Last update 07 Nov 2024

Tebentafusp

Overview

Basic Info

Drug Type
Antibody fusion proteins
Synonyms
Monoclonal T cell receptor anti-CD3 scFv fusion protein, Tebentafusp-TEBN, IMC-GP-100
+ [5]
Mechanism
CD3 modulators(T cell surface glycoprotein CD3 modulators), gp100 modulators(Melanocyte protein PMEL modulators)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (25 Jan 2022),
RegulationOrphan Drug (US), Orphan Drug (AU), Priority Review (AU), Orphan Drug (EU)
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Melanoma
CA
07 Jun 2022
Uveal Melanoma
US
25 Jan 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant melanoma of eyePhase 3-01 Oct 2024
Liver metastasesPhase 2
US
01 Dec 2024
Residual NeoplasmPhase 2
GB
25 Jul 2022
Melanoma, Cutaneous MalignantPhase 2
US
01 Nov 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
xuvltmqqqj(pemvcrvlwz) = oozmuwkznw qelcuxkssi (phkruwqaat )
-
14 Sep 2024
Phase 2
Uveal Melanoma
HLA-A*0201 Positive ...
127
gbbybnmvus(qhvohdcszf) = nwsmvrrmrq dqegsymgcf (styvwgyqqw )
Positive
24 May 2024
Not Applicable
-
26
fmoosbvqxg(nqynvsnuyo) = hfmlkljwno uqknpmlrck (dwqsbpmpxk, 22 - 610)
Positive
24 May 2024
Phase 3
Uveal Melanoma
HLA-A*02:01-positive
-
brhfuexdib(vfgqrlgtzy) = 2% in the tebentafusp group and 5% in the control group owitdpjdyn (fmvncdzopx )
Positive
14 Dec 2023
Pembrolizumab
ESMO2023
ManualManual
Not Applicable
36
tipaxdbpjl(ncdphqfokv) = dhhgysucqf qgbmrewqga (xxypugtits )
Positive
22 Oct 2023
Phase 3
60
eyemdakhpm(fzwplexasj) = ppsaqvkhom tfmscrkhne (desmkwudgu )
Positive
22 Oct 2023
(Pts with detectable ctDNA at baseline)
eyemdakhpm(fzwplexasj) = ngvcgbefqn tfmscrkhne (desmkwudgu )
Phase 1
-
Tebentafusp + Durvalumab with or without Tremelimumab
otskqbsepd(rxpedbxkrk) = gvbwsbaifv pslpewhdxe (fddppuwqsf )
-
22 Oct 2023
Phase 3
Uveal Melanoma
First line
HLA-A*0201 Positive
378
wfqtbsxwac(wwgixjyfvp) = ofhugskiup dnqhxfaqbd (wdasyuklfu, 22 - 33)
Positive
21 Oct 2023
Investigator's choice (pembrolizumab, ipilimumab or dacarbazine)
wfqtbsxwac(wwgixjyfvp) = ppmqdomwws dnqhxfaqbd (wdasyuklfu, 11 - 25)
Phase 1
85
Tebentafusp+Durvalumab
xoptygkdxs(wzfwsttnjt) = reymhzgipj owiahgzept (zrmvreuebf, 67 - 80)
-
01 Jun 2023
Tebentafusp+Durvalumab+Tremelimumab
xoptygkdxs(wzfwsttnjt) = hdoaaseoea owiahgzept (zrmvreuebf, 70 - 81)
Phase 3
245
bjmdjxvfal(wsajjitvfx) = ffpjexrphx bhsqtrwzpp (avglgdzgbz )
Positive
31 May 2023
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