The purpose of this study is to test the effectiveness of a drug called temsirolimus in combination with a drug called perifosine in treating brain tumors that have continued to grow after previous treatment. Temsirolimus is an intravenous drug approved by the FDA for treatment of other cancers (kidney cancer, certain types of lymphoma) but not for brain tumors. Perifosine is a pill that has not been approved by the FDA which blocks a messenger that tells cancer cells to grow. Research suggests that combined treatment with both drugs is better than either alone, and that it is reasonably safe.

Start Date08 Dec 2014

Sponsor / Collaborator

Columbia University

[+2]

JPRN-jRCT2080222238

Phase 2

Phase II trial of YHI-1003 monotherapy in patients with advanced or relapsed gynecologic cancer

Start Date01 Jun 2013

Sponsor / Collaborator

Yakult Honsha Co., Ltd.

JPRN-jRCT2080222084

Phase 1

Phase I study of YHI-1003 monotherapy in patients with relapsed or refractory neuroblastoma

Start Date01 May 2013

Sponsor / Collaborator

Yakult Honsha Co., Ltd.

100 Clinical Results associated with Perifosine

100 Translational Medicine associated with Perifosine

100 Patents (Medical) associated with Perifosine

464

Literatures (Medical) associated with Perifosine

01 Jan 2026·FOOD AND CHEMICAL TOXICOLOGY

MPP+ induces α-synuclein oligomerization and neurite impairment by disrupting mitochondrial function and Akt signaling, with apigenin emerging as a potential neuroprotective agent

Article

Author: Pilaiwanwadee Hutamekalin ; Ratchaneekorn Reudhabibadh ; Peungchaleoy Thammanichanon ; Nidanut Champoochana ; Thunwa Binlateh ; Zulkiflee Kuedo

Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by α-synuclein accumulation and mitochondrial impairment. Mitigating α-synuclein aggregation and mitochondrial dysfunction are prominent strategies in PD treatment. Apigenin, a dietary flavonoid, exhibits anti-inflammatory neuroprotective potential in PD models. However, it is still unclear whether apigenin possesses any impact on α-synuclein aggregation and mitochondrial dysfunction. Here, the effects and underlying mechanism of apigenin were investigated using MPP⁺-induced PD-like pathology in SH-SY5Y cells. Our results showed that apigenin significantly ameliorated neuronal apoptosis through inhibiting Bax/caspase-3 pathway and activating Bcl-2, increased size of SH-SY5Y neurospheres, and attenuated the levels of α-synuclein oligomers in MPP⁺-treated cells. Furthermore, apigenin improved MPP⁺-induced neurite damage as indicated by increased neurite length and expression of tyrosine hydroxylase (TH), growth associated protein 43 (GAP-43) and post-synaptic density protein (PSD-95). Increased ROS levels, depleted ATP levels, and decreased mitochondrial membrane potential and p-Drp1 expression in MPP⁺-treated cells were alleviated by apigenin. Further studies revealed that apigenin could enhance Akt activity. By using a specific Akt inhibitor, perifosine, the effects of apigenin on preventing MPP⁺-triggered PD pathologies were eliminated. Together, this work demonstrated that apigenin exerted neuroprotection by mitigating α-synuclein oligomers, neurite damage, mitochondrial dysfunction and neuronal apoptosis via Akt-dependent mechanism.

01 Dec 2025·JOURNAL OF COLLOID AND INTERFACE SCIENCE

Alkylphospholipids act through stabilization of planar membranes and inhibition of membrane budding and fusion

Article

Author: Fanani, María Laura ; Socas, Luis Benito Pérez ; Valdivia-Pérez, Jessica Aye ; Ambroggio, Ernesto Esteban

Alkylphospholipids (APLs) represent a novel class of anticancer drugs that disrupt lipid homeostasis by inhibiting lipid transport to the endoplasmic reticulum and altering cellular lipid metabolism. In this study, we use protein-free membrane models to investigate how the APLs miltefosine, edelfosine and perifosine influence membrane dynamics through lipid-APL interactions, resulting in the stabilization of planar membranes. This stabilization impedes critical remodelling processes such as membrane budding and fusion, essential for cellular processes. Our findings demonstrate that APLs modulate membrane curvature via geometric compensation between cone-shaped APLs and inverted cone-shaped lipids like phosphatidylethanolamine. We also explored the effects of both homogeneous and asymmetric incorporation of APLs into bilayer lipid structures, mimicking their interactions with cell membranes. The results reveal that APLs alter curved lipid structures, stabilizing planar membranes and reducing spontaneous curvature. This geometric compensation mechanism profoundly impacts membrane dynamics, where miltefosine and edelfosine exhibit greater activity compared to perifosine. These findings provide significant insights into how APLs disrupt lipid homeostasis in cellular environments.

