The two main aims of this clinical study is;
1. To investigate if the results from a series of physiological tests and questionnaires prior to treatment, can be used to predict the treatment response to obesity medication
2. To investigate the effect of combining semaglutide and pramlintide on various aspects of appetite, food preference and eating habits.
The study is planed as a 26 week, double blinded, randomized, placebo controlled trial. The goal is to include N=40. They will all receive weekly semaglutide injections. After 24 weeks they will be randomized to receive either an amylin analog (pramlintide) or placebo as a continuous infusion for two weeks, in addition to weekly semaglutide.
The results from this study will contribute to identifying possible predictors of treatment response, enabling optimal individualized medical weight loss treatment. As well as providing knowledge on the complex interplay between incretin hormones and their effects on appetite and eating habits.

Start Date01 Oct 2024

Sponsor / Collaborator-

NCT06186063 / RecruitingNot ApplicableIIT

The Role of Amylin in Bone Metabolism

The clinical study aims to investigate the effect of the intravenously administrated amylin analogue (pramlintide) on the circulating levels of C-terminal telopeptide of type I collagen (CTX-1) (a marker of bone resorption) and N-terminal propeptide of type I procollagen (P1NP) (a marker of bone formation) in individuals with type 1 diabetes and matched healthy controls during fasting euglycemic conditions.

Start Date12 Feb 2024

Sponsor / Collaborator-

NCT06046417 / RecruitingPhase 2/3IIT

A Randomized, Controlled, Crossover Trial to Assess a Fully Automated, Dual-hormone (Insulin-and-pramlintide) Delivery System Without Carbohydrate Counting in Regulating Glucose Levels in Adults With Type 1 Diabetes.

The aim of this clinical trial is to investigate whether a fully automated Lyumjev-and-pramlintide delivery system improves glycemic outcomes in adults with type 1 diabetes. The main question we aim to answer is whether a Lyumjev-pramlintide fully closed loop system improves time in range compared to a hybrid closed loop system with carbohydrate counting. We also aim to find the optimal insulin to pramlintide ratio for glycemic control in the fully automated system.
In this cross-over study, patients will undergo the following three interventions in a random order:
(i) fully automated Lyumjev insulin-and-pramlintide (8 μg/u) (ii) fully automated Lyumjev insulin-and-pramlintide (10 μg/u) (iii) rapid automated Lyumjev insulin-and-placebo with carbohydrate-matched boluses
For all interventions, participants will be required to wear two Ypsomed pumps programmed by our developed EuGlide system.

Start Date30 Nov 2023

Sponsor / Collaborator

Mcgill University Health Centre

[+1]

100 Clinical Results associated with Pramlintide Acetate

100 Translational Medicine associated with Pramlintide Acetate

100 Patents (Medical) associated with Pramlintide Acetate

404

Literatures (Medical) associated with Pramlintide Acetate

01 Dec 2024·ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Development of the novel amylin and calcitonin receptor activators by peptide mutagenesis

Article

Author: Lee, Sangmin

The amylin peptide hormone receptor is the complex of the calcitonin peptide hormone receptor and an accessory protein. The calcitonin receptor activation controls calcium homeostasis, while it also functions as the main component of the amylin receptor. Amylin receptor activation in brains controls blood glucose and appetite. Currently, non-selective amylin and calcitonin receptor activators have been tested for body weight reduction to treat obesity. Here, multiple peptide activators for human amylin and calcitonin receptors were developed by introducing comprehensive mutagenesis to rat amylin peptide. The rat amylin peptide C-terminal fragment that interacts with amylin receptor extracellular domain was used to screen for affinity-enhancing mutations. Up to twelve mutational combinations were found to significantly increase peptide affinity both for amylin and calcitonin receptor extracellular domains by over 100-fold. Using these affinity-enhancing mutations, three representative rat amylin analogs with thirty-seven amino acids were made to test the potency increase for amylin and calcitonin receptor activation. All three mutated rat amylin analogs showed significant potency increases by 5- to 10-fold compared to endogenous rat amylin. These mutated peptide activators also showed higher potency for human amylin and calcitonin receptor activation than a clinically available amylin receptor activator pramlintide. These amylin and calcitonin receptor activators developed in this study may be useful as the valuable pharmacological tools that activate amylin receptors in cell-based systems.

