Background:
Chronic hepatitis B virus (HBV) infection affects 292 million people worldwide; 887,000 die each year from cirrhosis, liver cancer, and related issues. Treatment options are limited.
Objective:
To test 2 drugs (VIR-2218 and peginterferon) in people with mild or inactive HBV infection.
Eligibility:
People aged 18 to 65 years with mild or inactive HBV infection.
Design:
Participants will be screened. They will have blood tests and an eye exam. They will have imaging scans of the liver to check the health of the liver.
Participants will be in the study for over 2 years.
VIR-2218 is an injection given under the skin of the stomach, upper arm, or thigh. Participants will come to the clinic to receive this injection once a month for 6 months.
Peginterferon is also injected under the skin. Participants will have this shot once a week for 6 months. They may either inject themselves at home or come to the clinic to get the injections.
Participants will get just the VIR-2218 for 3 months, then both shots for 3 months, then just the peginterferon for 3 months.
Participants will have two 3-day stays in the hospital. Tests will include:
Liver biopsy. A sample of tissue will be taken from their liver. After the procedure, participants will lie on their right side for 2 hours and then on their back for 4 hours.
Fine needle aspiration. A small needle will be used to collect cells from the liver.
After the last injection of peginterferon, follow-up visits will continue in the outpatient clinic every 4 to 12 weeks.

Start Date31 Jan 2025

Sponsor / Collaborator

National Institute of Diabetes & Digestive & Kidney Diseases

NCT06696664

/ RecruitingNot ApplicableIIT

Exploring the Genome-wide Association Study of the Advantageous Population for Clinical Cure of Chronic Hepatitis B With Long-acting Interferon Therapy

This study is a real-world case-control study conducted, with 120 CHB patients who received continuous treatment with PEG-IFN-α for more than 24 weeks as study subjects. Among them, the clinical cure group obtained through PEG-IFN-α treatment is the case group; The group that did not achieve clinical cure after PEG-IFN-α treatment was used as the control group, and the case group and control group were allocated cases in a 2:1 ratio. Collect blood samples from subjects as sequencing samples for candidate genes, use high-throughput sequencing technology to detect the whole genome of subjects, identify relevant genetic polymorphism that have predictive value for clinical cure of chronic hepatitis B treated with PEG-IFN-α, and establish a predictive model and calculation formula between gene polymorphism and the efficacy of PEG-IFN-α antiviral therapy.

Start Date01 Aug 2024

Sponsor / Collaborator-

NCT06144697

/ TerminatedPhase 1

A Phase 1, Randomized, Double-blind, Placebo-controlled, First-in-human, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Prodrug BMS-986465 and Its Active Derivative, BMS-986464, in Healthy Participants Including Healthy Participants of Japanese Ethnicity and an Open-label Assessment of Food, Formulation, and pH Effects on the Relative Bioavailability of BMS-986465 and BMS-986464

The purpose of this study is to evaluate safety, tolerability, drug and food effects on relative bioavailability of BMS-986465 and its active derivative BMS-986464 in healthy participants and healthy participants of Japanese ethnicity.

Start Date29 Jan 2024

Sponsor / Collaborator

Bristol Myers Squibb Co.

100 Clinical Results associated with Peginterferon alfa-2a

100 Translational Medicine associated with Peginterferon alfa-2a

100 Patents (Medical) associated with Peginterferon alfa-2a

3,025

Literatures (Medical) associated with Peginterferon alfa-2a

31 Dec 2025·ANNALS OF MEDICINE

The remodeling of B-cell subsets was correlated with the clearance of hepatitis B antigen during pegylated IFN α-2a therapy in CHB patients

Article

Author: Wu, Zeqian ; Tan, Lei ; Mo, Zhishuo ; Zhu, Jianyun ; Gao, Zhiliang ; Gan, Weiqiang

BACKGROUND:

B-cell may participate in the cellular immune process of hepatitis B antigen clearance. However, the function and specific mechanism of B-cell during interferon-pegylated interferon α-2a (Peg-IFN-α) treatment in chronic hepatitis B (CHB) patients have not yet been described.

METHODS:

A total of 150 CHB patients enrolled in this study, who received 48 weeks of Peg-IFN α treatment. The differentiation clusters CD19, CD24, CD27, CD38, CD40, and CD80 of B cell surface markers in CHB patients were detected by flow cytometry. Spearman correlation and Logistic regression analysis were performed for the analysis.

