A cross-sectional, national, multicenter, survey-based study to assess the effectiveness of Risk Minimization Measures related to Depakine® (sodium valproate) in Saudi Arabia. The study duration will be 7 months from 30 November 2024 to 30 May 2025. The end of study is defined as the end of the data collection period. No intervention will be administered, and no study related visits are required.

Start Date15 Feb 2025

Sponsor / Collaborator

Sanofi

CTR20244560

/ RecruitingNot Applicable

仁和堂药业有限公司研制的丙戊酸钠片（规格：0.2 g）与Kyowa Hakko Kirn Co., Ltd.持证的丙戊酸钠片（规格：0.2 g，Depakene®）在中国健康受试者中进行的单中心、随机、开放、单剂量、两序列、四周期、完全重复交叉设计空腹与餐后状态下的生物等效性研究

[Translation] A single-center, randomized, open-label, single-dose, two-sequence, four-period, completely repeated crossover design bioequivalence study of sodium valproate tablets (0.2 g) developed by Renhetang Pharmaceutical Co., Ltd. and sodium valproate tablets (0.2 g, Depakene®) licensed by Kyowa Hakko Kirn Co., Ltd. in healthy Chinese subjects under fasting and fed conditions

以仁和堂药业有限公司研制的丙戊酸钠片（规格：0.2 g）为受试制剂，Kyowa Hakko Kirn Co., Ltd.持证的丙戊酸钠片（规格：0.2 g，Depakene®）为参比制剂，考察两制剂在空腹与餐后状态下单次给药的药代动力学参数及相对生物利用度，评价两制剂是否具有生物等效性。同时评价两种制剂在健康人体中的安全性和耐受性。

[Translation]

The sodium valproate tablets (specification: 0.2 g) developed by Renhetang Pharmaceutical Co., Ltd. were used as the test preparation, and the sodium valproate tablets (specification: 0.2 g, Depakene®) certified by Kyowa Hakko Kirn Co., Ltd. were used as the reference preparation. The pharmacokinetic parameters and relative bioavailability of the two preparations were investigated in the fasting and postprandial states, and the bioequivalence of the two preparations was evaluated. At the same time, the safety and tolerability of the two preparations in healthy humans were evaluated.

Start Date16 Dec 2024

Sponsor / Collaborator

Shandong Province Renhetang Pharmaceutical Co. Ltd.

IRCT20240621062198N1

/ RecruitingPhase 2IIT

Comparing the Effect of Sodium valproate with Lithium carbonate on Suicidal Ideation of Patients with Bipolar Disorder in Manic Phase with Mediation of Interoception

Start Date22 Oct 2024

Sponsor / Collaborator

Mashhad University of Medical Sciences

100 Clinical Results associated with Sodium Valproate

100 Translational Medicine associated with Sodium Valproate

100 Patents (Medical) associated with Sodium Valproate

6,512

Literatures (Medical) associated with Sodium Valproate

01 Jun 2025·IBRO Neuroscience Reports

Potential of Khaya senegalensis to mitigate epileptogenesis and cognitive dysfunction on kainate-induced post-status epilepticus model

Article

Author: Kandeda, Antoine Kavaye ; Foutse, Liliane Yimta ; Lewale, Stéphanie ; Dimo, Théophile

Background and aim:

To date, there is no treatment to prevent the development of temporal lobe epilepsy, the most common form of drug-resistant epilepsy. A recent study revealed the antiepileptic-like effect of the aqueous extract of Khaya senegalensis. Given the potential of this extract, the antiepileptogenic- and learning and memory-facilitating-like effects of the aqueous extract of Khaya senegalensis were assessed using the kainate-induced post-status epilepticus model.

Methods:

Epilepsy was induced by injecting a single dose of kainate (12 mg/kg, i.p.) in rats. Animals that developed 2 hours of status-epilepticus were randomized and treated as follows: a negative control group received distilled water (10 ml/kg, p.o.); two positive control groups received sodium valproate (300 mg/kg, p.o.) or phenobarbital (20 mg/kg, p.o.); and three test groups received the extract (50, 100, 200 mg/kg, p.o.). A sham group was added and received distilled water (10 ml/kg, p.o.). All treatments were performed twice daily until the occurrence of the first spontaneous seizure (stage 4 or 5) in the negative control group, on day 14. After the completion of treatments, memory impairment was assessed using the T-maze. Two weeks following behavioral analysis, the rats that received the most effective dose of the extract on spontaneous recurrent were challenged with pentylenetetrazole (30 mg/kg, i.p.). This is to assess their susceptibility to generalized tonic-clonic seizures (stage 5). Rats were finally euthanized, and pro-inflammatory cytokines, or neurogenesis markers were quantified in the hippocampus.

