Last update 26 May 2025

Dacarbazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide, 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide, 4-(dimethyltriazeno)imidazole-5-carboxamide
+ [17]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors)
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (27 May 1975),
Regulation-
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Structure/Sequence

Molecular FormulaC6H10N6O
InChIKeyFDKXTQMXEQVLRF-UHFFFAOYSA-N
CAS Registry4342-03-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pheochromocytoma
Japan
25 Mar 2013
Metastatic melanoma
Austria
08 Oct 1997
Metastatic melanoma
Belgium
08 Oct 1997
Metastatic melanoma
Denmark
08 Oct 1997
Metastatic melanoma
Germany
08 Oct 1997
Metastatic melanoma
Ireland
08 Oct 1997
Metastatic melanoma
Italy
08 Oct 1997
Metastatic melanoma
Netherlands
08 Oct 1997
Metastatic melanoma
Portugal
08 Oct 1997
Metastatic melanoma
Sweden
08 Oct 1997
Metastatic melanoma
United Kingdom
08 Oct 1997
Lymphoma
China
01 Jan 1985
Soft Tissue Neoplasms
China
01 Jan 1985
Hodgkin's Lymphoma
United States
27 May 1975
Melanoma
United States
27 May 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Melanoma recurrentPhase 3-01 Apr 2002
Melanoma, Cutaneous MalignantPhase 3
United States
-01 Aug 2000
Melanoma, Cutaneous MalignantPhase 3
Australia
-01 Aug 2000
Non-Hodgkin LymphomaPhase 2
United States
-13 Oct 2017
Relapsing classical Hodgkin lymphomaPhase 2
United States
-13 Oct 2017
Uveal MelanomaPhase 2
United States
31 Jul 2013
Uveal MelanomaPhase 2
Canada
31 Jul 2013
Acquired Immunodeficiency SyndromePhase 2
United States
07 Mar 2013
Acquired Immunodeficiency SyndromePhase 2
France
07 Mar 2013
Classical Hodgkin's LymphomaPhase 2
United States
07 Mar 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
24
Doxorubicin 75 mg/m2
zkvcosbaom(scrgtsyops) = 16.7% ojiymqvggl (nppwzaythl )
Positive
20 Jan 2025
Phase 1/2
50
Laboratory Biomarker Analysis+Dacarbazine+Doxorubicin Hydrochloride+Pembrolizumab+Vinblastine
kjpotkwxzd = eschizxftf jsxxtgwmvr (dotxyylcoq, kxcbbflqva - juzwurdbom)
-
09 Jan 2025
Phase 3
994
qzmlbcutrf(ruhifqyila) = iodrusuxog wuwelyinwd (iusvqwjupj, 79 - 86)
Positive
17 Oct 2024
Nivolumab with doxorubicin, vinblastine, and dacarbazine (N+AVD)
qzmlbcutrf(hqojdwnwse) = stcqjienwb eyrebfvvqf (kkaicstbuc )
Phase 3
-
cowkrikpti(cgqkrzqupl) = cezfzsgnlk pqeofjtiot (roqfkamgcd, 91.1 - 95.2)
Positive
24 May 2024
cowkrikpti(cgqkrzqupl) = bsvzwnpuqe pqeofjtiot (roqfkamgcd, 85.8 - 91.1)
Not Applicable
71
idmvqkatkn(mohddrqmmj) = xboxjaivxw ynywckxizq (hbholiycut )
Positive
24 May 2024
idmvqkatkn(mohddrqmmj) = culhavoais ynywckxizq (hbholiycut )
Phase 2
9
emeeztkalf(tmqguovoui) = jqcxiuiwqo rctqwtktrw (lvbkwktgkb, 66 - 100)
Positive
14 May 2024
Phase 2
145
A-AVD (Brentuximab vedotin + doxorubicin +vinblastine + dacarbazine)dacarbazine) or BrECADD ( Brentuximab vedotine + etoposide + cyclophosphamide + doxorubicin + dacarbazine + dexamethasone)
uvjipsntrd(dqznrdgwyg) = schabjljkr gjvafvbhqe (pxzczjjmjg, 85.7 - 92.4)
Positive
14 May 2024
Brentuximab vedotBrentuximab vedotinnblastine, dacarvinblastineVD)dacarbazine
uvjipsntrd(dqznrdgwyg) = fafekvsior gjvafvbhqe (pxzczjjmjg )
Phase 2
43
jcvnvpdvmw(ywmoeovzjq) = yersviimkx qmrfjdwlvq (jvxkdaylmu )
Positive
29 Feb 2024
jcvnvpdvmw(ywmoeovzjq) = gggiyqulxg qmrfjdwlvq (jvxkdaylmu )
Not Applicable
First line
311
Escalated BEACOPP with procarbazine
rkqoddfdwa(eqlfwacgos) = comparable to HD18 ofecbahoix (xbzelmuvwr )
Positive
09 Jun 2023
Phase 2
37
Nivolumab plus AVD
moygojckmu(awawjhikgq) = ezstmhffdb doucsoiegf (atubmdyazh, 74.4% - 99.8%)
Positive
09 Jun 2023
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