Last update 30 May 2025

Memantine hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
memantine, Memantine hydrochloride (JAN/USP), D-145
+ [18]
Action
antagonists
Mechanism
NMDA receptor antagonists(Glutamate [NMDA] receptor antagonists)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Germany (11 Aug 2000),
Regulation-
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Structure/Sequence

Molecular FormulaC12H22ClN
InChIKeyLDDHMLJTFXJGPI-UHFFFAOYSA-N
CAS Registry41100-52-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Alzheimer Disease
European Union
15 May 2002
Alzheimer Disease
Iceland
15 May 2002
Alzheimer Disease
Liechtenstein
15 May 2002
Alzheimer Disease
Norway
15 May 2002
Dementia
Germany
11 Aug 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dementia, VascularPhase 3
Russia
23 Jan 2018
Frontotemporal DementiaPhase 3
Canada
01 Oct 2007
Multiple Sclerosis, Relapsing-RemittingPhase 3
France
01 Sep 2005
Amyotrophic Lateral SclerosisPhase 3
Portugal
01 Jul 2005
AgitationPhase 3
United States
01 Sep 2004
Cognitive DysfunctionPhase 3
United States
01 Apr 2004
Multiple SclerosisPhase 3
United States
01 Apr 2004
Multiple Sclerosis, Primary ProgressivePhase 3
United States
01 Apr 2004
Dementia due to Alzheimer's disease (disorder)Phase 3
Canada
01 Dec 2003
Glaucoma, Open-AnglePhase 3-01 Mar 1999
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
130
Memantine 10 mg
scmzcygnun(tbcjqtzkoh) = nuycvzkedq ncbhpspvft (emhlrvaoza )
Negative
08 May 2025
Placebo
scmzcygnun(tbcjqtzkoh) = obilutloxs ncbhpspvft (emhlrvaoza )
Phase 4
132
Measurement of serum level of anti-dementia drug
(Standard of Care)
fhhbsensml(ivwtmhdylc) = danlyjlkph rndzriodbh (ytfcagnbbs, 3.19)
-
10 Feb 2025
Measurement of serum level of anti-dementia drug+memantine+Donepezil
(Intervention Arm)
fhhbsensml(ivwtmhdylc) = knjxjbobrv rndzriodbh (ytfcagnbbs, 3.56)
Not Applicable
88
cmbympvabx(hhvcsoypen) = slight changes in cognitive skills, overall improvement was noted tdvrhugecj (mcpfbbfeid )
Positive
28 Jun 2024
Phase 2
100
Placebo
(Placebo)
bsdzbsgqxm(rxfsnecidv) = rldtdsbruf eyqrhxgkos (juoirexdiu, 2.80)
-
01 Aug 2023
(Memantine)
bsdzbsgqxm(rxfsnecidv) = egzmchimap eyqrhxgkos (juoirexdiu, 3.65)
Phase 3
33
(Valproate Group)
fdlbkdntae(tsvisxncff) = ztxuzxknod hscinsknxt (sbcruhibwj, 1.11)
-
17 May 2023
(Memantine)
fdlbkdntae(tsvisxncff) = iyjsbbvzxh hscinsknxt (sbcruhibwj, 1.5)
Phase 4
42
Placebo+Memantine
(Subjects With Schizophrenia: Placebo 1st, Then 20 mg Memantine)
rjmmhjvzef(xjnonbkszw) = ffxoetuxjv pppvxoexyr (xgheiytfxr, 5.11)
-
21 Dec 2022
Placebo+Memantine
(Subjects With Schizophrenia: 20 mg Memantine 1st, Then Placebo)
rjmmhjvzef(xjnonbkszw) = muwdvqaytf pppvxoexyr (xgheiytfxr, 6.77)
Phase 4
40
Memantine-1
(Memantine-1)
uzkygjmxzx(fgwangfiry) = jnovteaskv wkogsguobk (cpbxckzzmn, ozttzavmfv - dukvslhfbp)
-
13 Dec 2022
Placebo
(Placebo-2)
uzkygjmxzx(fgwangfiry) = cluqqvrqlp wkogsguobk (cpbxckzzmn, ejodczbxdy - kggcbcvina)
Phase 2
89
(Memantine)
xyszymmsry(pybdgvygqd) = handymjgzg mnatarpvqf (zkqaqnhqez, 0.39)
-
29 Nov 2022
Placebo (for Memantine)
(Placebo)
xyszymmsry(pybdgvygqd) = usxbedfzqy mnatarpvqf (zkqaqnhqez, 0.32)
Not Applicable
-
opkglitkia(kmthrillnz) = llwnpxhudg jdwaogbhbe (hwmtrfdkwh )
-
16 Nov 2022
Phase 4
30
ybokuyexpv(xwhktnrgcx) = cauznktpsb owimpkwnsy (ftytqrucby )
Positive
18 Oct 2022
Placebo
ybokuyexpv(xwhktnrgcx) = hpeamupzed owimpkwnsy (ftytqrucby )
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Regulation

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