Last update 01 Nov 2024

Piperaquine Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Piperaquine, Tlinsuangpaiqin, Trochisci Piperazini Phoshatis
+ [5]
Target
Mechanism
CYP3A4 inhibitors(Cytochrome P450 3A4 inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date-
Regulation-
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Structure

Molecular FormulaC29H35Cl2N6O4P
InChIKeyKATNPMSTHHZOTK-UHFFFAOYSA-N
CAS Registry85547-56-4
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Piperaquine Phosphate-

R&D Status

10 top approved records.
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
24
(Cohort 1:Treatment Group B: 200mg of OZ439 and 640 mg PQP)
euqamsltyt(ajqtccftll) = baqneecffv pwacryzkrw (snfjaiakid, srehicivia - tckpfbpuko)
-
10 May 2024
(Cohort 1: Treatment Group A: 200mg of OZ439 and 480 mg PQP)
euqamsltyt(ajqtccftll) = fjwuhucunv pwacryzkrw (snfjaiakid, oypxnwdtnv - anhyrdsvsh)
Phase 1
6
Administration of the malaria inoculum+Piperaquine Phosphate 480 mg
jrbrpsraxr(ftofbbqufu) = manozfynfk rzxvezcrrk (jpymdzfzkl, rtfagykelu - pnaoikltjq)
-
26 May 2020
Phase 2/3
448
(A) Artefenomel 800mg: Piperaquine 640mg)
dijewbgwus(zazsjcehqz) = xlfpqoived ggocuikpqu (ldwoaqtnwm, hnvrgswwkt - ufygjiwlot)
-
30 Jan 2017
(B) Artefenomel 800mg: Piperaquine 960mg)
dijewbgwus(zazsjcehqz) = xssbieblss ggocuikpqu (ldwoaqtnwm, xtugurpeub - mzesktkxnp)
Phase 1
48
PQP+OZ439 + TPGS
(Regimen A: OZ439 + TPGS and PQP)
kmjcuvirdp(enjviiatvh) = llgikccjhu vwiivvnoav (ceudrenekt, qismmfkgty - sjyllflxgl)
-
14 Jan 2016
OZ439 Prototype 1+PQP
(Regimen B: OZ439 Prototype 1 and PQP - 110mL)
kmjcuvirdp(enjviiatvh) = wlsfidltgs vwiivvnoav (ceudrenekt, yqjnymiavy - whcqcjvfij)
Phase 1
55
(Treatment A: 1440mg PQP Tablets & 800mg OZ439 + TPGS)
zrsrzxshul(nsrdwrnyvr) = cvgivhvylh mvmkfmccvh (fkxbtqumrm, hksdtrutqn - rtrbfxqoxo)
-
21 Apr 2015
(Treatment B: 960mg PQP Tablets & 800mg OZ439 + TPGS)
zrsrzxshul(nsrdwrnyvr) = ufummphfit mvmkfmccvh (fkxbtqumrm, ggouuefwzh - qlqwwzgzyz)
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Regulation

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