01 Jul 2025·EXPERIMENTAL CELL RESEARCH

Hypertension-related genes STOM, MEF2C promote proliferation and migration of clear cell renal cell carcinoma

Article

Author: Li, Mingrui ; Wang, Xiangyu ; Xue, Li ; Chong, Tie ; Dong, Yao ; Wang, Na ; Huang, Zhixin ; Fu, Delai ; Tang, Xiaoshuang ; He, Minxin

As one of the major subtypes of renal cell carcinoma (RCC), there is a distinct paucity of molecular studies exploring the effect of hypertension on the progression of clear cell renal cell carcinoma (ccRCC). In this study, we utilized multi-omics data, integrating it with AddModuleScore and Weighted Gene Co-Expression Network Analysis (WGCNA) algorithms. This approach enabled the identification of 30 hypertension-related genes (HRGs), of which 13 were found to be associated with ccRCC prognosis. The construction of a hypertension-related signature (HRS) utilizing 101 combinations of 10 machine learning algorithms was undertaken, with the objective of demonstrating a noteworthy forecasting capacity for the outcome of patients with ccRCC. In vitro, the co-culture of HUVEC with ccRCC cells has been shown to demonstrate that HUVEC can promote tumor proliferation and migration through the secretion of EGF, FGFB and VEGFA, which is regulated by STOM and MEF2C. Ultimately, through the utilisation of both Mendelian randomization analysis and molecular docking, that Perifosine, 7-Hydroxystaurosporine, and Mitoxantrone could represent efficacious treatment options for ccRCC patients by targeting PRAME. The findings provide novel evidence that hypertension influences the progression of ccRCC and offer new insights into the disease's pathophysiology.

