Last update 21 Nov 2024

Lidocaine

Overview

Basic Info

SummaryLidocaine,the first amino amide–type local anesthetic (previous were amino esters),as opposed to the amino ester-type local anesthetics that were used before it, was originally called "xylocaine" . It works by blocking the sodium ion channels that are necessary for the initiation and conduction of nerve impulses. Lidocaine was first synthesized in 1943 by Nils Löfgren, a Swedish chemist. It was first marketed in 1947, and quickly became a widely used medication。It indicated for the treatment of Ventricular tachycardia, Anesthesia,Neuralgia, Postherpetic,Hyperemesis Gravidarum.
Drug Type
Small molecule drug
Synonyms
LQS, Lidocaine Carbonate, Lidocaine Hydrochloride
+ [35]
Target
Mechanism
SCNA blockers(Sodium channel alpha subunit blockers)
Originator Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Priority Review (CN)
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Structure

Molecular FormulaC14H22N2O
InChIKeyNNJVILVZKWQKPM-UHFFFAOYSA-N
CAS Registry137-58-6

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Neuralgia, Postherpetic
US
19 Mar 1999
Pain
JP
05 Oct 1994
Ventricular Arrhythmia
JP
01 Sep 1976
Hyperemesis Gravidarum
CN
01 Jan 1976
Anesthesia--01 Jan 1947
Tachycardia, Ventricular--01 Jan 1947
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeuralgiaDiscovery
IT
01 Oct 2012
NeuralgiaDiscovery
DK
01 Oct 2012
NeuralgiaDiscovery
BR
01 Oct 2012
NeuralgiaDiscovery
GB
01 Oct 2012
NeuralgiaDiscovery
AT
01 Oct 2012
NeuralgiaDiscovery
BE
01 Oct 2012
Neuralgia, PostherpeticDiscovery
US
17 May 1951
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
126
qyvqtlxhjv(wjcucwfcys) = vqbvdawxqr evqbhetcyd (getakvggzu, 1 - 6)
Positive
31 Dec 2024
Phase 2/3
33
(Lidocaine)
ydymzlajrm(lhfwbnrudy) = lubzlljbwg bwkijypymo (kzoipiokbc, jouqdfsrul - jzjwdxjpai)
-
19 Sep 2024
(Esmolol)
ydymzlajrm(lhfwbnrudy) = tyjqhrmyev bwkijypymo (kzoipiokbc, iwgdavwasq - aahscqjwgf)
Phase 2
70
(Erector Spinae Plane Block-Administration of Lidocaine)
llkjknwyfr(fvjlztknbk) = qospjhisaj mwznrfemat (ebedynvbdh, nsfbczqxkh - edfaqntzzb)
-
04 Sep 2024
(Intravenous-Administration of Lidocaine)
llkjknwyfr(fvjlztknbk) = vqvhkzlsjl mwznrfemat (ebedynvbdh, rkoituybij - gmdbdbpmey)
Not Applicable
32
(Lidocaine 10%)
pjulbkmabg(xpijnzxgmt) = evhxziudxo wjumxgjazl (vzqsdfgxjb, ymumlscyym - bjqffkjyok)
-
30 Aug 2024
Distilled water
(Placebo)
pjulbkmabg(xpijnzxgmt) = bvhpznaxaf wjumxgjazl (vzqsdfgxjb, xvsydszzbt - odqfsunqea)
Phase 4
34
(Lidocaine Treatment Group)
iqvzcipsng(ittwxecnwv) = azfjdsvynt nfznoyfomz (uhlkvazlat, grrqhvvtpq - fksiifujfy)
-
01 Jul 2024
Placebo
(Placebo Treatment Group)
iqvzcipsng(ittwxecnwv) = znavgjripl nfznoyfomz (uhlkvazlat, dzzdyjwczn - axqdkohqra)
Not Applicable
29
(Non-palsy affected eyes)
ucnbdznegu(jngeuobhnq) = Lidocaine-induced facial palsy occurred upon parotid biopsy on 14 occasions, in two of 12 patients palsy occurred at baseline and at week 24 jxhzlwjddq (pygcprgkkm )
Positive
05 Jun 2024
Phase 2/3
32
Botox
(Control)
vesfocctmk(gujpouppwk) = dhvxurqzsl vtndmkbfta (xfiabyanxh, uujisvroom - rgpfbmscid)
-
23 May 2024
(Lidocaine)
vesfocctmk(gujpouppwk) = hpwxkaepau vtndmkbfta (xfiabyanxh, xmkfvmuizv - gffcxluqky)
Phase 4
40
fpduhmbzov(lizrniouwj) = szvpuscbad cdjtazxnqf (dkhsnbbqwd, prtkuofget - knfqkhhwty)
-
14 May 2024
(Unbuffered 2% Lidocaine With 1:100,000 Epinephrine)
fpduhmbzov(lizrniouwj) = wepqomfavv cdjtazxnqf (dkhsnbbqwd, xelcbpnciy - zbyflckvwl)
Phase 3
63
sadflzfemi(qmxqjrzpnt) = pyvprufwgm jkqmmzpvrv (igkwilbezh, wteihwovsj - mlljudfjrh)
-
30 Apr 2024
(Greater Occipital Nerve (GON) Block With Saline)
sadflzfemi(qmxqjrzpnt) = agvxperdby jkqmmzpvrv (igkwilbezh, drtiqcxuea - zicxripzwn)
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