01 Dec 2024·INTERNATIONAL JOURNAL OF PHARMACEUTICS

A microfluidic in vitro method predicting the fate of peptide drugs after subcutaneous administration

Article

Author: Wanselius, Marcus ; Abrahmsén-Alami, Susanna ; Hanafy, Belal I. ; Hansson, Per ; Mazza, Mariarosa ; Hanafy, Belal I

For many biopharmaceuticals, subcutaneous (sc) administration is the only viable route. However, there is no in vitro method available accurately predicting the absorption profiles of subcutaneously injected pharmaceuticals. In this work, we show that a recently developed microfluidics method for interaction studies (MIS) has the potential to be useful in this respect. The method utilises the responsiveness of polyelectrolyte microgel networks to oppositely charged molecules as a means to monitor the interaction between peptides and hyaluronic acid (HA), a major constituent of the subcutaneous extracellular matrix. We use the method to determine parameters describing the strength of interaction between peptide and HA as well as the peptide's aggregation tendency and transport properties in HA networks. The results from MIS studies of the peptide drugs exenatide, pramlintide, vancomycin, polymyxin B, lanreotide, MEDI7219 and AZD2820 are compared with results from measurements with the commercially available SCISSOR system and in vivo absorption and bioavailability data from the literature. We show that both MIS and SCISSOR reveal differences in the peptides' diffusivity and tendency to aggregate in the presence of HA. We show that MIS is particularly good at discriminating between peptides forming aggregates stabilised by non-electrostatic forces in the presence of HA, and peptides forming complexes stabilised by electrostatic interactions with HA. The method provides two parameters that can be used to quantify the peptides' aggregation tendency, the one describing the peptide packing density in complexes with HA and the other the apparent diffusivity upon release in a medium of physiological ionic strength and pH. The order of the peptides when ranked by increasing binding strength at pH 7.4 determined with MIS is shown to be in agreement with the order when ranked by the apparent 1st order absorption rate constant (k_a) after sc administration in humans: lanreotide (Autogel) < exenatide (IRF) < AZD2820 < pramlintide < lanreotide (IRF) (IRF: Immediate release formulation). A correlation is found between the 1st order release rate constant determined with SCISSOR and k_a for lanreotide (Autogel), exenatide and AZD2820. A mechanism relating the magnitude of k_a to the peptides' charge is proposed.

01 Nov 2024·INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Intranasal administration of dextran-pramlintide polyelectrolyte complex-coated nanoemulsions improves cognitive impairments in a mouse model of Alzheimer's disease

Article

Author: Lemos-Senna, Elenara ; França, Angela P ; Zuglianello, Carine ; França, Angela P. ; Prediger, Rui D. ; Agnes, Jonathan P. ; de Souza, Bruna S. ; Prediger, Rui D ; de Souza, Bruna S ; Agnes, Jonathan P

Nasal delivery has emerged as a non-invasive route to administer drugs for brain delivery. In particular, polyelectrolyte complexes-based nanocarriers have been demonstrated to be advantageous for nasal delivery of peptide drugs and vaccines. Pramlintide (Pram) is a peptide that emerges as a novel neuroprotective strategy to modify the pathogenesis of Alzheimer's disease (AD). In this study, we examined the effects of the intranasal administration of dextran-pramlintide polyelectrolyte complex-coated nanoemulsions (PEC-NE_DexS/Pram) in an experimental model of AD induced by intracerebroventricular (i.c.v.) infusion of amyloid-beta (Aβ₁_-₄₂) peptide in mice. PEC-NE_DexS/Pram displayed droplet size lower than 200 nm and a negatively charged surface. The locomotor activity of the animals was not affected by the i.c.v. Aβ₁_-₄₂ injection or Pram treatment. On the other hand, the intranasal administration of PEC-NE_DexS/Pram at a dose of 100 μg/day for 14 consecutive days restored the impairment induced by Aβ₁_-₄₂ injection in the discriminative learning and the short-term spatial reference memory of mice. However, Pram treatment did not alter the Aβ₁_-₄₂-induced anhedonic behavior, oxidative stress parameters, or the pre-synaptic SNAP-25 and post-synaptic PSD-95 levels in the hippocampus and prefrontal cortex. These findings indicate cognitive-enhancing properties of intranasal Pram administration in an animal model of AD.

News (Medical) associated with Pramlintide Acetate

21 Nov 2024

·www.businesswire.com

Versant Ventures Unveils Pep2Tango Therapeutics Inc.

