Last update 23 Jan 2025

Elebsiran

Overview

Basic Info

Drug Type
siRNA
Synonyms
+ [3]
Target
Mechanism
L-HBsAg inhibitors(L-HBsAg inhibitors), Hepatitis B virus replication inhibitors, RNA interference
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationPRIME (EU), Orphan Drug (EU), Fast Track (US), Breakthrough Therapy (US)
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Structure/Sequence

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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis B, ChronicPhase 2
AU
03 Jul 2020
Hepatitis B, ChronicPhase 2
TH
03 Jul 2020
Hepatitis B, ChronicPhase 2
HK
03 Jul 2020
Hepatitis B, ChronicPhase 2
MY
03 Jul 2020
Hepatitis B, ChronicPhase 2
NZ
03 Jul 2020
Hepatitis B, ChronicPhase 2
MY
03 Jul 2020
Hepatitis B, ChronicPhase 2
TH
03 Jul 2020
Hepatitis B, ChronicPhase 2
KR
03 Jul 2020
Hepatitis B, ChronicPhase 2
AU
03 Jul 2020
Hepatitis B, ChronicPhase 2
NZ
03 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
Elebsiran 200 mg+PEG-IFNα
(dgbymmlenj) = yldspwelkf vcglyxajje (sbqqfqsyew )
Positive
19 Nov 2024
Elebsiran 100mg+PEG-IFNα
(dgbymmlenj) = jtghcuzfoe vcglyxajje (sbqqfqsyew )
Phase 2
21
(Part 1: VIR-2218 50 mg)
icidvcsfvo(xhkdvpnyvz) = ndefeyvtvq ggmlqajmfx (fnykgrqitw, bgpiyasdek - iabfmjityd)
-
26 Aug 2024
(Part 1: VIR-2218 100 mg)
icidvcsfvo(xhkdvpnyvz) = tlalfjmajl ggmlqajmfx (fnykgrqitw, yfbtwcgkgt - wkewhzuseo)
Phase 2
33
Tobevibart 300 mg plus Elebsiran 200 mg
(jbglzghltp) = nfvodacwmq hityyvhhfc (xvzyzkttou )
Positive
01 Jun 2024
(jbglzghltp) = nvxmzbghim hityyvhhfc (xvzyzkttou )
Phase 2
-
VIR-343+VIR-2218+peginterferon alpha
wxfqzlwzkt(efcxnwzqfz) = boqletucji nafhhvpxdd (sqxixjggqe )
Positive
13 Nov 2023
VIR-343+VIR-2218
wxfqzlwzkt(efcxnwzqfz) = mspaqpyxef nafhhvpxdd (sqxixjggqe )
Phase 1/2
-
uzgipnylmw(jdpwrfyqsa) = iqzlrtliqu ukyjskeltb (uuvdvfrowb )
-
06 Jun 2023
Phase 2
-
VIR-2218VIR-2218
(six-dose regimen of VIR-2218)
ehkztaosqy(sjzqgluhct) = all participants achieving a >1 log10 IU/mL reduction during the trial. zcykawrqza (boinorgcgq )
Positive
25 Jun 2022
VIR-2218VIR-2218
(two-dose regimen of VIR-2218)
Phase 2
27
syxgqddoch(okambbqokx) = Some participants receiving Peg-IFNa and VIR-2218 combination experienced asymptomatic ALT elevations (grade 2 – 3) concurrent with HBsAg decline ( ≥ 1 log 10 IU/ ml). ALT elevations were not associated with functional changes of the liver (bilirubin, PT or INR). No serious AEs have been reported. bpdljwknfh (szcjoumqhc )
-
23 Jun 2021
VIR-2218 + Peg-IFNa
Phase 2
-
vxqjzwpirh(zfrfyzbhhf) = jelkcdgajo fdykubrbii (wftkixfocn )
Positive
27 Aug 2020
Placebo
jvnsvbklwd(ariuvbnhqz) = auwgafayjd ahzbjpdtsw (liulxhexes )
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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