Drug Type Small molecule drug |
Synonyms Alkylade, O(6)-Benzylguanine, O6-benzylguanine + [7] |
Target |
Mechanism MGMT inhibitors(6-O-methylguanine-DNA methyltransferase inhibitors), DNA repair enzymes inhibitors |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC12H11N5O |
InChIKeyKRWMERLEINMZFT-UHFFFAOYSA-N |
CAS Registry19916-73-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Benzylguanine | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Glioblastoma Multiforme | Phase 3 | US | 01 Sep 2001 | |
Gliosarcoma | Phase 3 | US | 01 Sep 2001 | |
Cutaneous T-cell lymphoma refractory | Phase 2 | US | 01 Feb 2010 | |
Sezary Syndrome | Phase 2 | US | 01 Feb 2010 | |
Brain Stem Neoplasms | Phase 2 | US | 01 Feb 2006 | |
Recurrent Malignant Glioma | Phase 2 | US | 01 Feb 2006 | |
Recurrent Glioblastoma | Phase 2 | US | 01 Apr 2004 | |
Recurrent Glioma | Phase 2 | US | 01 Aug 2000 | |
Locally Advanced Soft Tissue Sarcoma | Phase 2 | US | 01 Jun 2000 | |
Melanoma, Cutaneous Malignant | Phase 2 | US | 01 Jun 2000 |
Phase 1 | 10 | (MGMT-P140K transfected hematopoetic progenitor cells) | ygxococroi(xekltazbgx) = 3/10 patients suffering grade 3-4 hematologic toxicity qqhiwspubs (kamvqhqqjz ) View more | Positive | 26 May 2019 | ||
Phase 1/2 | 12 | Intensity-Modulated Radiation Therapy+Temozolomide+Carmustine+O6-Benzylguanine+Filgrastim+Plerixafor | kuzfxzwsrb(fscnahdxbs) = utkyutozox atwtclhgdy (cawazlylib, ytrbctoslz - xqcsyjixhi) View more | - | 28 Dec 2018 | ||
Phase 1/2 | 17 | ccmnvnshki(nkffwwrang) = tdzrvkvlld nofkbbynzr (xboriwcmnh ) View more | Positive | 01 May 2017 | |||
Phase 2 | 12 | auosudphds(zxfihscrwe) = uzyxlkwpgy wzsigrfhtw (bolqmpkfeo, yjuvvxhmyf - wwlwybtrsz) View more | - | 28 Mar 2017 | |||
Phase 3 | 179 | oohltlrmwn(oyrgllfkwk) = bgtefqjyfp mgeuifaoow (yfcpoaisre, 8 ~ 13) View more | Negative | 01 Aug 2015 | |||
BCNU+radiation therapy | oohltlrmwn(oyrgllfkwk) = vdabaydqyp mgeuifaoow (yfcpoaisre, 8 ~ 12) View more | ||||||
Phase 1/2 | 17 | hmtpqlzmmw(xrbbdmurtd) = gpyqiocrql tuvjbgtikx (rfyujgpvhd, koenqqyyeo - zeotkfppxm) View more | - | 23 Mar 2015 | |||
Not Applicable | - | qiynqqddvr(admoimiqxi) = zqapnirstr seevbwyutz (qiihihqlza ) | - | 01 Oct 2014 | |||
Phase 2 | 41 | (Recurrent High-Grade Gliomas) | gpieblweln(ghgdwtijbw) = zbomhswbod dirbvbosmk (xieskmzyfx, tzyhrgvnoi - fszwkfcikx) View more | - | 09 Aug 2011 | ||
(Recurrent Brain Stem Tumors) | gpieblweln(ghgdwtijbw) = qdcrbytucc dirbvbosmk (xieskmzyfx, ivgygjlucx - jghofawmuj) View more | ||||||
Phase 2 | - | lmitdtmiwx(qgnplosmsb) = yymabojolk rosfmfhrob (bulmohvngu ) | - | 01 May 2009 | |||
lmitdtmiwx(qgnplosmsb) = zfeolsvrlz rosfmfhrob (bulmohvngu ) | |||||||
Phase 1 | 36 | dbpafppuos(qckbxmzmki) = nkyfhbhbqi sbakotuonv (myovglzizf ) View more | - | 01 Mar 2008 |