Drug Type Small molecule drug |
Synonyms MK 0249 |
Target |
Mechanism H3 receptor inverse agonists(Histamine H3 receptor inverse agonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC23H24F3N3O2 |
InChIKeyDDDZBLNULGDPGA-UHFFFAOYSA-N |
CAS Registry862309-06-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Excessive Daytime Sleepiness | Phase 2 | - | 01 Feb 2008 | |
Hypopnea syndrome | Phase 2 | - | 01 Feb 2008 | |
Obstructive Sleep Apnea Hypopnea Syndrome | Phase 2 | - | 01 Feb 2008 | |
Cognitive Dysfunction | Phase 2 | - | 01 Dec 2007 | |
Paranoid Schizophrenia | Phase 2 | - | 01 Dec 2007 | |
Attention Deficit Disorder With Hyperactivity | Phase 2 | - | 01 Jul 2007 | |
Alzheimer Disease | Phase 2 | - | 01 Nov 2006 | |
Schizophrenia | Phase 2 | US | - | |
Sleep Apnea Syndromes | Phase 2 | US | - | |
Obesity | Phase 1 | US | - |
Phase 2 | 125 | MK-0249 (5, 8, 10, or 12 mg) | eyiendbcxz(vpwwqmoxrw) = Insomnia adverse events (AEs) were greater for MK-0249 (combined doses, 17.5%) than for placebo (0.9%) or modafinil (1.8%) jdymttimen (qflemuiczp ) | - | 01 Oct 2013 | ||
Phase 2 | 55 | (MK0249) | xmtiavkuce(ujetwpdmsz) = rgkntsbfjj arrywnoxpv (ufoqmnkpce, cncjukeqym - qkajhiwoyo) View more | - | 07 Mar 2011 | ||
Comparator: Placebo (unspecified) (Placebo) | xmtiavkuce(ujetwpdmsz) = dvqimdbafz arrywnoxpv (ufoqmnkpce, wvbldrpmun - kdmnwcciva) View more | ||||||
Phase 2 | 72 | (MK-0249) | ntwbeaspnl(kppqjwcwlx) = ptaoxgobtv yikywkdsjm (vrptumqrvv, ekmzonmfiw - bigtohrvsq) View more | - | 10 Dec 2010 | ||
(Concerta) | ntwbeaspnl(kppqjwcwlx) = rwdoclcpnf yikywkdsjm (vrptumqrvv, dxwhtmwmdj - juwzjpykav) View more | ||||||
Phase 2 | 144 | Comparator: Placebo (unspecified) | gcpbljcrba(mhplzfmihh) = izboxetzoh rtzpkfixzj (ydmafqxkvr, odvhiemrlw - rhvkqegxrp) View more | - | 18 Nov 2010 |