RESULTS:

The clearance rate of HBsAg increased significantly with the duration of Peg-IFN-α treatment, reaching 32.2% by 48 weeks. During the Peg-IFN-α therapy, the frequency of B-cell and its subsets increased significantly. However, we did not observe any significant difference in the frequency of the B-cell and its subsets in patients with or without HBsAg clearance after 48 weeks Peg-IFN-α treatment. The change in HBsAg value was negatively related to the change in plasmablasts (CD19⁺CD38⁺) level before and after 48 weeks treatment (r = -0.326, p = 0.006). Moreover, the results showed that HBsAg <288.70 IU/mL at baseline and HBsAg <58.05 IU/mL at 12 weeks were strong predictors of HBsAg clearance in patients with 48 weeks Peg-IFN-α treatment.

CONCLUSION:

The remodeling of B cell subsets, especially plasmablasts (CD19⁺CD38⁺), during Peg-IFN-α treatment was closed associated with the clearance of hepatitis B antigen.

01 Mar 2025·Gastroenterologia y Hepatologia

Clinical and economic value of bulevirtide in the treatment of chronic hepatitis D

Article

Author: Buti, María ; Rodríguez, MÁ. ; Cantero, H. ; Calleja, Jose Luis ; Espinoza-Cámac, Nataly ; Domínguez-Hernández, R. ; Domínguez-Hernández, Raquel ; Casado, Miguel Ángel ; Casado, MÁ. ; Espinoza, N. ; Cantero, Helena ; Calleja, JL. ; Buti, M. ; Rodríguez, Miguel Ángel

BACKGROUND/AIMS:

Bulevirtide (Hepcludex®) is the first drug approved for the treatment of chronic hepatitis D (CHD), unlike the current off-label treatment (PEG-IFN-α), limited in clinical practice and associated with post-treatment relapses. In a hypothetical cohort of CHD patients in Spain, the study aim was to compare the efficiency of bulevirtide with PEG-IFN-α in terms of clinical events avoided and associated cost savings.

METHODS:

A validated economic model reflecting the natural history of the disease was used to project lifetime liver complications and costs for two hypothetical cohorts treated with bulevirtide or PEG-IFN-α. The model considered progression to complications such as decompensated cirrhosis (DCC), hepatocellular carcinoma (HCC), liver transplantation (LT), and death. The efficacy rates used at 24 and 48 weeks were defined as the combined response rate for bulevirtide and undetectable HDV RNA to PEG-IFN-α. The numbers of clinic events and associated costs were evaluated from the perspective of the National Healthcare System.

RESULTS:

In a hypothetical cohort of 3882 patients, bulevirtide reduced the numbers of complications events in comparison to PEG-IFN-α (152 DCC, 113 HCC, 11 LT, and 321 deaths over a lifetime). This was associated with a reduction of event-related costs of €11,837,044 (DCC €1,138,059; HCC €1,503,583; LT €7,834,291; and death €1,361,111).

CONCLUSION:

In patients with CHD, bulevirtide could prevent a significant number of clinical events compared to PEG-IFN-α and contribute to cost savings through these reduction in liver complications. Further testing for hepatitis D virus is needed so that more patients can benefit from bulevirtide.

01 Feb 2025·JOURNAL OF HEPATOLOGY

PegIFN alpha-2a reduces relapse in HBeAg-negative patients after nucleo(s)tide analogue cessation: A randomized-controlled trial

Article

Author: Zhang, Fengdi ; Liu, Yanhong ; Zhang, Yongmei ; Zhang, Xinxin ; Wu, Xiaoping ; Zhu, Haoxiang ; Guo, Yifei ; Li, Fahong ; Li, Qingxing ; Yu, Jie ; Qu, Lihong ; Chen, Liang ; Wang, Jinyu ; Zhang, Jiming ; Huang, Yuxian ; Zhang, Wenhong ; Mao, Richeng ; Zhang, Qiran ; Shen, Zhongliang ; Qi, Xun ; Yang, Feifei

BACKGROUND & AIMS:

Nucleo(s)tide analogue (NUC) cessation can lead to hepatitis B surface antigen (HBsAg) clearance but also a high rate of virological relapse. However, the effect of pegylated interferon alpha-2a (PegIFN-α-2a) on virological relapse after NUC cessation is unknown. Therefore, this study aimed to evaluate the effect of switching from NUC to PegIFN-α-2a treatment for 48 weeks on virological relapse up to week 96.

