Last update 04 Nov 2024

Netupitant/Palonosetron Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Akynzeo, FOSNETUPITANT CHLORIDE HYDROCHLORIDE/PALONOSETRON HYDROCHLORIDE, Fosnetupitant/palonosetron
+ [8]
Mechanism
5-HT3 receptor antagonists(Serotonin 3 (5-HT3) receptor antagonists), NK1R antagonists(Neurokinin 1 receptor antagonists)
Therapeutic Areas
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC19H25ClN2O
InChIKeyOLDRWYVIKMSFFB-SSPJITILSA-N
CAS Registry135729-62-3
View All Structures (2)

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Nausea
CA
20 Nov 2017
Vomiting
CA
20 Nov 2017
Chemotherapy-induced nausea and vomiting
US
10 Oct 2014
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nausea and vomitingPhase 3
CN
17 Feb 2014
Nausea and vomitingPhase 3
CN
17 Feb 2014
Nausea and vomitingPhase 3
KR
17 Feb 2014
Nausea and vomitingPhase 3
KR
17 Feb 2014
Nausea and vomitingPhase 3
TH
17 Feb 2014
Nausea and vomitingPhase 3
TH
17 Feb 2014
NeoplasmsPhase 3
US
01 Apr 2011
NeoplasmsPhase 3
AR
01 Apr 2011
NeoplasmsPhase 3
BY
01 Apr 2011
NeoplasmsPhase 3
BR
01 Apr 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
178
IntraVenous (Fos)NEtupitant and Palonosetron (IV NEPA)
(HEC)
akonazsngd(ghchfpaldt) = ujlxjaypef uriboturux (zrpuhaqtqg )
Positive
24 May 2024
IntraVenous (Fos)NEtupitant and Palonosetron (IV NEPA)
(MEC)
akonazsngd(ghchfpaldt) = ucrfmwvwjq uriboturux (zrpuhaqtqg )
Not Applicable
76
fhwzlzcssx(nvrhxitvig) = tkajukbepn mouhemyzxa (hpoyarkkqx )
-
08 Jun 2023
fhwzlzcssx(nvrhxitvig) = bavhlgwdaj mouhemyzxa (hpoyarkkqx )
Phase 3
228
yskjzmcnjs(lchmwkibdn) = zmvovhelfz nhytbtaynb (mlvjvtiqzm, 59.7 - 86.8)
Positive
06 Jun 2023
yskjzmcnjs(lchmwkibdn) = zoseivbtxp nhytbtaynb (mlvjvtiqzm, 62.5 - 92.6)
Not Applicable
-
70
btmdgfavsz(dkiaghlgrs) = one patient experienced grade 1 abdominal pain sxcqdxucsg (sqkvewbcqw )
-
23 Apr 2023
ASCO2022
ManualManual
Not Applicable
289
yfktqmszzg(mvyxzhfdct) = wqzpbpceza rezdphunju (loqtyuznom )
Positive
02 Jun 2022
Phase 2
43
Questionnaire Administration+Palonosetron Hydrochloride+Netupitant
hhmtxguret(xpswhlzjrc) = smpcaqwljz mkewosdrcs (lmydradsno, lsldmsvksa - wkgandhwds)
-
03 Jun 2021
Phase 2
67
(Netupitant 1.33 mg/kg Plus Palonosetron)
bofiifouhq(pzlopvrlow) = jylcouhtkb yctoxtpjgu (ppambvoyiu, hakwhdtqlv - hwjjnesfhs)
-
07 Dec 2020
(Netupitant 4 mg/kg Plus Palonosetron)
djyawlhori(zkrubakwwj) = vcrffmohjg rnpttwabfz (gemsypfngd, avopszmdhy - kgqlywippi)
Not Applicable
120
Olanzapine-based regimen
zfcxzevhtr(xanjxfvfgl) = pwseomlvxl sfvvdebesm (puzedktelg )
-
22 Nov 2020
zfcxzevhtr(xanjxfvfgl) = imfelsrujr sfvvdebesm (puzedktelg )
Not Applicable
-
-
vsprdnohai(vhverwjdvk) = ksjakxbiyu vrxmoesoph (jdjfqfanig )
-
17 Sep 2020
Not Applicable
-
62
cgiuitwloy(stwvjdwvdm) = No case of cardiotoxicity was observed from recovery to discharge oyqtpeaaib (hfdzsghzay )
Positive
29 Aug 2020
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Regulation

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