Background:
Chronic hepatitis B virus (HBV) infection affects 292 million people worldwide; 887,000 die each year from cirrhosis, liver cancer, and related issues. Treatment options are limited.
Objective:
To test 2 drugs (VIR-2218 and peginterferon) in people with mild or inactive HBV infection.
Eligibility:
People aged 18 to 65 years with mild or inactive HBV infection.
Design:
Participants will be screened. They will have blood tests and an eye exam. They will have imaging scans of the liver to check the health of the liver.
Participants will be in the study for over 2 years.
VIR-2218 is an injection given under the skin of the stomach, upper arm, or thigh. Participants will come to the clinic to receive this injection once a month for 6 months.
Peginterferon is also injected under the skin. Participants will have this shot once a week for 6 months. They may either inject themselves at home or come to the clinic to get the injections.
Participants will get just the VIR-2218 for 3 months, then both shots for 3 months, then just the peginterferon for 3 months.
Participants will have two 3-day stays in the hospital. Tests will include:
Liver biopsy. A sample of tissue will be taken from their liver. After the procedure, participants will lie on their right side for 2 hours and then on their back for 4 hours.
Fine needle aspiration. A small needle will be used to collect cells from the liver.
After the last injection of peginterferon, follow-up visits will continue in the outpatient clinic every 4 to 12 weeks.

Start Date31 Jan 2025

Sponsor / Collaborator

National Institute of Diabetes & Digestive & Kidney Diseases

NCT06696664

/ RecruitingNot ApplicableIIT

Exploring the Genome-wide Association Study of the Advantageous Population for Clinical Cure of Chronic Hepatitis B With Long-acting Interferon Therapy

This study is a real-world case-control study conducted, with 120 CHB patients who received continuous treatment with PEG-IFN-α for more than 24 weeks as study subjects. Among them, the clinical cure group obtained through PEG-IFN-α treatment is the case group; The group that did not achieve clinical cure after PEG-IFN-α treatment was used as the control group, and the case group and control group were allocated cases in a 2:1 ratio. Collect blood samples from subjects as sequencing samples for candidate genes, use high-throughput sequencing technology to detect the whole genome of subjects, identify relevant genetic polymorphism that have predictive value for clinical cure of chronic hepatitis B treated with PEG-IFN-α, and establish a predictive model and calculation formula between gene polymorphism and the efficacy of PEG-IFN-α antiviral therapy.

Start Date01 Aug 2024

Sponsor / Collaborator-

NCT06144697

/ TerminatedPhase 1

A Phase 1, Randomized, Double-blind, Placebo-controlled, First-in-human, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Prodrug BMS-986465 and Its Active Derivative, BMS-986464, in Healthy Participants Including Healthy Participants of Japanese Ethnicity and an Open-label Assessment of Food, Formulation, and pH Effects on the Relative Bioavailability of BMS-986465 and BMS-986464

The purpose of this study is to evaluate safety, tolerability, drug and food effects on relative bioavailability of BMS-986465 and its active derivative BMS-986464 in healthy participants and healthy participants of Japanese ethnicity.

Start Date29 Jan 2024

Sponsor / Collaborator

Bristol Myers Squibb Co.

100 Clinical Results associated with Peginterferon alfa-2a

100 Translational Medicine associated with Peginterferon alfa-2a

100 Patents (Medical) associated with Peginterferon alfa-2a

3,033

Literatures (Medical) associated with Peginterferon alfa-2a

31 Dec 2025·ANNALS OF MEDICINE

The remodeling of B-cell subsets was correlated with the clearance of hepatitis B antigen during pegylated IFN α-2a therapy in CHB patients

Article

Author: Wu, Zeqian ; Tan, Lei ; Mo, Zhishuo ; Zhu, Jianyun ; Gao, Zhiliang ; Gan, Weiqiang

BACKGROUND:

B-cell may participate in the cellular immune process of hepatitis B antigen clearance. However, the function and specific mechanism of B-cell during interferon-pegylated interferon α-2a (Peg-IFN-α) treatment in chronic hepatitis B (CHB) patients have not yet been described.

