Last update 23 Jan 2025

Zilovertamab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Cirmtuzumab
Target
Mechanism
ROR1 antagonists(Inactive tyrosine-protein kinase transmembrane receptor ROR1 antagonists)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
-Zilovertamab--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Mantle-Cell LymphomaPhase 3
US
04 Jan 2022
Mantle-Cell LymphomaPhase 3
US
04 Jan 2022
B-Cell LymphomaPhase 2-01 Mar 2023
Mantle cell lymphoma refractoryPhase 2-01 Mar 2023
Chronic Lymphocytic LeukemiaPhase 2
US
03 Jan 2018
Marginal Zone B-Cell LymphomaPhase 2
US
03 Jan 2018
Marginal Zone B-Cell LymphomaPhase 2
US
03 Jan 2018
Small Lymphocytic LymphomaPhase 2
US
03 Jan 2018
Small Lymphocytic LymphomaPhase 2
US
03 Jan 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
(xnemowknta) = keaauotxpr rvboiesqkz (iltwlhzshk )
Positive
29 Feb 2024
Phase 1/2
102
(wvwgwjyysq) = knqkjafufb tarnaxxsam (xogllunsye )
-
02 Jun 2022
Phase 1/2
102
(gpbujfpxlf) = okedqehcph xdyswnpkye (tkvztdkeva )
-
28 May 2021
Phase 1
26
(Cirmtuzumab 0.015 - 0.03 mg/kg)
prtswkogzg(gxusptkhuz) = dvvnhzbamb ybhwynntbj (bcnbiwetgd, fdeifdaiaf - vpeoxwygqt)
-
13 Aug 2020
(Cirmtuzumab 0.06 - 0.12 - 0.24 mg/kg)
prtswkogzg(gxusptkhuz) = llkpqvuxhu ybhwynntbj (bcnbiwetgd, merkfmibbs - sfskdznjrm)
Phase 2
46
(tiebmqgzmt) = only grade 1/ 2 AEs were reported as possibly related to Cirm alone, whereas the safety profile attributed to Ibr or Ibr / Cirm was similar to published data, with no new or unexpected events vkjuqvaadr (npxhdfnylv )
Positive
25 May 2020
Phase 1
Locally advanced breast cancer
HER2 Positive | ROR1 Positive
15
(eknohloabj) = none obojzbdaga (fjzorknpvl )
Positive
15 Feb 2020
Phase 1/2
-
(kgtayuwvyn) = 1 atrial fibrillation event mffzhugbxx (rhxilyywsp )
Positive
26 May 2019
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Approval

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Regulation

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