This research is being done to evaluate tazemetostat in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy as a possible treatment for peripheral T-Cell Lymphoma (PTCL).
The name of the study drugs involved in this study are:
* Tazemetostat (a type of inhibitor for Enhancer of Zeste Homolog 2 (EZH2))
* Standard of care CHOP therapy:
* Cyclophosphamide (a type of alkylating agent)
* Doxorubicin (a type of anthracycline antibiotic)
* Vincristine (a type of vinca alkaloid)
* Prednisone (a type of corticosteroid)
* Standard of care BEAM conditioning regimen for autologous stem cell transplant:
* Carmustine (a type of alkylating agent)
* Etoposide (a type of Topoisomerase II inhibitor)
* Cytarabine (a type of antineoplastic)
* Melphalan (a type of alkylating agent)

Start Date01 Apr 2025

Sponsor / Collaborator

Dana-Farber Cancer Institute, Inc.

[+1]

NCT05617625

/ SuspendedPhase 2IIT

A Phase II Trial of CD34+ Enriched Transplants From HLA-Compatible Related or Unrelated Donors for Treatment of Patients With Myelodysplastic Syndrome

This study will evaluate whether processing blood stem cell transplants using an investigational device (the CliniMACS system) results in fewer complications for patients who undergo transplant to treat a blood malignancy (cancer) or blood disorder.
The CliniMACS system will be used to remove immune T-cells from the transplant donor's blood. Immune T-cells contribute to graft versus host disease (GVHD) - a serious complication that can happen after transplant. GVHD occurs when a patient's immune system attacks the donor's cells. The study aims to reduce the number of the donor immune T-cells thereby preventing or reducing the severity of GVHD.

Start Date01 Mar 2025

Sponsor / Collaborator

Baptist Health South Florida, Inc.

NCT05565105

/ Not yet recruitingPhase 2IIT

A Phase II Trial of CD34+ Enriched Transplants From HLA-Compatible Related or Unrelated Donors for Treatment of Patients With Leukemia or Lymphoma

This study will evaluate whether processing blood stem cell transplants using an investigational device (the CliniMACS system) results in less complications for patients undergoing transplant for treatment of a blood malignancy (cancer) or blood disorder.

Start Date01 Mar 2025

Sponsor / Collaborator

Baptist Health South Florida, Inc.

100 Clinical Results associated with Melphalan

100 Translational Medicine associated with Melphalan

100 Patents (Medical) associated with Melphalan

12,965

Literatures (Medical) associated with Melphalan

01 Dec 2025·CANCER CHEMOTHERAPY AND PHARMACOLOGY

Lipidomic profiling of plasma from patients with multiple myeloma receiving bortezomib: an exploratory biomarker study of JCOG1105 (JCOG1105A1)

Article

Author: Suzuki, Yasuhiro ; Tabayashi, Takayuki ; Maruta, Masaki ; Kuroda, Junya ; Saito, Yoshiro ; Harada, Yasuhiko ; Katsuya, Hiroo ; Yoshida, Shinichiro ; Takayama, Nobuyuki ; Iida, Shinsuke ; Norifumi, Tsukamoto ; Mizuno, Ishikazu ; Negoro, Eiju ; Yoshida, Isao ; Minami, Yosuke ; Miyazaki, Kana ; Maruyama, Dai ; Asano, Arisa ; Takamatsu, Yasushi ; Ohtsuka, Eiichi ; Munakata, Wataru ; Tsujimura, Hideki ; Yoshimitsu, Makoto ; Nagai, Hirokazu ; Fukuhara, Suguru ; Kanato, Keisuke ; Fukuhara, Noriko ; Ri, Masaki ; Ota, Shuichi ; Saito, Kosuke ; Saito, Toko

PURPOSE:

A comprehensive analysis of metabolites (metabolomics) has been proposed as a new strategy for analyzing liquid biopsies and has been applied to identify biomarkers predicting clinical responses or adverse events associated with specific treatments. Here, we aimed to identify metabolites associated with bortezomib (Btz)-related toxicities and response to treatment in newly diagnosed multiple myeloma (MM).

METHODS:

Fifty-four plasma samples from transplant-ineligible MM patients enrolled in a randomized phase II study comparing two less-intensive regimens of melphalan, prednisolone and Btz (MPB) were subjected to the lipidomic profiling analysis. The amount of each lipid metabolite in plasma obtained prior to MPB therapy was compared to toxicity grades and responses to MPB therapy.

