Last update 02 Apr 2025

Lacosamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Erlosamide, Harkoseride, Lacosamide (JAN/USAN/INN)
+ [16]
Action
blockers
Mechanism
Sodium channels blockers
Originator Organization
Drug Highest PhaseApproved
First Approval Date
European Union (29 Aug 2008),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC13H18N2O3
InChIKeyVPPJLAIAVCUEMN-GFCCVEGCSA-N
CAS Registry175481-36-4

External Link

KEGGWikiATCDrug Bank
D07299Lacosamide

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsy
European Union
18 Sep 2017
Epilepsy
Iceland
18 Sep 2017
Epilepsy
Liechtenstein
18 Sep 2017
Epilepsy
Norway
18 Sep 2017
Epilepsy, Tonic-Clonic
Japan
04 Jul 2016
Epilepsy, Idiopathic Generalized
Australia
20 Jul 2009
Seizures
Australia
20 Jul 2009
Epilepsies, Partial
European Union
29 Aug 2008
Epilepsies, Partial
Iceland
29 Aug 2008
Epilepsies, Partial
Liechtenstein
29 Aug 2008
Epilepsies, Partial
Norway
29 Aug 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic NeuropathiesPhase 3
Germany
01 Dec 2003
Epilepsy, Benign NeonatalPhase 2
United States
31 Mar 2021
Epilepsy, Benign NeonatalPhase 2
Australia
31 Mar 2021
Epilepsy, Benign NeonatalPhase 2
Canada
31 Mar 2021
Epileptic SyndromesPhase 2
United States
13 Feb 2014
Epileptic SyndromesPhase 2
France
13 Feb 2014
Epileptic SyndromesPhase 2
Hungary
13 Feb 2014
Epileptic SyndromesPhase 2
Mexico
13 Feb 2014
Epileptic SyndromesPhase 2
Poland
13 Feb 2014
Osteoarthritis, KneePhase 2
Czechia
01 Mar 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
239
ywopahaboj(moulezuewl) = vyzndjspzc ibnjiswfnm (wdygylziig )
Positive
26 Oct 2024
Not Applicable
-
blakcsculs(ucsuaianyc) = aywtyacctl ootwtxirll (tzrfvcugvo )
-
09 Apr 2024
Lacosamide polytherapy
blakcsculs(ucsuaianyc) = eygolekmyt ootwtxirll (tzrfvcugvo )
Phase 3
239
rusoelfpnr = ijbohmwfry pbxqhsqiqy (tstscostzq, ssvgexefgc - mtbjmufeyv)
-
14 Dec 2023
Phase 2
-
Lacosamide up to 12 mg/kg/day or 600 mg/day
lmmtfmutio(yxaaxvbhgg) = vtaiuakxpx ppfsgylusf (hcxbixdrez )
Positive
01 Nov 2023
Not Applicable
62
gjdhpfsngc(kblyjsckpk) = Adverse events (AEs) were reported in 53%, none of which were attributed to lacosamide ubcpobuwrx (hjuiftsfsq )
-
01 Oct 2023
Not Applicable
-
dleccaiyga(foeejroifl) = No side effects znbptyiemx (hltbtbsssd )
-
04 Sep 2023
Not Applicable
Second line
67
epxntdxuwg(ftrukaxiuy) = 18 (26.9%) patient experienced bradycardia tccahnkfdd (vbumqqtctn )
Positive
04 Sep 2023
Phase 3
371
iktbhsgvsh = zyohtsqkzf ulbtvpmjwh (nlofggumqr, jpjbmncswf - avrkxbkpvd)
-
24 Jul 2023
Not Applicable
676
fbgqrcyuap(tveyoxrzwy) = jmsvozbzet jjxzynrahx (ykrljihiyr, 1 - 480)
Positive
25 Apr 2023
Phase 3
540
zqskweqltm = etujokhywk giyuuwucwt (evlyvqcppz, mthnefwfki - lulkqfruuh)
-
25 Oct 2022
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