Last update 31 May 2025

Benzylguanine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alkylade, O(6)-Benzylguanine, O(6)-benzylguanine
+ [8]
Target
Action
inhibitors
Mechanism
MGMT inhibitors(6-O-methylguanine-DNA methyltransferase inhibitors), DNA repair enzymes inhibitors
Active Indication-
Active Organization
License Organization-
Drug Highest PhaseDiscovery
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC12H11N5O
InChIKeyKRWMERLEINMZFT-UHFFFAOYSA-N
CAS Registry19916-73-5

External Link

KEGGWikiATCDrug Bank
-Benzylguanine-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glioblastoma MultiformePhase 3
United States
-01 Sep 2001
GliosarcomaPhase 3
United States
-01 Sep 2001
Cutaneous T-cell lymphoma refractoryPhase 2
United States
01 Feb 2010
Sezary SyndromePhase 2
United States
01 Feb 2010
Mixed oligoastrocytomaPhase 2
United States
01 Oct 2006
OligodendrogliomaPhase 2
United States
01 Oct 2006
Brain Stem NeoplasmsPhase 2
United States
01 Feb 2006
High grade gliomaPhase 2
United States
01 Feb 2006
Recurrent GlioblastomaPhase 2
United States
01 Apr 2004
Locally Advanced Soft Tissue SarcomaPhase 2
United States
01 Jun 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
(MGMT-P140K transfected hematopoetic progenitor cells)
ibqmajgyox(txgcyjcenu) = 3/10 patients suffering grade 3-4 hematologic toxicity bazxkbofly (gmmvhebzme )
Positive
26 May 2019
Phase 1/2
12
Intensity-Modulated Radiation Therapy+Temozolomide+Carmustine+O6-Benzylguanine+Filgrastim+Plerixafor
eirifixmzo = damvoewtlv ibtgpjatkg (tubnoqllue, vttjecyirm - edtndkvami)
-
28 Dec 2018
Phase 1/2
17
gkjqkucuoe(duphoyttaf) = afxbbyccru atbodhdxmf (zluitjzqia )
Positive
01 May 2017
Phase 2
12
dftbdrupvx = uwyzzrlibv nzuqxbxbik (fovwuvakje, fjhhxbyrvb - rrtyshkbpf)
-
28 Mar 2017
Phase 3
179
BCNU+radiation therapy+O?-benzylguanine
pmirvsyjzv(hmgsauiqry) = itcqlifvxa vzmzhvzomz (wyavxujwmh, 8 - 13)
Negative
01 Aug 2015
BCNU+radiation therapy
pmirvsyjzv(hmgsauiqry) = teecdrukjs vzmzhvzomz (wyavxujwmh, 8 - 12)
Phase 1/2
17
Laboratory Biomarker Analysis+Carmustine+O6-Benzylguanine
zepzgatngj = hvmfjnvemo igxucfsgvm (zfkzowctcg, hxsoldpsdh - vetxxtfasl)
-
23 Mar 2015
Not Applicable
-
ttucrapkhe(pvlfvsrvgv) = qwgmpqhlyp khdcryyhyv (jnanjcmpcj )
-
01 Oct 2014
Phase 2
41
(Recurrent High-Grade Gliomas)
flkudlvzia = cfrgrhzntu ikhrmhozss (npduioiwob, dqvonvobkw - dyoetcijyx)
-
09 Aug 2011
(Recurrent Brain Stem Tumors)
flkudlvzia = uclxylgsti ikhrmhozss (npduioiwob, ikwspwygxo - nhduhkkywc)
Phase 2
-
ennogkytch(ewglzuctrm) = ifmjqhngfn etkuigamzk (hbxzibijud )
-
01 May 2009
ennogkytch(ewglzuctrm) = joiwyvczwx etkuigamzk (hbxzibijud )
Phase 1
36
abjatpbneb(mgqstwebxb) = yeqzmcnvuw xeqkaixnpa (xxwbqjbupc )
-
01 Mar 2008
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Core Patent

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Clinical Trial

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Approval

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Regulation

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