METHODS:

A total of 150 CHB patients enrolled in this study, who received 48 weeks of Peg-IFN α treatment. The differentiation clusters CD19, CD24, CD27, CD38, CD40, and CD80 of B cell surface markers in CHB patients were detected by flow cytometry. Spearman correlation and Logistic regression analysis were performed for the analysis.

RESULTS:

The clearance rate of HBsAg increased significantly with the duration of Peg-IFN-α treatment, reaching 32.2% by 48 weeks. During the Peg-IFN-α therapy, the frequency of B-cell and its subsets increased significantly. However, we did not observe any significant difference in the frequency of the B-cell and its subsets in patients with or without HBsAg clearance after 48 weeks Peg-IFN-α treatment. The change in HBsAg value was negatively related to the change in plasmablasts (CD19⁺CD38⁺) level before and after 48 weeks treatment (r = -0.326, p = 0.006). Moreover, the results showed that HBsAg <288.70 IU/mL at baseline and HBsAg <58.05 IU/mL at 12 weeks were strong predictors of HBsAg clearance in patients with 48 weeks Peg-IFN-α treatment.

CONCLUSION:

The remodeling of B cell subsets, especially plasmablasts (CD19⁺CD38⁺), during Peg-IFN-α treatment was closed associated with the clearance of hepatitis B antigen.

01 Apr 2025·Liver International

Incidence and Predictors of HBsAg Loss in Paediatric Patients With Chronic Hepatitis B Undergoing Antiviral Treatment

Article

Author: Peng, Songxu ; Yao, Zhenzhen ; Ouyang, Wenxian ; Lai, Xin ; Gu, Yingping ; Li, Shuangjie

ABSTRACT:

Background and Aims:

Achieving HBsAg loss is a critical clinical milestone in the management of chronic hepatitis B (CHB) towards the eradication of hepatitis B. However, there are limited researches on the incidence and determinants of HBsAg loss in paediatric CHB patients undergoing antiviral treatment. Therefore, we aimed to analyse the incidence and potential determinants of HBsAg loss in children who suffered from CHB and received antiviral treatment.

Methods:

This retrospective cohort study was performed on paediatric patients with progressive CHB who initiated either monotherapy or combination therapy using interferon/peg‐interferon and entecavir. We utilised Cox regression models to evaluate the relationships between HBsAg loss and various determining factors.

Results:

In total of 306 subjects with an average age of 4.99 years (range 1–15) were identified in this study, of whom 200 (65.4%) were male. After a median follow‐up of 26 months, HBsAg loss occurred in 135 participants. The accumulated rate of HBsAg loss was 67.8% at the end of the follow‐up evaluation. Multivariate Cox regression analysis revealed that older age (HR = 0.84, 95% CI: 0.79–0.90), female sex (HR = 1.61, 95% CI: 1.13–2.30), baseline HBsAg levels (HR = 0.72, 95% CI: 0.62–0.84), HBsAb positivity (HR = 1.77, 95% CI: 1.20–2.59) and serum bilirubin levels (HR = 0.96, 95% CI: 0.92–0.99) were statistically significant predictors of HBsAg loss.

Conclusion:

The incidence of HBsAg loss continues to increase in paediatric patients with CHB after antiviral treatment. Age, sex, baseline HBsAg and bilirubin levels and HBsAb positivity are found to be associated with sustained HBsAg loss.

25 Mar 2025·Blood Advances

Relationship between additional mutations at diagnosis and treatment response in patients with essential thrombocythemia

Article

Author: Orvain, Corentin ; Bellal, Sarah ; Riou, Jérémie ; Boyer, Françoise ; Hunault-Berger, Mathilde ; Copin, Marie-Christine ; Jouanneau-Courville, Rébecca ; Pawlicki, Bertille ; Argentin, Joris ; Malinge, Anaïs ; Mosnier, Carole ; Ugo, Valérie ; Bachelot, Amélie ; Luque Paz, Damien ; Cottin, Laurane ; Lemoine, Sandrine

