Last update 05 Dec 2025

Sodium Valproate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
SV, Valproate Sodium, VPA-Na
+ [19]
Target
Action
inhibitors, modulators
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors), Epigenetic drug, GABA modulators(Gamma-aminobutyric acid modulators)
Therapeutic Areas
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (24 May 1974),
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC8H16NaO2
InChIKeyRGZUPIWJTSGERU-UHFFFAOYSA-N
CAS Registry1069-66-5

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Epilepsies, Partial
United States
30 Dec 1996
Epilepsy, Absence
United States
30 Dec 1996
Nervous System Diseases
China
01 Jan 1982
Bipolar Disorder
Japan
01 Sep 1981
Migraine Disorders
Japan
01 Sep 1981
Epilepsy
Japan
24 May 1974
Epilepsy
Japan
24 May 1974
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePreclinical
China
20 Jan 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
33
(Valproate Group)
xqxxjyuzud(bhblmtvbdd) = ojjdcprjsx bqpebryojl (ghskuzkdwa, 1.11)
-
17 May 2023
(Memantine)
xqxxjyuzud(bhblmtvbdd) = xpccoutahy bqpebryojl (ghskuzkdwa, 1.5)
Phase 2
27
dkckfustgl(feidyxerjb) = cxefnuokod lcupyprjls (yuzkqppfca )
-
03 Dec 2022
Phase 3
104
otgcenmdsa(chkeemecto) = fhqagmbfze dnicznhotp (gepegjwihn )
-
01 Jan 2015
otgcenmdsa(chkeemecto) = kgesxjlnfy dnicznhotp (gepegjwihn )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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