RESULTS:

High levels of 7 phospholipids (4 lysophosphatidylcholines and 3 phosphatidylcholines) were observed in cases with Btz-induced ≥ grade 2 peripheral neuropathy (BiPN) (n = 11). In addition, low levels of 3 fatty acids (FAs)-FA (18:2), FA (18:1), and FA (22:6)-were observed in patients who developed severe skin disorders ≥ grade 2 (n = 10). No metabolite significantly associated with treatment response was identified.

CONCLUSION:

We conclude that levels of specific plasma lipid metabolites are associated with the severity of BiPN and skin disorders in patients with MM. These metabolites may serve as candidate biomarkers to predict Btz-induced toxicity in patients with MM before initiating Btz-containing therapy.

01 Feb 2025·Journal of Neurological Surgery Part B-Skull Base

Feasibility and Safety of Cone-Beam Computed Tomography Advanced Navigation to Optimize Intra-arterial Chemotherapy Infusion of Skull Base Tumors

Article

Author: Lin, Andrew ; Tabar, Viviane ; Cornelis, Francois H. ; Lis, Eric

Abstract:

Purpose To assess the feasibility and safety of cone-beam computed tomography (CBCT) advanced navigation for optimizing intra-arterial chemotherapy infusion (IACI) in patients with skull base tumors. Materials and Methods Retrospective review on 10 consecutive IACI procedures performed in five patients (four women, 1 man) over a 1-year period. The median age of the patients was 71 years (interquartile range: 34–74). During the procedures, a CBCT-based navigation software was employed to evaluate tumor perfusion and guide the infusion methods. Catheterization of the primary tumor feeding vessel was performed in seven cases when it originated from the external carotid artery, whereas a temporary balloon-assisted occlusion technique was utilized in the remaining three cases where the tumor was primarily fed by the internal carotid artery. Carboplatin, topotecan, and melphalan were injected over a 10-minute period. Fluoroscopy time, reference dose, and Kerma area product, which estimates effective dose, were analyzed. Results The technical success rate was 100%, with a median procedure length of 82 minutes (79–90). The median fluoroscopy time was 11.3 minutes (9.4–16.9), reference dose was 93.5 mGy (62–256.5), and Kerma area product was 11.6 Gy.cm2 (9.5–25.4). The median effective dose was 3.8 mSv (1.5–5.1). The median follow-up duration was 233.5 days (186.3–432). One severe adverse event was reported, involving a right brachial hematoma and brachiocephalic artery dissection related to catheterization through a type III aortic arch. Three patients exhibited disease progression, but two patients showed stable disease. Conclusion IACI for skull base tumors guided by CBCT navigation is both feasible and safe.

01 Jan 2025·EUROPEAN JOURNAL OF HAEMATOLOGY

Reduced Intensity Conditioning Prior Autologous Stem Cell Transplantation in Elderly DLBCL Patients

Article

Author: Engelhardt, Monika ; Finke, Jürgen ; Strüßmann, Tim ; Hermes, Philipp ; Duque‐Afonso, Jesús ; Marks, Reinhard ; Ihorst, Gabriele ; Duyster, Justus

ABSTRACT:

High‐dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT) is widely used in patients with diffuse large B‐cell lymphoma. HDCT/ASCT is associated with increased morbidity in elderly/unfit patients. We retrospectively evaluated the use of reduced intensity conditioning in DLBCL patients. Our study included 146 patients aged 60 years and older treated at our institution between 2005 and 2019; 86 patients received standard intensity conditioning (SI group) with BEAM or TEAM (BCNU or thiotepa, etoposide, cytarabine, melphalan). Sixty patients received reduced intensity high‐dose conditioning (RI group) with BM (BCNU, melphalan, 43.3%), TM (thiotepa, melphalan, 16.7%), BCNU or busulfan thiotepa (38.4%), or bendamustine melphalan (1.7%). Median follow‐up was 62.4 months. We observed comparable toxicities in the SI and RI groups. The cumulative incidence of relapse at 3 years was higher in the RI group (30.8% vs. 23.4%, p = 0.034). There was no difference in nonrelapse mortality (NRM). In univariate analyses, SI vs. RI conditioning resulted in superior progression‐free survival (PFS) (HR 1.80 CI 1.11–2.92, p = 0.017) but not in superior overall survival (OS) (HR 1.48 CI 0.86–2.56, p = 0.152). On multivariate analysis, we observed no difference in PFS (HR 0.74 CI 0.40–1.38, p = 0.345) and a trend toward better OS with RI conditioning (HR 0.45 CI 0.22–0.94, p = 0.032). Age 60–69 versus ≥ 70 years and remission prior to ASCT were the only factors predicting better PFS. Factors associated with better OS were RI conditioning, age 60–69 versus ≥ 70 years, ECOG 0 versus ≥ 1 performance status, bulky disease, and prior lines 1 versus ≥ 2. In conclusion, RI conditioning prior to ASCT may be feasible in elderly patients and led to a comparable outcome when corrected for several significant confounders.