Results:

The extract of Khaya senegalensis significantly prevented spontaneous recurrent seizures on day 14. It also reduced cognitive decline. Furthermore, it significantly decreased pro-inflammatory cytokines levels and increased those of neurotrophic factors.

Conclusions:

These findings thus suggest that the extract is endowed with antiepileptogenic- and learning and memory-enhancing-like effects. These effects are likely mediated by anti-inflammatory and neurotrophic pathways. This justifies, therefore, its use to treat empirically epilepsy.

01 Mar 2025·EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABAA1 and Nav1.2 with antiepileptic activity

Article

Author: Huang, Longjiang ; Liang, Wenhui ; Yu, Haibo ; Wang, Weina ; Li, Xiufen ; Wu, Jun ; Du, Tongtong ; Li, Yunjie ; Guo, Chuanlong

A novel class of 7-phenyl-[1,2,4]triazol-5(4H)-one derivatives was designed and synthesized, and their in vivo anticonvulsant activities were evaluated using subcutaneous pentylenetetrazole (Sc-PTZ) and maximal electroshock (MES) tests. Compounds 3u, 4f and 4k exhibited significant anticonvulsant activities in the Sc-PTZ model with ED₅₀ values of 23.7, 17.1 and 18.3 mg/kg, respectively. Neurotoxicity was accessed using the rotarod assay and none of the compounds demonstrated neurotoxicity at maximum solubility, with all TD₅₀ values exceeding 267 mg/kg. This resulted in protective indexes (PI = TD₅₀/ED₅₀) values of greater than 11.3, 15.6 and 14.6, respectively. Compared to control drugs such as sodium phenytoin, sodium valproate, and carbamazepine, compounds 3u, 4f and 4k displayed superior anticonvulsant activities and reduced neurotoxicity. Mechanism results indicated that compounds 4k and 4f were sensitive to the subunit configuration of synaptic α₁β₂γ₂ GABA_A receptors, while compounds 3u and 4f dose-dependently reduced the peak amplitude of Na_v1.2 currents. These structural compounds may provide a foundation for the further design of novel antiepileptic molecules with low neurotoxicity.

01 Mar 2025·PATIENT EDUCATION AND COUNSELING

Embedding an illustrator in the process of co-producing resources to enhance communication and shared decision-making for patients prescribed high-risk medication

Article

Author: James, Delyth H ; Morgan, Amelia Huw

OBJECTIVES:

To examine how embedding an illustrator in the process of co-producing resources to support shared decision-making (SDM) can enhance communication between patients and healthcare professionals (HCPs).

METHODS:

Three case studies were identified involving high-risk medications where the utility of effective visual communication resources is key to SDM due to the risk of information being misinterpreted leading to potential serious adverse effects. An iterative approach was adopted to the phases of co-production, where the Illustrator acted as a conduit between patients and specialist knowledge of the clinical team. The expertise of the Illustrator was harnessed to balance the use of visual and written information, working with the HCPs in co-creating the messaging.

RESULTS:

Case Study 1 relates to the urgent administration of hydrocortisone injection for adrenal crisis in adults and children. Case Study 2 relates to self-management of the need to adjust oral corticosteroid dosing during periods of adrenal insufficiency to prevent adrenal crisis. Case Study 3 focused on women with reproductive potential prescribed or considering sodium valproate for the management of epilepsy. The benefits of involving an Illustrator were evident across all case studies, invoking supportive, empowering and empathic visual communication throughout, leading to removal of some text by the clinical team.

CONCLUSIONS:

Harnessing the expertise of Illustrators as part of a multi-disciplinary team with patients was seen as an enabler for authentic co-production to support an empathic approach to SDM in these three case studies. Further evaluation is needed to assess the impact of the use of visual communication resources of this nature in healthcare, and the impact on patient behaviours and clinical outcomes.

