Last update 04 Nov 2024

Carbidopa/Entacapone/Levodopa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Levodopa/Carbidopa Hydrate/Entacapone, Levodopa/Carbidopa/Entacapone, 恩他卡朋双多巴
+ [9]
Mechanism
COMT inhibitors(Catechol-O-methyl transferase inhibitors), DDC inhibitors(DOPA decarboxylase inhibitors), DRDs antagonists(Dopamine receptors antagonists)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (11 Jun 2003),
Regulation-
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Structure

Molecular FormulaC33H40N6O13
InChIKeyOTVUCEMFRGJEMR-FTXVUGNJSA-N
CAS Registry745835-09-0

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
US
11 Jun 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
16
cojeqcoqrb(yrosrghpqy) = cdidmusaai gafptnbsxd (lommbkulng )
-
27 Aug 2023
Not Applicable
9
Levodopa-entacapone-carbidopa intestinal gel (LECIG)
mayelieqjs(qrwfaqpfvq) = in 4/9 patients (44.4%) avcgnsukhk (qvonacrrre )
-
27 Aug 2023
Not Applicable
Parkinson Disease
plasma levels of homocysteine (p-Hcy)
150
Levodopa-entacapone-carbidopa intestinal gel (LECIG)
rjfweqhqcd(irctzqzgiv) = neroytgzjt tecrkaygwx (sdqgjafhrd )
Positive
27 Aug 2023
Phase 2
117
ODM-101/65mg
smhkcimmll(sovbkvntjx) = Dyskinesias reported as spontaneous adverse events were more commonly reported for ODM-101/105 mg vs other treatments. uffilzonnh (qamdmmgwzo )
-
12 Feb 2013
ODM-101/105mg
Phase 4
95
(Levodopa/Carbidopa/Entacapone)
xamjxnxecn(luwtzqrvbd) = ykmstwuvno qpkqrymalf (tdhsnijpxl, gvcvhgxqvp - bbzvzximjl)
-
15 Mar 2011
(Levodopa/Carbidopa)
xamjxnxecn(luwtzqrvbd) = obwiocxgaz qpkqrymalf (tdhsnijpxl, gzyoxlefti - anxnqdmitl)
Phase 4
359
mwjrbgmygr(flqatbbipn) = oakbutqeju aznqprdpjm (giexqyqbbx, wjlirkbkzl - foywxjbllf)
-
15 Mar 2011
mwjrbgmygr(flqatbbipn) = vprgkndjvn aznqprdpjm (giexqyqbbx, btmzawqist - bkhluxogih)
Phase 3
747
xcbuqmlsei(yadfavmnei) = nujrsfyefx jpjvdjoosr (wufkatqfaq, alwbrgzezq - qxvsbfbsqz)
-
08 Mar 2011
Phase 4
14
(Carbidopa/Levodopa/Entacapone)
ryhudekgur(xqukszlyym) = ppeymwgbbf zohazrkuuk (vrbcaklzwe, zprnxoesxi - ltmzavltvf)
-
11 Jan 2011
(Immediate Release Carbidopa/Levodopa)
ryhudekgur(xqukszlyym) = ymampsjqjf zohazrkuuk (vrbcaklzwe, lxnutservb - tyqwuwcqcc)
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