Abstract:

Patients with essential thrombocythemia (ET) have a chronic evolution with a risk of hematologic transformation associated with a dismal outcome. Because patients with resistance or intolerance have adverse prognosis, it is important to identify which patient will respond to first-line treatment. We, therefore, aim to describe the association between additional mutations and response to first-line treatment in patients with ET. In this retrospective study, we analyzed the molecular landscape of 121 ET patients first-line treated with hydroxyurea (HU; n = 86) or pegylated interferon (peg-IFN; n = 35). Patients undergoing peg-IFN therapy were younger and had higher proportion of low and very low risk of thrombosis recurrence. A total of 62 patients (51%) had ≥1 additional mutations at diagnosis. At 12 months of treatment, 75 patients (62%) achieved complete response (CR), 37 (31%) partial response, and 7 (6%) no response. The presence of at least 1 additional mutation at diagnosis was associated with not achieving CR (hazard ratio [HR], 0.65; P = .038), whereas treatment with peg-IFN was associated with higher CR (HR, 2.00; P = .002). The number of additional mutations at diagnosis was associated with hematologic progressions (P < .0001). None of the patients receiving peg-IFN therapy progressed to myelofibrosis, whereas 16 of 86 patients (19%) treated with HU developed secondary myelofibrosis. In conclusion, our results suggest that the presence of at least 1 additional mutation at diagnosis is associated with failure to achieve CR and also with an increased risk of hematologic evolution.

News (Medical) associated with Peginterferon alfa-2a

10 Feb 2025

·www.globenewswire.com

Tonix Pharmaceuticals Announces Acquisition of Preclinical Infectious Disease Portfolio from Healion Bio, Inc.