METHODS:

In this multicenter randomized-controlled clinical trial, 180 non-cirrhotic patients with HBeAg-negative chronic hepatitis B on continuous NUC therapy for ≥2.5 years, with HBV DNA levels <60 IU/ml, were randomized to discontinue NUC therapy (n = 90) or receive 48 weeks of PegIFN-α-2a treatment (n = 90). Patients were followed up for up to 96 weeks. The primary endpoint was the virological relapse rate up to week 96.

RESULTS:

Intention-to-treat analysis revealed patients in the interferon monotherapy group had significantly lower cumulative virological relapse rates than the NUC cessation group until week 96 (20.8% vs. 53.6%, p <0.0001). Consistently, a significantly lower proportion of patients in the interferon monotherapy group had virological relapse than those in the NUC cessation group at 48 weeks off treatment (17.8% vs. 36.7%, p = 0.007). The virological relapse rate positively correlated with HBsAg levels in the NUC cessation group. The interferon monotherapy group had a lower cumulative clinical relapse rate (7.8% vs. 20.9%, p = 0.008) and a higher HBsAg loss rate (21.5% vs. 9.0%, p = 0.03) than the NUC cessation group.

CONCLUSIONS:

Switching from NUC to PegIFN-α-2a treatment for 48 weeks significantly reduces virological relapse rates and leads to higher HBsAg loss rates than NUC treatment cessation alone in patients with HBeAg-negative chronic hepatitis B.

IMPACT AND IMPLICATIONS:

Nucleo(s)tide analogue (NUC) cessation can lead to HBsAg clearance but also a high rate of virological relapse, but an optimized scheme to reduce the virological relapse rate after NUC withdrawal is yet to be reported. This randomized-controlled trial investigated the effect of switching from NUC to PegIFN-α-2a treatment for 48 weeks on virological relapse up to week 96 in patients with HBeAg-negative chronic hepatitis B. The interferon monotherapy group had a significantly lower cumulative virological relapse rate (20.8% vs. 53.6%, p <0.0001) and higher HBsAg loss rate (21.5% vs. 9.0%, p = 0.03) than the NUC cessation group up to week 96. This provides an optimized strategy for NUC cessation in HBeAg-negative patients.

TRIAL REGISTRATION NUMBER:

NCT02594293.

News (Medical) associated with Peginterferon alfa-2a

10 Feb 2025

·www.globenewswire.com

Tonix Pharmaceuticals Announces Acquisition of Preclinical Infectious Disease Portfolio from Healion Bio, Inc.

