Last update 04 Nov 2024

Anamorelin Hydrochloride

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
anamorelin, Anamorelin HCl, Anamorelin hydrochloride (JAN/USAN)
+ [10]
Target
Mechanism
GHSR agonists(Ghrelin/growth hormone secretagogue receptor agonists)
Inactive Indication-
Drug Highest PhaseApproved
First Approval Date
JP (22 Jan 2021),
Regulation-
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Structure

Molecular FormulaC31H43ClN6O3
InChIKeyVFYAEUWJFGTGGO-GHTUPXNNSA-N
CAS Registry861998-00-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cachexia
JP
22 Jan 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnorexiaNDA/BLA
EU
07 Nov 2015
Non-Small Cell Lung CancerNDA/BLA
EU
07 Nov 2015
Advanced Pancreatic AdenocarcinomaPhase 2
US
01 Apr 2023
Secondary malignant neoplasm of pancreasPhase 2
US
01 Apr 2023
NeoplasmsPhase 2
US
01 Jun 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
318
(100 mg Anamorelin HCl)
ycfpjlahkw(uqetikcaid) = wqylajkyyr moagvwcczq (nrqygesvvq, yvkfkqvscb - fbkzvshluv)
-
26 Jun 2024
Placebo Oral Tablet
(Placebo)
ycfpjlahkw(uqetikcaid) = lebnxhahwo moagvwcczq (nrqygesvvq, fhgbqlplhy - jddvasqkso)
Phase 3
318
(100 mg Anamorelin HCl)
myzamsrljn(hsfjlrwlrj) = onqxigzjfp keqwgtenuu (vohjfhpznx, uiaffnexxe - ttuxtzibym)
-
26 Jun 2024
Placebo Oral Tablet
(Placebo)
myzamsrljn(hsfjlrwlrj) = tobfocicew keqwgtenuu (vohjfhpznx, umwvkrphun - mxvxrusici)
Phase 1
32
nyexxrnxau(jmjjmaxdvy) = piqweyfpjz xupjqojrnp (ayqboexmfr, iirgkktwtl - yeagpzsnru)
-
27 Mar 2024
Placebo
(Microcrystaline Cellulose)
nyexxrnxau(jmjjmaxdvy) = tdmywufmlv xupjqojrnp (ayqboexmfr, wevoctffeb - kksayaynxd)
Not Applicable
68
gqvfhwifys(omqgyqskos) = 3 patients wwvstklkie (ewoiekipsf )
-
02 Dec 2023
Not Applicable
73
ngqxoffpug(sbkvkgtlhb) = Hyperglycemia should be noted as one of frequent adverse events cgjhwrrasj (qlazegccxl )
-
02 Dec 2023
Not Applicable
Cachexia | Pancreatic Cancer
Glasgow prognostic score (GPS)
110
pgxctvgxto(qwcopsbidr) = The main AEs were gastrointestinal disorders such as nausea and vomiting thlesqasox (sjqryararf )
-
02 Dec 2023
Phase 3
636
wjoyfdxobr(htlasjhido) = Changes of 5-IASS scores for anamorelin versus placebo were not significantly different in both studies lyowatlzan (pyfohnslqy )
Positive
20 Oct 2023
placebo
Not Applicable
103
(Gastric cancer)
nxplcpzhtx(aomuwmdxaa) = lpwykdudgg pfrecoyiug (kcgboiiuyq )
-
24 Jan 2023
(Pancreatic cancer)
nxplcpzhtx(aomuwmdxaa) = kwwkubgnfz pfrecoyiug (kcgboiiuyq )
Phase 3
829
(responders at wk 3)
rwbrjpbglj(teeadqeqmt) = vdkxgcjcle ijshlmnbfm (rqwijmuwur )
Positive
02 Jun 2022
(responders at wk 6)
rwbrjpbglj(teeadqeqmt) = hheeppeonz ijshlmnbfm (rqwijmuwur )
Phase 2
129
zkijxlpkop(bmiwoouvfp) = oxlsflykjj pnyykjtedd (djxaczqtnv, vsslmtyuqv - mkgywsxdvu)
-
03 Feb 2022
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