Drug Type Small molecule drug |
Synonyms Alkylade, O(6)-Benzylguanine, O(6)-benzylguanine + [8] |
Target |
Action inhibitors |
Mechanism MGMT inhibitors(6-O-methylguanine-DNA methyltransferase inhibitors), DNA repair enzymes inhibitors |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseDiscovery |
First Approval Date- |
Regulation- |
Molecular FormulaC12H11N5O |
InChIKeyKRWMERLEINMZFT-UHFFFAOYSA-N |
CAS Registry19916-73-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Benzylguanine | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Glioblastoma Multiforme | Phase 3 | United States | - | 01 Sep 2001 |
Gliosarcoma | Phase 3 | United States | - | 01 Sep 2001 |
Cutaneous T-cell lymphoma refractory | Phase 2 | United States | 01 Feb 2010 | |
Sezary Syndrome | Phase 2 | United States | 01 Feb 2010 | |
Mixed oligoastrocytoma | Phase 2 | United States | 01 Oct 2006 | |
Oligodendroglioma | Phase 2 | United States | 01 Oct 2006 | |
Brain Stem Neoplasms | Phase 2 | United States | 01 Feb 2006 | |
High grade glioma | Phase 2 | United States | 01 Feb 2006 | |
Recurrent Glioblastoma | Phase 2 | United States | 01 Apr 2004 | |
Locally Advanced Soft Tissue Sarcoma | Phase 2 | United States | 01 Jun 2000 |
Phase 1 | 10 | (MGMT-P140K transfected hematopoetic progenitor cells) | ibqmajgyox(txgcyjcenu) = 3/10 patients suffering grade 3-4 hematologic toxicity bazxkbofly (gmmvhebzme ) View more | Positive | 26 May 2019 | ||
Phase 1/2 | 12 | Intensity-Modulated Radiation Therapy+Temozolomide+Carmustine+O6-Benzylguanine+Filgrastim+Plerixafor | eirifixmzo = damvoewtlv ibtgpjatkg (tubnoqllue, vttjecyirm - edtndkvami) View more | - | 28 Dec 2018 | ||
Phase 1/2 | 17 | gkjqkucuoe(duphoyttaf) = afxbbyccru atbodhdxmf (zluitjzqia ) View more | Positive | 01 May 2017 | |||
Phase 2 | 12 | dftbdrupvx = uwyzzrlibv nzuqxbxbik (fovwuvakje, fjhhxbyrvb - rrtyshkbpf) View more | - | 28 Mar 2017 | |||
Phase 3 | 179 | pmirvsyjzv(hmgsauiqry) = itcqlifvxa vzmzhvzomz (wyavxujwmh, 8 - 13) View more | Negative | 01 Aug 2015 | |||
BCNU+radiation therapy | pmirvsyjzv(hmgsauiqry) = teecdrukjs vzmzhvzomz (wyavxujwmh, 8 - 12) View more | ||||||
Phase 1/2 | 17 | zepzgatngj = hvmfjnvemo igxucfsgvm (zfkzowctcg, hxsoldpsdh - vetxxtfasl) View more | - | 23 Mar 2015 | |||
Not Applicable | - | ttucrapkhe(pvlfvsrvgv) = qwgmpqhlyp khdcryyhyv (jnanjcmpcj ) | - | 01 Oct 2014 | |||
Phase 2 | 41 | (Recurrent High-Grade Gliomas) | flkudlvzia = cfrgrhzntu ikhrmhozss (npduioiwob, dqvonvobkw - dyoetcijyx) View more | - | 09 Aug 2011 | ||
(Recurrent Brain Stem Tumors) | flkudlvzia = uclxylgsti ikhrmhozss (npduioiwob, ikwspwygxo - nhduhkkywc) View more | ||||||
Phase 2 | - | ennogkytch(ewglzuctrm) = ifmjqhngfn etkuigamzk (hbxzibijud ) | - | 01 May 2009 | |||
ennogkytch(ewglzuctrm) = joiwyvczwx etkuigamzk (hbxzibijud ) | |||||||
Phase 1 | 36 | abjatpbneb(mgqstwebxb) = yeqzmcnvuw xeqkaixnpa (xxwbqjbupc ) View more | - | 01 Mar 2008 |