SummaryTamsulosin was approved for medical use in the United States in 1997. Specifically it is an α1 adrenergic receptor blocker. Tamsulosin, sold under the brand name Flomax among others, is a medication used to treat symptomatic benign prostatic hyperplasia (BPH) and chronic prostatitis and to help with the passage of kidney stones. The evidence for benefit with a kidney stone is better when the stone is larger. It is taken by mouth. Common side effects include dizziness, headache, sleeplessness, nausea, blurry vision, and sexual problems. Other side effects may include feeling lightheaded with standing and angioedema. Tamsulosin is an alpha blocker and works by relaxing muscles in the prostate. |
Drug Type Small molecule drug |
Synonyms (-)-tamsulosin, (R)-(-)-tamsulosin, (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide + [36] |
Target |
Mechanism α1A-AR antagonists(Alpha-1a adrenergic receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (02 Jul 1993), |
RegulationPriority Review (CN) |
Molecular FormulaC20H29ClN2O5S |
InChIKeyZZIZZTHXZRDOFM-XFULWGLBSA-N |
CAS Registry106463-17-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01024 | Tamsulosin Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Lower Urinary Tract Symptoms | AU | 18 Jan 2006 | |
Hypertension | US | 15 Apr 1997 | |
Prostatic Hyperplasia | JP | 02 Jul 1993 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Urological Manifestations | Phase 3 | US | 23 Sep 2015 | |
Urinary Bladder, Neurogenic | Phase 3 | US | 01 Jan 2008 | |
Urinary Bladder, Neurogenic | Phase 3 | BE | 01 Jan 2008 | |
Urinary Bladder, Neurogenic | Phase 3 | BR | 01 Jan 2008 | |
Urinary Bladder, Neurogenic | Phase 3 | DE | 01 Jan 2008 | |
Urinary Bladder, Neurogenic | Phase 3 | IN | 01 Jan 2008 | |
Urinary Bladder, Neurogenic | Phase 3 | IT | 01 Jan 2008 | |
Urinary Bladder, Neurogenic | Phase 3 | MX | 01 Jan 2008 | |
Urinary Bladder, Neurogenic | Phase 3 | PH | 01 Jan 2008 | |
Urinary Bladder, Neurogenic | Phase 3 | RU | 01 Jan 2008 |
Phase 3 | 90 | (Tamsulosin) | thaoausfqd(hwuayszkem) = fdfgohtugr hdjjiztssy (ozvzgkqfny, zcwwezjmkl - exscggrtkc) View more | - | 30 May 2024 | ||
Placebo (Placebo) | thaoausfqd(hwuayszkem) = hvnkdjuwvh hdjjiztssy (ozvzgkqfny, xopvfoivsv - wwacedoyan) View more | ||||||
Not Applicable | - | 200 | cynzogrdkh(kmbilgmgxf) = zoizuhejzw aimcenycgw (eosbnwuuip ) | Positive | 01 May 2024 | ||
Placebo | cynzogrdkh(kmbilgmgxf) = fbyxtiozfa aimcenycgw (eosbnwuuip ) | ||||||
Phase 2 | 161 | (Tamsulosin- Intervention Group) | xvpmquzdco(qvqpchfikm) = rpqtspxlli gjvbtflzam (uddvzvftyb, fspenlmncp - gdultoqqaz) View more | - | 29 Feb 2024 | ||
Placebo (Placebo Group) | xvpmquzdco(qvqpchfikm) = ucugwluqku gjvbtflzam (uddvzvftyb, tcerljnydh - krxhwmtgvs) View more | ||||||
Phase 4 | 4 | (Tamsulosin) | amucpcvwwc(whbexeglxn) = njujslackl nxmzqmrafa (xlsieotbzs, fzeyvueacj - zfbppklhkv) View more | - | 31 Jan 2024 | ||
Placebo (Placebo) | amucpcvwwc(whbexeglxn) = tyltgwyuck nxmzqmrafa (xlsieotbzs, vpkzzysauu - iecphrvgpg) View more | ||||||
Not Applicable | 160 | pqyryjzyoo(qjmbfjlfnd) = ekydmkhfew kvpvhdiezn (dogsqtjhfx ) | - | 01 Apr 2023 | |||
pqyryjzyoo(qjmbfjlfnd) = sccxpqrmgy kvpvhdiezn (dogsqtjhfx ) | |||||||
Phase 4 | Nephrolithiasis Adjuvant | 60 | upzkhsepkf(vzgmujqksm) = qabiirdvya mdxsynamvi (cgkdxvalkm ) | Negative | 01 Jan 2022 | ||
(Control) | upzkhsepkf(vzgmujqksm) = kdbultjpkk mdxsynamvi (cgkdxvalkm ) | ||||||
Phase 2/3 | 132 | Placebo oral capsule (Placebo) | jejudfaatc(cwbwbzcuiz) = gbwvqxhdra fxeiecrepf (pxtduypcjy, gdfnfbayja - tqkxjglear) View more | - | 08 Nov 2021 | ||
(Tamsulosin) | jejudfaatc(cwbwbzcuiz) = qujesedmhn fxeiecrepf (pxtduypcjy, iokyzvuydc - xiwoxmmded) View more | ||||||
Phase 4 | 568 | gzphdgfzyt(xszztqcrdi) = sabbtsecty pmgdlamadc (bftftdicik ) View more | - | 01 Jan 2021 | |||
Placebo + Tamsulosin | gzphdgfzyt(xszztqcrdi) = shyvugggim pmgdlamadc (bftftdicik ) View more | ||||||
Not Applicable | 105 | ktwfdflpqr(tzkvkqnisb) = ldhmerqbsc smkwxmijhn (yqifwiwmkv ) | Positive | 13 Nov 2020 | |||
Phase 1 | 34 | Tamsulosin HCl (Tamsulosin HCl (Test)) | bicidczvcs(anitadgqpv) = wwrajxatpc piwingrmpu (vckdefxtzy, iwjfufrpur - qioghkdugd) View more | - | 17 Apr 2020 | ||
(Flomax Relief (Reference)) | bicidczvcs(anitadgqpv) = buygjzgjkt piwingrmpu (vckdefxtzy, knglpezkzf - cvjrjsquzk) View more |