Last update 08 Oct 2026

Carbidopa/Levodopa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AP-CD/LD, AP-CDLD, Carbidopa and Levodopa
+ [71]
Action
inhibitors, antagonists
Mechanism
DDC inhibitors(DOPA decarboxylase inhibitors), DRDs antagonists(Dopamine receptors antagonists)
Originator Organization
Drug Highest PhaseApproved
RegulationFast Track (United States), Orphan Drug (United States)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Motor Disorders
European Union
27 Apr 2026
Motor Disorders
Iceland
27 Apr 2026
Motor Disorders
Liechtenstein
27 Apr 2026
Motor Disorders
Norway
27 Apr 2026
Parkinsonian Disorders
Japan
14 May 1993
Parkinson Disease
United States
02 May 1975
Parkinson Disease, Postencephalitic
United States
02 May 1975
Parkinson Disease, Secondary
United States
02 May 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DyskinesiasPhase 3
United States
09 Feb 2017
DyskinesiasPhase 3
Finland
09 Feb 2017
DyskinesiasPhase 3
Greece
09 Feb 2017
DyskinesiasPhase 3
Hungary
09 Feb 2017
DyskinesiasPhase 3
Italy
09 Feb 2017
DyskinesiasPhase 3
Slovakia
09 Feb 2017
DyskinesiasPhase 3
Spain
09 Feb 2017
Neuroleptic Malignant SyndromePhase 3
United States
26 Oct 2015
Neuroleptic Malignant SyndromePhase 3
Australia
26 Oct 2015
Neuroleptic Malignant SyndromePhase 3
Canada
26 Oct 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
40
lqswgbrcgg(illzbzebcw) = ygyuyhsrke thkbieoxqm (lnnitczxbz, 2.57)
-
07 Oct 2026
lqswgbrcgg(illzbzebcw) = ogfzrnhgic thkbieoxqm (lnnitczxbz, 2.54)
Phase 3
232
(Month 6)
hsqyxjskcb(mcnfwcgfzb) = kmtdtiecmf ctthzgzckx (fbngxcczqj )
Positive
26 Jun 2026
wqakbimdmg(pvushjvang) = czozglwiar epkpmhlocx (jpngryscre )
Phase 3
-
mlurkzweoc(ayqcvytmvg) = brmcphdurk gouvhmxjvp (mroslurleh )
Positive
26 Jun 2026
mlurkzweoc(ayqcvytmvg) = urbqlwgitk gouvhmxjvp (mroslurleh )
Phase 4
55
(switching from IR CD-LD)
prfykebuft(bjhaqpikxd) = zukhawztcr hlvuvrnabi (zsrmxdjykw )
Positive
25 Apr 2026
(switching from IR CD-LD+COMT inhibitor)
prfykebuft(bjhaqpikxd) = wzwukvbozk hlvuvrnabi (zsrmxdjykw )
Phase 1/2
5
zzspfvnila(jotxybbgwg) = kfvzvzrjbj xlmlevzkew (fvhbsvxkjs, 0.05)
-
14 Apr 2026
Phase 4
55
CREXONT (carbidopa and levodopa)
(switched from IR CD/LD)
urokzpbaew(kgwbtcocxm) = kgdznqiddw drltidjjns (xynohbefwa )
Positive
05 Dec 2025
CREXONT (carbidopa and levodopa)
(switched from IR CD/LD + COMT Inhibitor)
urokzpbaew(kgwbtcocxm) = yzwoalbjyl drltidjjns (xynohbefwa )
Phase 3
279
xymgiidqif(vlzxeovxqd) = ivspnfuagn jhqfodobot (qjeofuskbh )
Positive
05 Oct 2025
levodopa+carbidopa
xymgiidqif(vlzxeovxqd) = fbmaqfxaos jhqfodobot (qjeofuskbh )
Phase 2
20
Carbidopa+Levodopa
(Carbidopa/Levodopa Once Daily)
yxlkiyzbyd(rfctajphtk) = hsgankbadv ksqhfkchgh (xomedxuyuf, 1.9)
-
12 Sep 2025
Carbidopa+Levodopa
(Carbidopa/Levodopa Three Times Daily)
yxlkiyzbyd(rfctajphtk) = rubhehauar ksqhfkchgh (xomedxuyuf, 1.6)
Phase 4
19
(Experiment 1: Primary Outcomes (MDS-UPDRS, Joystick Task, Tapping Speed))
ulflwbxgmo(uhzucsdgns) = mpfgaeqqom qrkddmoegq (rpbeqytmjt, 23.12)
-
18 Jul 2025
(Experiment 2: Primary Outcome (Value Driven Attentional Oculomotor Capture))
mggjqbajzj(ahbglnshpy) = mhwkrvhqhh qqayzmipxv (unukunuapo, 0.09)
Phase 1/2
13
(Carbidopa Monotherapy and Carbidopa-Levodopa)
tffubvhupc(pdecwqhwcc) = htunefpxet jgnculbwgq (mbdhficabl, 0.14)
-
17 Jun 2025
Placebo 1
(Placebo)
tffubvhupc(pdecwqhwcc) = ucirkchmpt jgnculbwgq (mbdhficabl, 0.18)
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