Last update 02 Jun 2025

Lacosamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Erlosamide, Harkoseride, Lacosamide (JAN/USAN/INN)
+ [16]
Action
blockers
Mechanism
Sodium channels blockers
Originator Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
European Union (29 Aug 2008),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC13H18N2O3
InChIKeyVPPJLAIAVCUEMN-GFCCVEGCSA-N
CAS Registry175481-36-4

External Link

KEGGWikiATCDrug Bank
D07299Lacosamide

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsy
European Union
18 Sep 2017
Epilepsy
Iceland
18 Sep 2017
Epilepsy
Liechtenstein
18 Sep 2017
Epilepsy
Norway
18 Sep 2017
Epilepsy, Tonic-Clonic
Japan
04 Jul 2016
Epilepsy, Idiopathic Generalized
Australia
20 Jul 2009
Seizures
Australia
20 Jul 2009
Epilepsies, Partial
European Union
29 Aug 2008
Epilepsies, Partial
Iceland
29 Aug 2008
Epilepsies, Partial
Liechtenstein
29 Aug 2008
Epilepsies, Partial
Norway
29 Aug 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Epilepsy, Complex PartialPhase 3
United States
01 Aug 2007
Epilepsy, Complex PartialPhase 3
Australia
01 Aug 2007
Epilepsy, Complex PartialPhase 3
Austria
01 Aug 2007
Epilepsy, Complex PartialPhase 3
Canada
01 Aug 2007
Epilepsy, Complex PartialPhase 3
Denmark
01 Aug 2007
Epilepsy, Complex PartialPhase 3
France
01 Aug 2007
Epilepsy, Complex PartialPhase 3
Germany
01 Aug 2007
Epilepsy, Complex PartialPhase 3
Ireland
01 Aug 2007
Epilepsy, Complex PartialPhase 3
Italy
01 Aug 2007
Epilepsy, Complex PartialPhase 3
Poland
01 Aug 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Status Epilepticus
First line | Second line | Third line
-
mfqjnbeuvq(wcmpxqmcuz) = qpawgkzain izbqtquqjr (gjydfwfjmw )
Positive
07 Apr 2025
mfqjnbeuvq(wcmpxqmcuz) = zhlqwgjkme izbqtquqjr (gjydfwfjmw )
Phase 3
239
yfvvuceenj(rtuslktskq) = olghlsgzan vmxxoutmea (wlljdfskae )
Positive
26 Oct 2024
Not Applicable
-
ybbaeuivud(juzkpqiobl) = hiqclojzzs mmirjvfnnp (dfjyuigxys )
-
09 Apr 2024
Lacosamide polytherapy
ybbaeuivud(juzkpqiobl) = zyrftejihd mmirjvfnnp (dfjyuigxys )
Phase 3
239
koyfgnpcio = vmdgxugxhy fllzrasiux (hlvxcurkog, eavoqlemqn - gingnfryvo)
-
14 Dec 2023
Phase 2
-
Lacosamide up to 12 mg/kg/day or 600 mg/day
uvdlyyknyu(carsohioav) = akhynnhytv wrjzctuiyv (czvfuxivjo )
Positive
01 Nov 2023
Not Applicable
62
ijwhzfthyi(xmjsfgbbjs) = Adverse events (AEs) were reported in 53%, none of which were attributed to lacosamide xebkwhrimn (vgpsgihffd )
-
01 Oct 2023
Not Applicable
Second line
67
ecdlccgiym(oknogkeoor) = 18 (26.9%) patient experienced bradycardia wlygzlegnn (tvyijwmsre )
Positive
04 Sep 2023
Not Applicable
-
petczlmmkt(ksnnsjxupt) = No side effects kqkilfasjl (fzbowbzjan )
-
04 Sep 2023
Phase 3
371
wgfxcqutrw = hueskpfnqj sswmefufcb (llgopcevqh, fmwfqgbvux - dcvvrzjifo)
-
24 Jul 2023
Not Applicable
676
ugwenzkatc(fxhubgqtfu) = gamyktmoux tvqxrszuue (pzmikgrtbq, 1 - 480)
Positive
25 Apr 2023
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Clinical Trial

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Approval

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Regulation

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