News (Medical) associated with Sodium Valproate

27 Dec 2024

·cerenoscientific.com

Cereno Scientific has enrolled 9 additional patients in its Expanded Access Program with CS1 providing more long-term safety and efficacy data in rare disease PAH

Cereno Scientific (Nasdaq First North: CRNO B), an innovative biotech pioneering treatments to enhance and extend life for people with rare cardiovascular and pulmonary diseases, today announced that 9 additional patients have entered its Expanded Access Program (EAP) with drug candidate CS1 in rare disease pulmonary arterial hypertension (PAH). In total, the EAP now includes 10 patients with the possibility of more patients being included in the coming months. The additional data collected on the patients in the EAP will strengthen the long-term safety and efficacy documentation of CS1 and support regulatory interactions for future clinical trials. “We are very pleased to see the high interest from patients and physicians to continue with the treatment of CS1 after the completed Phase IIa study,” said Sten R. Sörensen, CEO, Cereno Scientific. “From a drug development perspective, it is very valuable for us to be able to collect long-term clinical data on CS1 as we move forward with our plans for the next clinical program.” Drug candidate CS1 has been approved by the FDA for an Expanded Access Program as an extension of the Phase IIa trial in PAH. This program allows patients who have completed the Phase IIa trial to continue CS1 treatment if deemed suitable by physicians in the study. Through the recently entered collaboration with innovative medical company Fluidda, their non-invasive imaging technology called Functional Respiratory Imaging (FRI) will be used on certain patients enrolled in the EAP to visualize how long-term use of CS1 influences changes in pulmonary arteries. The EAP, an FDA-approved protocol, enables Cereno to obtain valuable long-term safety and efficacy data of CS1 in PAH patients supporting required regulatory interactions and planning future Phase IIb or pivotal Phase III trials. For further information, please contact: Tove Bergenholt, Head of IR & Communications Email: tove.bergenholt@cerenoscientific.com Phone: +46 732- 33 62 46 Sten R. Sörensen, CEO Email: sten.sorensen@cerenoscientific.com Phone: +46 73-374 03 74 About CS1 Drug candidate CS1 is an HDAC inhibitor (HDACi) that works through epigenetic modulation, being developed as a safe, effective and disease-modifying treatment for the rare disease pulmonary arterial hypertension (PAH). CS1 targets the root mechanism of the disease, aiming to reverse the pathological vascular remodeling of the small lung arteries. In a Phase IIa study, CS1 successfully met the primary endpoint of safety and tolerability. CS1 further showed compelling positive impact on exploratory clinical efficacy parameters over the 12-week treatment period. The Phase IIa data, together with preclinical data from the HDACi program, directly demonstrates the HDACi program’s dose-dependent positive impact on reverse remodeling in small lung arteries. This provides a basis of assumption that CS1 may act with disease-modifying capacity in PAH. In preclinical cardiovascular disease models, HDAC inhibitors have also shown anti-fibrotic, anti-inflammatory, pulmonary pressure-reducing, and anti-thrombotic effects. CS1’s unique efficacy profile aligns well with the underlying mechanisms of disease that drives the progression of PAH, positioning it to address the critical unmet need for more effective treatment options. The goal of CS1's development is to enhance and extend life for patients with PAH. CS1 is part of Cereno’s HDACi portfolio, untapping the potential of epigenetic modulation in rare cardiovascular and pulmonary diseases. CS1 has been granted orphan drug status in both the US and EU. CS1 has been approved by the FDA for an Expanded Access Program (EAP) as an extension of the Phase IIa trial in PAH, which enables Cereno to obtain valuable long-term safety and efficacy data of CS1 in PAH patients. Ten patients are currently enrolled in the program, which allows patients who have completed the Phase IIa trial to continue CS1 treatment if deemed suitable by physicians in the study. Through a collaboration with innovative medical company Fluidda, their non-invasive imaging technology called Functional Respiratory Imaging (FRI) will be used on certain patients enrolled in the EAP to visualize how long-term use of CS1 influences changes in pulmonary arteries. The data obtained by the EAP supports required regulatory interactions and planning future Phase IIb or pivotal Phase III trials. About Cereno Scientific AB Cereno Scientific is pioneering treatments to enhance and extend life. Our innovative pipeline offers disease-modifying drug candidates to empower people suffering from rare cardiovascular and pulmonary diseases to live life to the full. Lead candidate CS1 is an HDACi that works through epigenetic modulation, being developed as a safe, effective and disease modifying treatment for rare disease Pulmonary Arterial Hypertension (PAH). A Phase IIa trial evaluating CS1’s safety, tolerability, and exploratory efficacy in patients with PAH demonstrated that CS1 was safe, well-tolerated and showed a positive impact on exploratory clinical efficacy parameters. An Expanded Access Program enables patients that have completed the Phase IIa trial to gain access to CS1. HDACi CS014, in Phase I development, is a new chemical entity with disease-modifying potential. CS014 employs a multi-modal mechanism of action as an epigenetic modulator, targeting key unmet needs in patients with rare disease Idiopathic Pulmonary Fibrosis (IPF). Cereno Scientific is also pursuing a preclinical program with CS585, an oral, highly potent and selective prostacyclin (IP) receptor agonist that has demonstrated the potential to significantly improve disease mechanisms relevant to cardiovascular diseases. While CS585 has not yet been assigned a specific indication for clinical development, preclinical data indicates that it could potentially be used in indications like Thrombosis prevention without increased risk of bleeding and Pulmonary Hypertension. The Company is headquartered in GoCo Health Innovation City, in Gothenburg, Sweden, and has a US subsidiary; Cereno Scientific Inc. based in Kendall Square, Boston, Massachusetts, US. Cereno Scientific is listed on the Nasdaq First North (CRNO B). The Certified Adviser is Carnegie Investment Bank AB, certifiedadviser@carnegie.se. More information can be found on www.cerenoscientific.com. Read PDF Share