The Acquired Portfolio of Infectious Disease Assets Includes a Class of Potential Broad Spectrum Oral Antiviral Agents, TNX-3900 with a Host-Directed Mechanism Tonix Plans to Develop the TNX-3900 Series of Molecules as Oral Antivirals Either as Monotherapy or in Combination with Other Antivirals The TNX-3900 Class of Antivirals Has a Novel Mechanism of Action Based on Inhibition of Certain Cathepsin Proteases which are Required for Cell Infection by Many Viruses like SARS-CoV-2 Sina Bavari, Ph.D., Tonix EVP of Infectious Disease R&D and Director of the Frederick, MD Research and Development Center (RDC) was a Scientific Founder of Healion Bio, Inc. Feb. 02, 2023 -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) (Tonix or the Company), a clinical-stage biopharmaceutical company, today announced an agreement whereby Tonix has acquired all of the assets of Healion Bio, Inc. (Healion) including its entire portfolio of next-generation antiviral technology assets. Healion’s drug portfolio includes a class of broad-spectrum small molecule oral antiviral drug candidates with a novel host-directed mechanism of action. Host-directed antivirals modulate human cells and tissues and are different from direct-acting antivirals which inhibit virus proteins and processes. Tonix’s TNX-3900, formerly known as HB-121, are cathepsin protease inhibitors, some of which have strong activity in vitro against SARS-CoV-2. “We are excited to develop Healion’s drug programs that include TNX-3900, which is a class of drugs with potential broad spectrum anti-viral activity, either as monotherapies or in combination with other antivirals”, said Seth Lederman, M.D., Chief Executive Officer of Tonix Pharmaceuticals. “Broad-spectrum antiviral agents have the potential to reduce viral load and allow the adaptive immune system to alert the other arms of the immune system to mount a protective response. Examples of other classes of host-directed antivirals that have been approved by the U.S. Food and Drug Administration (FDA) include alpha interferon like Pegasys® (peginterferon alfa-2a) for viral hepatitis, the CCR5 antagonist Selzentry® (maraviroc) for HIV, and the anti-IL-6 receptor antagonist monoclonal antibody Actemra® (tocilizumab) for COVID-19.” Sina Bavari, Ph.D., Executive Vice President for Infectious Disease Research at Tonix said, “I am pleased to be reunited with the infectious disease assets of Healion, since I was the scientific founder of Healion after I retired from my position as Chief of R&D at the United States Army Medical Research Institute of Infectious Disease (USAMRIID). While Healion made some progress developing these advanced technologies, Tonix’s state-of-the art facilities and depth of drug development expertise have the potential to advance the TNX-3900 class of drugs into clinical trials. On behalf of the talented scientific team that I direct at our 48,000 square-foot cutting-edge infectious disease research facility in Frederick, Md., I am pleased to add this technology to the therapeutic development programs underway.” TNX-3900 is the term for a series of molecules that inhibit essential cathepsins which are required by viruses such as coronaviruses and filoviruses to infect cells. Because of the unique antiviral mechanism of these compounds, the Company believes they can potentiate the activity of other antivirals with differing mechanisms. The Company believes this makes cathepsin inhibitors suitable for combination therapy. Tonix is a clinical-stage biopharmaceutical company focused on discovering, licensing, acquiring and developing therapeutics to treat and prevent human disease and alleviate suffering. Tonix’s portfolio is composed of central nervous system (CNS), rare disease, immunology and infectious disease product candidates. Tonix’s CNS portfolio includes both small molecules and biologics to treat pain, neurologic, psychiatric and addiction conditions. Tonix’s lead CNS candidate, TNX-102 SL (cyclobenzaprine HCl sublingual tablet), is in mid-Phase 3 development for the management of fibromyalgia with a new Phase 3 study launched in the second quarter of 2022 and interim data expected in the second quarter of 2023. TNX-102 SL is also being developed to treat Long COVID, a chronic post-acute COVID-19 condition. Tonix initiated a Phase 2 study in Long COVID in the third quarter of 2022. TNX-1300 (cocaine esterase) is a biologic designed to treat cocaine intoxication and has been granted Breakthrough Therapy designation by the FDA. A Phase 2 study of TNX-1300 is expected to be initiated in the second quarter of 2023. TNX-1900 (intranasal potentiated oxytocin), a small molecule in development for chronic migraine, is expected to enter the clinic with a Phase 2 study in the first quarter of 2023. TNX-601 ER (tianeptine hemioxalate extended-release tablets) is a once-daily formulation of tianeptine being developed as a potential treatment for major depressive disorder (MDD) with a Phase 2 study expected to be initiated in the first quarter of 2023. Tonix’s rare disease portfolio includes TNX-2900 (intranasal potentiated oxytocin) for the treatment of Prader-Willi syndrome. TNX-2900 has been granted Orphan Drug designation by the FDA. Tonix’s immunology portfolio includes biologics to address organ transplant rejection, autoimmunity and cancer, including TNX-1500, which is a humanized monoclonal antibody targeting CD40-ligand (CD40L or CD154) being developed for the prevention of allograft and xenograft rejection and for the treatment of autoimmune diseases. A Phase 1 study of TNX-1500 is expected to be initiated in the second quarter of 2023. Tonix’s infectious disease pipeline includes a vaccine in development to prevent smallpox and monkeypox, TNX-801, a next-generation vaccine to prevent COVID-19, TNX-1850, a platform to make fully human monoclonal antibodies to treat COVID-19, TNX-3600, and humanized anti-SARS-CoV-2 monoclonal antibodies, TNX-3800, recently licensed from Curia. TNX-801, Tonix’s vaccine in development to prevent smallpox and monkeypox, also serves as the live virus vaccine platform or recombinant pox vaccine (RPV) platform for other infectious diseases. A Phase 1 study of TNX-801 is expected to be initiated in Kenya in the second half of 2023. The content above comes from the network. if any infringement, please contact us to modify.