POTOMAC, Md.--( BUSINESS WIRE )--Versant Ventures today announced the debut of Pep2Tango Therapeutics Inc., a startup focused on innovative, next-generation weight loss therapies. Proceeds from the significant, undisclosed round will support development of the company’s novel unimolecular tetra-receptor agonist peptides to treat obesity and related conditions. GLP-1-based therapies have proven efficacy in treating obesity and associated co-morbidities, but come with significant drawbacks. These include up to 40% of weight loss from muscle mass reduction, potentially leading to long-term side effects, especially in elderly patients. This limitation, in addition to tolerability issues, reduces the long-term utility of these agents. Pep2Tango’s lead drug candidates are engineered to overcome these drawbacks. They are unimolecular multi-receptor peptide agonists that target GLP-1, GIP, amylin and calcitonin receptors. This unique combination of targets in one molecule is truly differentiated with key advantages compared with first-generation drugs on the market and therapies currently in development. Preclinical studies of Pep2Tango’s molecules have demonstrated superior weight loss versus tirzepatide, primarily through selective fat mass loss with preservation of muscle mass, improved blood lipid profiles, better glycemic control, and beneficial effects on the liver. The company’s programs were developed by a deeply experienced team led by President, CEO and Chairperson Cristina Rondinone, Ph.D., and CSO Soumitra Ghosh, Ph.D. Dr. Rondinone previously was president of Cellarity, and SVP and head of cardiovascular, renal and metabolic diseases at AstraZeneca plc. Prior to that, she held roles of increasing responsibility in cardio-metabolic disease research and development at MedImmune Inc., Roche and Abbott Laboratories, where she led the research and development of multiple molecules that moved to clinical trials including Rezdiffra ™ , dorzagliatin and bentracimab. Dr. Ghosh is a co-founder of multiple biotech companies and served as executive director for research at Amylin Pharmaceuticals Inc., where he was involved in development efforts culminating in the approvals of Byetta ® , Symlin ® , Bydureon ® and Myalept ® . Dr. Ghosh also served as president of the Peptide Therapeutics Foundation. “We are delighted that Versant is backing Pep2Tango as we advance our programs towards clinical development,” said Dr. Rondinone. “There is a critical need to develop safe and highly efficacious drug therapies for obesity that preserve muscle mass and Pep2Tango’s approach should positively impact the lives of patients.” “We are thrilled to partner with the seasoned team of experts at Pep2Tango,” said Carlo Rizzuto, Ph.D., managing director at Versant and a Pep2Tango board member. “We are convinced that the company’s tetra-receptor agonists have best-in-category potential with respect to magnitude and quality of weight loss, as well as improving metabolic and cardiovascular health, that could redefine obesity treatment.” Pep2Tango Therapeutics is focused on CMC development activities to scale up drug candidate manufacturing and on running IND-enabling studies for a rapid transition to first-in-human clinical studies. An IND submission is expected in 2025. About Pep2Tango Therapeutics Inc. Pep2Tango Therapeutics is a biotechnology company founded in 2021 by seasoned pharmaceutical executives with a long track record of successful drug development. The company’s vision is to develop next generation peptide drugs that target unmet medical needs, including for metabolic, endocrine, CNS and cardiovascular disorders. Pep2Tango’s novel drug development approach for obesity focuses on unimolecular peptides that target multiple receptors, allowing for superior weight loss efficacy, muscle mass preservation, improved tolerability, and streamlined development and manufacturability. The company is backed by Versant Ventures. About Versant Ventures Versant Ventures is a leading healthcare venture capital firm committed to helping exceptional entrepreneurs build the next generation of great companies. The firm’s emphasis is on biotechnology companies that are discovering and developing novel therapeutics. With $5.5 billion under management and offices in the U.S., Canada and Europe, Versant has built a team with deep investment, operating and R&D expertise that enables a hands-on approach to company building. Since the firm’s founding in 1999, more than 100 Versant companies have achieved successful acquisitions or IPOs. For more information, please visit www.versantventures.com .