Phase 2Phase 1Clinical ResultOrphan Drug

20 Dec 2024

·cerenoscientific.com

Cereno Scientific announces that the registration of warrants and convertibles to Fenja and Arena has been completed and that delivery of the warrants has been initiated

20 Dec 2024 07:00Regulatory Cereno Scientific (Nasdaq First North: CRNO B), an innovative biotech pioneering treatments to enhance and extend life for people with rare cardiovascular and pulmonary diseases, announced on 11 November 2024 that the Company has entered into a financing agreement (the “Financing Agreement”) with Fenja Capital II A/S and the US-based investor Arena Investors, LP (the “Financiers”) securing loan financing of at least 250 MSEK. The Financing Agreement is divided into three components: (i) a cash loan in two tranches totaling 175 MSEK (the “Loan”), (ii) the issue of convertible loans of 75 MSEK to the Financiers (the “Convertibles”), and (iii) the issue without consideration of 5,749,017 warrants to the Financiers (the “Warrants”). The Company today announce that the Convertibles and the Warrants have been registered with the Swedish Companies Registration Office and that the transfer of the Warrants to the Financiers’ custody accounts has been initiated. Completed registration and ongoing delivery The Company hereby announces that the Convertibles and the Warrants have been registered with the Swedish Companies Registration Office and that the delivery of the Warrants following their connection to Euroclear has been initiated to the custody accounts designated by the Financiers. Main terms of the Convertibles, the Warrants and the Loan The convertible loans of 75 MSEK is represented by convertible promissory notes in the nominal amount of SEK 1 per Convertible. The Convertibles will be due for repayment on 30 April 2026 (the "Maturity Date"), unless Conversion has occurred before that date. The rate of interest on the Convertibles are calculated quarterly and determined at the percentage rate per annum which is the aggregate of STIBOR90 with an additional 11 percentage points. The Company has a right but no obligation to repay the Convertibles, in whole or in part, at any time prior to the Maturity Date without separate costs. In connection with any premature repayment, accrued interest of the amount so prepaid should be paid at the same time. During the term of the Convertibles, the Financiers may demand conversion of all or part of the Convertibles into new B shares in the Company at a conversion price fixed at SEK 6.09. Presuming full conversion of the Convertibles the number of shares in Cereno Scientific will increase by 12,315,270 B-shares and the share capital will increase by SEK 1,231,527 corresponding to a dilution effect of approximately 4.19 per cent of the currently outstanding shares in the company and approximately 4.10 per cent of the currently outstanding votes in the company. In relation to the Warrants, the Financiers are entitled to subscribe for one new B share for each Warrant at a subscription price of SEK 6.82 per B share during the term of the Warrants (up to and including 8 November 2029). Exercise of the Warrants can be done during the whole term of the Warrants. Upon full exercise of the Warrants, the company will receive additional issue proceeds of approximately 39.2 MSEK. Presuming full exercise of the Warrants, the number of shares in Cereno Scientific will increase by 5,749,017 B-shares and the share capital will increase by SEK 574,901.70 corresponding to a dilution effect of approximately 2.00 per cent of the currently outstanding shares in the