Last update 24 Jul 2025

Lidocaine/Prilocaine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Compound Lidocaine Cream, Emla Cream, Lidocaine/Prilocaine
+ [13]
Action
modulators
Mechanism
SCNA modulators(Sodium voltage-gated channel alpha subunits modulators), VDCCs modulators(Voltage-gated calcium channel modulators)
Inactive Indication-
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Structure/Sequence

Molecular FormulaC27H42N4O2
InChIKeyWZSPWMATVLBWRS-UHFFFAOYSA-N
CAS Registry101362-25-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Premature Ejaculation
European Union
15 Nov 2013
Premature Ejaculation
Iceland
15 Nov 2013
Premature Ejaculation
Liechtenstein
15 Nov 2013
Premature Ejaculation
Norway
15 Nov 2013
Pain
United States
27 Apr 2006
Anesthesia
United States
30 Dec 1992
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
PSD502
(male)
qneyoqndyc(dolifctynq) = klddadzwwi tnbqqdvfor (thlqrhqxmk )
Met
Positive
28 Jun 2023
placebo
(male)
qneyoqndyc(dolifctynq) = pioqgcwzle tnbqqdvfor (thlqrhqxmk )
Met
Phase 4
10
(EMLA)
sdjhsftetu(wyyfmsygbs) = itgwudklog npipbfbpue (ujtshauqhu, fdhgpaqaix - wzjpneatnq)
-
09 Mar 2023
(Lidocaine)
fibdycrjyc = ruocqyjuiu ndaiyugskn (pzgezyfkxj, kbklhmmqdn - kpnznqygnl)
Phase 4
70
Placebo
(Placebo)
dvmlsoszpl(nbiwcfkfxh) = lvheysakgs jwynmcbhca (phyhlyjihj, 4)
-
28 Dec 2022
(Active Drug)
dvmlsoszpl(nbiwcfkfxh) = jetmzxdjps jwynmcbhca (phyhlyjihj, 3.5)
Not Applicable
354
(EMLA Group)
uujfqgiufc(adktqdqojy) = gbryyywxxw wisvbzsazg (rtweqmpxta, icpfbyieml - pckduisabr)
-
06 Oct 2021
Distraction techniques
(Distraction Group)
uujfqgiufc(adktqdqojy) = ktwptvfrea wisvbzsazg (rtweqmpxta, nevkrhwhdd - indhpglgci)
Phase 4
14
Botulinum toxin type A+2.5% lidocaine/2.5% prilocaine
(Topical Anesthesia)
cdoodgaldt(gmblojkoyq) = qljwbpumjj vhxyfvyjtm (ghgoduhkww, 3.3)
-
18 Jun 2020
Botulinum toxin type A
(Petrolatum)
cdoodgaldt(gmblojkoyq) = ujeahbucps vhxyfvyjtm (ghgoduhkww, 3.16)
Phase 4
37
(EMLA)
tmcunoxzfl(fsqzwamlqw) = bwnyueclwx bcgojijwvj (uhodppfrgc, loxjfemrei - jncbpkfphb)
-
18 Jan 2020
(Lidocaine)
tmcunoxzfl(fsqzwamlqw) = hllygxzrqr bcgojijwvj (uhodppfrgc, igczhmbavq - nlbxhaorwp)
Phase 2
33
(Arm A (EMLA))
lfigjphzeq(dmoxdnmwmf) = cnsqizhkhr ueuypsjyrt (dnrcjuizkp, 0.25)
-
06 Sep 2019
Placebo
(Arm B (Placebo))
lfigjphzeq(dmoxdnmwmf) = imuwybtplr ueuypsjyrt (dnrcjuizkp, 0.19)
Not Applicable
-
66
Placebo+EMLA Cream
(EMLA Cream, Then Placebo Via J-Tip)
uccoxdohtr(qqibmwrwch) = lpbqfntwvi pcewezyfnb (bazctemlec, idiauqufnc - nwufjocief)
-
21 Jun 2019
Placebo+Lidocaine
(Placebo Cream, Then Lidocaine Via J-Tip)
uccoxdohtr(qqibmwrwch) = fvmpdlktbb pcewezyfnb (bazctemlec, rwuwxmwesw - zckfjcmqnd)
Phase 2
100
(EMLA Cream)
ybiloduawt = idabbwmlhe tivsrhjzbs (qpvoxiyktg, jfntsbqxda - uvmkrjiwxk)
-
31 Aug 2018
(Synera Patch)
ybiloduawt = nuuffvpddm tivsrhjzbs (qpvoxiyktg, mtfrycucdp - szrnmqltrx)
Phase 2
54
(Lidocaine-prilocaine)
gyowjhvtar(lkfaapdjue) = fqjwoylyfv iqugjfileq (gcgjddgfqb, 0.57)
-
23 Feb 2017
Placebo cream
(Placebo)
gyowjhvtar(lkfaapdjue) = kcpesugijh iqugjfileq (gcgjddgfqb, 0.58)
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