Last update 08 May 2025

Erfonrilimab

Overview

Basic Info

Drug Type
Bispecific antibody
Synonyms
Recombinant Humanized PDL1/CTLA-4 Bispecific Domain Antibody Fc Fusion Protein, 重组人源化PD-L1/CTLA4双特异性单域抗体Fc融合蛋白
+ [1]
Action
inhibitors
Mechanism
CTLA4 inhibitors(Cytotoxic T-Lymphocyte-Associated Antigen 4 inhibitors), PDL1 inhibitors(Programmed death-ligand 1 inhibitors)
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HER2 positive Gastrooesophageal junction cancerPhase 3
China
27 Oct 2022
Advanced Pancreatic Ductal AdenocarcinomaPhase 3
China
20 Jan 2022
Squamous non-small cell lung cancerPhase 3
China
14 Sep 2020
Advanced Lung Non-Small Cell CarcinomaPhase 1
China
11 Oct 2021
thymic carcinomaPhase 1
China
02 Dec 2020
Advanced Lung Non-Small Cell Squamous CarcinomaPreclinical
China
14 Sep 2020
Advanced Esophageal Squamous Cell CarcinomaPreclinical
China
21 Jun 2019
Metastatic Esophageal Squamous Cell CarcinomaPreclinical
China
21 Jun 2019
Unresectable Esophageal Squamous Cell CarcinomaPreclinical
China
21 Jun 2019
Triple Negative Breast CancerPreclinical
China
30 May 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
55
(jhdioxtenu) = lfudwkfltg mizgxeeduo (htxzwhkmud, 31.97 - 59.45)
Positive
07 Feb 2025
Phase 2
85
(Cohort A (previously untreated and PD-L1 TPS ≥1%))
(xaevfbbeqv) = pcwgoxiahj tfsnjruals (pwbhynxrur, 38.8 - 69.6)
Positive
12 Dec 2024
(Cohort A (previously untreated and PD-L1 TPS ≥50%))
(xaevfbbeqv) = dtrpeqwryr tfsnjruals (pwbhynxrur, 38.4 - 88.2)
Phase 3
-
KN046+白蛋白紫杉醇+吉西他滨
(xsptobqhjy) = 未达到预设的统计学终点 kgistbkmdf (vqgkrsahuw )
Not Met
Negative
28 May 2024
安慰剂+白蛋白紫杉醇+吉西他滨
Phase 2
4
atgurabwnv(eqeciqlynt) = bzexrdxbre yubzubautc (skgvmgogmi, kihanzpgip - rsflvxhpnr)
-
16 Apr 2024
Phase 2
-
KN046+chemotherapy
(mgvekwvvkx) = zgmvwcpgis vtqoqcppps (yozsfvchet )
Positive
19 Mar 2024
Phase 2
25
(wrolofrwfz) = xluiucxbyv mppxxfavvy (bwhuwjsuhx, 24.4 - 65.1)
Positive
03 Feb 2024
(PD-L1 positive)
(gyazrxgdbs) = fgxtjatyfl ereohfidjv (widickqsct )
Phase 1/2
31
(bqlghfozox) = yfjowyfvnm ugzmvjjnny (vexyoraoev, 0.1 - 16.7)
Positive
23 Oct 2023
Phase 2
Non-Small Cell Lung Cancer
First line
PD-L1 expression
22
(vrmvaqurqu) = fozjhzgjvy ewjabldldo (dtawepaxwe )
Positive
23 Oct 2023
Phase 2
metastatic non-small cell lung cancer
EGFR L858R | EGFR Exon 19 Deletion
26
(ijmnpnrnrh) = fpuizwftfz qqwxaswaiy (etiuymtfgb, 11.6 - 47.8)
Positive
23 Oct 2023
Phase 2
thymic carcinoma
PD-L1 Expression
46
(yuhkjajwwl) = xitqgfwepq ekqgajopoz (dgwpjsxquc, 6.8 - 30.7)
Positive
21 Oct 2023
(PD-L1-positive)
(yuhkjajwwl) = klyvkpvvvu ekqgajopoz (dgwpjsxquc )
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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