VaccineBreakthrough TherapyImmunotherapyOrphan Drug

02 Jan 2025

·www.businesswire.com

PharmaEssentia Reaffirms its Commitment to Robust and Reliable Access to Interferon Therapies Amid Global Supply Challenges

BURLINGTON, Mass.--( BUSINESS WIRE )--In light of the reported global shortage of Pegasys® (peginterferon alfa-2a), PharmaEssentia (TWSE: 6446), a global biopharmaceutical company, reaffirms its enduring commitment to creating robust and reliable access to critical interferon therapies. Amidst growing global concerns about drug shortages of other therapies, PharmaEssentia’s established cGMP manufacturing network and patient-focused approach enable it to help meet the needs of healthcare providers and their patients during this period. “Our longstanding commitment to operational resilience has positioned us to navigate these challenges effectively,” said Dr. Ko Chung Lin, CEO of PharmaEssentia. “We recognize that dependable medication supply is essential, and we are working closely with our partners around the world to ensure the continuity of these important therapies. We have made substantial investment to ensure that all of our supply chain elements are strong, of the highest quality, and reliable.” Key Factors Supporting PharmaEssentia’s Reliability: Robust Supply Chain Infrastructure: PharmaEssentia has invested in a network designed to maintain strong and steady production and distribution. This approach helps ensure consistent availability, even amidst global shortages and fluctuations of drug supplies. Comprehensive Support for Patients and Providers: Beyond robust product availability, PharmaEssentia makes resources available to healthcare professionals and patients globally where permitted. These tools are intended to help with patient education, contributing to better overall care by healthcare professionals for appropriate patients. Focus on Quality and Operational Rigor: PharmaEssentia adheres to stringent quality standards to ensure reliable supply of therapies, to meet regulatory and industry benchmarks and to deliver on our commitment to patients and healthcare professionals. “Our priority, as always, remains ensuring that patients receive their prescribed therapy without delays,” added Dr. Lin. “We appreciate the trust placed in us by healthcare professionals and patients and will continue working diligently to uphold it.” About PharmaEssentia PharmaEssentia U.S. Corporation is a wholly owned subsidiary of PharmaEssentia. PharmaEssentia (TWSE: 6446), headquartered in Taipei, Taiwan, is a global and rapidly growing biopharmaceutical innovator. Leveraging deep expertise and proven scientific principles, PharmaEssentia aims to deliver effective new biologics for challenging diseases in the areas of hematology, oncology, and immunology with one approved product and a diversifying pipeline. Founded in 2003 by a team of Taiwanese-American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today PharmaEssentia is expanding its global presence with operations in the U.S., Japan, China, and Korea, along with a world-class biologics production facility in Taichung, Taiwan. Healthcare professionals and patients seeking information about PharmaEssentia can visit, for the U.S., https://us.pharmaessentia.com/ or contact https://us.pharmaessentia.com/contact/ . For global, https://hq.pharmaessentia.com/ . For more information about PharmaEssentia USA, visit the website , LinkedIn or Twitter . Additional Disclosure: zr pharma& GmbH owns worldwide rights to Pegasys® (peginterferon alfa-2a) exclusive of China and Japan. Pegasys® is a registered trademark of Hoffmann-LaRoche Inc. © 2025 PharmaEssentia Corporation. All rights reserved.

06 Sep 2024

·synapse.patsnap.com

Grünenthal acquires Valinor for $250 million to obtain an opioid antagonist product

