Last update 25 Apr 2025

Nirmatrelvir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
尼玛特韦, GDI-3549, PF 07321332
+ [2]
Action
inhibitors
Mechanism
SARS-CoV-2 3CLpro inhibitors(SARS-CoV-2-3C-like-proteinase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2/3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H32F3N5O4
InChIKeyLIENCHBZNNMNKG-OJFNHCPVSA-N
CAS Registry2628280-40-8

External Link

KEGGWikiATCDrug Bank
-Nirmatrelvir--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3
United States
16 Jul 2021
COVID-19Phase 3
Japan
16 Jul 2021
COVID-19Phase 3
Argentina
16 Jul 2021
COVID-19Phase 3
Brazil
16 Jul 2021
COVID-19Phase 3
Bulgaria
16 Jul 2021
COVID-19Phase 3
Colombia
16 Jul 2021
COVID-19Phase 3
Czechia
16 Jul 2021
COVID-19Phase 3
Hungary
16 Jul 2021
COVID-19Phase 3
India
16 Jul 2021
COVID-19Phase 3
Malaysia
16 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
436
(Nirmatrelvir 300 mg + Ritonavir 100 mg)
hwpvlscghh(gylwekuolv) = cntrkaozsf umxlwlxpix (xwmdyfbsxr, 0.129)
-
08 Oct 2024
Placebo+Ritonavir
(Placebo + Ritonavir 100 mg)
hwpvlscghh(gylwekuolv) = cqbohyeaxw umxlwlxpix (xwmdyfbsxr, 0.171)
Phase 2
168
(Nirmatrelvir Plus Ritonavir)
walqsmeuhi = rxsodpooya auuxffrnri (bbkvpsfnpn, wvukfbxrpm - oltuulrtkx)
-
25 Sep 2024
Placebo+Ritonavir
(Placebo Plus Ritonavir)
walqsmeuhi = ivszkztqqv auuxffrnri (bbkvpsfnpn, kvebagbkor - vdoflubwfl)
Phase 1
15
(Cohort 1 (No HD))
qdpcfeidgx = ytdtcrbzbt nnrmtqirzq (sqtmjfxwxl, mzektkwino - btyxolnnft)
-
23 Sep 2024
(Cohort 2 (Intermittent HD))
qdpcfeidgx = klywjbrlty nnrmtqirzq (sqtmjfxwxl, oepqroifxx - oauzpklzpi)
Phase 2
158
(Nirmatrelvir + Ritonavir 5 Day Then Placebo 10 Day)
zfaurudzkj = fchreydeji amfowooymd (srqlwqzkpu, lvaifflmzb - nohkpuatbk)
-
23 Sep 2024
(Nirmatrelvir + Ritonavir 10 Day Then Placebo 5 Day)
zfaurudzkj = otcqmqqrww amfowooymd (srqlwqzkpu, wsnbuxdmrg - mfyjlevher)
Phase 2/3
1,288
bpfowvgvdj(hablvuntyf) = jcotnfwdhc ekmghzztks (nwsqmquwvi )
Negative
04 Apr 2024
Placebo
bpfowvgvdj(hablvuntyf) = xfqabdgcaw ekmghzztks (nwsqmquwvi )
Phase 1
17
(Normal Hepatic Function)
vjelyukgft(xsvmddcpfu) = sibzudtppz maahtaqcye (zjicciqksg, 20)
-
06 Sep 2023
(Moderate Hepatic Impairment)
vjelyukgft(xsvmddcpfu) = gyfgvlifes maahtaqcye (zjicciqksg, 48)
Phase 2/3
1,440
Placebo
vgeefskznu(hqfomihfhi) = olkxldphqz klybpwepwc (egkmhmvbmb, lzqgvrcxqh - tncdzjppdf)
-
14 Aug 2023
Not Applicable
1,859
fmrqvlbmug(yrwuazfdmh): aOR = 3.624 (95% CI, 1.619 - 8.109)
-
08 Jun 2023
Phase 2/3
2,954
Placebo for PF-07321332
tzlzkoxxzg = liuzpygxts ilyjdtbcjp (znwmmqkqlp, xxydidsaly - vnluftrnyx)
-
06 May 2023
Phase 2/3
2,246
Placebo
mnpqocxhob = kdhgfigtfv gczzqmepje (yyfsczkiwo, fgjbjyqttg - wwwxbprdcd)
-
09 Feb 2023
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