News (Medical) associated with Perifosine

09 Oct 2023

·synapse.patsnap.com

Analysis on the Clinical Research Progress of Akt inhibitors

Akt, also known as protein kinase B, is a crucial enzyme that plays a significant role in various cellular processes within the human body. It is a key mediator of cell survival, growth, and metabolism. Akt is involved in regulating multiple signaling pathways, including those related to cell proliferation, apoptosis, and glucose metabolism. It promotes cell survival by inhibiting apoptosis and stimulating cell growth and proliferation. Akt also regulates glucose metabolism by promoting glucose uptake and utilization. Dysregulation of Akt signaling has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders. Understanding the role of Akt is essential for developing targeted therapies in the pharmaceutical industry. Akt Competitive LandscapeAccording to Patsnap Synapse, as of 27 Sep 2023, there are a total of 73 Akt drugs worldwide, from 103 organizations, covering 96 indications, and conducting 409 clinical trials. 👇Please click on the picture link below for free registration or login directly if you have freemium accounts, you can browse the latest research progress on drugs , indications, organizations, clinical trials, clinical results, and drug patents related to this target. Based on the analysis of the data, AstraZeneca PLC, Roche Holding AG, and Otsuka Holdings Co., Ltd. are the companies growing fastest under the current target Akt. AstraZeneca PLC has the highest stage of development with drugs in multiple phases. Several drugs under the target Akt have been approved for relevant indications, including breast cancer, prostatic cancer, neoplasms, ovarian cancer, colorectal cancer, and lung cancer. Small molecule drugs and synthetic peptides are progressing rapidly under this target. China is showing progress in the development of drugs under the target Akt, with drugs in phase 3 and preclinical stages. The competitive landscape for target Akt is dynamic, with multiple companies and countries actively involved in research and development. The future development of target Akt is expected to continue with a focus on advancing drugs through clinical trials and expanding indications for approved drugs. Key drug：Ipatasertib DihydrochlorideIpatasertib Dihydrochloride is a small molecule drug that targets Akt, a protein involved in cell survival and growth. It has shown potential therapeutic benefits in various therapeutic areas including neoplasms, urogenital diseases, digestive system disorders, endocrinology and metabolic disease, other diseases, and skin and musculoskeletal diseases. In terms of active indications, Ipatasertib Dihydrochloride has demonstrated efficacy in treating breast cancer, castration-resistant prostatic cancer, prostatic cancer, solid tumors, ovarian cancer, stomach cancer, gastrointestinal neoplasms, etc. This wide range of indications suggests its potential as a versatile treatment option for different types of cancers. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. The drug was developed by Array BioPharma, Inc., a pharmaceutical company specializing in the discovery, development, and commercialization of targeted small molecule drugs. It has reached phase 3 globally, which is the highest phase of clinical development. Phase 3 trials are the final stage of clinical testing before seeking regulatory approval, indicating that Ipatasertib Dihydrochloride has progressed significantly in its development process. Furthermore, Ipatasertib Dihydrochloride has been designated as an orphan drug, which means it is intended to treat rare diseases or conditions that affect a small number of patients. This regulatory status provides certain incentives and benefits to the drug developer, such as market exclusivity and financial incentives, to encourage the development of treatments for rare diseases. In summary, Ipatasertib Dihydrochloride is a small molecule drug developed by Array BioPharma, Inc. that targets Akt. It has shown promise in treating various types of cancers and has reached the advanced stage of phase 3 clinical trials globally. Its designation as an orphan drug highlights its potential to address unmet medical needs in rare diseases. PerifosinePerifosine is a small molecule drug that is being developed by AEterna Zentaris GmbH. It is designed to target Akt, a protein that plays a role in cell survival and proliferation. The drug is currently in phase 3 of clinical trials, which is the final stage before seeking regulatory approval. Perifosine has shown potential in treating a range of therapeutic areas, including neoplasms (abnormal growth of cells), nervous system diseases, urogenital diseases, and digestive system disorders. Specifically, it has demonstrated efficacy in treating colorectal cancer, female urogenital diseases, and glioma, a type of brain tumor. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. One notable aspect of Perifosine is its designation as an orphan drug. Orphan drugs are medications developed to treat rare diseases or conditions that affect a small number of patients. This designation provides certain incentives and benefits to the drug developer, such as extended market exclusivity and financial support for clinical trials. The fact that Perifosine has reached phase 3 of clinical trials indicates that it has shown promising results in earlier stages of testing. Phase 3 trials involve a larger number of participants and aim to further evaluate the drug's safety and effectiveness. If the results continue to be positive, AEterna Zentaris GmbH may seek regulatory approval to bring Perifosine to market. In summary, Perifosine is a small molecule drug developed by AEterna Zentaris GmbH that targets Akt. It has shown potential in treating neoplasms, nervous system diseases, urogenital diseases, and digestive system disorders. The drug is currently in phase 3 of clinical trials and has demonstrated efficacy in treating colorectal cancer, female urogenital diseases, and glioma. Its designation as an orphan drug provides certain benefits and incentives to the developer.