120

News (Medical) associated with Melphalan

30 Jan 2025

·www.pharmaceutical-technology.com

MHRA launches refreshed ILAP to speed up NHS drug access

The refreshed ILAP pathway has been outlined by the UK’s MHRA. Credit: georgeclerk via Getty Images. The UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) has launched a refreshed Innovative Licensing and Access Pathway (ILAP) to accelerate patient access to new medicines by integrating regulatory and health technology assessment procedures. The revised pathway, developed by the MHRA alongside the All Wales Therapeutics and Toxicology Centre (AWTTC), the National Institute for Health and Care Excellence ( Nice ), the Scottish Medicines Consortium ( SMC ) and the National Health Service (NHS), aims to streamline collaboration between medicine developers and the national health systems. First introduced in 2021, the pathway was designed to create a single platform for engagement between the MHRA and UK Health Technology Assessment (HTA) bodies. The latest updates reflect feedback from industry stakeholders and recommendations from the Pro-innovation Regulation of Technologies Review. The changes aim to enhance the efficiency and predictability of the approval process while maintaining standards of safety, quality, and effectiveness. Under the refreshed pathway, the NHS will be a core partner focusing on system preparedness and operational planning for new medicines. Engagement with patients will be done earlier, and a single point of contact will be assigned for each product. The pathway will also provide support for drug-device combinations, which are being investigated in a range of diseases such as cancer and Alzheimer’s disease. For example, Delcath System is developing its drug-device combo Hepzato Kit (melphalan/hepatic delivery system) as an add-on treatment for patients with liver-dominant metastatic colorectal cancer (mCRC) and started enrolment in a Phase II trial studying it in December 2024. The MHRA outlined plans for the revised ILAP in its 2024/25 business plan , which identified improved patient access to safe and effective products as a priority. The agency, along with its ILAP partners, committed to an iterative approach, allowing for further refinements to be based on industry needs and regulatory developments. Several companies have already used ILAP to enable their medicines to be accessible on the NHS. UK-based biotech LightOx has developed LXD191, a light-activated drug designed to eliminate pre-cancerous and cancerous cells at an early stage. The company – which aims to bring the drug to the clinic this year – plans to use the ILAP to enter Project Orbis, an international regulatory incentive, which also involves the US Food and Drug Administration (FDA), to accelerate the approval of oncology treatments. The MHRA joined Project Orbis in 2021 to support faster patient access to cancer therapies.

Phase 2

13 Jan 2025

·www.businesswire.com

Delcath Systems Announces Preliminary Fourth Quarter and Full Year 2024 Financial Results

