Quinine Sulfate

Bilirubin (Bil) is crucial for diagnosing jaundice and assessing liver function.Dynamic monitoring of Bil levels helps evaluate disease progression and therapy efficacy.Consequently, developing a method for rapid and accurate detection of bilirubin is essential for clin. diagnosis and therapeutic decision-making.With an emphasis on green and sustainable development, this study employed discarded peels of Dioscorea polystachya (yam) as a carbon source to create green carbon dots (CDs) using a one-step hydrothermal process.The preparation method was uncomplicated and energy-efficient without any specialized treatment.The prepared carbon dots (Dp-CDs) derived from the peel of yam exhibit high water solubility, remarkable photostability, and exceptional biocompatibility.Static quenching, the inner filter effect (IFE) and the aggregation quenching effect among the groups were the main causes of the decrease in fluorescence intensity of Dp-CDs produced by Bil.The fluorescence sensor constructed with the peel of yam presented a favorable response to Bil, with its fluorescence intensity showing a linear relationship with Bil concentration in the range of 0.30 and 200μM and a detection limit of 0.28μM.This method effectively identified and detected Bil in serum and urine in clin. practice, achieving recoveries between 95.6% and 104.5%.In addition, a paper-based test strip was designed for this experiment, characterized by its portability, economy, and simplicity of visualization.Dp-CDs provide a solid foundation for rapid and accurate Bil detection, which is critical for early diagnosis and illness monitoring.

This study integrated nitrogen-doped carbon dots (nitrogen-doped CDs) with remarkable fluorescence into a high-porosity inverse opal photonic crystal (IOPC) structure. A portable fluorescent hydrogel strip was developed by incorporating molecular imprinted biomimetic recognition, enabling the rapid identification and accurate detection of the insecticide imidacloprid (IMI). The ordered and hierarchical architecture of the IOPCs was advantageous to the uniform dispersion of nitrogen-doped CDs while providing efficient mass transfer channels for IMI. Additionally, the sensing strips achieved adsorption equilibrium within 20 min and demonstrated excellent selectivity, stability, and reusability. They showed a linear response to IMI across the range of 0.1-50 μg/mL (R² = 0.9905) with a detection limit of 0.065 μg/mL (S/N = 3). The spiked recoveries ranged from 88.2 % to 102.8 %, aligning well with HPLC results. This indicates that the developed fluorescent molecularly imprinted hydrogel sensing strip is an effective analytical tool for detecting IMI residues in food products.