Drug ApprovalIPO

17 Apr 2024

·www.biospace.com

Xeno Biosciences Announces New CEO and Financing - April 17, 2024

CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Xeno Biosciences Inc., a clinical stage drug discovery and development company advancing therapeutics for the treatment of obesity and metabolic diseases, announced today a change in executive leadership as of September 2023, and the completion of an additional financing round in February of 2024. This financing of $1.15M will fund a Phase 1b trial of the company’s lead compound, Xen-101, in obese individuals. The trial is expected to have top line results by the end of the year. The new president and CEO, Dennis D. Kim, MD, MBA, has 25 years of obesity and metabolic drug development expertise experience and has brought multiple obesity and metabolic disease drugs to the clinic and to market, including Byetta® (exenatide), Symlin® (pramlintide), Contrave® (bupropion/naltrexone), and seladelpar. He has been involved in numerous IPO’s/secondary offerings and has been the chief medical officer of multiple public companies, most recently at CymaBay Therapeutics, where he oversaw the design and execution of seladelpar Phase 3 Pivotal Program. “I’m excited to be spearheading the development of Xeno’s new oral obesity drug which has been shown to have high tolerability in initial Phase I trial and has a novel mechanism of action.” said Dr. Dennis Kim. “I have dedicated my career to this area of science and medicine. After many years of development, I am truly gratified to see obesity pharmaceuticals as having the potential to impact the lives of billions of people around the world. There is a strong unmet need for a drug with the pro Xen-101 and I look forward to our Phase 1b clinical trial results in obese adults in the near future.” “Dennis has an extraordinary depth of knowledge and is highly respected in the obesity field; I could not imagine anyone more perfect to lead our company,” said Jeff Arnold, Chairman and a Director at Xeno since 2017. “We are delighted that he has decided to join us and lead this exciting project.” For more information about Xeno Biosciences please contact Dr. Dennis Kim at dk23@xenobiosciences.com. About Xeno Biosciences Inc. Xeno Biosciences Inc. is a privately held drug development company dedicated to finding safe and effective treatments for obesity and metabolic diseases. Xeno is advancing its lead development candidate, XEN-101, to address the unmet need for an effective, well-tolerated, orally administered obesity treatment. With a new understanding of the underlying mechanism of action of Roux-en-Y Gastric Bypass Surgery (RYGB), Xeno has developed a substitute for gastric bypass in a daily oral pill. XEN-101 has been shown to have wide safety margins and high tolerability in initial clinical trials. Dennis D. Kim, MD, MBA Dr. Dennis Kim is a scientist and a physician executive who brings 25 years of clinical research and biopharmaceutical industry experience to Xeno Biosciences. Dr. Kim served in a variety of senior executive positions in the industry, most recently as Chief Medical Officer at CymaBay, Emerald Biosciences, and Zafgen, Inc., as well as at Orexigen Therapeutics as the Senior Vice President of Medical Affairs. He also held various senior management positions at Amylin Pharmaceuticals, Inc. for over 7 years, including Executive Director of Corporate Strategy and Program Medical Lead for the development and commercialization of Byetta® (exenatide) for the treatment of type 2 diabetes. Dr. Kim completed his fellowship in Endocrinology/Metabolism at the University of California, San Diego (UCSD) School of Medicine during which time he investigated the pathophysiology of diabetes and metabolic syndrome. He is extensively published in top peer-reviewed medical and scientific journals with over 50 publications to his name. Dr. Kim also received an MBA degree with honors from UCSD Rady School of Management with an emphasis on biotech structure and strategy. The securities sold in the aforementioned private placement have not been registered under the Securities Act of 1933, as amended, and may not be offered or sold in the United States in the absence of an effective registration statement or an applicable exemption from the registration requirements of the Securities Act. This press release shall not constitute an offer to sell or the solicitation of an offer to buy the aforementioned shares. In addition, this press release contains certain forward-looking statements regarding, among other things, statements relating to goals, plans and projections regarding the company’s financial position, results of operations, market position, product development and business strategy. Such forward-looking statements are based on current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual outcomes and results to differ materially from current expectations. No forward-looking statements can be guaranteed and actual results may differ materially from such statements. The information in this release is provided only as of the date of this release, and the company undertakes no obligation to update any forward-looking statements contained in this release on account of new information, future events, or otherwise, except as required by law. View source version on businesswire.com: Contacts Dr. Dennis Kim dk23@xenobiosciences.com Source: Xeno Biosciences Inc. View this news release online at:

Executive ChangePhase 1Phase 2

01 Dec 2023

·www.businesswire.com

Perpetual Medicines Completes $8 Million Seed Round to Advance Integrated Computational Design-Synthesis Platform for Peptide Drug Discovery