The Acquired Portfolio of Infectious Disease Assets Includes a Class of Potential Broad Spectrum Oral Antiviral Agents, TNX-3900 with a Host-Directed Mechanism Tonix Plans to Develop the TNX-3900 Series of Molecules as Oral Antivirals Either as Monotherapy or in Combination with Other Antivirals The TNX-3900 Class of Antivirals Has a Novel Mechanism of Action Based on Inhibition of Certain Cathepsin Proteases which are Required for Cell Infection by Many Viruses like SARS-CoV-2 Sina Bavari, Ph.D., Tonix EVP of Infectious Disease R&D and Director of the Frederick, MD Research and Development Center (RDC) was a Scientific Founder of Healion Bio, Inc. Feb. 02, 2023 -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) (Tonix or the Company), a clinical-stage biopharmaceutical company, today announced an agreement whereby Tonix has acquired all of the assets of Healion Bio, Inc. (Healion) including its entire portfolio of next-generation antiviral technology assets. Healion’s drug portfolio includes a class of broad-spectrum small molecule oral antiviral drug candidates with a novel host-directed mechanism of action. Host-directed antivirals modulate human cells and tissues and are different from direct-acting antivirals which inhibit virus proteins and processes. Tonix’s TNX-3900, formerly known as HB-121, are cathepsin protease inhibitors, some of which have strong activity in vitro against SARS-CoV-2. “We are excited to develop Healion’s drug programs that include TNX-3900, which is a class of drugs with potential broad spectrum anti-viral activity, either as monotherapies or in combination with other antivirals”, said Seth Lederman, M.D., Chief Executive Officer of Tonix Pharmaceuticals. “Broad-spectrum antiviral agents have the potential to reduce viral load and allow the adaptive immune system to alert the other arms of the immune system to mount a protective response. Examples of other classes of host-directed antivirals that have been approved by the U.S. Food and Drug Administration (FDA) include alpha interferon like Pegasys® (peginterferon alfa-2a) for viral hepatitis, the CCR5 antagonist Selzentry® (maraviroc) for HIV, and the anti-IL-6 receptor antagonist monoclonal antibody Actemra® (tocilizumab) for COVID-19.” Sina Bavari, Ph.D., Executive Vice President for Infectious Disease Research at Tonix said, “I am pleased to be reunited with the infectious disease assets of Healion, since I was the scientific founder of Healion after I retired from my position as Chief of R&D at the United States Army Medical Research Institute of Infectious Disease (USAMRIID). While Healion made some progress developing these advanced technologies, Tonix’s state-of-the art facilities and depth of drug development expertise have the potential to advance the TNX-3900 class of drugs into clinical trials. On behalf of the talented scientific team that I direct at our 48,000 square-foot cutting-edge infectious disease research facility in Frederick, Md., I am pleased to add this technology to the therapeutic development programs underway.” TNX-3900 is the term for a series of molecules that inhibit essential cathepsins which are required by viruses such as coronaviruses and filoviruses to infect cells. Because of the unique antiviral mechanism of these compounds, the Company believes they can potentiate the activity of other antivirals with differing mechanisms. The Company believes this makes cathepsin inhibitors suitable for combination therapy. Tonix is a clinical-stage biopharmaceutical company focused on discovering, licensing, acquiring and developing therapeutics to treat and prevent human disease and alleviate suffering. Tonix’s portfolio is composed of central nervous system (CNS), rare disease, immunology and infectious disease product candidates. Tonix’s CNS portfolio includes both small molecules and biologics to treat pain, neurologic, psychiatric and addiction conditions. Tonix’s lead CNS candidate, TNX-102 SL (cyclobenzaprine HCl sublingual tablet), is in mid-Phase 3 development for the management of fibromyalgia with a new Phase 3 study launched in the second quarter of 2022 and interim data expected in the second quarter of 2023. TNX-102 SL is also being developed to treat Long COVID, a chronic post-acute COVID-19 condition. Tonix initiated a Phase 2 study in Long COVID in the third quarter of 2022. TNX-1300 (cocaine esterase) is a biologic designed to treat cocaine intoxication and has been granted Breakthrough Therapy designation by the FDA. A Phase 2 study of TNX-1300 is expected to be initiated in the second quarter of 2023. TNX-1900 (intranasal potentiated oxytocin), a small molecule in development for chronic migraine, is expected to enter the clinic with a Phase 2 study in the first quarter of 2023. TNX-601 ER (tianeptine hemioxalate extended-release tablets) is a once-daily formulation of tianeptine being developed as a potential treatment for major depressive disorder (MDD) with a Phase 2 study expected to be initiated in the first quarter of 2023. Tonix’s rare disease portfolio includes TNX-2900 (intranasal potentiated oxytocin) for the treatment of Prader-Willi syndrome. TNX-2900 has been granted Orphan Drug designation by the FDA. Tonix’s immunology portfolio includes biologics to address organ transplant rejection, autoimmunity and cancer, including TNX-1500, which is a humanized monoclonal antibody targeting CD40-ligand (CD40L or CD154) being developed for the prevention of allograft and xenograft rejection and for the treatment of autoimmune diseases. A Phase 1 study of TNX-1500 is expected to be initiated in the second quarter of 2023. Tonix’s infectious disease pipeline includes a vaccine in development to prevent smallpox and monkeypox, TNX-801, a next-generation vaccine to prevent COVID-19, TNX-1850, a platform to make fully human monoclonal antibodies to treat COVID-19, TNX-3600, and humanized anti-SARS-CoV-2 monoclonal antibodies, TNX-3800, recently licensed from Curia. TNX-801, Tonix’s vaccine in development to prevent smallpox and monkeypox, also serves as the live virus vaccine platform or recombinant pox vaccine (RPV) platform for other infectious diseases. A Phase 1 study of TNX-801 is expected to be initiated in Kenya in the second half of 2023. The content above comes from the network. if any infringement, please contact us to modify.

