Delving into the Latest Updates on Tinidazole with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitroimidazole, Timidazole, Tinidazole (JP17/USP/INN)

+ [17]

Target

DNA

Mechanism

DNA modulators(DNA modulators)

Therapeutic Areas

Infectious DiseasesDigestive System DisordersUrogenital Diseases

Active Indication

Bacterial VaginosisAmebiasisGiardiasis+ [2]

Inactive Indication-

Originator Organization

Zhejiang Sukean Pharmaceutical Co Ltd.

Active Organization

Mission Pharmacal Co.

Zhejiang Sukean Pharmaceutical Co Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

CN (01 Jan 1994),

Bacterial Infections

RegulationOrphan Drug (US)

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Structure

Molecular FormulaC8H13N3O4S

InChIKeyHJLSLZFTEKNLFI-UHFFFAOYSA-N

CAS Registry19387-91-8

Esophagectomy is an important means of radical treatment of esophageal cancer, but due to local recurrence and metastasis, the 5-year survival rate of patients with esophageal cancer is only 20-30%. Studies have reported that about 50% of patients relapse within 1 year after surgery, and the short-term recurrence rate is high. Therefore, reducing the recurrence rate of esophageal cancer after operation is an important way to improve its prognosis. Porphyromonas gingivalis infection in ESCC tissues was significantly higher than that in paracancer tissues, and was significantly positively correlated with cancer cell differentiation, lymph node metastasis, TNM stage, and shortened survival of ESCC patients. In summary, porphyromonas gingivalis plays an important role in postoperative recurrence of esophageal cancer. Elimination of porphyromonas gingivalis can significantly reduce the recurrence rate of esophageal cancer after operation. Tinidazole is a class of nitroimidazole drugs. It has been pointed out that the pharmacological mechanism of Tinidazole is to inhibit the DNA synthesis of pathogenic bacteria, so as to eliminate bacteria in periodontal tissues and inhibit local inflammation. Based on this, we designed and fabricated a novel oral microneedle patch loaded with tinidazole. Tinidazole oral microneedle patch can effectively remove porphyromonas gingivalis and promote the repair of gingival tissue. In this study, based on the combination of mechanical removal and antibacterial treatment, a combination of ultrasonic dental cleaning and tinidazole oral composite microneedle patch was designed to completely remove porphyromonas gingivalis in oral cavity, and to evaluate the effect of removal of porphyromonas gingivalis in oral cavity on the prognosis of esophageal cancer after radical surgery.

Start Date01 Aug 2024

Sponsor / Collaborator-

IRCT20210519051345N17 / RecruitingIIT

Fasted-state in vivo bioequivalence study of Tinidazole 500 mg tablet

Start Date06 Nov 2022

Sponsor / Collaborator

Tabriz University of Medical Sciences

100 Clinical Results associated with Tinidazole

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100 Translational Medicine associated with Tinidazole

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100 Patents (Medical) associated with Tinidazole

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1,516

Literatures (Medical) associated with Tinidazole

01 Nov 2024·Advanced Materials

Ultrasound‐Activated Probiotics Vesicles Coating for Titanium Implant Infections Through Bacterial Cuproptosis‐Like Death and Immunoregulation

Article

Author: Wang, Wenqi ; Wan, Xufeng ; Zhou, Zongke ; Chen, Xiaoting ; Cao, Jian ; Li, Shuoyuan ; Yue, Yan ; Yang, Jiaojiao ; Li, Jiyao ; Cheng, Lei ; Li, Jianshu ; Han, Mingyue ; Wang, Duan ; Zhang, Yangming ; Li, Qiaochu

AbstractImplant‐associated infections (IAIs) are the main cause of prosthetic implant failure. Bacterial biofilms prevent antibiotic penetration, and the unique metabolic conditions in hypoxic biofilm microenvironment may limit the efficacy of conventional antibiotic treatment. Escaping survival bacteria may not be continually eradicated, resulting in the recurrence of IAIs. Herein, a sonosensitive metal‐organic framework of Cu‐TCPP (tetrakis(4‐carboxyphenyl) porphyrin) nanosheets and tinidazole doped probiotic‐derived membrane vesicles (OMVs) with high‐penetration sonodynamic therapy (SDT), bacterial metabolic state interference, and bacterial cuproptosis‐like death to eradicate IAIs is proposed. The Cu‐TCPP can convert O2 to toxic 1O2 through SDT in the normoxic conditions, enhancing the hypoxic microenvironment and activating the antibacterial activity of tinidazole. The released Cu(II) under ultrasound can be converted to Cu(I) by exogenous poly(tannic acid) (pTA) and endogenous glutathione. The disruption of the bacterial membrane by SDT can enhance the Cu(I) transporter activity. Transcriptomics indicate that the SDT‐enhanced Cu(I) overload and hypoxia‐activated therapy hinder the tricarboxylic acid cycle (TCA), leading to bacterial cuproptosis‐like death. Moreover, the OMVs‐activated therapy can polarize macrophages to a M2‐like phenotype and facilitate bone repair. The sonodynamic biofilm microenvironment modulation strategy, whereby the hypoxia‐enhanced microenvironment is potentiated to synergize SDT with OMVs‐activated therapy, provides an effective strategy for antibacterial and osteogenesis performance.

