Delving into the Latest Updates on Tinidazole with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitroimidazole, Timidazole, Tinidazole (JP17/USP/INN)

+ [17]

Target

DNA

Action

modulators

Mechanism

DNA modulators(DNA modulators)

Therapeutic Areas

Infectious DiseasesDigestive System DisordersUrogenital Diseases

Active Indication

Bacterial VaginosisAmebiasisGiardiasis+ [2]

Inactive Indication-

Originator Organization

Zhejiang Sukean Pharmaceutical Co Ltd.

Active Organization

Mission Pharmacal Co.

Zhejiang Sukean Pharmaceutical Co Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

China (01 Jan 1994),

Bacterial Infections

RegulationOrphan Drug (United States)

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Structure/Sequence

Molecular FormulaC8H13N3O4S

InChIKeyHJLSLZFTEKNLFI-UHFFFAOYSA-N

CAS Registry19387-91-8

Esophagectomy is an important means of radical treatment of esophageal cancer, but due to local recurrence and metastasis, the 5-year survival rate of patients with esophageal cancer is only 20-30%. Studies have reported that about 50% of patients relapse within 1 year after surgery, and the short-term recurrence rate is high. Therefore, reducing the recurrence rate of esophageal cancer after operation is an important way to improve its prognosis. Porphyromonas gingivalis infection in ESCC tissues was significantly higher than that in paracancer tissues, and was significantly positively correlated with cancer cell differentiation, lymph node metastasis, TNM stage, and shortened survival of ESCC patients. In summary, porphyromonas gingivalis plays an important role in postoperative recurrence of esophageal cancer. Elimination of porphyromonas gingivalis can significantly reduce the recurrence rate of esophageal cancer after operation. Tinidazole is a class of nitroimidazole drugs. It has been pointed out that the pharmacological mechanism of Tinidazole is to inhibit the DNA synthesis of pathogenic bacteria, so as to eliminate bacteria in periodontal tissues and inhibit local inflammation. Based on this, we designed and fabricated a novel oral microneedle patch loaded with tinidazole. Tinidazole oral microneedle patch can effectively remove porphyromonas gingivalis and promote the repair of gingival tissue. In this study, based on the combination of mechanical removal and antibacterial treatment, a combination of ultrasonic dental cleaning and tinidazole oral composite microneedle patch was designed to completely remove porphyromonas gingivalis in oral cavity, and to evaluate the effect of removal of porphyromonas gingivalis in oral cavity on the prognosis of esophageal cancer after radical surgery.

Start Date01 Aug 2024

Sponsor / Collaborator-

IRCT20210519051345N17

/ RecruitingNot ApplicableIIT

Fasted-state in vivo bioequivalence study of Tinidazole 500 mg tablet

Start Date06 Nov 2022

Sponsor / Collaborator

Tabriz University of Medical Sciences

100 Clinical Results associated with Tinidazole

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100 Translational Medicine associated with Tinidazole

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100 Patents (Medical) associated with Tinidazole

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3,090

Literatures (Medical) associated with Tinidazole

01 Jun 2025·Journal of the Taiwan Institute of Chemical Engineers

Graphitic carbon nitride-embedded MXene tungsten carbide nanoflakes for sensitive detection of cytotoxic tinidazole in biological samples

Author: Li, Ying ; Ganesan, Muthusankar ; Tu, Hsiung-Lin ; Chen, Shen-Ming ; Gopu, Gopalakrishnan ; Devi, Ramadhass Keerthika ; Duann, Yeh-Fang ; Wang, Chih-Min