QUEENSBURY, N.Y.--( BUSINESS WIRE )--Delcath Systems, Inc. (Nasdaq: DCTH) (“Delcath” or the “Company”), an interventional oncology company focused on the treatment of primary and metastatic cancers of the liver, today announced preliminary financial results for the fourth quarter and year-ended December 31, 2024. Preliminary Fourth Quarter and Full-Year 2024 Financial Results (unaudited) Total fourth quarter and full year revenue expected to be approximately $15.1 million and $37.2 million, respectively HEPZATO KIT™ fourth quarter and full year revenue expected to be approximately $13.7 million and $32.3 million, respectively CHEMOSAT ® fourth quarter and full year revenue expected to be approximately $1.4 million and $4.9 million, respectively Gross margins expected to be in the 80%-85% range As of December 31, 2024, the Company had approximately $53.2 million of cash, cash equivalents and short-term investments and no debt Final financial results for the fourth quarter and full year 2024 and a detailed business update will be provided during Delcath’s annual financial results release and investor call scheduled for March 6, 2025. About Delcath Systems, Inc., HEPZATO KIT and CHEMOSAT Delcath Systems, Inc. is an interventional oncology company focused on the treatment of primary and metastatic liver cancers. The company's proprietary products, HEPZATO KIT™ (HEPZATO (melphalan) for Injection/Hepatic Delivery System) and CHEMOSAT ® Hepatic Delivery System for Melphalan percutaneous hepatic perfusion (PHP), are designed to administer high-dose chemotherapy to the liver while controlling systemic exposure and associated side effects during a PHP procedure. In the United States, HEPZATO KIT is considered a combination drug and device product and is regulated and approved for sale as a drug by the FDA. HEPZATO KIT is comprised of the chemotherapeutic drug melphalan and Delcath's proprietary Hepatic Delivery System (HDS). The HDS is used to isolate the hepatic venous blood from the systemic circulation while simultaneously filtrating hepatic venous blood during melphalan infusion and washout. The use of the HDS results in loco-regional delivery of a relatively high melphalan dose, which can potentially induce a clinically meaningful tumor response with minimal hepatotoxicity and reduce systemic exposure. HEPZATO KIT is approved in the United States as a liver-directed treatment for adult patients with metastatic uveal melanoma (mUM) with unresectable hepatic metastases affecting less than 50% of the liver and no extrahepatic disease, or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues, or lung that is amenable to resection or radiation. Please see the full Prescribing Information , including BOXED WARNING for the HEPZATO KIT. In Europe, the device-only configuration of the HDS is regulated as a Class III medical device and is approved for sale under the trade name CHEMOSAT Hepatic Delivery System for Melphalan, or CHEMOSAT, where it has been used in the conduct of percutaneous hepatic perfusion procedures at major medical centers to treat a wide range of cancers of the liver. Preliminary and Unaudited Nature of Reported Results The Company has not yet completed its financial close process for the fourth quarter and full year 2024 and, as a result, actual results may vary from the estimated preliminary results set forth in this press release due to a number of factors, including audit adjustments and other developments that may arise between now and the time the financial results for the fourth quarter and fiscal year ended December 31, 2024, are finalized. The estimated preliminary financial results have not been audited or reviewed by the Company’s independent registered public accounting firm. These estimates should not be viewed as a substitute for the Company’s full interim or annual audited financial statements. Safe Harbor / Forward-Looking Statements The Private Securities Litigation Reform Act of 1995 provides a safe harbor for forward-looking statements made by the Company or on its behalf. This press release contains forward-looking statements, which are subject to certain risks and uncertainties, that can cause actual results to differ materially from those described. The words "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "will," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Factors that may cause such differences include, but are not limited to, uncertainties relating to: changes to the estimated preliminary results set forth in this press release as a result of audit adjustments and other developments that may arise between now and the time the financial results for the fourth quarter and fiscal year ended December 31, 2024, are finalized; the Company's commercialization plans and its ability to successfully commercialize the HEPZATO KIT; the Company's successful management of the HEPZATO KIT supply chain, including securing adequate supply of critical components necessary to manufacture and assemble the HEPZATO KIT; successful FDA inspections of the facilities of the Company and those of its third-party suppliers/manufacturers; the Company's successful implementation and management of the HEPZATO KIT Risk Evaluation and Mitigation Strategy; the potential benefits of the HEPZATO KIT as a treatment for patients with primary and metastatic disease in the liver; the Company's ability to obtain reimbursement for the HEPZATO KIT; and the Company's ability to successfully enter into any necessary purchase and sale agreements with users of the HEPZATO KIT. For additional information about these factors, and others that may impact the Company, please see the Company's filings with the Securities and Exchange Commission, including those on Forms 10-K, 10-Q, and 8-K. However, new risk factors and uncertainties may emerge from time to time, and it is not possible to predict all risk factors and uncertainties. Accordingly, you should not place undue reliance on these forward-looking statements, which speak only as of the date they are made. We undertake no obligation to publicly update or revise these forward-looking statements to reflect events or circumstances after the date they are made.

