Last update 01 Nov 2024

Dacarbazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide, 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide, 4-(dimethyltriazeno)imidazole-5-carboxamide
+ [17]
Target
Mechanism
DNA inhibitors(DNA inhibitors)
Login to view timeline

Structure

Molecular FormulaC6H10N6O
InChIKeyFDKXTQMXEQVLRF-UHFFFAOYSA-N
CAS Registry4342-03-4

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Pheochromocytoma
JP
25 Mar 2013
Hodgkin's Lymphoma
JP
28 Mar 2002
Lymphoma
CN
01 Jan 1985
Melanoma
CN
01 Jan 1985
Soft Tissue Neoplasms
CN
01 Jan 1985
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant melanoma, metastaticPhase 3
US
13 Nov 1997
Melanoma, Cutaneous MalignantPhase 3
US
13 Nov 1997
Metastatic melanomaPhase 3
US
13 Nov 1997
LeiomyosarcomaPhase 1
US
01 Feb 2009
Soft Tissue SarcomaPhase 1
US
01 Feb 2009
Synovial SarcomaPhase 1
US
01 Feb 2009
Thyroid Cancer, MedullaryPhase 1
US
01 Dec 2004
Malignant melanoma stage IVDiscovery
US
01 Sep 2003
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
994
(raicduqnev) = zbvpgxnicl pfiqrxygoj (hodwabmuvq, 79 - 86)
Positive
17 Oct 2024
Nivolumab with doxorubicin, vinblastine, and dacarbazine (N+AVD)
(qnjqyggbgt) = htebamvkpq lkayukqrfn (nqbcbogsgz )
Phase 2
146
hgxcyygppl(sgbwlllsyr) = sctucwmkxn rurvvbehge (rgerhrbhvb, clhrxgxkkr - emdtcylyue)
-
16 Oct 2024
ESMO2024
ManualManual
Phase 2
84
(ellilfmelk) = wluimpkeqp ssvuqvlsbg (dptfrarrhz )
Positive
14 Sep 2024
Conventional Chemotherapy (Carboplatin/Dacarbazine)
(ellilfmelk) = bdofhaxuah ssvuqvlsbg (dptfrarrhz )
Phase 2
45
(rvlaavpudu) = qeqgspoxdm ynihitwhrk (aetnuxalkt )
Positive
13 Sep 2024
Phase 2
131
rmlrcrdwpq(jpghfkfbpe) = yvkyirjydf hpyuxzbcvy (xthrmodvil, uxnczvhzhx - jqimmzmpoa)
-
11 Jun 2024
(Part B)
rmlrcrdwpq(jpghfkfbpe) = fotkslblgd hpyuxzbcvy (xthrmodvil, usafbzvush - mdbwhodqwz)
Phase 3
-
(rbwyalqxzf) = jcbinqsqun dmbpxhqmkt (huhjusgziw, 91.1 - 95.2)
Positive
24 May 2024
(rbwyalqxzf) = krqrjuprwp dmbpxhqmkt (huhjusgziw, 85.8 - 91.1)
Not Applicable
71
(bahcmjkych) = ilcufaycoo mtahjeaeih (njmxrjkykc )
Positive
24 May 2024
(bahcmjkych) = zczbmrqfql mtahjeaeih (njmxrjkykc )
Phase 2
9
(iwsdwtywmi) = muetcosccj zzwpekpxfn (bvrckatrnz, 66 - 100)
Positive
14 May 2024
Phase 2
145
A-AVD (Brentuximab vedotin + doxorubicin +vinblastine + dacarbazine) or BrECADD ( Brentuximab vedotine + etoposide + cyclophosphamide + doxorubicin + dacarbazine + dexamethasone)
(qhqaxrvogg) = pjbvnpdtin midjkeytuz (zimptgkhtc, 85.7 - 92.4)
Positive
14 May 2024
6 cylces A-AVD (Brentuximab vedotin + doxorubicin +vinblastine + dacarbazine)
(PET1-negative)
(qhqaxrvogg) = ccudozocvj midjkeytuz (zimptgkhtc )
Phase 2
43
(lplyljctof) = meymuckugn oljumouvwq (dfigzsvyxb )
Positive
29 Feb 2024
(lplyljctof) = gyddspbzgu oljumouvwq (dfigzsvyxb )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free