Delving into the Latest Updates on Levomenthol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(-)-(1R,3R,4S)-menthol, (-)-Menthol, (1R,3R,4S)-(-)-menthol

+ [12]

Target

TRPA1 x TRPM8 x κ opioid receptor

Action

inhibitors, agonists, antagonists

Mechanism

TRPA1 inhibitors(Transient receptor potential cation channel subfamily A member 1 inhibitors), TRPM8 agonists(Transient receptor potential cation channel subfamily M member 8 agonists), κ opioid receptor antagonists(Kappa opioid receptor antagonists)

Therapeutic Areas

Digestive System Disorders

Active Indication-

Inactive Indication

Intestinal Diseases

Originator Organization

University Hospitals Cleveland Medical Center

Active Organization

Fuji Pharma Co., Ltd.

Inactive Organization

Nihon Pharmaceutical Co., Ltd.

Drug Highest PhaseApproved

First Approval Date

Japan (20 Jan 1986)

Regulation-

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Structure/Sequence

Molecular FormulaC10H20O

InChIKeyNOOLISFMXDJSKH-KXUCPTDWSA-N

CAS Registry2216-51-5

This study aimed to evaluate the potential of pH-driven assembled soy peptide nanoparticle (SPN) to prepare high internal phase emulsions (HIPEs) containing sweet orange essential oil (SOEO), and the effects of SPN concentration and oil phase fraction on the formation, stability and flavor release characteristics were investigated. Results showed that stable HIPEs with excellent self-supporting state were successfully fabricated at relative high SPN concentrations (0.5-3.0 wt%). And the increase in SPN concentration could cause smaller droplet size, better viscoelastic properties and stability. The flavor release of SOEO in SPN-stabilized HIPEs could be slowed down and modulated by regulating SPN concentration, and the retention of key flavor compound (d-limonene) in SOEO encapsulated in HIPEs could be reached to higher than 70 % after 120 days of storage. All these indicated the effective encapsulation and delivery of SOEO in SPN-stabilized HIPEs and their prospective application as fat substitutes in plant-based food systems.

01 Apr 2025·Food Chemistry

Odor-induced saltiness enhancement of volatile compounds screened from duck stewed with chili pepper

Article

Author: Zhang, Jianyou ; Qiu, Yue ; Ding, Yuting ; Zheng, Wenbo ; Cheng, Zhi ; He, Xinglan ; Lyu, Fei

Odor-induced saltiness enhancement (OISE) is thought to be a unique salt reduction technique which capitalizes on olfactory-gustatory interaction. Volatile compounds of stewed duck obtained from orthonasal (no-treatment) and retronasal (saliva-treatment) pathways and their capacity on OISE were analyzed by GC-O-MS and molecular simulation in order to ascertain the role of odors in duck stewed with chili pepper on saltiness enhancement. Totally 17 unique volatile compounds were identified in retronasal pathways. Eight salty-congruent volatile compounds were screened from the stewed duck, one of which being E-2-decenal, specific to retronasal volatile compounds following oral enzymatic digestion. These volatile compounds' OISE in NaCl solution was confirmed, and the retronasal pathway effect outweighed the orthonasal one. Molecular docking revealed that volatile compounds interacted with saltiness receptors through hydrogen bonding and hydrophobic force, which may be responsible for its enhanced saltiness. These findings suggest that olfactory pathways and specific odors might simultaneously mediate OISE.

01 Apr 2025·Journal of Molecular Liquids

Thermodynamic and spectroscopic study of solutions of therapeutic deep eutectic solvents (THEDES) in supercritical CO2

Author: Perez, Eduardo ; Diaz, Sara ; Olmos-Greco, Ramiro J. ; Gutierrez, Sebastian ; Cabanas, Albertina

The solubilities of the Deep Eutectic Solvents (DES) ibuprofen:thymol and ibuprofen:L-menthol in supercritical CO₂ were determined up to 250 bar at 40, 50 and 60 °C using a variable volume view cell.The solubility of DES at different compositions was compared to that of the individual components showing little deviation from the linear trend.The vapor-phase compositions for some conditions were also determined by ¹H NMR showing that the CO₂ preferentially extracts the most volatile component.A FTIR spectroscopic study of the DES at room pressure and the DES dissolved in CO₂ was also conducted.At room temperature, ibuprofen was present either forming a dimer or bonded to the terpene.When the DES was dissolved in CO₂, significant amounts of free ibuprofen were also found.A simple association model was proposed and some thermodn. magnitudes were determinedThe spectroscopic information is consistent with the thermodn. data.

100 Deals associated with Levomenthol

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Levomenthol	-	DB00825

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Intestinal Diseases	Discovery	Japan	Nihon Pharmaceutical Co., Ltd.	01 Oct 2014

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


UEGW2017	Not Applicable	-	-	Menthol infusion	lqvvltmhiz(eytgxrrjcc) = hetmzfqrlw xuauzcspec (tbrzvpfygs, 116.2) View more	-	01 Oct 2017
UEGW2017	Not Applicable	-	-	L-Menthol (Baseline recording)	lqvvltmhiz(eytgxrrjcc) = qnmoundlfz xuauzcspec (tbrzvpfygs, 126.2) View more	-	01 Oct 2017
NCT01687101 (CTgov)	Not Applicable	Migraine Disorders \| Headache	32	STOPAIN topical gel	vvbmuvbgce(ppqoptfvga) = aenwazhcae jenxwjrjko (nstsjbyszv, rlmtrluwyi - nnxzqlrlsh) View more	-	27 Apr 2015