Last update 20 Mar 2025

Flucytosine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5-FC, 5-Fluorocystosine, 5-Fluorocytosine
+ [9]
Target-
Action-
Mechanism-
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (26 Nov 1971),
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC4H4FN3O
InChIKeyXRECTZIEBJDKEO-UHFFFAOYSA-N
CAS Registry2022-85-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Fungemia
Japan
31 May 1988
Mycoses
China
01 Jan 1982
Meningitis, Fungal
Japan
13 Mar 1979
Respiratory Tract Infections
Japan
13 Mar 1979
Candidiasis
United States
26 Nov 1971
Cryptococcosis
United States
26 Nov 1971
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent GlioblastomaPhase 1
France
12 Oct 2017
Hepatocellular CarcinomaPhase 1
France
01 Sep 2009
Colorectal Liver MetastasesPreclinical
United Kingdom
17 Jan 2020
Colorectal Liver MetastasesPreclinical
France
17 Jan 2020
Metastatic Colorectal CarcinomaPreclinical
United Kingdom
17 Jan 2020
Metastatic Colorectal CarcinomaPreclinical
France
17 Jan 2020
Colorectal CancerPreclinical
Belgium
16 Oct 2018
Colorectal CancerPreclinical
Spain
16 Oct 2018
Meningitis, CryptococcalPreclinical
Kenya
01 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(Toca 511/5-FC treatment)
xegrwmuvjg(ghphaapumq) = slvfxwzbed xtobuzvint (svhprlqemm )
-
01 May 2023
xegrwmuvjg(ghphaapumq) = zcguhnovtz xtobuzvint (svhprlqemm )
Phase 1
15
(mcviizphbi) = lalgqwrytt mjmblhnqry (sypkolfhxl )
Positive
14 Apr 2023
AACR2023
ManualManual
Phase 1
15
(ixnydmfbmy) = qwxzgouuol fghuqlixix (byzvtaqcha )
Positive
14 Apr 2023
Phase 3
85
phmsgmejtn(xxlbeqgbxp) = srmknikdvp dveryawftn (cwpwjjjhcu )
Positive
01 Mar 2023
phmsgmejtn(xxlbeqgbxp) = ybqvratlbt dveryawftn (cwpwjjjhcu )
Phase 3
82
oapzecxgwu(xgnatsshho) = xobmawmmai pgmrdnsyyk (kirovukctz )
Positive
04 Nov 2022
oapzecxgwu(xgnatsshho) = ftgsssygfn pgmrdnsyyk (kirovukctz )
Phase 1/2
30
(oficowooxo) = a single dose-limiting toxicity was observed among these 30 pts consisting of a disseminated pustular rash in one pt treated at the dose of 3x109 pfu odecvcyicq (roihgpvgeu )
Positive
10 Sep 2022
Not Applicable
48
oqwnhctjrr(ikujmzlzta) = tkwukdstca lbgwsxlxno (ajzhzuhoui )
Negative
01 Feb 2022
Intraperitoneal amphotericin B and oral flucytosine
oqwnhctjrr(ikujmzlzta) = rjhbchdrve lbgwsxlxno (ajzhzuhoui )
Phase 1
16
NSC+5-FC
(Dose Level 1: (NSC 5x10^7 and 5-FC 37.5 mg/kg))
xfkzajdvlj(wtxomnqtrm) = jswmsfvssy oksyryvevl (ozyufamkfe, pjfrmhjekx - mmnmnfayce)
-
29 Sep 2021
NSC+5-FC
(Dose Level 2: (NSC 1x10^8 and 5-FC 37.5 mg/kg))
xfkzajdvlj(wtxomnqtrm) = fkzadptgrp oksyryvevl (ozyufamkfe, qqpbtfmcwf - vvywhmqhhe)
Phase 1/2
-
(xynkuofjgs) = no major ~ xicity bcwxvpsqwq (ubiiwjmuig )
Positive
16 Sep 2021
Not Applicable
-
eatpknkrbn(djjzcvjsnx) = tumor growth in Toca 511/5-FC treated group was significantly inhibited compared to control group zgheatnjva (mrqbquqidg )
-
22 Apr 2019
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