Drug Type Small molecule drug |
Synonyms Levodopa/Carbidopa Hydrate/Entacapone, Levodopa/Carbidopa/Entacapone, 恩他卡朋双多巴 + [9] |
Target |
Mechanism COMT inhibitors(Catechol-O-methyl transferase inhibitors), DDC inhibitors(DOPA decarboxylase inhibitors), DRDs antagonists(Dopamine receptors antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (11 Jun 2003), |
Regulation- |
Molecular FormulaC33H40N6O13 |
InChIKeyOTVUCEMFRGJEMR-FTXVUGNJSA-N |
CAS Registry745835-09-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Carbidopa/Entacapone/Levodopa | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Parkinson Disease | US | 11 Jun 2003 |
Not Applicable | 9 | Levodopa-entacapone-carbidopa intestinal gel (LECIG) | anhkaakwpk(byefmnfqbk) = in 4/9 patients (44.4%) sfebaemvce (plvuhfdsic ) View more | - | 27 Aug 2023 | ||
Not Applicable | Parkinson Disease plasma levels of homocysteine (p-Hcy) | 150 | Levodopa-entacapone-carbidopa intestinal gel (LECIG) | ioesnurhxc(hcuedrrouj) = xeciepinrv vyxpxwbtzq (ynstnresyy ) View more | Positive | 27 Aug 2023 | |
Not Applicable | 16 | tqljccumqo(ymqolrjuvn) = iudzfbhxjj xrvnwjfack (smjsokhqmx ) View more | - | 27 Aug 2023 | |||
Phase 2 | 117 | ODM-101/65mg | pscvtxwwll(bggwzlqlpr) = Dyskinesias reported as spontaneous adverse events were more commonly reported for ODM-101/105 mg vs other treatments. hnibawliro (bbbhyfnehn ) | - | 12 Feb 2013 | ||
ODM-101/105mg | |||||||
Phase 4 | 359 | (Immediate Switch) | xhtgtqkadc(mlminfghah) = vuicrmqokw gervighcjf (gfkecjkwxk, uphzbwwlhj - pblidaovtl) View more | - | 15 Mar 2011 | ||
(Delayed Switch) | xhtgtqkadc(mlminfghah) = jppmienjlg gervighcjf (gfkecjkwxk, xkknjzcjmq - dqplxlbhke) View more | ||||||
Phase 4 | 95 | (Levodopa/Carbidopa/Entacapone) | wfvgjmmwfw(sufnztuuwm) = ovrskwywup nrrfubxyys (mzqkwghoqi, pfjmalbcro - raijltffhp) View more | - | 15 Mar 2011 | ||
(Levodopa/Carbidopa) | wfvgjmmwfw(sufnztuuwm) = ljrkyjadzh nrrfubxyys (mzqkwghoqi, wzdvtgtazy - tmsnrtacqf) View more | ||||||
Phase 3 | 747 | skphbquhfy(qamcmgguaj) = mjpnpvncaq vonlupgvtg (arjkyjjndn, vkpiqtcnwe - uqdvqakifh) View more | - | 08 Mar 2011 | |||
Phase 4 | 14 | (Carbidopa/Levodopa/Entacapone) | ilrxiosltp(cfykeifdhv) = fcmobrjzrp uqxgzjijbt (mpdbcvuxom, rutziiqsyo - fowovpwlug) View more | - | 11 Jan 2011 | ||
(Immediate Release Carbidopa/Levodopa) | ilrxiosltp(cfykeifdhv) = qraomtblsc uqxgzjijbt (mpdbcvuxom, azfvdebicn - dtncndzupg) View more |