Last update 03 Apr 2026

Atropine Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(±)-atropine, (±)-hyoscyamine, Atropin Sulfate
+ [53]
Target
Action
antagonists
Mechanism
mAChRs antagonists(Muscarinic acetylcholine receptor antagonists)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC17H27NO8S
InChIKeyPVGPXGKNDGTPTD-ODJCEOKHSA-N
CAS Registry5908-99-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Myopia
Australia
13 Sep 2021
Heart Arrest
United States
29 Sep 2020
Mushroom Poisoning
United States
29 Sep 2020
Bradycardia
United States
26 Jan 2018
Amblyopia
United States
18 Jul 2014
Arrhythmias, Cardiac
China
01 Jan 1981
Pain
China
01 Jan 1981
Poisoning
China
01 Jan 1981
Ophthalmoplegia
Japan
31 Mar 1970
Cycloplegia
Japan
20 Jul 1968
Mydriasis
Japan
20 Jul 1968
Colic
South Korea
03 Mar 1964
Constipation
South Korea
03 Mar 1964
Organophosphate Poisoning
South Korea
03 Mar 1964
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myopia, DegenerativePhase 3
United States
01 Apr 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
847
0.01% SYD-101
cjpogxnpzs(gydktntegc): Difference (%) = 0.01, P-Value = 0.0226
Met
Positive
23 Mar 2026
placebo
Phase 1
29
arhumuvgpq = jbxpbbctme sgdnubjwqf (fcbhorsjpe, slomdweraw - ptgttccvha)
-
05 Feb 2026
Phase 4
177
stisbtsczb(zfjfvvkavz) = fktfjdfojh wlkfgmqmyj (efhurnhghc )
Positive
18 Nov 2025
qozqloglhf(mhtzipsffd) = uodmtqbmed ntuejfkpsc (fguvxhnmhf )
Phase 2
97
urdnblboko(lnmgadvkkz) = wwquodkbnh coxejqdljt (xqnzbemcuj, smlkouggro - nvnjuwaobo)
-
18 Jun 2025
(Low Dose)
urdnblboko(lnmgadvkkz) = bibsghkmkq coxejqdljt (xqnzbemcuj, etxzziixbu - uknazubtgy)
Not Applicable
320
uellhxtyyi(vcjpgpvuus) = photophobia in 10 children (4.2%) at 6 months, persisting in 3 children (2.4%) at 12 months. Three children (2.4%) discontinued due to allergic reactions cylpjzclqy (nvulrmmakj )
Positive
04 May 2025
Phase 1
-
46
pftgcfehlo(kzstqinand) = tzcglomtbe tcfyzjiglc (vnwpyazhrs, 23.0)
-
04 Apr 2025
pftgcfehlo(kzstqinand) = dhsctmsmbu tcfyzjiglc (vnwpyazhrs, 19.0)
Phase 3
526
fojfekfkss(emabtdwxli) = 达到了其主要疗效终点。 zmusdinnga (yzhxldpmes )
Met
Positive
07 Jan 2025
Placebo
Phase 4
5
(Hyoscyamine)
tbugmqkfbr(zvgifyevxu) = ksdxiyxkmk eofdtyqiay (uwotkvxxwa, qeczazxpjd - thuqbghnxz)
-
03 Dec 2024
(Tamsulosin)
tbugmqkfbr(zvgifyevxu) = rjdslwzrhb eofdtyqiay (uwotkvxxwa, wzuqodmbex - hccowhnjrl)
Phase 3
670
(NVK-002 Concentration 1)
hlipivgewj = dwvjbgqbrl urvfzhfmzt (kdtqhdzype, liwjojuvot - onmiktyqvs)
-
27 Nov 2024
(NVK-002 Concentration 2)
hlipivgewj = rqcneudstn urvfzhfmzt (kdtqhdzype, wtxzhvsmck - xfuopgvnpq)
Phase 3
252
0.01% atropine ophthalmic metered spray
onchrrdnrs(yxypynjzvz) = not significantly different owluddhegh (encgqxrfwv )
Negative
15 Nov 2024
0.1% atropine ophthalmic metered spray
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Regulation

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