03 Apr 2012

·www.biospace.com

Keryx Biopharmaceuticals, AEterna Zentaris Colorectal Cancer Drug Fails Trial

NEW YORK, April 2, 2012 /PRNewswire/ -- Keryx Biopharmaceuticals, Inc. (NASDAQ: KERX) reported today that the Phase 3 "X-PECT" (Xeloda® + Perifosine Evaluation in Colorectal cancer Treatment) clinical trial evaluating perifosine (KRX-0401) + capecitabine (Xeloda) in patients with refractory advanced colorectal cancer did not meet the primary endpoint of improving overall survival versus capecitabine + placebo. This Phase 3 trial was conducted pursuant to a Special Protocol Assessment (SPA) agreement with the FDA. 468 patients at sixty-five U.S. sites participated in this study. Ron Bentsur, Chief Executive Officer of Keryx, stated, "We are all extremely disappointed with the results of the study. We thank the investigators who participated in what we believe was a well-run study, despite the outcome. We will evaluate whether our Phase 3 study of Perifosine in relapsed/refractory multiple myeloma will continue as planned." Mr. Bentsur commented further, "With approximately $31 million in cash as of March 31, 2012, and a well-controlled burn rate, we plan to focus our resources on the pending completion of the Zerenex (ferric citrate) long-term Phase 3 study for end stage renal disease (ESRD) patients with hyperphosphatemia, expected in the fourth quarter of 2012, and the New Drug Application (NDA) filing for Zerenex which will hopefully follow shortly thereafter." KRX-0401 (perifosine) is in-licensed by Keryx from AeternaZentaris Inc. in the United States, Canada and Mexico. Keryx will host a conference call today, April 2, 2012, at 8:00am EDT. In order to participate in the conference call, please call 1-877-869-3847 (U.S.), 1-201-689-8261 (outside the U.S.), call-in ID: KERYX. The audio recording of the conference call will be available for replay at , for a period of 15 days after the call. ABOUT KERYX BIOPHARMACEUTICALS, INC. Keryx Biopharmaceuticals is focused on the acquisition, development and commercialization of medically important pharmaceutical products for the treatment of renal disease and cancer. Keryx is developing Zerenex (ferric citrate), an oral, ferric iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. The Phase 3 clinical program of Zerenex for the treatment of hyperphosphatemia (elevated phosphate levels) in patients with end-stage renal disease is being conducted pursuant to an SPA agreement with the FDA. Keryx is also developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway, and potentially also affects a number of other key signal transduction pathways. KRX-0401 is currently in Phase 3 clinical development for multiple myeloma, being conducted pursuant to an SPA agreement with the FDA, and in Phase 1 and 2 clinical development for several other tumor types. Keryx is headquartered in New York City. Cautionary Statement Some of the statements included in this press release, particularly those anticipating future clinical trials and business prospects for Zerenex (ferric citrate) and KRX-0401 (perifosine) may be forward-looking statements that involve a number of risks and uncertainties. For those statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Among the factors that could cause our actual results to differ materially are the following: if, upon final analysis, it is determined that all trials of KRX-0401 should be terminated, our ability to successfully adjust our strategy and reduce our operating expenses relating to KRX-0401 clinical trials in order to properly support the trials of Zerenex; our ability to successfully and cost-effectively complete clinical trials for Zerenex and KRX-0401; the risk that the data (both safety and efficacy) from the ongoing Phase 3 trials will not coincide with the data analyses from previous clinical trials reported by the Company; and other risk factors identified from time to time in our reports filed with the Securities and Exchange Commission. Any forward-looking statements set forth in this press release speak only as of the date of this press release. We do not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof. This press release and prior releases are available at . The information found on our website is not incorporated by reference into this press release and is included for reference purposes only. KERYX CONTACT: Lauren Fischer Director Investor Relations Keryx Biopharmaceuticals, Inc. Tel: 212.531.5965 E-mail: lfischer@keryx.com SOURCE Keryx Biopharmaceuticals, Inc.

CollaborateFirst in ClassAcquisition

29 Apr 2011

·www.biospace.com

Keryx Biopharmaceuticals Announces Positive Final Data from Zerenex Short-Term Phase 3 Study