company and 1.96 per cent of the currently outstanding votes in the company. The Loan is divided into two tranches where Tranche 1 consists of a cash loan of 125 MSEK which was paid out in connection with the signing of the Financing Agreement. Tranche 2 consists of a cash loan of 50 MSEK and is conditional upon the Company having received approval by the FDA regarding CS1 for a phase IIB study or a pivotal study for phase III as well as certain additional financial conditions being fulfilled. The Loan was subject to a customary setup fee amounting to approximately 3,87 per cent of the funding under the Financing Agreement. Parts of Tranche 1 of the Loan have been used to repay the currently outstanding loan to Fenja of approximately 91 MSEK. The interest rate of the Loan under the Financing Agreement is fixed annually starting at the time of payment and bears an annual interest rate set at the percentage rate per annum which is the sum of STIBOR plus 11 percentage points. Repayment of the Loan (both Tranches, if applicable) shall be made on 30 April 2026. Further fundamental information about the Convertibles, the Warrants and the Financing Agreement can be found in the press release of 11 November 2024: Press release | Cereno Scientific. For further information, please contact: Eva Jagenheim, CFO Email: eva.jagenheim@cerenoscientific.com Phone: +46 70 492 35 63 Sten R. Sörensen, CEO Email: sten.sorensen@cerenoscientific.com Phone: +46 73-374 03 74 About Cereno Scientific AB Cereno Scientific is pioneering treatments to enhance and extend life. Our innovative pipeline offers disease-modifying drug candidates to empower people suffering from rare cardiovascular and pulmonary diseases to live life to the full. Lead candidate CS1 is an HDACi that works through epigenetic modulation, being developed as a safe, effective and disease modifying treatment for rare disease Pulmonary Arterial Hypertension (PAH). A Phase IIa trial evaluating CS1’s safety, tolerability, and exploratory efficacy in patients with PAH demonstrated that CS1 was safe, well-tolerated and showed a positive impact on exploratory clinical efficacy parameters. An Expanded Access Program enables patients that have completed the Phase IIa trial to gain access to CS1. HDACi CS014, in Phase I development, is a new chemical entity with disease-modifying potential. CS014 employs a multi-modal mechanism of action as an epigenetic modulator, targeting key unmet needs in patients with rare disease Idiopathic Pulmonary Fibrosis (IPF). Cereno Scientific is also pursuing a preclinical program with CS585, an oral, highly potent and selective prostacyclin (IP) receptor agonist that has demonstrated the potential to significantly improve disease mechanisms relevant to cardiovascular diseases. While CS585 has not yet been assigned a specific indication for clinical development, preclinical data indicates that it could potentially be used in indications like thrombosis prevention without increased risk of bleeding and Pulmonary Hypertension. The Company is headquartered in GoCo Health Innovation City, in Gothenburg, Sweden, and has a US subsidiary; Cereno Scientific Inc. based in Kendall Square, Boston, Massachusetts, US. Cereno Scientific is listed on the Nasdaq First North (CRNO B). The Certified Adviser is Carnegie Investment Bank AB, certifiedadviser@carnegie.se. More information at www.cerenoscientific.com. Read PDF Share

Phase 1Phase 2Clinical Result

06 Dec 2024

·cerenoscientific.com

Cereno Scientific to present preclinical data for drug candidate CS585 at the ASH Annual Meeting and Exposition 2024