VaccineBreakthrough TherapyImmunotherapyOrphan Drug

02 Jan 2025

·www.businesswire.com

PharmaEssentia Reaffirms its Commitment to Robust and Reliable Access to Interferon Therapies Amid Global Supply Challenges

BURLINGTON, Mass.--( BUSINESS WIRE )--In light of the reported global shortage of Pegasys® (peginterferon alfa-2a), PharmaEssentia (TWSE: 6446), a global biopharmaceutical company, reaffirms its enduring commitment to creating robust and reliable access to critical interferon therapies. Amidst growing global concerns about drug shortages of other therapies, PharmaEssentia’s established cGMP manufacturing network and patient-focused approach enable it to help meet the needs of healthcare providers and their patients during this period. “Our longstanding commitment to operational resilience has positioned us to navigate these challenges effectively,” said Dr. Ko Chung Lin, CEO of PharmaEssentia. “We recognize that dependable medication supply is essential, and we are working closely with our partners around the world to ensure the continuity of these important therapies. We have made substantial investment to ensure that all of our supply chain elements are strong, of the highest quality, and reliable.” Key Factors Supporting PharmaEssentia’s Reliability: Robust Supply Chain Infrastructure: PharmaEssentia has invested in a network designed to maintain strong and steady production and distribution. This approach helps ensure consistent availability, even amidst global shortages and fluctuations of drug supplies. Comprehensive Support for Patients and Providers: Beyond robust product availability, PharmaEssentia makes resources available to healthcare professionals and patients globally where permitted. These tools are intended to help with patient education, contributing to better overall care by healthcare professionals for appropriate patients. Focus on Quality and Operational Rigor: PharmaEssentia adheres to stringent quality standards to ensure reliable supply of therapies, to meet regulatory and industry benchmarks and to deliver on our commitment to patients and healthcare professionals. “Our priority, as always, remains ensuring that patients receive their prescribed therapy without delays,” added Dr. Lin. “We appreciate the trust placed in us by healthcare professionals and patients and will continue working diligently to uphold it.” About PharmaEssentia PharmaEssentia U.S. Corporation is a wholly owned subsidiary of PharmaEssentia. PharmaEssentia (TWSE: 6446), headquartered in Taipei, Taiwan, is a global and rapidly growing biopharmaceutical innovator. Leveraging deep expertise and proven scientific principles, PharmaEssentia aims to deliver effective new biologics for challenging diseases in the areas of hematology, oncology, and immunology with one approved product and a diversifying pipeline. Founded in 2003 by a team of Taiwanese-American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today PharmaEssentia is expanding its global presence with operations in the U.S., Japan, China, and Korea, along with a world-class biologics production facility in Taichung, Taiwan. Healthcare professionals and patients seeking information about PharmaEssentia can visit, for the U.S., https://us.pharmaessentia.com/ or contact https://us.pharmaessentia.com/contact/ . For global, https://hq.pharmaessentia.com/ . For more information about PharmaEssentia USA, visit the website , LinkedIn or Twitter . Additional Disclosure: zr pharma& GmbH owns worldwide rights to Pegasys® (peginterferon alfa-2a) exclusive of China and Japan. Pegasys® is a registered trademark of Hoffmann-LaRoche Inc. © 2025 PharmaEssentia Corporation. All rights reserved.

06 Sep 2024

·synapse.patsnap.com

Grünenthal acquires Valinor for $250 million to obtain an opioid antagonist product