NEW YORK, April 28, 2011 /PRNewswire/ -- Keryx Biopharmaceuticals (Nasdaq:KERX - News) today announced the final dataset from the Phase 3 short-term clinical trial of Zerenex™ (ferric citrate) for the treatment of hyperphosphatemia in end-stage renal disease patients on dialysis. The Zerenex data was presented earlier today at the National Kidney Foundation Spring Clinical Meetings being held in Las Vegas, Nevada, in an oral presentation by David S. Goldfarb, M.D., Clinical Chief of Nephrology, NYU Langone Medical Center, Professor of Medicine & Physiology, NYU School of Medicine. On November 30, 2010, the Company issued a press release announcing positive top-line results from this Phase 3 short-term study. Phase 3 short-term study design This Phase 3 study was a multicenter, randomized, open-label trial with a two-week washout period, following which patients were randomized 1:1:1 to receive a fixed dose of Zerenex of either 1 gram, 6 grams or 8 grams per day for a treatment period of 28 days. Zerenex was administered using a 1 gram oral caplet formulation, hence, the fixed-dose arms of 1 gram, 6 grams and 8 grams per day represent 1, 6 and 8 pills per day, respectively. One hundred fifty-one dialysis patients were enrolled into the study. The Intent-to-Treat (ITT) group included 146 patients, representing all patients who took at least one dose of Zerenex and provided a Baseline (at the end of washout) and at least one post-Baseline efficacy assessment. Efficacy assessments were taken weekly starting at Baseline and subsequently at days 7, 14, 21 and 28. EFFICACY DATA ANALYSES The primary endpoint of the study was to determine whether there was a dose response in the change in serum phosphorus from Baseline to Day 28 in the ITT group, using a regression analysis to evaluate this objective. The study met the primary endpoint, with the regression analysis indicating a highly statistically significant dose response (p Additional highlights from Dr. Goldfarb's presentation on Zerenex are as follows: * Statistically significant dose response increase in serum bicarbonate suggests potential to address metabolic acidosis * Statistically significant dose response reduction in calcium x phosphorus product * Modest upward trends in Ferritin and TSAT in 6 grams/day and 8 grams/day dose groups further supports theory that Zerenex could reduce the need for intravenous iron and erythropoiesis-stimulating agent (ESA) use * Zerenex appeared to be safe and well-tolerated in the study * GI adverse events were mostly mild and transient in nature * No SAEs were deemed to be drug-related by the Data Safety Monitoring Committee Dr. Goldfarb concluded that Zerenex has the potential to become a viable alternative to the currently approved phosphate binders used to treat ESRD patients. Ron Bentsur, Chief Executive Officer of Keryx, stated, "We are encouraged by the final efficacy and safety data from the Phase 3 short term study presented earlier today, which confirm the top-line data previously reported." Mr. Bentsur continued, "We thank Dr. Goldfarb for his time and effort in preparing for and delivering this morning's presentation." In accordance with the Company's Special Protocol Assessment (SPA) agreement with the FDA, the Phase 3 clinical program for Zerenex consists of two clinical studies, the completed short-term study, and a long-term safety and efficacy study that is currently ongoing. About Keryx Biopharmaceuticals, Inc. Keryx Biopharmaceuticals is focused on the acquisition, development and commercialization of medically important pharmaceutical products for the treatment of cancer and renal disease. Keryx is developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway, and also affects a number of other key signal transduction pathways, including the JNK pathway, all of which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 has demonstrated both safety and clinical efficacy in several tumor types, both as a single agent and in combination with approved therapies. KRX-0401 is currently in Phase 3 clinical development for both refractory advanced colorectal cancer and multiple myeloma, and in Phase 1 and 2 clinical development for several other tumor types. Each of the KRX-0401 Phase 3 studies is being conducted under a Special Protocol Assessment (SPA) agreement with the FDA. Keryx is also developing Zerenex (ferric citrate), an oral, ferric iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. The Phase 3 clinical program of Zerenex for the treatment for hyperphosphatemia (elevated phosphate levels) in patients with end-stage renal disease on dialysis is being conducted pursuant to an SPA agreement with the FDA. Keryx is headquartered in New York City. Cautionary Statement Some of the statements included in this press release, particularly those anticipating future clinical trials and business prospects for Zerenex™ (ferric citrate) may be forward-looking statements that involve a number of risks and uncertainties. For those statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Among the factors that could cause our actual results to differ materially are the following: our ability, and our Japanese partner's ability, to successfully and cost-effectively complete clinical trials for Zerenex (ferric citrate); uncertainties related to the regulatory process; and other risk factors identified from time to time in our reports filed with the Securities and Exchange Commission. Any forward-looking statements set forth in this press release speak only as of the date of this press release. We do not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof. This press release and prior releases are available at The information found on our website is not incorporated by reference into this press release and is included for reference purposes only. KERYX CONTACT: Lauren Fischer Director - Investor Relations Keryx Biopharmaceuticals, Inc. Tel: 212.531.5965 E-mail: lfischer@keryx.com