Cereno Scientific (Nasdaq First North: CRNO B), an innovative biotech pioneering treatments to enhance and extend life for people with rare cardiovascular and pulmonary diseases, today announces that an abstract on the preclinical drug candidate, novel IP receptor agonist CS585 will be presented at the ASH Annual Meeting and Exposition 2024, in San Diego 7-10 December 2024. The abstract titled “Selectivity and Long Action of In Vivo Efficacy of CS585, a Novel Prostacyclin Receptor Agonist, Compared to FDA-Approved Prostacyclin Agonists Iloprost and Selexipag in the Prevention of Thrombosis”, was authored by L. Stanger, M Flores, K Goerger and M. Holinstat, at the University of Michigan, Ann Arbor, USA; and B. Dahlöf, Cereno Scientific. The poster will be presented by Livia Stanger, Graduate student at the Holinstat Lab at University of Michigan, led by Prof. Michael Holinstat, Professor in the Department of Pharmacology, the Department of Internal Medicine (Division of Cardiovascular Medicine), and the Department of Vascular Surgery at the University of Michigan. Prof. Holinstat leads Cereno’s development programs at the University of Michigan and is Director of Translational Research at Cereno. Presentation Date: Sunday, 8 December 2024, 18:00–20:00 PST Part of Session: Platelets and Megakaryocytes: Basic and Translational: Poster II Read more about ASH Annual Meeting and Exposition 2024. About ASH The ASH (American Society of Hematology) Annual Meeting and Exposition is one of the world's largest conferences for professionals in hematology, including clinicians, scientists, and researchers. The conference features trends and discoveries in hematology followed by panel discussions and Q&As. This year's edition marks the 66th conference since its inception, and the conference is an important part of the development and growth in hematology. About CS585 Drug candidate CS585 is an oral, highly potent, and selective prostacyclin (IP) receptor agonist that has demonstrated the potential to significantly improve disease mechanisms relevant to cardiovascular disease. While CS585 has not yet been assigned a specific indication for clinical development, preclinical data indicates that it could potentially be used in indications like Thrombosis prevention without increased risk of bleeding and Pulmonary Hypertension. A license agreement for drug candidate CS585 with the University of Michigan provides Cereno exclusive rights to further development and commercialization of CS585. In early November 2023, CS585 was highlighted by top-tier medical journal Blood as a promising novel anti-thrombotic strategy without risk of bleeding. New preclinical data for Cereno Scientific’s novel IP Receptor Agonist CS585 was presented at ESC Congress 2024, indicating that CS585 inhibits platelet activation and clot formation up to 24 hours post-administration. For further information, please contact: Julia Fransson, Director Business Development Email: julia.fransson@cerenoscientific.com Phone: +46 708-14 31 75 Sten R. Sörensen, CEO Email: sten.sorensen@cerenoscientific.com Phone: +46 73-374 03 74 About Cereno Scientific AB Cereno Scientific is pioneering treatments to enhance and extend life. Our innovative pipeline offers disease-modifying drug candidates to empower people suffering from rare cardiovascular and pulmonary diseases to live life to the full. Lead candidate CS1 is an HDACi that works through epigenetic modulation, being developed as a safe, effective and disease modifying treatment for rare disease Pulmonary Arterial Hypertension (PAH). A Phase IIa trial evaluating CS1’s safety, tolerability, and exploratory efficacy in patients with PAH demonstrated that CS1 was safe, well-tolerated and showed a positive impact on exploratory clinical efficacy parameters. An Expanded Access Program enables patients that have completed the Phase IIa trial to gain access to CS1. HDACi CS014, in Phase I development, is a new chemical entity with disease-modifying potential. CS014 employs a multi-modal mechanism of action as an epigenetic modulator, targeting key unmet needs in patients with rare disease Idiopathic Pulmonary Fibrosis (IPF). Cereno Scientific is also pursuing a preclinical program with CS585, an oral, highly potent and selective prostacyclin (IP) receptor agonist that has demonstrated the potential to significantly improve disease mechanisms relevant to cardiovascular diseases. While CS585 has not yet been assigned a specific indication for clinical development, preclinical data indicates that it could potentially be used in indications like Thrombosis prevention without increased risk of bleeding and Pulmonary Hypertension. The Company is headquartered in GoCo Health Innovation City, in Gothenburg, Sweden, and has a US subsidiary; Cereno Scientific Inc. based in Kendall Square, Boston, Massachusetts, US. Cereno Scientific is listed on the Nasdaq First North (CRNO B). The Certified Adviser is Carnegie Investment Bank AB, certifiedadviser@carnegie.se. More information to be found on www.cerenoscientific.com. Read PDF Share