Recently, the German company Grünenthal, specializing in the development of pain relief medications, announced the acquisition of the American pharmaceutical manufacturer Valinor Pharma for $250 million in order to obtain the rights to Movantik (naloxegol), a treatment for opioid-induced constipation developed by Valinor. It is reported that in 2023, sales of this product reached $200 million in the United States. Since Grünenthal already holds the rights to Movantik in the European Union, the acquisition of Valinor will allow Grünenthal to have complete control over the Movantik brand in all markets outside of Canada. The United States is considered the company's most important growth market, and the acquisition of Valinor will strengthen Grünenthal's position in the pain management sector in the U.S. About NaloxegolNaloxegol is a selective peripherally-acting μ-opioid receptor antagonist (PAMORA) and a pegylated form of naloxone. This product was originally developed by Nektar Therapeutics and further developed by AstraZeneca. It was approved by the U.S. FDA in September 2014 for the treatment of opioid-induced constipation in adults with chronic non-cancer pain. Notably, Nektar holds a patent for its drug pegylation technology, and naloxegol's advantage over the opioid receptor antagonist naloxone stems from its pegylated structure, which confers high selectivity for peripheral opioid receptors while not crossing the blood-brain barrier. According to a pharmacological study published in 2017, naloxegol is a potent antagonist at human μ-opioid receptors in vitro, with a Ki value of 7.42 nM, demonstrating an action similar to that of non-PEGylated naloxone. AstraZeneca published the clinical study results of Naloxegol in the New England Journal of Medicine in 2014. Compared to placebo, the use of Naloxegol significantly improved treatment response rates without reducing the analgesic effects mediated by opioids. In addition to Naloxegol, Nektar developed ADYNOVATE in collaboration with Baxter and Baxalta. ADYNOVATE is an extended half-life recombinant Factor VIII (rFVIII) product for the treatment of hemophilia. In January 2019, Takeda Pharmaceutical acquired Shire, gaining ownership of Baxalta and ADYNOVATE as a result. About PEGylated PharmaceuticalsPEGylated pharmaceuticals are composed of various reagents, including linkers, crosslinkers, and labels. Different types of reagents include amine, carboxyl, and carboxyl PEGylation. Currently, PEGylated drugs are primarily used to treat conditions such as cancer, chronic kidney disease, hepatitis, multiple sclerosis, hemophilia, and gastrointestinal diseases. In March 1990, ADAGEN produced by Enzon Pharmaceuticals was the first PEGylated protein approved by the U.S. Food and Drug Administration (FDA) for market entry. Since the launch of ADAGEN, a large number of PEGylated proteins and peptide drugs have followed suit, and many more are in clinical trials or development stages. Among the FDA-approved drugs, Pegasys and Neulasta generated sales exceeding $5 billion in 2011. How to obtain the latest research advancements in the field of biopharmaceuticals? In the Synapse database, you can keep abreast of the latest research and development advances in drugs, targets, indications, organizations, etc., anywhere and anytime, on a daily or weekly basis. Click on the image below to embark on a brand new journey of drug discovery!

100 Deals associated with Peginterferon alfa-2a

External Link

KEGG	Wiki	ATC	Drug Bank
D02747	Peginterferon alfa-2a	L03AB11	DB00008

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Hepatitis B	JP	Chugai Pharmaceutical Co., Ltd.	16 Oct 2003
Hepatitis C	JP	Chugai Pharmaceutical Co., Ltd.	16 Oct 2003
Hepatitis B, Chronic	EU	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis B, Chronic	IS	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis B, Chronic	LI	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis B, Chronic	NO	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis C, Chronic	EU	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis C, Chronic	IS	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis C, Chronic	LI	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis C, Chronic	NO	Pharma& Schweiz GmbH	20 Jun 2002

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Polycythemia Vera	NDA/BLA	EU	Pharma& Schweiz GmbH	27 Jun 2024
Thrombocythemia, Essential	NDA/BLA	EU	Pharma& Schweiz GmbH	27 Jun 2024
Compensated cirrhosis	Phase 3	JP	Chugai Pharmaceutical Co., Ltd.	01 Jun 2006
Chronic hepatitis C genotype 3	Phase 3	DE	Hoffmann-La Roche, Inc.	01 Nov 2005
Hepatitis D, Chronic	Phase 3	RO	Hoffmann-La Roche, Inc.	01 Oct 2005
Complete atrioventricular block	Phase 3	IT	Hoffmann-La Roche, Inc.	01 Jul 2005
Kidney Failure, Chronic	Phase 3	AT	Hoffmann-La Roche, Inc.	01 Jun 2004
Kidney Failure, Chronic	Phase 3	BR	Hoffmann-La Roche, Inc.	01 Jun 2004
Kidney Failure, Chronic	Phase 3	FR	Hoffmann-La Roche, Inc.	01 Jun 2004
Kidney Failure, Chronic	Phase 3	GR	Hoffmann-La Roche, Inc.	01 Jun 2004