SHANGHAI & BOSTON--( BUSINESS WIRE )--Perpetual Medicines today announced it has closed an $8 million seed financing to advance its integrated computational design and synthesis platform for peptide drug discovery. The financing round was led by Chengwei Capital. The company also announced key appointments to its leadership team, including Kerry L. Blanchard, MD, PhD, Co-founder, Chairman and Chief Executive Officer; Ved Srivastava, PhD, Chief Technology Officer; and Xiang Ye, PhD, Chief Scientific Officer. “Perpetual Medicines is capitalizing on recent advances in computational modeling based on artificial intelligence, deep learning and machine learning that enable access for the first time to the enormous, untapped peptide chemical space for drug discovery,” said Dr. Blanchard. “We have built an integrated platform that allows us to virtually iterate through millions of peptide sequences using physics-based computations to predict binding and drug-like properties followed by integration with experimental data to discover and optimize product candidates. This approach has the potential to accelerate peptide drug discovery, reduce cost, and increase the quality of drug candidates. With the financing the company will advance our most advanced program to the clinical stage and continue to build our preclinical portfolio of projects in oncology, autoimmunity, and metabolic diseases.” Dr. Blanchard noted that peptide therapeutics have become the most rapidly growing sector of the pharmaceutical industry with predicted sales exceeding $140 billion 1 /year by 2030. “Peptides fill the gap between small molecule drugs and therapeutic antibodies,” he said. “They are large enough and selective enough to block interactions between proteins inside and outside cells. These attributes, along with access to vastly expanded chemical space, will open new target classes and allow us to attack previously undruggable pathobiology.” Senior Management Team Named Perpetual has assembled a highly experienced senior management team, who have collectively accrued more than 120 years of drug hunting experience and have helped lead the development of more than ten marketed peptide-based therapeutics. The senior management team includes: Kerry L. Blanchard, MD, PhD – Co-Founder, Chairman and Chief Executive Officer. Dr. Blanchard is an experienced entrepreneur who has built deep R&D leadership and management experience over a 40+ year career. He was instrumental in the discovery of four marketed products, oversaw the clinical development and approval of more than 25 new medicines in China, and led two successful IPOs on the Hong Kong stock exchange. He has deep experience in developing peptide therapeutics from vancomycin and colistins to incretins. Prior to co-founding Perpetual Medicines, he was CEO of Everest Medicines. Previously, he was Chief Scientific Officer at Innovent, and he held several senior R&D leadership positions at Eli Lilly and Company over a nearly 18-year career, most recently as Senior Vice President China Drug Development. Prior to his industry career, he spent nearly 20 years in academic roles at LSU Health Science Center and Harvard Medical School. Ved Srivastava, PhD, Chief Technology Officer – Dr. Srivastava brings to Perpetual Medicines more than 25 years of experience in the discovery and development of peptide therapeutics. He joined Perpetual from Aktis Oncology. He was instrumental in the development of several peptide-based drugs, including Byetta™, Symlin™ and Bydureon™. He has served as Head of Peptide Chemistry at both GlaxoSmithKline and Amylin Pharmaceuticals. He was also a co-founder at Phoundry Pharma and Vice President of Chemistry at both Intarcia and Aktis. Ved is a former president of the American Peptide Society (APS). Xiang Ye, PhD – Chief Scientific Officer. Dr. Ye’s experience includes a more than 22-year career at Eli Lilly, where he focused on drug research and translational medicine. During his career, he led the discovery and development of eight clinical candidates, including a globally approved cancer drug, Verzenio® (abemaciclib). He joined Perpetual Medicines from Risen Pharmaceuticals, where he served as Chief Scientific Officer. Prior to Risen, he also served as Chief Scientific Officer at Ionova Life Sciences. About Chengwei Capital Chengwei Capital is a Shanghai-headquartered venture capital firm specialized in investing in high-end technology and innovative startups. It is one of the earliest venture capital firms in China and launched China’s first evergreen fund in 2004. Chengwei Capital currently has over USD $3 billion in NAV under management. About Perpetual Medicines Perpetual Medicines is a fully integrated computational peptide therapeutics company that aims to build a next-generation peptide drug discovery engine. The company’s platform combines the predictive power of leading-edge computational physics methods and next-generation AI technologies with advanced synthetic chemistry to access vast, unexplored peptide chemical space. The platform is designed to address previously undruggable targets, accelerate discovery and enhance the quality of peptide drug candidates. The company has operations in Shanghai, China and Boston, MA. Learn more at: perpetualmeds.com ________________________________ 1 Evaluate Pharma

Executive Change

100 Deals associated with Pramlintide Acetate

External Link

KEGG	Wiki	ATC	Drug Bank
D05595	Pramlintide Acetate	A10BX05	DB01278

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Diabetes Mellitus, Type 1	US	AstraZeneca AB	16 Mar 2005
Diabetes Mellitus, Type 2	US	AstraZeneca AB	16 Mar 2005

