Last update 21 Nov 2024

Piperaquine Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Piperaquine, Tlinsuangpaiqin, Trochisci Piperazini Phoshatis
+ [5]
Target
Mechanism
CYP3A4 inhibitors(Cytochrome P450 3A4 inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date-
Regulation-
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Structure

Molecular FormulaC29H35Cl2N6O4P
InChIKeyKATNPMSTHHZOTK-UHFFFAOYSA-N
CAS Registry85547-56-4
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Piperaquine Phosphate-

R&D Status

10 top approved records.
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
24
(Cohort 1:Treatment Group B: 200mg of OZ439 and 640 mg PQP)
pxbwsbmlhd(dsrjhxoyza) = pqgvhenlqw zuurpqjfgl (liniybuvuy, acgpbhclgz - xzndywxeug)
-
10 May 2024
(Cohort 1: Treatment Group A: 200mg of OZ439 and 480 mg PQP)
pxbwsbmlhd(dsrjhxoyza) = fagrbwyglu zuurpqjfgl (liniybuvuy, qqbdsmryfj - mckcfoelak)
Phase 1
6
Administration of the malaria inoculum+Piperaquine Phosphate 480 mg
awgjingcon(ljtvvkyuhn) = gkncomvfbw dciaopzxin (kammdcsdhf, ihdzdlivnj - lchryumhyt)
-
26 May 2020
Phase 2/3
448
(A) Artefenomel 800mg: Piperaquine 640mg)
fzcrfdjbup(tdikoybohk) = ptpvzlgadt ctibqaakiw (jzmavvxjom, ryizamjmcw - gntiwobexg)
-
30 Jan 2017
(B) Artefenomel 800mg: Piperaquine 960mg)
fzcrfdjbup(tdikoybohk) = jejvkmejbh ctibqaakiw (jzmavvxjom, xgchtsalyn - bixlntwnbk)
Phase 1
48
PQP+OZ439 + TPGS
(Regimen A: OZ439 + TPGS and PQP)
hhxxrqnwbm(jopwjgektr) = xdiqkcgegv ysppfvqppn (btnehupigu, muraepfwvo - uefbhzyuvo)
-
14 Jan 2016
OZ439 Prototype 1+PQP
(Regimen B: OZ439 Prototype 1 and PQP - 110mL)
hhxxrqnwbm(jopwjgektr) = gonrehfnvi ysppfvqppn (btnehupigu, tfosrsbccb - jchgdirzmd)
Phase 1
55
(Treatment A: 1440mg PQP Tablets & 800mg OZ439 + TPGS)
aviehxldpy(gdkduzwchc) = ujhbaamrbv wmyctoljlq (hovqyyjeun, owjxsdrbqw - ahrqzrzdii)
-
21 Apr 2015
(Treatment B: 960mg PQP Tablets & 800mg OZ439 + TPGS)
aviehxldpy(gdkduzwchc) = wqwjbnppdf wmyctoljlq (hovqyyjeun, egfucjwrqp - hkwyhspjrm)
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Regulation

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