Drug ApprovalFinancial Statement

03 Jan 2025

·www.businesswire.com

Delcath Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

QUEENSBURY, N.Y.--( BUSINESS WIRE )--Delcath Systems, Inc. (Nasdaq: DCTH) (the “Company” or “Delcath”), an interventional oncology company focused on the treatment of primary and metastatic cancers of the liver, announces that the Company granted an equity award, previously approved by the Company’s Compensation Committee, as a material inducement to the employment of an individual whose employment commenced on November 4, 2024. The grant totaled the right to purchase 30,000 shares of the Company’s common stock and is subject to the terms and conditions of the Company’s 2023 Inducement Plan (“Plan”). The options were granted on December 31, 2024, the date the Compensation Committee approved the stock option included within the equity inducement and are subject to an exercise price equal to $12.04, the closing price of Delcath’s common stock on December 31, 2024. One-third of the options will vest on the first anniversary of the grant date with the remaining two-thirds of the options vesting in equal monthly installments over the following twenty-four months. The options have a ten-year term and the vesting of the options is subject to the employee’s continued employment with Delcath on each vesting date. The above-described award was granted in accordance with Nasdaq Listing Rule 5635(c)(4) and granted pursuant to the terms of the Plan. About Delcath Systems, Inc. Delcath Systems, Inc. is an interventional oncology company focused on the treatment of primary and metastatic liver cancers. The company’s proprietary products, HEPZATO KIT™ (HEPZATO (melphalan) for Injection/Hepatic Delivery System) and CHEMOSAT ® Hepatic Delivery System for Melphalan percutaneous hepatic perfusion (PHP), are designed to administer high-dose chemotherapy to the liver while controlling systemic exposure and associated side effects during a PHP procedure. In the United States, HEPZATO KIT is considered a combination drug and device product and is regulated and approved for sale as a drug by the FDA. HEPZATO KIT is comprised of the chemotherapeutic drug melphalan and Delcath's proprietary Hepatic Delivery System (HDS). The HDS is used to isolate the hepatic venous blood from the systemic circulation while simultaneously filtrating hepatic venous blood during melphalan infusion and washout. The use of the HDS results in loco-regional delivery of a relatively high melphalan dose, which can potentially induce a clinically meaningful tumor response with minimal hepatotoxicity and reduce systemic exposure. HEPZATO KIT is approved in the United States as a liver-directed treatment for adult patients with metastatic uveal melanoma (mUM) with unresectable hepatic metastases affecting less than 50% of the liver and no extrahepatic disease, or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues, or lung that is amenable to resection or radiation. Please see the full Prescribing Information, including BOXED WARNING for the HEPZATO KIT . In Europe, the device-only configuration of the HDS is regulated as a Class III medical device and is approved for sale under the trade name CHEMOSAT Hepatic Delivery System for Melphalan, or CHEMOSAT, where it has been used in the conduct of percutaneous hepatic perfusion procedures at major medical centers to treat a wide range of cancers of the liver.

Drug Approval

100 Deals associated with Melphalan

External Link

KEGG	Wiki	ATC	Drug Bank
D00369	Melphalan	L01AA03	DB01042

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Polycythemia Vera	CN	Glaxo Wellcome, Inc.	01 Jan 1998
Retinoblastoma	CN	Glaxo Wellcome, Inc.	01 Jan 1998
Breast Cancer	CA	Apotex, Inc.	01 Jan 1963
Melanoma	CA	Apotex, Inc.	01 Jan 1963
Multiple Myeloma	CA	Apotex, Inc.	01 Jan 1963
Ovarian Cancer	CA	Apotex, Inc.	01 Jan 1963

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Diffuse Large B-Cell Lymphoma	Phase 2	US	Celgene Corp.	22 Jun 2016
Smoldering Multiple Myeloma	Phase 2	ES	Amgen, Inc.	01 May 2015
Smoldering Multiple Myeloma	Phase 2	ES	Celgene Corp.	01 May 2015
Unresectable Melanoma	Phase 2	US	Bristol Myers Squibb Co.	01 Feb 2011
Relapse multiple myeloma	Phase 2	US	Celgene Corp.	01 Aug 2010
Chronic Myelomonocytic Leukemia	Phase 2	CA	Celgene Corp.	01 Jan 2008
Myelodysplastic Syndromes	Phase 2	CA	Celgene Corp.	01 Jan 2008
Bone Marrow Neoplasms	Phase 2	US	Smithkline Beecham Plc	18 Feb 2002
Recurrent Multiple Myeloma	Phase 1	US	Novartis Pharmaceuticals Corp.	10 Jul 2018
Refractory Multiple Myeloma	Phase 1	US	Novartis Pharmaceuticals Corp.	10 Jul 2018

