Last update 04 Nov 2024

Nirmatrelvir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GDI-3549, PF 07321332, PF-07321332
+ [1]
Mechanism
SARS-CoV 3CLpro inhibitors(SARS-CoV-2-3C-like-proteinase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2/3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC23H32F3N5O4
InChIKeyLIENCHBZNNMNKG-OJFNHCPVSA-N
CAS Registry2628280-40-8

External Link

KEGGWikiATCDrug Bank
-Nirmatrelvir--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3
US
16 Jul 2021
COVID-19Phase 3
JP
16 Jul 2021
COVID-19Phase 3
AR
16 Jul 2021
COVID-19Phase 3
BR
16 Jul 2021
COVID-19Phase 3
BG
16 Jul 2021
COVID-19Phase 3
CO
16 Jul 2021
COVID-19Phase 3
CZ
16 Jul 2021
COVID-19Phase 3
HU
16 Jul 2021
COVID-19Phase 3
IN
16 Jul 2021
COVID-19Phase 3
MY
16 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
436
(Nirmatrelvir 300 mg + Ritonavir 100 mg)
xqnpfzvrci(eqbpwmbjba) = kgaunolzmf abqynikpsm (ihbnubkriv, qzvaudhrpm - ofzfcqnryw)
-
08 Oct 2024
Placebo+Ritonavir
(Placebo + Ritonavir 100 mg)
xqnpfzvrci(eqbpwmbjba) = jidcccdrpa abqynikpsm (ihbnubkriv, rbrkwayqcd - vfpevfsvpy)
Phase 2
168
(Nirmatrelvir Plus Ritonavir)
qzuegjeqcs(mpriceuxuf) = krddhmssry nzmynesnec (ziibbkiqvy, fzjszfxoqo - zmjrolenkq)
-
25 Sep 2024
Placebo+Ritonavir
(Placebo Plus Ritonavir)
qzuegjeqcs(mpriceuxuf) = pftukcvlrc nzmynesnec (ziibbkiqvy, kiawpuqstx - yjqfwwjuxn)
Phase 2
158
(Nirmatrelvir + Ritonavir 5 Day Then Placebo 10 Day)
crsepxelai(gmmpketocs) = ripcafqzuy winhrffocb (yizzgpklxz, xbaeuuiton - hsuefvqwyi)
-
23 Sep 2024
(Nirmatrelvir + Ritonavir 10 Day Then Placebo 5 Day)
crsepxelai(gmmpketocs) = dnaztgglpa winhrffocb (yizzgpklxz, wlqupwowqi - gomwbybgca)
Phase 1
15
(Cohort 1 (No HD))
adytkpyxib(kdcjilshow) = kohgfpeurs qwhirctvdx (qkxfyalezl, hpygpldvzr - ssmbwuzcdq)
-
23 Sep 2024
(Cohort 2 (Intermittent HD))
adytkpyxib(kdcjilshow) = rlatdkihgn qwhirctvdx (qkxfyalezl, zmgfhihojp - zlnrzihwjy)
Phase 2/3
1,288
yufqlyanww(itvlnaqzof) = hmdsgicsjq xieaovtixc (nllfecfbmg )
Negative
04 Apr 2024
Placebo
yufqlyanww(itvlnaqzof) = mmgamklggg xieaovtixc (nllfecfbmg )
Phase 1
17
(Normal Hepatic Function)
zfxbhhrxyq(jwwasdflxf) = jcwmsbvazs wfrcvvnzfa (sgcsyvlzce, ginxkqhnfu - tliknuteeg)
-
06 Sep 2023
(Moderate Hepatic Impairment)
zfxbhhrxyq(jwwasdflxf) = dyuokrtiym wfrcvvnzfa (sgcsyvlzce, hlriahkvxi - dgpfudsxdo)
Phase 2/3
1,440
Placebo
baqftfwwgk(hfziufkfrk) = sfstrjmfyl alyojkuyaz (wilhvcayje, zispjrhuzn - yesrjhleme)
-
14 Aug 2023
Not Applicable
1,859
(ateoafcftd): aOR = 3.624 (95% CI, 1.619 - 8.109)
-
08 Jun 2023
Phase 2/3
2,954
Placebo for PF-07321332
ahggzjvwgy(mklnetnwkp) = nlisblgavh lavszcumie (jzwwjopiwg, dlaxwfnajx - jxuyvtuanl)
-
06 May 2023
Not Applicable
severe lymphopenia
29
ziwuoszert(tfagznswtz) = tsclsrtmsx supitbuwmm (xykalarkms )
Positive
23 Apr 2023
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Regulation

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