CollaborateFirst in ClassAcquisition

100 Deals associated with Perifosine

External Link

KEGG	Wiki	ATC	Drug Bank
-	Perifosine	-	DB06641

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Refractory Colorectal Carcinoma	Phase 3	United States	Æterna Zentaris, Inc.	01 Apr 2010
Multiple Myeloma	Phase 3	United States	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Canada	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Czechia	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Ireland	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Israel	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Russia	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Slovakia	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	South Korea	Æterna Zentaris, Inc.	01 Dec 2009
Multiple Myeloma	Phase 3	Spain	Æterna Zentaris, Inc.	01 Dec 2009

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00590954 (CTgov)	Phase 2	Recurrent Malignant Glioma	32	Perifosine	wtsiiiwthw(olaekfhpvc) = whoeotmohr sjbtwhhuwv (lxrnukpvkv, icywualvkm - ocladlnwad) View more	-	19 Oct 2020
NCT01002248 (Pubmed) Manual	Phase 3	Multiple Myeloma	135	bortezomib+perifosine	fdnbdydsbw(xihmbdqgim) = zktnwiivht tatcjulwsb (ukzsxifkha, 16.0 - 45.4) View more	Negative	06 Apr 2020
NCT01002248 (Pubmed) Manual	Phase 3	Multiple Myeloma	135	bortezomib+Placebo	fdnbdydsbw(xihmbdqgim) = houxscfdtf tatcjulwsb (ukzsxifkha, 18.3 - 50.1) View more	Negative	06 Apr 2020
NCT00590954 (Pubmed \| J Neurooncol) Manual	Phase 2	Recurrent Glioblastoma	30	Perifosine	wovwmclgkz(myjhsjmhsp) = pgepiaevzj thgmmowagm (smxmejslop, 1.08 - 1.84) View more	Negative	01 Sep 2019
NCT00776867 (Pubmed \| Int J Cancer) Manual	Phase 1	High Risk Neuroblastoma	27	perifosine	ocvzjthfgi(jnkoljcmjg) = ambdmegcbo bypkzsykzb (tdhngoomif ) View more	Positive	15 Jan 2017
NCT01051557 (CTgov)	Phase 1/2	Gliosarcoma \| Glioblastoma \| Diffuse Astrocytoma ... View more	36	Laboratory Biomarker Analysis+Perifosine+Temsirolimus	bbafyvgxth = zfxspocdaw llqwfjdmpu (bpadhjzbkk, brujljmllg - frmqkubamd)	-	18 Apr 2016
NCT00058214 (CTgov)	Phase 2	Recurrent Prostate Carcinoma \| Castration-sensitive prostate cancer \| Adenocarcinoma of prostate	25	laboratory biomarker analysis+perifosine	fjqvxwhudh = ntmvncgaia fshixinfta (zjehjwvysn, qnbldqmqne - syluplunfd) View more	-	23 Feb 2015
NCT00873457 (CTgov)	Phase 2	Chronic Lymphocytic Leukemia \| Small Lymphocytic Lymphoma	16	perifosine	rtolcprumj = qlbehngaig jxairymeon (xxwekzthtv, fdsvxmixmb - kttklcmzqn) View more	-	24 Jan 2013
Pubmed \| Br J Haematol	Phase 1	Multiple Myeloma phospho-Akt	-	Perifosine-lenalidomide-dexamethasone	bbayjfdsey(qivvtnykpn) = cyrbmawkhu ldyabbdkwn (dgcorzzzwr ) View more	Positive	01 Aug 2012
NCT01097018 (X-PECT, ASCO 12012 \| ASCO 22012) Manual	Phase 3	Metastatic Colorectal Carcinoma	468	Capecitabine+perifosine	ymtsieixft(oxwlrmzxgs) = fmjimzfswx cfqsuabzoi (odqgxgdtdi ) View more	Negative	20 Jun 2012
NCT01097018 (X-PECT, ASCO 12012 \| ASCO 22012) Manual	Phase 3	Metastatic Colorectal Carcinoma	468	Capecitabine+placebo	ymtsieixft(oxwlrmzxgs) = zipnxqamea cfqsuabzoi (odqgxgdtdi ) View more	Negative	20 Jun 2012
NCT00422656 (CTgov)	Phase 2	Waldenstrom Macroglobulinemia	37	Perifosine	nisnzmbljg = iaguzymjsi hvmiaarfyx (iperpyephi, duezvogtct - nkvnuyydng) View more	-	16 Feb 2012

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