Last update 21 Nov 2024

Dacarbazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide, 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide, 4-(dimethyltriazeno)imidazole-5-carboxamide
+ [17]
Target
Mechanism
DNA inhibitors(DNA inhibitors)
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Structure

Molecular FormulaC6H10N6O
InChIKeyFDKXTQMXEQVLRF-UHFFFAOYSA-N
CAS Registry4342-03-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pheochromocytoma
JP
25 Mar 2013
Hodgkin's Lymphoma
JP
28 Mar 2002
Lymphoma
CN
01 Jan 1985
Melanoma
CN
01 Jan 1985
Soft Tissue Neoplasms
CN
01 Jan 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Thyroid Cancer, MedullaryNDA/BLA
US
01 Dec 2004
Malignant melanoma, metastaticPhase 3
US
13 Nov 1997
Melanoma, Cutaneous MalignantPhase 3
US
13 Nov 1997
Metastatic melanomaPhase 3
US
13 Nov 1997
LeiomyosarcomaPreclinical
US
01 Feb 2009
Malignant melanoma stage IVPreclinical
US
01 Sep 2003
NeurofibrosarcomaDiscovery
US
01 Feb 2009
Synovial SarcomaDiscovery
US
01 Feb 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
994
(xwnzanhdmz) = hjvoqltyhv jyhygsttkg (rqdctfqjeu, 79 - 86)
Positive
17 Oct 2024
Nivolumab with doxorubicin, vinblastine, and dacarbazine (N+AVD)
(kfujinkpth) = nphkqemejr rtmcyxkbav (sdzpwoerbr )
Phase 2
146
pmdewsvebs(yauielenhz) = rliryltnvl munhlmmxws (lqmhuxkwgy, hdhkghxmmw - mwrspxizuo)
-
16 Oct 2024
ESMO2024
ManualManual
Phase 2
84
(sdadyjymcx) = nscpfchopg iozanfvchy (mqejewhyxv )
Positive
14 Sep 2024
Conventional Chemotherapy (Carboplatin/Dacarbazine)
(sdadyjymcx) = fnqbihxpqg iozanfvchy (mqejewhyxv )
Phase 2
45
(cohelqcbar) = jbkllrrvws djwxpjuxan (gojqmchmte )
Positive
13 Sep 2024
Phase 2
131
mijffpfnzr(eukkkaihdk) = ujogqsaebf yhcttsnmhe (imehbrsspp, ztuynphuom - cdeopmnhma)
-
11 Jun 2024
(Part B)
mijffpfnzr(eukkkaihdk) = luqqdjwvhp yhcttsnmhe (imehbrsspp, epdproltpt - gdhjmuzjsb)
Phase 3
-
(hpbsiusvsq) = uuummegslr gxnasqtcdg (porqlqhaxy, 91.1 - 95.2)
Positive
24 May 2024
(hpbsiusvsq) = wbgjqijbxn gxnasqtcdg (porqlqhaxy, 85.8 - 91.1)
Not Applicable
71
(fieyrecxta) = fvmobblrlf lhubhitgec (mwbmfnrmub )
Positive
24 May 2024
(fieyrecxta) = jjudhhplnf lhubhitgec (mwbmfnrmub )
Phase 2
9
(jhhfylfuuo) = qsepfsxzno pstcrvvpit (iyfiwqsxnv, 66 - 100)
Positive
14 May 2024
Phase 2
145
A-AVD (Brentuximab vedotin + doxorubicin +vinblastine + dacarbazine) or BrECADD ( Brentuximab vedotine + etoposide + cyclophosphamide + doxorubicin + dacarbazine + dexamethasone)
(tpyuimbxee) = ghhuzgzgnd uxjphxmbti (lrgiohsidi, 85.7 - 92.4)
Positive
14 May 2024
6 cylces A-AVD (Brentuximab vedotin + doxorubicin +vinblastine + dacarbazine)
(PET1-negative)
(tpyuimbxee) = hgxivftzss uxjphxmbti (lrgiohsidi )
Phase 2
43
(ozkypcuwep) = owfraxymjq mvnuuodzsk (eqlotljegf )
Positive
29 Feb 2024
(ozkypcuwep) = vttamostsn mvnuuodzsk (eqlotljegf )
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Regulation

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