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASH2024 Manual	Not Applicable	Acute Megakaryoblastic Leukemia	59	Busulfan/Cyclophosphamide	ynyqqbcrqo(kxuipqtofs) = hbetkeqxxw osukamyaqg (varcuiwnfu ) View more	Positive	08 Dec 2024
				Busulfan/Cyclophosphamide+Melphalan	ynyqqbcrqo(kxuipqtofs) = swncxjaxrb osukamyaqg (varcuiwnfu ) View more
NCT02880293 (CTgov)	Not Applicable	Hematologic Neoplasms	44	Mesna+Fludarabine+cyclophosphamide+melphalan+Filgrastim+Tacrolimus+Mycophenolate Mofetil+thiotepa	ucyktzkluj(ijejxnpnop) = ymosyllndi tjlajhlasb (fwshemjndo, uyfwhheaak - pmrzizlpeu) View more	-	06 Dec 2024
MM-746 (SOHO2024)	Not Applicable	Multiple Myeloma	74	MEL140	zibjkdnwpv(enqkzewnnb) = nunhonnkew cbwjxyunfm (fxzmluqoak ) View more	Positive	04 Sep 2024
				MEL200	zibjkdnwpv(enqkzewnnb) = mwjzsulouf cbwjxyunfm (fxzmluqoak ) View more
NCT00936936 (CTgov)	Phase 2	Testicular Neoplasms \| Germ Cell and Embryonal Neoplasms	64	Bevacizumab (Cohort 1: HD GeM-DMC+ ICE + Bevacizumab for Refractory GCT)	ppvdmsrkkc(nnxvivjuwo) = ussjebxwmk fcgjkxdlnw (rjyzpytwms, ryljohinjd - afbrycyjtt) View more	-	26 Aug 2024
				Mesna+Etoposide+Carboplatin+Melphalan+Ifosfamide+Gemcitabine+Docetaxel (Cohort 2: HD GeM-DMC+ ICE for Refractory GCT)	ppvdmsrkkc(nnxvivjuwo) = sqwooddzft fcgjkxdlnw (rjyzpytwms, nykkcemrmw - wsogfiyehx) View more
NCT02678572 (FOCUS, Pubmed)	Phase 3	Uveal Melanoma	102	Melphalan/Hepatic Delivery System	uiohowvxxj(mabloaghcd) = udsivcpxhf wbxwoinzjv (ltnivhbzdx, 26.44 - 47.01) View more	Positive	01 Aug 2024
NCT02678572 (FOCUS, ASCO2024) Manual	Phase 3	Uveal Melanoma	129	Melphalan/Hepatic Delivery System	volqfyeqti(ooqtcsioun) = vyqgvvduao ehbsmqxboo (yzykkpayza ) View more	Positive	24 May 2024
				Melphalan/hepatic delivery system (Best Alternative Care)	volqfyeqti(ooqtcsioun) = lukgzeybli ehbsmqxboo (yzykkpayza ) View more
ASCO2024	Not Applicable	Multiple Myeloma	246	melphalan (Extramedullary multiple myeloma (EMM))	qmtjtrjvod(zdhconglgn) = fsskfuyrzt rgtnmrnesg (cvijtitlap ) View more	Positive	24 May 2024
				melphalan (Multiple myeloma without extramedullary involvement (non-EMM))	qmtjtrjvod(zdhconglgn) = fbflrgdbbb rgtnmrnesg (cvijtitlap ) View more
NCT02700841 (CTgov)	Phase 2	Multiple Myeloma	8	Peripheral Blood Stem Cell Transplantation--CD34 HSCT+melphalan (Arm I (Vaccine, CD34 Transplant, DLI))	qbftzwfjuz(xkpkyuyulr) = iiwdhxyovh hehidypznx (fpgnmeoyus, ehynhvuhmg - umuxxgrkxu) View more	-	12 Mar 2024
				Tetanus Toxoid Vaccine+melphalan (Arm II (Vaccine, Stem Cell Transplant))	qbftzwfjuz(xkpkyuyulr) = vrfiqqdbhz hehidypznx (fpgnmeoyus, rgomchiwia - jmcgpsjzop) View more
NCT02251821 (CTgov)	Phase 2	Primary Myelofibrosis	61	Umbilical Cord Blood Transplantation+Fludarabine Phosphate+Busulfan+cyclophosphamide+Melphalan+Tacrolimus+Ruxolitinib+Mycophenolate Mofetil+Methotrexate	uvobdxfixz(zyykdikdvd) = gmmwectqwr wrtmmvokqy (vcffbcaupn, adkatfwcue - ogtfgeyafi) View more	-	05 Mar 2024
NCT04191187 (Tandem Meetings ASTCT and CIBMTR2024) Manual	Phase 2	Peripheral Stem Cell Transplantation	34	Fludarabine,Melphalann 70 mg/m2, and Total Body Irradiation	ukuzbnuwvd(eetbcnxzhx) = mteeivzhdx toqhhldxqq (bgboogzwlc, ≥ 59.1%) Met View more	Positive	01 Feb 2024

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