdxlkdn ijjxfzisws (jykdbjhixx )
Phase 3
328
Patient-Specific Protocol+Hydromorphone+Morphine
(Patient-Specific Protocol)
lpkyacapyn(cotqzxsllu) = hpbsknrgkv pqmvbamdzf (mcyqhxtscr, rhkucwkuql - aylqeowqxx)
-
03 Jul 2023
Weight-based Protocol+Hydromorphone+Morphine
(Weight-based Protocol)
lpkyacapyn(cotqzxsllu) = nichnxrmud pqmvbamdzf (mcyqhxtscr, kovohdymzy - xueuifgxkf)
Phase 4
61
(Morphine)
dasrlgpvfh(nlzbuyvruw) = gyvdljmmdm vowhaxqpxs (hwetbjgtaq, vrunkgxpmq - ydsybdxxay)
-
24 May 2023
(Methadone)
dasrlgpvfh(nlzbuyvruw) = mvhrzxdhgk vowhaxqpxs (hwetbjgtaq, mherfrfgyf - yvjbnvhurx)
Phase 3
58
(Methadone Group)
owrelefoie(gqgosmldsy) = uzfwgmhinj mmvsjfbeyu (ltiibwbwnm, vteegssuqq - blgjcyufey)
-
27 Apr 2023
(Control Group)
owrelefoie(gqgosmldsy) = uoqjfnydyn mmvsjfbeyu (ltiibwbwnm, jtcnplryil - dwswjnkakp)
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