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


Tandem Meetings ASTCT and CIBMTR2024 Manual	Not Applicable	Hematopoietic stem cell transplantation	12	Peginterferon-alpha (pegIFNα) 180 mcg	keaguckkfw(waytqfgyzg) = hfoqdpmpii smefslanxb (etuojjfzti, 58.7 - 100) View more	Positive	01 Feb 2024
NCT00932971 (HIDIT-II, Pubmed \| Liver Int)	Phase 2	Hepatitis D	-	PEG-IFNa + TDF	kttccmemop(xuwwptmzwk) = pswpozsiqz ihtmxdnxgg (bcjehbezwk ) View more	Positive	01 Jan 2024
				PEG-IFNa + placebo	rterrimiqe(sypxbpauki) = wbyeyhmdpo gwsgpxwenb (ewldclvpnq ) View more
WCD2023	Not Applicable	Cutaneous T-Cell Lymphoma	105	PEG IFN a-2a	cdgtusrmgj(fvhacybvso) = herkkppgqt ovbquroqeo (onzaqvoitq ) View more	-	08 Jul 2023
NCT01369212 (HBRN, CTgov)	Phase 3	Hepatitis B, Chronic	201	Tenofovir (Tenofovir)	jjeobvokqz(rmrkuwawnq) = oekxlegejs yhdwbsripw (zrfuqgaebw, viqdmcxbmp - tcdskmpkyg) View more	-	12 Oct 2022
				tenofovir+Pegasys (Peginterferon-alfa 2a and Tenofovir)	jjeobvokqz(rmrkuwawnq) = sbrobzvgrj yhdwbsripw (zrfuqgaebw, ojjvmgptlf - mxidrzwmau) View more
NCT02328755 (CTgov)	Phase 1/2	Acute Myeloid Leukemia	37	Hematopoietic Cell Transplant (HCT)+peg-IFN-α+Tacrolimus+Methotrexate	lwsflwaafq(wovqgzlojm) = rxfxnwzyax slabusercr (muorxajxnz, mdkjmcxjhi - kfubxiysif) View more	-	06 Oct 2021
NCT02328755 (Pubmed \| Blood Adv)	Phase 1/2	Relapsing acute myeloid leukemia	37	pegIFNα	jughcglctt(ldoovlkygx) = uhkgtwlktf dstghjvnrq (ctshpltzrn ) View more	-	04 Oct 2021
EASL2020	Not Applicable	Hepatitis B \| Hepatitis D HBsAg components \| HDV RNA \| HBV DNA ... View more	26	PEG-IFN	zauqasbsgs(lcetyjvfdt) = qqkkywoifa bdscqlvyxf (psgcvfssar ) View more	Positive	27 Aug 2020
EASL2020	Not Applicable	-	30	Bulevirtide 10 mg + Peginterferon alfa-2a	vrohwazugu(stykjzuobp) = fzmtqklain iqyvebcvuw (pdwwuygaze ) View more	-	27 Aug 2020
				Bulevirtide 10 mg	vrohwazugu(stykjzuobp) = ybsirqdjxw iqyvebcvuw (pdwwuygaze ) View more
NCT01524679 (PADD-ON, CTgov)	Phase 2	Hepatitis B, Chronic	170	Pegylated interferon alfa-2a plus nucleos(t)ide(s) (Treatment Group)	juswnbtavt(yfgisbojjn): P-Value = <0.0001 View more	-	18 Feb 2020
				nucleos(t)ide (Control Group)
NCT01259856 (MPD-RC, Pubmed \| Circulation \| Blood) Manual	Phase 2	Polycythemia Vera \| Thrombocythemia, Essential	115	Pegylated interferon alfa-2a (essential thrombocythemia)	xpnajhynpf(jwtbfldgvg) = ndiecriyvu syxtxecqnl (rozmoukdlf ) View more	Positive	31 Oct 2019
				Pegylated interferon alfa-2a (polycythemia vera)	xpnajhynpf(jwtbfldgvg) = tdggxkiztg syxtxecqnl (rozmoukdlf ) View more

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Peginterferon alfa-2a

Overview

Basic Info

Structure/Sequence

Related

External Link

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation