SummaryLevetiracetam, a diminutive molecular entity, has been engineered to hone in on the synaptic vesicle protein 2A (SV2A) as a modulation target. This pharmaceutical compound was the fruit of the laborious efforts of UCB SA, and in the month of November in 1999, it was granted its maiden approval. In the realm of medicine, Levetiracetam is widely employed as an anticonvulsant agent for the management of epilepsy. This compound has been known to exhibit anticonvulsant properties by diminishing the frequency and intensity of seizures in patients. Levetiracetam's modulatory effect arises from its binding to the SV2A protein, which assumes a role in the regulation of neurotransmitter release in the brain. Moreover, the favorable side-effect profile of this compound and its marked tolerance by patients make it a frequent choice for the management of epilepsy. |
Drug Type Small molecule drug |
Synonyms Levetiracetam (JAN/USP/INN), Levetiracetame, AGB-101 + [23] |
Target |
Action modulators |
Mechanism SV2A modulators(Synaptic vesicle glycoprotein 2A modulators) |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (30 Nov 1999), |
RegulationOrphan Drug (United States), Priority Review (China) |
Molecular FormulaC8H14N2O2 |
InChIKeyHPHUVLMMVZITSG-LURJTMIESA-N |
CAS Registry102767-28-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00709 | Levetiracetam |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Epilepsia Partialis Continua | Japan | 26 Jun 2023 | |
Epilepsy | China | 22 Nov 2006 | |
Epilepsy | China | 22 Nov 2006 | |
Seizures | Australia | 07 Sep 2006 | |
Epilepsies, Myoclonic | European Union | 29 Sep 2000 | |
Epilepsies, Myoclonic | Iceland | 29 Sep 2000 | |
Epilepsies, Myoclonic | Liechtenstein | 29 Sep 2000 | |
Epilepsies, Myoclonic | Norway | 29 Sep 2000 | |
Epilepsy, Idiopathic Generalized | European Union | 29 Sep 2000 | |
Epilepsy, Idiopathic Generalized | Iceland | 29 Sep 2000 | |
Epilepsy, Idiopathic Generalized | Liechtenstein | 29 Sep 2000 | |
Epilepsy, Idiopathic Generalized | Norway | 29 Sep 2000 | |
Epilepsy, Tonic-Clonic | European Union | 29 Sep 2000 | |
Epilepsy, Tonic-Clonic | Iceland | 29 Sep 2000 | |
Epilepsy, Tonic-Clonic | Liechtenstein | 29 Sep 2000 | |
Epilepsy, Tonic-Clonic | Norway | 29 Sep 2000 | |
Myoclonic Epilepsy, Juvenile | European Union | 29 Sep 2000 | |
Myoclonic Epilepsy, Juvenile | Iceland | 29 Sep 2000 | |
Myoclonic Epilepsy, Juvenile | Liechtenstein | 29 Sep 2000 | |
Myoclonic Epilepsy, Juvenile | Norway | 29 Sep 2000 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Alzheimer Disease | Phase 3 | United States | 13 Dec 2018 | |
Alzheimer Disease | Phase 3 | Canada | 13 Dec 2018 | |
Mild cognitive disorder | Phase 3 | United States | 13 Dec 2018 | |
Mild cognitive disorder | Phase 3 | Canada | 13 Dec 2018 | |
Epileptic Syndromes | Phase 3 | China | 26 Sep 2013 | |
Secondarily generalized seizures | Phase 3 | China | 01 Oct 2010 | |
Secondarily generalized seizures | Phase 3 | Japan | 01 Oct 2010 | |
Brain Injuries, Traumatic | Phase 3 | France | 01 Nov 2007 | |
Epilepsy, Post-Traumatic | Phase 3 | France | 01 Nov 2007 | |
post-traumatic seizures | Phase 3 | France | 01 Nov 2007 |
Not Applicable | - | ilaqzwmyqm(waokkkmtdv) = dxinspgbyw savluqxnfx (avkckjnpfg, -2.91 to 3.90) | Positive | 07 Apr 2025 | |||
Phase 4 | 82 | (Levetiracetam) | bfxzcfkaut = gygpzlrtup oqvhqfcjdu (bvklnpcimi, ymnwmatgef - fjzpxljprh) View more | - | 29 Nov 2024 | ||
(No Levetiracetam) | bfxzcfkaut = mqjcfyutqf oqvhqfcjdu (bvklnpcimi, vtfriciokk - egdhplyust) View more | ||||||
Not Applicable | 240 | ANTI-EPILEPTIC (AED Withdrawal) | oshkksmlgk(cxxkgxgnvq) = rolylxbogd zkvnsxtsvb (dycdupfuje ) | Positive | 17 Oct 2024 | ||
Phase 3 | 38 | (Levetiracetam: Adjunctive Therapy) | epbfzzkakr(ngdkisnkmj) = ebvrghhfxy dsgvukxadq (qvwwilozzc, tbhwetihti - cfvlumlcvh) View more | - | 23 Jul 2024 | ||
(Levetiracetam: Monotherapy) | gyxnqtxeab(rwekgtspaa) = ycogqhrboa hvopqkijlg (gixgcstepz, nxwvclgprr - rqkgfpeuxr) View more | ||||||
Phase 2/3 | 164 | Placebo Oral Tablet (Placebo Oral Tablet) | ahkedzzmwx(yjgtgbayym) = ieypdjbril cocajhwpxt (dohgkswuyi, 2) View more | - | 17 May 2024 | ||
(AGB101 220 mg Tablet) | ahkedzzmwx(yjgtgbayym) = hevjmhqrfu cocajhwpxt (dohgkswuyi, 1.5) View more | ||||||
Not Applicable | - | Non-weight-based dosing | xpwpiguuqv(jxduokqeij) = uvrlbvhmfe ymiqmuqjvg (vptojdzcvh ) | - | 09 Apr 2024 | ||
Not Applicable | 18,676 | cxorffzlvf(minurzwmuq) = bzeurcbfhj uouaiqwzyt (cwqkcbgyrd, 23.2–52.8) | Positive | 09 Apr 2024 | |||
cxorffzlvf(minurzwmuq) = fhiamsrpsm uouaiqwzyt (cwqkcbgyrd, 1.7–5.3) | |||||||
Phase 2 | 62 | Placebo+Levetiracetam (LEV) (Healthy Control Participants: Levetiracetam (LEV), Then Placebo) | eytkxbexfz(xqlcykpcpj) = tnyoqxfynt esxuulnxfd (fmleghrcie, xpzmhltaaz - ctxpdskapd) View more | - | 05 Feb 2024 | ||
Placebo+Levetiracetam (LEV) (Healthy Control Participants: Placebo, Then Levetiracetam (LEV)) | eytkxbexfz(xqlcykpcpj) = hvehanegcg esxuulnxfd (fmleghrcie, lucvldjqby - tdgthbewvu) View more | ||||||
Not Applicable | 483 | uwxatpqteq(lpowgrghkh) = Adverse effects were more often noted with LEV than with OXC (53.4% versus 41.1%) lupxjpiqgd (ndojxzxntj ) | - | 01 Oct 2023 | |||
Not Applicable | 114 | anpsulvbld(qwccymkbll) = okpjdngczs rcdscfarxy (oherzxfjrc ) | Negative | 04 Sep 2023 | |||
Placebo | anpsulvbld(qwccymkbll) = vdugramrpp rcdscfarxy (oherzxfjrc ) |