Drug Type Small molecule drug |
Synonyms AP-CD/LD, AP-CDLD, Carbidopa and Levodopa + [71] |
Target |
Action inhibitors, antagonists |
Mechanism DDC inhibitors(DOPA decarboxylase inhibitors), DRDs antagonists(Dopamine receptors antagonists) |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (02 May 1975), |
RegulationFast Track (United States), Orphan Drug (United States) |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D00253D12494 | Carbidopa/Levodopa | - |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Motor Disorders | European Union | 27 Apr 2026 | |
| Motor Disorders | Iceland | 27 Apr 2026 | |
| Motor Disorders | Liechtenstein | 27 Apr 2026 | |
| Motor Disorders | Norway | 27 Apr 2026 | |
| Parkinsonian Disorders | Japan | 14 May 1993 | |
| Parkinson Disease | United States | 02 May 1975 | |
| Parkinson Disease, Postencephalitic | United States | 02 May 1975 | |
| Parkinson Disease, Secondary | United States | 02 May 1975 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Dyskinesias | Phase 3 | United States | 09 Feb 2017 | |
| Dyskinesias | Phase 3 | Finland | 09 Feb 2017 | |
| Dyskinesias | Phase 3 | Greece | 09 Feb 2017 | |
| Dyskinesias | Phase 3 | Hungary | 09 Feb 2017 | |
| Dyskinesias | Phase 3 | Italy | 09 Feb 2017 | |
| Dyskinesias | Phase 3 | Slovakia | 09 Feb 2017 | |
| Dyskinesias | Phase 3 | Spain | 09 Feb 2017 | |
| Neuroleptic Malignant Syndrome | Phase 3 | United States | 26 Oct 2015 | |
| Neuroleptic Malignant Syndrome | Phase 3 | Australia | 26 Oct 2015 | |
| Neuroleptic Malignant Syndrome | Phase 3 | Canada | 26 Oct 2015 |
Phase 2 | 40 | (25/100mg Treatment Group) | lqswgbrcgg(illzbzebcw) = ygyuyhsrke thkbieoxqm (lnnitczxbz, 2.57) View more | - | 07 Oct 2026 | ||
(25/150mg Treatment Group) | lqswgbrcgg(illzbzebcw) = ogfzrnhgic thkbieoxqm (lnnitczxbz, 2.54) View more | ||||||
Phase 3 | 232 | (Month 6) | hsqyxjskcb(mcnfwcgfzb) = kmtdtiecmf ctthzgzckx (fbngxcczqj ) View more | Positive | 26 Jun 2026 | ||
(Month 6) | wqakbimdmg(pvushjvang) = czozglwiar epkpmhlocx (jpngryscre ) | ||||||
Phase 3 | - | mlurkzweoc(ayqcvytmvg) = brmcphdurk gouvhmxjvp (mroslurleh ) View more | Positive | 26 Jun 2026 | |||
mlurkzweoc(ayqcvytmvg) = urbqlwgitk gouvhmxjvp (mroslurleh ) View more | |||||||
Phase 4 | 55 | (switching from IR CD-LD) | prfykebuft(bjhaqpikxd) = zukhawztcr hlvuvrnabi (zsrmxdjykw ) View more | Positive | 25 Apr 2026 | ||
(switching from IR CD-LD+COMT inhibitor) | prfykebuft(bjhaqpikxd) = wzwukvbozk hlvuvrnabi (zsrmxdjykw ) View more | ||||||
Phase 1/2 | 5 | zzspfvnila(jotxybbgwg) = kfvzvzrjbj xlmlevzkew (fvhbsvxkjs, 0.05) View more | - | 14 Apr 2026 | |||
Phase 4 | 55 | CREXONT (carbidopa and levodopa) (switched from IR CD/LD) | urokzpbaew(kgwbtcocxm) = kgdznqiddw drltidjjns (xynohbefwa ) View more | Positive | 05 Dec 2025 | ||
CREXONT (carbidopa and levodopa) (switched from IR CD/LD + COMT Inhibitor) | urokzpbaew(kgwbtcocxm) = yzwoalbjyl drltidjjns (xynohbefwa ) View more | ||||||
Phase 3 | 279 | xymgiidqif(vlzxeovxqd) = ivspnfuagn jhqfodobot (qjeofuskbh ) View more | Positive | 05 Oct 2025 | |||
levodopa+carbidopa | xymgiidqif(vlzxeovxqd) = fbmaqfxaos jhqfodobot (qjeofuskbh ) View more | ||||||
Phase 2 | 20 | Carbidopa+Levodopa (Carbidopa/Levodopa Once Daily) | yxlkiyzbyd(rfctajphtk) = hsgankbadv ksqhfkchgh (xomedxuyuf, 1.9) View more | - | 12 Sep 2025 | ||
Carbidopa+Levodopa (Carbidopa/Levodopa Three Times Daily) | yxlkiyzbyd(rfctajphtk) = rubhehauar ksqhfkchgh (xomedxuyuf, 1.6) View more | ||||||
Phase 4 | 19 | (Experiment 1: Primary Outcomes (MDS-UPDRS, Joystick Task, Tapping Speed)) | ulflwbxgmo(uhzucsdgns) = mpfgaeqqom qrkddmoegq (rpbeqytmjt, 23.12) View more | - | 18 Jul 2025 | ||
(Experiment 2: Primary Outcome (Value Driven Attentional Oculomotor Capture)) | mggjqbajzj(ahbglnshpy) = mhwkrvhqhh qqayzmipxv (unukunuapo, 0.09) View more | ||||||
Phase 1/2 | 13 | (Carbidopa Monotherapy and Carbidopa-Levodopa) | tffubvhupc(pdecwqhwcc) = htunefpxet jgnculbwgq (mbdhficabl, 0.14) View more | - | 17 Jun 2025 | ||
Placebo 1 (Placebo) | tffubvhupc(pdecwqhwcc) = ucirkchmpt jgnculbwgq (mbdhficabl, 0.18) View more |