Recently, the German company Grünenthal, specializing in the development of pain relief medications, announced the acquisition of the American pharmaceutical manufacturer Valinor Pharma for $250 million in order to obtain the rights to Movantik (naloxegol), a treatment for opioid-induced constipation developed by Valinor. It is reported that in 2023, sales of this product reached $200 million in the United States. Since Grünenthal already holds the rights to Movantik in the European Union, the acquisition of Valinor will allow Grünenthal to have complete control over the Movantik brand in all markets outside of Canada. The United States is considered the company's most important growth market, and the acquisition of Valinor will strengthen Grünenthal's position in the pain management sector in the U.S. About NaloxegolNaloxegol is a selective peripherally-acting μ-opioid receptor antagonist (PAMORA) and a pegylated form of naloxone. This product was originally developed by Nektar Therapeutics and further developed by AstraZeneca. It was approved by the U.S. FDA in September 2014 for the treatment of opioid-induced constipation in adults with chronic non-cancer pain. Notably, Nektar holds a patent for its drug pegylation technology, and naloxegol's advantage over the opioid receptor antagonist naloxone stems from its pegylated structure, which confers high selectivity for peripheral opioid receptors while not crossing the blood-brain barrier. According to a pharmacological study published in 2017, naloxegol is a potent antagonist at human μ-opioid receptors in vitro, with a Ki value of 7.42 nM, demonstrating an action similar to that of non-PEGylated naloxone. AstraZeneca published the clinical study results of Naloxegol in the New England Journal of Medicine in 2014. Compared to placebo, the use of Naloxegol significantly improved treatment response rates without reducing the analgesic effects mediated by opioids. In addition to Naloxegol, Nektar developed ADYNOVATE in collaboration with Baxter and Baxalta. ADYNOVATE is an extended half-life recombinant Factor VIII (rFVIII) product for the treatment of hemophilia. In January 2019, Takeda Pharmaceutical acquired Shire, gaining ownership of Baxalta and ADYNOVATE as a result. About PEGylated PharmaceuticalsPEGylated pharmaceuticals are composed of various reagents, including linkers, crosslinkers, and labels. Different types of reagents include amine, carboxyl, and carboxyl PEGylation. Currently, PEGylated drugs are primarily used to treat conditions such as cancer, chronic kidney disease, hepatitis, multiple sclerosis, hemophilia, and gastrointestinal diseases. In March 1990, ADAGEN produced by Enzon Pharmaceuticals was the first PEGylated protein approved by the U.S. Food and Drug Administration (FDA) for market entry. Since the launch of ADAGEN, a large number of PEGylated proteins and peptide drugs have followed suit, and many more are in clinical trials or development stages. Among the FDA-approved drugs, Pegasys and Neulasta generated sales exceeding $5 billion in 2011. How to obtain the latest research advancements in the field of biopharmaceuticals? In the Synapse database, you can keep abreast of the latest research and development advances in drugs, targets, indications, organizations, etc., anywhere and anytime, on a daily or weekly basis. Click on the image below to embark on a brand new journey of drug discovery!

100 Deals associated with Peginterferon alfa-2a

External Link

KEGG	Wiki	ATC	Drug Bank
D02747	Peginterferon alfa-2a	L03AB11	DB00008

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Hepatitis B	Japan	Chugai Pharmaceutical Co., Ltd.	16 Oct 2003
Hepatitis C	Japan	Chugai Pharmaceutical Co., Ltd.	16 Oct 2003
Hepatitis B, Chronic	European Union	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis B, Chronic	Iceland	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis B, Chronic	Liechtenstein	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis B, Chronic	Norway	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis C, Chronic	European Union	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis C, Chronic	Iceland	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis C, Chronic	Liechtenstein	Pharma& Schweiz GmbH	20 Jun 2002
Hepatitis C, Chronic	Norway	Pharma& Schweiz GmbH	20 Jun 2002

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Polycythemia Vera	NDA/BLA	European Union	Pharma& Schweiz GmbH	27 Jun 2024
Thrombocythemia, Essential	NDA/BLA	European Union	Pharma& Schweiz GmbH	27 Jun 2024
Compensated cirrhosis	Phase 3	Japan	Chugai Pharmaceutical Co., Ltd.	01 Jun 2006
Chronic hepatitis C genotype 3	Phase 3	Germany	Hoffmann-La Roche, Inc.	01 Nov 2005
Hepatitis D, Chronic	Phase 3	Romania	Hoffmann-La Roche, Inc.	01 Oct 2005
Complete atrioventricular block	Phase 3	Italy	Hoffmann-La Roche, Inc.	01 Jul 2005
Kidney Failure, Chronic	Phase 3	Austria	Hoffmann-La Roche, Inc.	01 Jun 2004
Kidney Failure, Chronic	Phase 3	Brazil	Hoffmann-La Roche, Inc.	01 Jun 2004
Kidney Failure, Chronic	Phase 3	France	Hoffmann-La Roche, Inc.	01 Jun 2004
Kidney Failure, Chronic	Phase 3	Greece	Hoffmann-La Roche, Inc.	01 Jun 2004

