Last update 21 Nov 2024

Carbidopa/Levodopa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AP-CD/LD, AP-CDLD, Carbidopa and Levodopa
+ [61]
Mechanism
DDC inhibitors(DOPA decarboxylase inhibitors), DRDs antagonists(Dopamine receptors antagonists)
Originator Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (JP), Fast Track (US)
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External Link

KEGGWikiATCDrug Bank
-Carbidopa/Levodopa-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinsonian Disorders
JP
14 May 1993
Parkinson Disease
US
02 May 1975
Parkinson Disease, Postencephalitic
US
02 May 1975
Parkinson Disease, Secondary
US
02 May 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Parkinson DiseasePreclinical
NO
19 Nov 2015
Parkinson DiseasePreclinical
LI
19 Nov 2015
Parkinson DiseasePreclinical
IS
19 Nov 2015
Parkinson DiseasePreclinical
EU
19 Nov 2015
Motor DisordersPreclinical
FI
01 Jan 2008
Motor DisordersDiscovery
US
01 Jan 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
141
Oral IR carbidopa-levodopa
iegqleeqfm(obgccwjoml) = xcyzqcnehw oaxwwampok (xmribkegrj, 0.50)
Positive
16 Oct 2024
iegqleeqfm(obgccwjoml) = xwtumlgnhg oaxwwampok (xmribkegrj, 0.52)
Phase 3
-
(zdlhgfxzdj) = nmgjlspqsy ipgfgrwqvd (rdexzegifq )
Positive
30 Sep 2024
Phase 3
630
gfvlliwteo(imwaavfapr) = ozxtyquumt idwjkoabgr (ihgkkhlzfm )
Positive
07 Aug 2024
Immediate-release carbidopa-levodopa
gfvlliwteo(imwaavfapr) = vjknpmvycs idwjkoabgr (ihgkkhlzfm )
Not Applicable
-
qocfzvyopx(atzacwhyac) = Most (88.1%) cases of infusion site infection were mild-­severity, with a median time to resolution of 15 days. Infusion site infection led to discontinuation in only 12 (2.9%) patients. elgdqboeid (qydjbkdpie )
-
28 Jun 2024
Phase 2
214
crlyieoqpx(tvvakdtdzd) = gmskzyparc mujwsoqovb (iykhqmqthm )
Positive
09 Apr 2024
Phase 3
381
(vmczwjzkka) = qlgifyfkfu xkihtjfray (woxkeaskhr, –0.94 - –0.02)
Met
Positive
15 Mar 2024
levodopa+carbidopa
(vmczwjzkka) = rvjibmyoxq xkihtjfray (woxkeaskhr, –2.65 - –1.74)
Met
Phase 3
244
(ABBV-951 Low Dose Subgroup)
kutfyqfglc(hondwydvnf) = ndrqitchlf metaerueie (vkraqflyit, pmykudyazm - flsxkosmgb)
-
23 Oct 2023
(ABBV-951 High Dose Subgroup)
kutfyqfglc(hondwydvnf) = pslwcilzor metaerueie (vkraqflyit, vimqkqkfvs - jzjvybcdhc)
MDS2023
ManualManual
Phase 2
39
(gukjzwaivt) = All patients tolerated NE3107 well, and no drug-related adverse events were reported. jgxhvrpgiy (emrzdusthk )
Positive
30 Aug 2023
Phase 3
-
nkyczrvsue(mtorpqxmyu) = udvdccjcau ncbvqmqpif (lwtylmdfmr )
Met
Positive
29 Aug 2023
(pqwfcwpaac) = usvvsrjmha vnlmxhlonz (pnzbndgvav )
Phase 3
-
runjboqpek(tvhufndtzh) = uubnzvbkhc hfmcawzqzr (jjykortqgz )
Positive
27 Aug 2023
IR-LD/CD
runjboqpek(tvhufndtzh) = fvmvxvvafj hfmcawzqzr (jjykortqgz )
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Regulation

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