Nitroimidazole derivatives, extensively utilized as antibiotics in the pharmaceutical, healthcare, and animal industries, pose a significant environmental threat as potential pollutants.Industrial discharge can introduce these compounds into water sources, where even trace levels of residues, such as tinidazole (TNZ), can adversely affect human health and aquatic ecosystems.However, the electrochem. detection of TNZ remains challenging due to limited sensitivity.To address this challenge, a novel nanocomposite comprising MXene tungsten carbide (WC) decorated with graphitic carbon nitride nanosheets (WC/gCN NSs) was developed for highly sensitive TNZ detection.The WC/gCN NSs were synthesized through a straightforward approach, yielding stable nanosheets.The WC/gCN NSs-modified electrode demonstrated superior TNZ detection performance compared to conventional methods.This enhancement is attributed to the synergistic interaction between the conductive gCN NSs and the catalytic MXene WC, which generated abundant active sites and facilitated efficient electron transfer.The sensor exhibited exceptional performance, achieving a detection limit of 3.6 nM, high sensitivity (4.2μA μM-1 cm^-2), and a recovery rate of 99.9% (n = 3).It also demonstrated excellent repeatability (RSD 2.4%), reproducibility, and stability over 30 days.This study provides a promising strategy for designing electrocatalysts with tuneable architectures, contributing to sustainable materials for environmental protection.

01 Jun 2025·Environmental Research

Retraction notice to “Photocatalytic assessed adsorptive removal of tinidazole from aqueous environment using reduced magnetic graphene oxide-bismuth oxychloride and its silver composite” [Environ. Res. 215-P2 (2022) 114262]

Article

Author: Sohani, Saba ; Khan, Mansoor ; Gul, Kashif ; Khan, Hamayun ; Ara, Behisht

01 Jun 2025·Emerging Contaminants

Exposure assessment of 113 exogenous chemicals simultaneously in serum samples from children in north Shandong, China, and their association with sex, age, and body mass index

Author: Zhi, Mengxue ; Zhang, Fenghong ; Wang, Danyang ; Wang, Jianshe

Children are particularly vulnerable to adverse effects from exposure to environmental chems., necessitating comprehensive assessment to mitigate health risks.In this study, we analyzed 477 serum samples from children aged 2-6 years in North Shandong, China, using liquid chromatog.-mass spectrometry (LC-MS) to create an exposure profile of 184 exogenous chems.These chems. encompass pesticides, pharmaceuticals, industrial and consumer chems., and food additives.Of these, 113 exogenous chems. were identified above the limit of detection in the serum of at least one child participant, and 37 were detected in more than 30% of the children.Notably, 17 of the 24 selected perfluoroalkyl and polyfluoroalkyl substances (PFAS) were detected.PFOA, PFBA, and PFHxS exhibited the highest concentrations, with geometric means of 38.11 ng/mL, 17.39 ng/mL, and 7.35 ng/mL, resp.The elevated levels of short-chain PFBA suggests increased production and environmental release in recent years.Anal. of sex-based differences revealed significant differences in the serum levels of 11 chems., with nine compounds displaying higher concentrations in girls than in boys.Notably, long-chain PFAS, including PFUnDA, PFDA, and PFTrDA, were present at higher concentrations in girls, while short-chain PFHpA and PFBS were higher in boys.Addnl., serum levels of di-Ph phosphate and fipronil sulfone declined slightly with age, indicating heightened exposure risk during early childhood.Pos. associations between monoethyl phthalate and fipronil sulfone concentrations with BMI categories were observed, suggesting a potential obesogenic effect of these compoundsThis study provides critical insights into the profiles of exogenous chems. in young children and highlights the need for targeted risk assessment of environmental pollutants impacting pediatric health.

100 Deals associated with Tinidazole

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External Link

KEGG	Wiki	ATC	Drug Bank
D01426	Tinidazole	P01AB02 J01XD02	DB00911

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Bacterial Vaginosis	United States	Mission Pharmacal Co.	21 May 2007
Amebiasis	United States	Mission Pharmacal Co.	17 May 2004
Giardiasis	United States	Mission Pharmacal Co.	17 May 2004
Trichomonas Infections	United States	Mission Pharmacal Co.	17 May 2004
Bacterial Infections	China	Zhejiang Sukean Pharmaceutical Co Ltd.	01 Jan 1994

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00334633 (CTgov)	Phase 4	Bacterial Vaginosis	593	tinidazole, metronidazole (Tinidazole 1 gm)	ixaemcnkfj(najoqichnm) = muhormksvn pysojggpwk (hqbidhcxtm, cacendnseo - jhahawxqka) View more	-	23 Jun 2011
				tinidazole, metronidazole (Control)	kmiwtgckeg(buobmtaemq) = fjzzqrraoh rxddvzpsvy (xttnaghthp, asfjgylrhr - dbxlzvnxrz)