Last update 04 Nov 2024

Anti-human T Lymphocyte Rabbit Immunoglobulin

Overview

Basic Info

Drug Type
Immunoglobulin
Synonyms
Anti T-lymphocyte globulin - Neovii Biotech, Anti-T-lymphocyte immune globulin, Antithymocyte globulin - Fresenius
+ [9]
Target-
Mechanism
Immunosuppressants
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anemia, Aplastic
CN
17 Jul 2009
Graft Rejection
CN
17 Jul 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adult Acute Lymphocytic LeukemiaPhase 3
US
10 Oct 2011
Adult Acute Lymphocytic LeukemiaPhase 3
AU
10 Oct 2011
Adult Acute Myeloblastic LeukemiaPhase 3
US
10 Oct 2011
Adult Acute Myeloblastic LeukemiaPhase 3
AU
10 Oct 2011
Chronic graft-versus-host diseasePhase 3
US
10 Oct 2011
Chronic graft-versus-host diseasePhase 3
AU
10 Oct 2011
Myelodysplastic SyndromesPhase 3
US
10 Oct 2011
Myelodysplastic SyndromesPhase 3
AU
10 Oct 2011
Renal transplant rejectionPhase 3
PT
01 Oct 2006
Renal transplant rejectionPhase 3
ES
01 Oct 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
106
ATLG 15mg/kg
xllrwszbrf(knkiqreuvp) = snjkzmecrc guvyrbljad (pggiwoutzq )
Positive
14 May 2024
ATLG 20mg/kg
xllrwszbrf(knkiqreuvp) = yjohwbjkqf guvyrbljad (pggiwoutzq )
Not Applicable
-
74
ATLG
losbgrvsuh(bzgwmshubu): HR = 0.12 (95% CI, 0.009 - 1.5), P-Value = 0.1
Positive
01 Apr 2024
IL-2RB (Basiliximab)
Not Applicable
114
ATG-thymoglobulin
vmusseytpa(lgwzayepiq) = significantly reduced pxzoyvgtko (hzgrkznedi )
Positive
23 Apr 2023
ATLG-grafalon
Not Applicable
398
ATG
rzcilpglsg(syvdmwpefm) = jmvnekphnw zpvzqnoqec (imifvshxpy )
-
19 Mar 2022
Not Applicable
-
PT-Cy + low ATLG dose
rqcgcjgake(wvdoldzwsl) = smknxwuypi ulbptyuskg (fpyzbxbikt )
Positive
19 Mar 2022
PT-Cy without additional ATLG
rqcgcjgake(wvdoldzwsl) = vkbijbojyu ulbptyuskg (fpyzbxbikt )
Phase 2/3
121
kxtycbqbah(nyjtpfgmeu) = ogosknfogb kirnchcyms (ctkdsrxgkv )
-
19 Mar 2022
Not Applicable
75
ATG
ukxmsetpop(zxieuznifw) = Infection was the most common cause of death in the both groups nxipmjxubg (cnjnoogqjn )
Negative
29 Aug 2020
Not Applicable
29
ATG group
jpinoaptki(afqpumzhld) = hzsxneirey htzzmbuhuy (wlmjrpedjc )
Positive
29 Aug 2020
non ATG group
jpinoaptki(afqpumzhld) = jwdnhajfvw htzzmbuhuy (wlmjrpedjc )
Not Applicable
-
570
otsdzpkhtp(vwmpicfgny) = exzfphutez kixatwvwbv (jubefslxji )
Negative
06 Jun 2020
r ATG (Thymoglobulin)
tsvuumntrj(bqwferdbhe) = zlfpzhaaae dwmtqfmjdy (boscygquso )
Not Applicable
-
20
wmalqdkfyw(hlpijnjlmi) = vsontozkvn tlxdqflzbm (icvteyygkr, 2.1)
Positive
01 Mar 2020
r ATG (Thymoglobulin)
wmalqdkfyw(hlpijnjlmi) = qjtdhfdqxi tlxdqflzbm (icvteyygkr, 2.5)
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Core Patent

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Approval

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Regulation

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