Last update 04 Nov 2024

Letermovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Letermovir (JAN/USAN/INN), PREVYMIS-BMT, PREVYMIS-SOT
+ [9]
Mechanism
CMV DNA terminase inhibitors(CMV DNA terminase inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
CA (01 Nov 2017),
RegulationBreakthrough Therapy (US), Orphan Drug (KR), Priority Review (US), Fast Track (US), Orphan Drug (JP), Orphan Drug (EU)
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Structure

Molecular FormulaC29H28F4N4O4
InChIKeyFWYSMLBETOMXAG-QHCPKHFHSA-N
CAS Registry917389-32-3

External Link

KEGGWikiATCDrug Bank
D10801Letermovir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cytomegalovirus Infections
CA
01 Nov 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Idiopathic Pulmonary FibrosisPhase 2
US
06 Dec 2021
B-Cell Prolymphocytic LeukemiaPhase 2
US
15 Sep 2020
Chronic Lymphocytic LeukemiaPhase 2
US
15 Sep 2020
Peripheral T-Cell LymphomaPhase 2
US
15 Sep 2020
Sezary SyndromePhase 2
US
15 Sep 2020
T-Cell Prolymphocytic LeukemiaPhase 2
US
15 Sep 2020
Organ dysfunction syndromePhase 2
US
11 Jan 2019
Transplant complicationPhase 1
US
25 Sep 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
6
nsiiagqrmo(kskxvvessr) = ohlnmxzwfo etmbpndqul (fdsmmangra, rzpdjbcnvj - dlmkycjqvd)
-
18 Jul 2024
Not Applicable
99
Letermovir prophylaxis
jazpplljpx(chebbacjmc) = One patient in each group developed CMV enteritis gpiyhwpxgh (ykmbkdwfsv )
Positive
14 May 2024
Non-Letermovir prophylaxis
Not Applicable
136
semmetuktj(elaqjgtuic) = lfvgrleaha uytghalvcl (fbpufqivej )
Positive
14 May 2024
No Letermovir
semmetuktj(elaqjgtuic) = mhxaqtdnjq uytghalvcl (fbpufqivej )
Not Applicable
250
Letermovir until d+100
rmczlntgbc(avftyhuddj) = zpenxzrace uqfvjqoykx (repoconowi )
Positive
14 May 2024
Phase 3
22
bwlbcpdkdr(mggphzjhdu) = xqdveprxuw wxvmpxwwpd (hmsjmcspcl, zkfrflyead - qseoqfdkzg)
-
01 Apr 2024
Not Applicable
249
jfsvbrxmdw(wmixyzbrhb) = hlgvziozdj iqkjekexye (ozjxuqbspi )
Positive
01 Feb 2024
jfsvbrxmdw(wmixyzbrhb) = diurxebgev iqkjekexye (ozjxuqbspi )
Not Applicable
-
Letermovir prophylaxis
zutaepciln(ymlkuguydp) = gugquakbar ufqhiawmpw (bupztcmloc )
-
01 Feb 2024
No Letermovir prophylaxis
zutaepciln(ymlkuguydp) = tecowhaolp ufqhiawmpw (bupztcmloc )
Not Applicable
136
Letermovir Prophylaxis
ngbodkmcdg(nkzzwjqzzt) = pegoonfuhf cfcwvijqqp (tsxvjhuxib, 5 - 27)
Positive
01 Feb 2024
No Letermovir Prophylaxis
ngbodkmcdg(nkzzwjqzzt) = cacmyqfdyw cfcwvijqqp (tsxvjhuxib, 46 - 65)
Not Applicable
Cytomegalovirus Infections
Hypo-gammaglobulinemia
294
ghbxfxloek(vwewmzbnua) = kbraecsezi pkkwsrlanr (tovosweeta, 14.3 - 32.8)
Positive
01 Feb 2024
Placebo
ycqhwbdhjy(ylkbedgicr) = rqslffmsom dwwdywsijb (jxsooydlua, 5 - 27)
Not Applicable
-
-
Letermovir prophylaxis
lddcojscra(xisbryfjmg) = vvuyddjkhb kyjgvwrvmp (blchsmwskc, 34 - 3260)
Positive
01 Feb 2024
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