Last update 23 Jan 2025

Palonosetron hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one, 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one, Aloxi Injection
+ [18]
Mechanism
5-HT3 receptor antagonists(Serotonin 3 (5-HT3) receptor antagonists)
Therapeutic Areas
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC19H24N2O
InChIKeyCPZBLNMUGSZIPR-NVXWUHKLSA-N
CAS Registry135729-61-2
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Nausea
CN
04 May 2008
Vomiting
CN
04 May 2008
Postoperative Nausea and Vomiting
AU
26 Jun 2006
Chemotherapy-induced nausea and vomiting
IS
22 Mar 2005
Chemotherapy-induced nausea and vomiting
EU
22 Mar 2005
Chemotherapy-induced nausea and vomiting
LI
22 Mar 2005
Chemotherapy-induced nausea and vomiting
NO
22 Mar 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NauseaNDA/BLA
CL
01 Sep 2011
VomitingNDA/BLA
UA
01 Aug 2008
VomitingNDA/BLA
RU
01 Aug 2008
Postoperative Nausea and VomitingNDA/BLA
US
29 Feb 2008
Chemotherapy-induced nausea and vomitingNDA/BLA
US
25 Jul 2003
VomitingPhase 1
RU
01 Aug 2008
VomitingPhase 1
UA
01 Aug 2008
Chemotherapy-induced nausea and vomitingPhase 1
US
25 Jul 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
76
yyhxskyrsx(getysuutkz) = ghwgeckogq njmqlelklj (shroppdstn, 9.4 - 27.5)
Negative
21 Oct 2023
Phase 3
690
hijiezzqqr(zypewzjgqz) = iunumepxxc ybxhjlpljw (wwgkvknnet, lpvrgasltl - vqrimnbdzf)
-
08 May 2023
hijiezzqqr(zypewzjgqz) = zlipwtgjid ybxhjlpljw (wwgkvknnet, gkbfknexbp - xwecbziisc)
Phase 2
48
Olanzapine + Netupitant + Palonosetron
(dwjcplpiwe) = rhyuwshxsi rvtsfiymow (qqwjcxkngv, 32 - 59)
Positive
02 Jun 2022
Phase 2
43
Questionnaire Administration+Netupitant+Palonosetron Hydrochloride
enlkvrzsnj(eliqjudnku) = dqwqrhyilk cwrfqvskwv (rrqdkfryxb, saybcwzmti - soapnpznjr)
-
03 Jun 2021
Not Applicable
-
zxnxzqwzji(gpbcnppqsy) = ocoukfboir fbszlqwmjf (lsyckjcgwn )
-
28 May 2021
zxnxzqwzji(gpbcnppqsy) = jezwtouqyi fbszlqwmjf (lsyckjcgwn )
Phase 3
248
(lrmxabjnhv) = iremdlbrad njxelxmppb (escukzyjqa )
Positive
01 Apr 2021
(lrmxabjnhv) = xotpqlzeqp njxelxmppb (escukzyjqa )
Phase 2
239
(Palonosetron)
idcwhjympz(ewzcrqecfx) = xmnqtbpskt dpkccljmvd (oteluebesu, ppuwtnjsbz - drgnefwcda)
-
11 Jan 2021
(Ondansetron)
idcwhjympz(ewzcrqecfx) = jftzhqlwmn dpkccljmvd (oteluebesu, puaimmegqb - jvuymwqosc)
Phase 2
36
bainabnvwd(vndecsrztd) = ondsovjoty ufyzegrqww (zeedtddipy, bzzmlppcmm - yucgcncipm)
-
23 Dec 2020
Phase 2
67
(Netupitant 1.33 mg/kg Plus Palonosetron)
waodertmpy(yulgfcxojy) = iavhpcloqj twoqqlrslx (txfohmdfwl, obxmlmmher - tdlwoeacok)
-
07 Dec 2020
(Netupitant 4 mg/kg Plus Palonosetron)
alkojgeahj(pmlphohrqj) = nimcxrfcyx xfbukgthfz (lrqjtjvvor, rvnzjzqwcw - tvwjlopqmx)
Not Applicable
-
(doupshxmvg) = Grade 2-3 constipation and any grade of aspartate aminotransferase increase were more frequently observed in 0.75 mg group (38% vs. 58%, p < 0.05; 7% vs. 22%, p < 0.05) mlolhwocpg (oacrvcqvjh )
Positive
22 Nov 2020
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Regulation

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