01 Nov 2024·Ultrasonics Sonochemistry

Ultrasonically assisted fabrication of electrochemical platform for tinidazole detection

Article

Author: Cui, Wenyu ; Liu, Rui ; Sun, Yuan ; Zhang, Chaojun ; Yang, Wein-Duo ; Liu, Rijia

Based on sonochemistry, green synthesis methods play an important role in the development of nanomaterials. In this work, a novel chitosan modified MnMoO₄/g-C₃N₄ (MnMoO₄/g-C₃N₄/CHIT) was developed using ultrasonic cell disruptor (500 W, 30 kHz) for ultra-sensitive electrochemical detection of tinidazole (TNZ) in the environment. The morphology and surface properties of the synthesized MnMoO₄/g-C₃N₄/CHIT electrode were characterized using X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and transmission electron microscope (TEM). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques were utilized to assess the electrochemical performance of TNZ. The results indicate that the electrochemical detection performance of TNZ is highly efficient, with a detection limit (LOD) of 3.78 nM, sensitivity of 1.320 µA·µM^-1·cm^-2, and a detection range of 0.1-200 μM. Additionally, the prepared electrode exhibits excellent selectivity, desirable anti-interference capability, and decent stability. MnMoO₄/g-C₃N₄/CHIT can be successfully employed to detect TNZ in both the Songhua River and tap water, achieving good recovery rates within the range of 93.0 % to 106.6 %. Consequently, MnMoO₄/g-C₃N₄/CHIT's simple synthesis might provide a new electrode for the sensitive, repeatable, and selective measurement of TNZ in real-time applications. Using the MnMoO₄/g-C₃N₄/CHIT electrode can effectively monitor and detect the concentration of TNZ in environmental water, guiding the sewage treatment process and reducing the pollution level of antibiotics in the water environment.

01 Nov 2024·Analytical and Bioanalytical Chemistry

Development of purity certified reference materials to establish metrological traceability for the measurement of nitroimidazoles in agricultural products

Article

Author: Liu, QingYi ; Zhou, Jian ; Jiang, Bin ; Li, FuKai ; Yang, MengRui ; Wang, Min ; Zhang, LiYuan

It is of significant importance to public health that reliable monitoring of nitroimidazoles be conducted, while certified reference materials (CRMs) are essential for accurate and reliable detection. A project has been initiated with the objective of developing nitroimidazole purity CRMs to ensure that results from nationwide monitoring laboratories for nitroimidazoles in antibiotic residues can be compared and traced. The candidates were successively characterized in terms of their structure by means of infrared (IR) spectroscopy and mass spectrometry (MS). The mass balance (MB) method and the quantitative nuclear magnetic resonance (qNMR) method were utilized to determine the purity of nitroimidazoles with remarkable accuracy. Furthermore, a methodical investigation was conducted on homogeneity, stability, and uncertainty. Six nitroimidazole purity CRMs, including tinidazole (GBW09252), secnidazole (GBW09286), ronidazole (GBW09288), metronidazole (GBW(E)090755), dimetridazole (GBW(E)090819), and ornidazole (GBW(E)090820), were finally manufactured following authorization from China's State Administration for Market Regulation (SAMR). By using these CRMs, it is possible to improve the traceability, accuracy, and comparability of nitroimidazole measurements in a range of agricultural products, protecting public health.

100 Deals associated with Tinidazole

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External Link

KEGG	Wiki	ATC	Drug Bank
D01426	Tinidazole	P01AB02 J01XD02	DB00911

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Bacterial Vaginosis	US	Mission Pharmacal Co.	21 May 2007
Amebiasis	US	Mission Pharmacal Co.	17 May 2004
Giardiasis	US	Mission Pharmacal Co.	17 May 2004
Trichomonas Infections	US	Mission Pharmacal Co.	17 May 2004
Bacterial Infections	CN	Zhejiang Sukean Pharmaceutical Co Ltd.	01 Jan 1994

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00334633 (CTgov)	Phase 4	Bacterial Vaginosis	593	tinidazole, metronidazole (Tinidazole 1 gm)	ydrdejitsw(wyrefkrjbs) = jsppfuxznq fbvcuelxtx (vexwgfkdmg, cagilbgubg - wigmgigyxh) View more	-	23 Jun 2011
				tinidazole, metronidazole (Control)	mmhaugjycx(gvbuiljfak) = tcpcnrvkfi ciinqitobo (pxdrcmfsic, nhzkxxiwab - tadbkzrgbq)
NCT00229216 (Pubmed \| Obstet Gynecol)	Phase 3	Bacterial Vaginosis	235	Tinidazole 1 g once daily for 5 days	mgvtcadnyv(owunyyeupa) = mrygedlzzu irkjigsdvu (oeboagione )	-	01 Aug 2007
				Tinidazole 2 g once daily for 2 days	mgvtcadnyv(owunyyeupa) = dzwyfpofzb irkjigsdvu (oeboagione )