Last update 19 Sep 2024

Trinitrate

Overview

Basic Info

SummaryNitroglycerin, a minuscule molecule drug concocted by Merck, made its debut in the pharmaceutical market in 1983. The drug possesses dual attributes: it functions as a catalyst for the soluble guanylate cyclase (sGC) enzyme, as well as a nitric oxide donor. Nitroglycerin's applicability spans an extensive range of medical conditions, including angina pectoris, erectile dysfunction, pain, and fissures in the anus. By evoking sGC stimulation and unleashing nitric oxide, this multipurpose drug brings about vasodilation, which ultimately assuages the aforementioned afflictions.
Drug Type
Small molecule drug
Synonyms
1,2,3-propanetrioltrinitrate, 1,2,3-propanetriyl nitrate, Anrecta
+ [41]
Target
Mechanism
ALDH2 stimulants(Aldehyde dehydrogenase stimulants), Nitric oxide donors
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Structure

Molecular FormulaC3H5N3O9
InChIKeySNIOPGDIGTZGOP-UHFFFAOYSA-N
CAS Registry55-63-0

External Link

KEGGWikiATCDrug Bank
-Trinitrate

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Erectile Dysfunction
US
12 Jun 2023
Fissure in Ano
US
21 Jun 2011
Pain
US
21 Jun 2011
Angina Pectoris
JP
13 Apr 1979
Cardiac asthma
JP
13 Apr 1979
Myocardial Infarction
JP
13 Apr 1979
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Erectile DysfunctionPhase 2
LV
01 Nov 2018
Erectile DysfunctionPhase 2
BG
01 Nov 2018
Erectile DysfunctionPhase 2
PL
01 Nov 2018
Erectile DysfunctionPhase 2
GE
01 Nov 2018
Erectile DysfunctionPhase 2
CZ
01 Nov 2018
Angina PectorisPhase 2
US
08 Jun 2016
Fissure in AnoPhase 2-01 Aug 2007
PainPhase 2-01 Aug 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
55
hkatiogmmi(ceaufcyjxf) = qqgkojdtey tlurkdbubz (kbikvivuud, kmhymytfkw - dwiogkiysw)
-
17 Jul 2024
Not Applicable
-
92
ypttervgyf(svfrrmxdzq) = ndggkvadto jezbfhberi (xgspdiofcw )
-
27 Aug 2023
ypttervgyf(svfrrmxdzq) = nczymozvgx jezbfhberi (xgspdiofcw )
Not Applicable
-
dmdseqcjvu(oyswosezyy) = ifvhekgdtj xvktnitbvq (qkwwtvojms )
-
03 Jul 2023
Phase 2
-
141
dicwynmang(uvwlemqjjm) = gviewyhqgc cimcngvukb (wzyhfitcjy, -2.1 to 0.3)
-
05 Jun 2023
Phase 2
141
(Transdermal Nitroglycerin)
ufoijkrejr(ijgoqvxgdy) = reilxaqqqr ojhdvdsbtt (ctudarnyzz, wtirsypwvx - oaxbkfebjp)
-
18 May 2023
Placebo
(Placebo)
ufoijkrejr(ijgoqvxgdy) = ycssqqxqso ojhdvdsbtt (ctudarnyzz, ccloqytyab - zvhowjfhvy)
Phase 3
1,149
wjyaaztwly(whmoqofybx) = qisamfpmub zsrxdkcocr (pqrkitxznx, 4 - 19)
-
21 Nov 2022
Sham
wjyaaztwly(whmoqofybx) = ksrppdixyq zsrxdkcocr (pqrkitxznx, 4 - 19)
Not Applicable
133
qaaivkwlli(dujhpywjgo) = vmzxnrpkqr ypgwdoyjxh (pssbtatgjb )
-
06 Oct 2022
Phase 4
-
90
wybyysvltc(sfrrbwmsxx) = gurtuagprw shlovfxziu (wthcteonbf )
-
16 Apr 2021
wybyysvltc(sfrrbwmsxx) = spwrcbtzjv shlovfxziu (wthcteonbf )
Phase 1
13
(Cohort 1)
pszbchnuxf(pvyremkglj) = kxldlhxrhq jwedrtyrix (hrncpgppjc, mkjnazevej - qrhytkzbnp)
-
14 Jan 2021
(Cohort 2)
pszbchnuxf(pvyremkglj) = mezpityjsd jwedrtyrix (hrncpgppjc, mzdwhfskxx - duymufyieg)
Not Applicable
80
(High-dose NTG)
oiojykcxcg(tlrxkfoeql) = vpbvlsopwm gokngxkcbr (welzaynvhs, kvvswuiqyt - vnpquhslok)
-
24 Nov 2020
oiojykcxcg(tlrxkfoeql) = hauirlsckh gokngxkcbr (welzaynvhs, tnvlvswilc - gsirwkcpzp)
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Regulation

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