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Diabetes Mellitus, Insulin-Dependent, 2	Phase 3	US	AstraZeneca PLC	01 Apr 2003
Obesity	Phase 2	US	AstraZeneca PLC	01 Aug 2004

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


Pubmed \| Diabetes Obes Metab	Not Applicable	Diabetes Mellitus, Type 1	-	ADO09	(xodpkzlmqk) = jnijxndbkv ohnxssbasd (kgbfkreiht ) View more	-	12 Jan 2023
				Insulin aspart	(xodpkzlmqk) = muenthkdxx ohnxssbasd (kgbfkreiht ) View more
NCT01841359 (CTgov)	Phase 4	Hypoglycemia \| Stomach Diseases	22	Pramlintide (Baseline (Prior to Pramlintide Treatment) Mixed Meal #1)	qplwjzzynj(jcuizodtpn) = yucynzjwiy vxuyvhmuaw (rnbhbsojcb, wxtmzftcck - eukijfgyos) View more	-	26 May 2022
				Pramlintide (Pramlintide - Mixed Meal #2)	qplwjzzynj(jcuizodtpn) = gqxwefaxyq vxuyvhmuaw (rnbhbsojcb, yasdelxirq - vkqwybqcmz) View more
ADA2019	Not Applicable	Diabetes Mellitus, Type 1	24	BCPramIns	vdcelqqgdm(jlnerxkyzm) = Hypoglycemia during dosing visit days were balanced between the three treatment groups (4-3-3) kdotuhoway (tcgnxqjqoi ) View more	-	01 Jun 2019
				PRAM+INS
NCT00690235 (CTgov)	Phase 4	Diabetes Mellitus \| Schizoaffective disorder \| Schizophrenia ... View more	33	Pramlintide (Pramlintide)	ftkuozzkoc(uivddwklzr) = ccqipvjdqo fxcfefouyl (ydjzkfgdwz, vbmrqlkrgs - wauhvktgtz) View more	-	16 Nov 2018
				Placebo (Placebo)	ftkuozzkoc(uivddwklzr) = ibxmnnwoun fxcfefouyl (ydjzkfgdwz, csqpfgmiye - citqrsurbn) View more
NCT02500979 (CTgov)	Phase 1	Diabetes Mellitus, Type 1	34	Insulin (Placebo & Regular Insulin)	dybaqkwwcq(lcsblxzcky) = pkssqsosaf ivorkpgngg (uupshxyfjb, egjxizrpol - rktahbvish) View more	-	02 Nov 2018
				Insulin+Pramlintide (Pramlintide & Regular Insulin)	dybaqkwwcq(lcsblxzcky) = pbpyinjxat ivorkpgngg (uupshxyfjb, ancusksyvv - hixmyqiotu) View more
NCT02500979 (Pubmed \| Diabetes Care)	Phase 1	Diabetes Mellitus, Type 1	34	Pramlintide	(bclnadroqj) = rgkehpipxa fhxtmfgmgh (fimzzcyinl )	-	01 Nov 2018
				Placebo	(bclnadroqj) = gwktpunfip fhxtmfgmgh (fimzzcyinl )
EASD2018	Not Applicable	-	-	BC Pram Ins	dmdbxviaak(hkcdxgfvjb) = 0.45 [0.20; 1.05] gdpvnqjqak (cbxqksklbv ) View more	Positive	02 Oct 2018
				Humulin
NCT00442767 (CTgov)	Phase 4	Diabetes Mellitus, Type 1 \| Hyperglycemia	8	Insulin (Rapid Acting Insulin Therapy - Before Meal)	ujwmgteydg(retoeujwiy) = badwztvavl olztaeoirh (hsepknwlbh, ibrvkvtzqh - kovtazzmmc) View more	-	10 Jul 2018
				Insulin+Pramlintide (Pre-meal Pramlintide and Post-meal Insulin Therapy)	ujwmgteydg(retoeujwiy) = ffgmxtlnug olztaeoirh (hsepknwlbh, ubrxrxijht - zfdebysowa) View more
NCT01269047 (CTgov)	Phase 4	Diabetes Mellitus, Type 1 \| Hyperglycemia	37	Insulin (Insulin Monotherapy)	ndvamdyvey(ddrxmqmfmv) = aggniqnukn utfbascpvs (ualxpeecid, vnhnevuuwt - eujsmykvss) View more	-	08 Feb 2018
				Pramlintide (Pramlintide + Insulin Group)	artxeltjhu(skcvimumdd) = mjbcyvkkss rruvefsmmg (hxolfmdrpc, drjsehdxqe - cftwudymlq) View more

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