Last update 01 Nov 2024

Lifirafenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lifirafenib (USAN/INN), Lifirafenib maleate
+ [4]
Mechanism
ARAF inhibitors(Serine/threonine-protein kinase A-Raf inhibitors), BRAF V600E inhibitors, BRAF inhibitors(Serine/threonine-protein kinase B-raf inhibitors)
+ [2]
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC25H17F3N4O3
InChIKeyNGFFVZQXSRKHBM-FKBYEOEOSA-N
CAS Registry1446090-79-4

External Link

KEGGWikiATCDrug Bank
D11410--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
CN
08 Oct 2015
Colorectal CancerPhase 2
NZ
-
Colorectal CancerPhase 2
AU
-
Colorectal CancerPhase 2
CN
-
MelanomaPhase 2
NZ
-
MelanomaPhase 2
AU
-
MelanomaPhase 2
CN
-
Non-Small Cell Lung CancerPhase 2
NZ
-
Non-Small Cell Lung CancerPhase 2
AU
-
Non-Small Cell Lung CancerPhase 2
CN
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
AACR2023
ManualManual
Phase 1
56
(vvfrvsvwjt) = bxgjrsdybc aafvrlcdix (dkuutcsoeq )
Positive
14 Apr 2023
(vvfrvsvwjt) = lufkmcuzel aafvrlcdix (dkuutcsoeq )
Phase 1
Solid tumor
BRAF V600 Mutation | KRAS Mutation
-
(mxloyqqopt) = dose-limiting toxicities included reversible thrombocytopenia and nonhematologic toxicity. godlbnjxsw (lgebcodxed )
Positive
01 Jul 2020
Phase 1
96
(vizrcuwegd) = wsvhsebskf tasjqcqifs (itrfdxibqi, 9.9 - 81.6)
Positive
01 Jul 2017
Phase 1
31
puwkihgjms(jsffmbdpkw) = 48% tuytrebhrt (ghxxgttack )
Positive
15 Jul 2016
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Clinical Trial

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Approval

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Regulation

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