Phase 1License out/inPhase 2Clinical ResultASH

100 Deals associated with Sodium Valproate

External Link

KEGG	Wiki	ATC	Drug Bank
-	Sodium Valproate	N03AG01	DBSALT001257

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Epilepsies, Partial	US	AbbVie, Inc.	30 Dec 1996
Epilepsy, Absence	US	AbbVie, Inc.	30 Dec 1996
Nervous System Diseases	CN	Jiangsu Hengrui Pharmaceuticals Co., Ltd.	01 Jan 1982
Bipolar Disorder	JP	Sumitomo Pharma Co., Ltd.	01 Sep 1981
Migraine Disorders	JP	Sumitomo Pharma Co., Ltd.	01 Sep 1981
Epilepsy	JP	Kyowa Kirin Co., Ltd.	24 May 1974

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05224531 (CS1-003, PipelineReview) Manual	Phase 2	Pulmonary Arterial Hypertension	21	CS1	xabjftybca(powuysohav) = ksddcbqbki tanfxmjcef (falmripmki ) View more	Positive	29 Sep 2024
EADV2023	Not Applicable	Alopecia Areata beta catenin	66	Topical Sodium Valproate (SV) -loaded nanospanlastics	ywevlmbvss(evbhnbkncj) = Baseline beta catenin was found to significantly negatively correlate with improvement in the representative patch in patients with baseline level above 0.42 ng/ml bhqrdmursl (fykxabxedj ) View more	-	11 Oct 2023
				Topical Mometasone Furoate Lotion
IEC2023	Not Applicable	Epilepsy, Generalized	225	Sodium valproate (VPA) up to 700 mg	vdqnvmuzke(udixqzwdij) = oxxkblqupj iejarshlcj (pmplyvufiz )	Positive	04 Sep 2023
NCT04698525 (CTgov)	Phase 3	Migraine Disorders	33	Valproate Sodium (Valproate Group)	mkltrhbqdn(rjdqwskeqq) = gonhkdatph emyjiairop (xyalotzvfp, gkkrhjitlc - knimhdcnvr) View more	-	17 May 2023
				memantine (Memantine)	mkltrhbqdn(rjdqwskeqq) = dsutpmlnxq emyjiairop (xyalotzvfp, tydmspwraj - sdrxuswkqk) View more
CTRI/2020/01/022781 (ESMO_ASIA2022)	Phase 2	Platinum-Resistant Ovarian Carcinoma	27	Oral etoposide + Sodium valproic acid (VPA)	mkwmonijjm(qubtvwypbp) = vzqgwyksmw loniwtukim (essvfdaaff ) View more	-	03 Dec 2022
IEC2017	Not Applicable	Status Epilepticus	100	Sodium Valproate	kqdwuaurbv(atxspxmqej) = aiyvorpkwz heogbiqwjm (tcstgheonu ) View more	Positive	03 Sep 2017
				Levetiracetam	bwsnlaomal(yrzhstudeb) = xhdupsxnbg ojxuzywygz (kyxnixmpcf )
EAN2016	Not Applicable	-	-	Valproic acid (VPA)	vnsorhclas(fucyraosby) = jpthhtdpkj lwktwdnlzn (xeznrmvydc, 19 - 82)	-	23 Jun 2016
IEC2015	Not Applicable	Epilepsy antioxidant parameters	66	Vitamin E	agqndzkgjc(prgtilghpb) = malondialdehyde decreased but was not statistically significant in case (p = 0.1),but in control don ’ t decreased(p = 0.53) itucexyvyu (achzpahbvv )	Positive	08 Sep 2015
				Sodium valproate (Placebo)
IRCT201202199014N1 (Pubmed \| PLoS One)	Phase 3	Migraine Disorders	104	Intravenous sodium valproate	enkwnxtnwd(ctzhctmlts) = iquartkkbw gjympgmeoo (gozixqawwz )	-	01 Jan 2015
				Intravenous dexamethasone	enkwnxtnwd(ctzhctmlts) = wbrnoydkbi gjympgmeoo (gozixqawwz )
IEC2013	Not Applicable	Status Epilepticus	364	Intravenous sodium valproate	loyibknggl(vgmmxfbxzv): RR = 1.07 (95% CI, 0.91 - 1.24)	Negative	24 Jun 2013
				Intravenous phenytoin

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