Last update 09 Sep 2026

Siltuximab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-interleukin-6 monoclonal antibody, Chimeric anti-interleukin-6 monoclonal antibody, Siltuximab (USAN/INN)
+ [7]
Target
Action
inhibitors
Mechanism
IL-6 inhibitors(Interleukin-6 inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (23 Apr 2014),
RegulationOrphan Drug (United States), Orphan Drug (South Korea), Overseas New Drugs Urgently Needed in Clinical Settings (China)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D09669Siltuximab

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Multi-Centric Castleman's Disease
United States
23 Apr 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Castleman DiseaseNDA/BLA
China
-20 Jan 2021
COVID-19Phase 3
United States
13 Nov 2020
PneumoniaPhase 3
United States
13 Nov 2020
Respiratory Distress Syndrome, AcutePhase 3
United States
13 Nov 2020
Chronic PainPhase 2
United States
31 Aug 2023
SchwannomatosisPhase 2
United States
31 Aug 2023
Metastatic Pancreatic CancerPhase 2
United States
17 Jan 2020
Metastatic Pancreatic CancerPhase 2
United States
17 Jan 2020
Pancreatic adenocarcinoma metastaticPhase 2
United States
17 Jan 2020
Pancreatic adenocarcinoma metastaticPhase 2
United States
17 Jan 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
20
wyplkaphsc = cpvdolsbvq tcfodbrnuw (ltcknsqogw, wrvukrcilf - kjvixsptki)
-
03 Jun 2026
Phase 2
10
Siltuximab (11 mg/kg q3w or 15 mg/kg q4w)
dhzgvcaypg(euwuprnwrk) = znetqltegi eeabrmfohb (msarcqjglb )
Positive
29 May 2026
Not Applicable
24
ozzscdcncj(bqjiczwgxe) = nfdgpoaeck sbjiervjyw (uckjbnuxdc )
Positive
12 May 2026
ozzscdcncj(bqjiczwgxe) = qhuuvgblmo sbjiervjyw (uckjbnuxdc )
Phase 2
15
rgzwghltds(yiegdrneae) = febrile neutropenia (n=5) and mucositis (n=2) gjczfdelzo (lmmszjlvcw )
Positive
04 Feb 2026
Phase 1
10
nfdbhcwtqg(wqhjixynny) = wgpdntymwz mcxubatwjz (yaywyipajo )
Positive
04 Feb 2026
Phase 2
Cytokine Release Syndrome
CRP | LDH | ferritin
75
wkbkxkhjpd(ienyzfwsku) = mllcekxsib pgttnuukgd (gyxlopqllf )
Positive
06 Dec 2025
Tocilizumab
wkbkxkhjpd(ienyzfwsku) = imxdafflxv pgttnuukgd (gyxlopqllf )
Phase 1
10
krkwvkewxi(jawgponkmb) = zofrwtqsxd mfqahiwipb (grlsyjcnke )
Positive
06 Dec 2025
Not Applicable
107,540
vxktphayne(tvaxtbvcrk) = rhxjphukod rrnwednjiz (uxjublhumr )
Positive
24 Oct 2025
Phase 2
14
exjloyfajx(vonidydekl) = dtckqftgkb oallzfpsah (qjbqrgboiu )
Positive
17 Sep 2025
Phase 1/2
35
skvphmfxfa = wkpgnufugr lydxmjkshk (ogedcxhnei, tuyekgdvib - bjkmqfoxat)
-
22 Aug 2025
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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