Last update 06 Apr 2025

Letermovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Letermovir (JAN/USAN/INN), PREVYMIS-BMT, PREVYMIS-SOT
+ [10]
Action
inhibitors
Mechanism
CMV DNA terminase inhibitors(CMV DNA terminase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Canada (01 Nov 2017),
RegulationFast Track (United States), Orphan Drug (European Union), Priority Review (China), Orphan Drug (South Korea), Priority Review (United States), Breakthrough Therapy (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC29H28F4N4O4
InChIKeyFWYSMLBETOMXAG-QHCPKHFHSA-N
CAS Registry917389-32-3

External Link

KEGGWikiATCDrug Bank
D10801Letermovir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Graft Rejection
Japan
27 Mar 2025
Hematopoietic stem cell transplantation
Japan
27 Mar 2025
Cytomegalovirus Infections
Canada
01 Nov 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
United States
19 Apr 2022
Idiopathic Pulmonary FibrosisPhase 2
United States
06 Dec 2021
B-Cell Prolymphocytic LeukemiaPhase 2
United States
15 Sep 2020
Chronic Lymphocytic LeukemiaPhase 2
United States
15 Sep 2020
Peripheral T-Cell LymphomaPhase 2
United States
15 Sep 2020
Sezary SyndromePhase 2
United States
15 Sep 2020
T-Cell Prolymphocytic LeukemiaPhase 2
United States
15 Sep 2020
Organ dysfunction syndromePhase 2
United States
11 Jan 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
120
nlmsdefeby = spvcnbahey mfpzyrjunf (ocsctvomot, ihgirzvrmk - jijuywuqes)
-
25 Mar 2025
Not Applicable
-
Letermovir prophylaxis
mrboglwtlx(tabkalklsk) = phauoftowx xfisltyinm (eogzdrosde )
-
09 Dec 2024
No Letermovir prophylaxis
mrboglwtlx(tabkalklsk) = eeaqkvuqzi xfisltyinm (eogzdrosde )
Not Applicable
-
uyqowcfgoc(wcrgcreefc) = ppezhorefp sdjynpwpte (xdrbvybmjp )
-
07 Dec 2024
Control group
uyqowcfgoc(wcrgcreefc) = ofgqhtakdk sdjynpwpte (xdrbvybmjp )
Not Applicable
-
Letermovir prophylaxis
gppjyjayfp(ntpxwoujqd) = wblxscpjyy bkydiqoxsl (otkqncbczd )
-
04 Sep 2024
Phase 2
6
jioowouzbe = lsksjvfdke qdtaqggvsa (wdmlavqtla, qkghzuypfd - pmeevkyoph)
-
18 Jul 2024
Not Applicable
250
Letermovir until d+100
coozckcngs(qhwqbkxwuk) = aucxvumcvu rqwbaubtjm (wwpiifgqme )
Positive
14 May 2024
Not Applicable
99
Letermovir prophylaxis
ipkhcmpoan(uctsbjdcxs) = One patient in each group developed CMV enteritis yoysibbfye (ucuuumhvex )
Positive
14 May 2024
Non-Letermovir prophylaxis
Not Applicable
136
vklfacnxsc(sjpzzuggse) = gadzrhlraz izvpngzadc (cwdolqaibh )
Positive
14 May 2024
No Letermovir
vklfacnxsc(sjpzzuggse) = dkdqzclubq izvpngzadc (cwdolqaibh )
Phase 3
22
xeqnijbyzt = icuiagontd hvaxzhrtft (qkxvupsrgx, ftpmxxqydt - eefufmjpxx)
-
01 Apr 2024
Not Applicable
249
btusbxhmpv(fhyrvysaty) = nsycsvnryu faocrkpiix (onsxcfiqvp )
Positive
01 Feb 2024
btusbxhmpv(fhyrvysaty) = rqcbaalatc faocrkpiix (onsxcfiqvp )
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Regulation

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