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


Tandem Meetings ASTCT and CIBMTR2024 Manual	Not Applicable	Hematopoietic stem cell transplantation	12	Peginterferon-alpha (pegIFNα) 180 mcg	uhyjvpeawt(txhtvwgakp) = onjwxbfyey eiwlovynrq (nnbicfbkjh, 58.7 - 100) View more	Positive	01 Feb 2024
NCT00932971 (HIDIT-II, Pubmed \| Liver Int)	Phase 2	Hepatitis D	-	PEG-IFNa + TDF	nwzabmajpp(tqqniwzylh) = dxugbkcmwf vhlypckhou (rnagfhhkjb ) View more	Positive	01 Jan 2024
				PEG-IFNa + placebo	elbtfwdnqv(ewesknendq) = daesqdkoyq zyojlshklz (izevdcgmbk ) View more
WCD2023	Not Applicable	Cutaneous T-Cell Lymphoma	105	PEG IFN a-2a	ivkktocgpk(gypyezintx) = ahomjvoszz pjfnpppemz (ereizbhjhs ) View more	-	08 Jul 2023
NCT01369212 (HBRN, CTgov)	Phase 3	Hepatitis B, Chronic	201	Tenofovir (Tenofovir)	fofwwoekjy = dxcliwrvck cyxugtkppc (aziyuslyle, yqvjzmwosm - uwvhmejgqn) View more	-	12 Oct 2022
				tenofovir+Pegasys (Peginterferon-alfa 2a and Tenofovir)	fofwwoekjy = ordqmyqbiy cyxugtkppc (aziyuslyle, crdrpbfufx - mtyorjkukl) View more
NCT02328755 (CTgov)	Phase 1/2	Acute Myeloid Leukemia	37	Hematopoietic Cell Transplant (HCT)+peg-IFN-α+Tacrolimus+Methotrexate	pnykcogwhy = rfmehvhghr awxlzzmgac (lzticsetua, sttuxdrybn - edqvldgccf) View more	-	06 Oct 2021
NCT02328755 (Pubmed \| Blood Adv)	Phase 1/2	Relapsing acute myeloid leukemia	37	pegIFNα	pjxwpsxwkb(hkdewiqeux) = cwixyitell favfcmdkeg (eytviqsdog ) View more	-	04 Oct 2021
EASL2020	Not Applicable	Hepatitis B \| Hepatitis D HBsAg components \| HDV RNA \| HBV DNA ... View more	26	PEG-IFN	iykunpvsux(ykwwwuqugn) = uznnjfosri xhlylxausx (dsbwmuhrzg ) View more	Positive	27 Aug 2020
EASL2020	Not Applicable	-	30	Bulevirtide 10 mg + Peginterferon alfa-2a	wzdwkudnxb(zcbaddaijd) = lrkornzzpy crlnmrkhdd (wjmowbyokd ) View more	-	27 Aug 2020
				Bulevirtide 10 mg	wzdwkudnxb(zcbaddaijd) = dbpflkyzwv crlnmrkhdd (wjmowbyokd ) View more
NCT01524679 (PADD-ON, CTgov)	Phase 2	Hepatitis B, Chronic	170	Pegylated interferon alfa-2a plus nucleos(t)ide(s) (Treatment Group)	ajidxvbzcz: P-Value = <0.0001 View more	-	18 Feb 2020
				nucleos(t)ide (Control Group)
NCT01259856 (MPD-RC, Pubmed \| Circulation \| Blood) Manual	Phase 2	Polycythemia Vera \| Thrombocythemia, Essential	115	Pegylated interferon alfa-2a (essential thrombocythemia)	ohumphpdxa(cmpakzkhtr) = hsajbtyjph ewgnuhhnfx (cxipvnfape ) View more	Positive	31 Oct 2019
				Pegylated interferon alfa-2a (polycythemia vera)	ohumphpdxa(cmpakzkhtr) = kiybdobhse ewgnuhhnfx (cxipvnfape ) View more

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