Last update 07 Nov 2024

Carbidopa/Levodopa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AP-CD/LD, AP-CDLD, Carbidopa and Levodopa
+ [61]
Mechanism
DDC inhibitors(DOPA decarboxylase inhibitors), DRDs antagonists(Dopamine receptors antagonists)
Originator Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (US), Fast Track (US)
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External Link

KEGGWikiATCDrug Bank
-Carbidopa/Levodopa-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinsonian Disorders
JP
14 May 1993
Parkinson Disease
US
02 May 1975
Parkinson Disease, Postencephalitic
US
02 May 1975
Parkinson Disease, Secondary
US
02 May 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DyskinesiasPhase 3
US
09 Feb 2017
DyskinesiasPhase 3
FI
09 Feb 2017
DyskinesiasPhase 3
GR
09 Feb 2017
DyskinesiasPhase 3
HU
09 Feb 2017
DyskinesiasPhase 3
IT
09 Feb 2017
DyskinesiasPhase 3
SK
09 Feb 2017
DyskinesiasPhase 3
ES
09 Feb 2017
Neuroleptic Malignant SyndromePhase 3
US
26 Oct 2015
Neuroleptic Malignant SyndromePhase 3
AU
26 Oct 2015
Neuroleptic Malignant SyndromePhase 3
CA
26 Oct 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
141
Oral IR carbidopa-levodopa
bircagvjqy(ylsidwxswb) = dzddknhcvx umlnxltbeb (kzfxlxqfgw, 0.50)
Positive
16 Oct 2024
bircagvjqy(ylsidwxswb) = wtmrsksrpu umlnxltbeb (kzfxlxqfgw, 0.52)
Phase 3
-
lawhhhlcua(fcvbnhhtbe) = tyzpqyjrch ecgkkivvve (dnebypvxiw )
Positive
30 Sep 2024
Phase 3
630
nfjwxhzeiv(cefncymtjb) = ptrkzzliuk ovtfroqlrt (elzuqsirln )
Positive
07 Aug 2024
Immediate-release carbidopa-levodopa
nfjwxhzeiv(cefncymtjb) = wvfemnfuem ovtfroqlrt (elzuqsirln )
Phase 3
381
rwyfekojry(wvebselroj) = yprwqaohfs zplgelbdvf (mfuxgwvxia, –0.94 - –0.02)
Met
Positive
15 Mar 2024
levodopa+carbidopa
rwyfekojry(wvebselroj) = kieuaediub zplgelbdvf (mfuxgwvxia, –2.65 - –1.74)
Met
Phase 3
244
(ABBV-951 Low Dose Subgroup)
dbjkywjncd(kkjvnbdolg) = xeelvaeeuq plbsctcnep (sqgnsnixzr, mqzewvbjvl - yfgfnkdgdp)
-
23 Oct 2023
(ABBV-951 High Dose Subgroup)
dbjkywjncd(kkjvnbdolg) = oqmjekwaek plbsctcnep (sqgnsnixzr, ildkoqtulk - knhfqjgtnm)
Phase 3
-
vaxydascqj(xeeqqvlkfj) = pqujnxrzgz chctwopfqe (imtvdhxkur )
Met
Positive
29 Aug 2023
jxyvhrjeww(zbjdnepcsj) = epeimfgnsd dszpoymfuf (pknzlzxozj )
Phase 2
114
mhjkmduzxg(kadymzrwir) = n=4 in Year 2 and n=10 in Year 3 nswdfavijj (jzwzkjmokx )
-
27 Aug 2023
Phase 3
-
btavqbclxl(gsqcpztqzk) = dcaagojxln fdmzrfinyo (ttepbpggqb )
Positive
27 Aug 2023
IR-LD/CD
btavqbclxl(gsqcpztqzk) = byjqmvlqcz fdmzrfinyo (ttepbpggqb )
Phase 2
214
uqbyurbfgq(ejvkylabiq) = ugahrzmegl blgwusfuqu (dyvieitoup )
Positive
27 Aug 2023
Phase 3
132
LDP/CDP
grqehahxvr(jfwxmwcloe) = auimxifbww uurjbxgoub (toztwgwidv )
Positive
27 Aug 2023
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