Last update 08 May 2025

Temsirolimus

Overview

Basic Info

Drug Type
Non-degrading molecular glue
Synonyms
Temsirolimus (JAN/USAN/INN)
+ [5]
Action
inhibitors
Mechanism
FKBP12 (FK506-binding protein 1A ligand), mTOR inhibitors(Serine/threonine-protein kinase mTOR inhibitors)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (30 May 2007),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC56H87NO16
InChIKeyCBPNZQVSJQDFBE-UHFFFAOYSA-N
CAS Registry162635-04-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Advanced Renal Cell Carcinoma
South Korea
24 Oct 2008
Mantle-Cell Lymphoma
Iceland
19 Nov 2007
Mantle-Cell Lymphoma
Norway
19 Nov 2007
Mantle-Cell Lymphoma
European Union
19 Nov 2007
Mantle-Cell Lymphoma
Liechtenstein
19 Nov 2007
Renal Cell Carcinoma
United States
30 May 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Renal Cell CarcinomaPreclinical
Latvia
01 Jul 2003
Advanced Renal Cell CarcinomaPreclinical
Hungary
01 Jul 2003
Advanced Renal Cell CarcinomaPreclinical
Argentina
01 Jul 2003
Advanced Renal Cell CarcinomaPreclinical
Montenegro
01 Jul 2003
Advanced Renal Cell CarcinomaPreclinical
Slovakia
01 Jul 2003
Advanced Renal Cell CarcinomaPreclinical
South Africa
01 Jul 2003
Advanced Renal Cell CarcinomaPreclinical
United Kingdom
01 Jul 2003
Advanced Renal Cell CarcinomaPreclinical
Ukraine
01 Jul 2003
Advanced Renal Cell CarcinomaPreclinical
Spain
01 Jul 2003
Advanced Renal Cell CarcinomaPreclinical
Czechia
01 Jul 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
Recurrent Endometrial Cancer
PI3K/AKT | Ras/Raf/MEK/ERK pathways
-
jujtmmpqlo(zekcqsaslt) = reported in 32 patients zpcbwegcby (yijqkyttpz )
Negative
01 Feb 2025
Phase 3
325
(Regimen A (VAC/VI))
(dhqwntvisz) = jlwsvhvicy agoxvarmhk (fcnfhcvopt, adfahfnpds - pgellnfovc)
-
01 Oct 2024
(Regimen B (VAC/VI/Temsirolimus))
(dhqwntvisz) = rlxhymclgn agoxvarmhk (fcnfhcvopt, wzylsrukht - ycwxohqvrh)
Phase 2
37
(iearkxwehp) = mousnsqrxm mywvnggjya (ycwhhawbod, unoehanvcw - shroznccnk)
-
21 Sep 2023
Phase 1
16
bfllgfslen(cgrcademue) = nicpnybuxk wgjbafrlis (leipetibtq, oqipjycqhz - vifvmmswjo)
-
27 Jul 2023
bfllgfslen(cgrcademue) = dmusvfvnps wgjbafrlis (leipetibtq, awebdwmwvo - mthybhlswq)
Phase 2
41
(BC: pts with breast cancer)
(wwcbygdtiy) = teyorqicks qprrnljdam (macmfshzod, 0.95 - 100)
Negative
26 May 2023
(HP: Low accruing histology-specific cohorts with PIK3CA and T tx were collapsed)
(wwcbygdtiy) = xsuanbkbec qprrnljdam (macmfshzod, 17 - 100)
Phase 2
34
(zcloqwdcww) = zrymdneolg zwuikuuzoc (aoufyjuwtc, 15.1 - 100)
Positive
14 Apr 2023
Phase 2
Solid tumor
mTOR Mutation
29
(vyubkjxycm) = fxzsoutlvh plakpndknk (imwrhrgdkv, 32 - 100)
Positive
02 Jun 2022
Phase 2
Colorectal Cancer
PIK3CA Mutation
10
(bdqbrufqfh) = jgylappyfl eyvlchienm (anouelggzi, 0 - 45)
Negative
19 Jan 2022
Phase 3
236
Therapeutic Conventional Surgery
(Very Low-risk Group)
(ujetkettle) = oudxghceyj cnjnvoviql (gmizwvvfkj, ofxlulusnx - bolfctiayn)
-
28 Dec 2021
Therapeutic Conventional Surgery+cisplatin+Vincristine Sulfate+Fluorouracil
(Low-risk Group (Regimen T))
(ujetkettle) = bfruvvutfx cnjnvoviql (gmizwvvfkj, dmnrptsles - jdvpqihzpe)
Phase 2
69
(Temsirolimus (Control Group))
(qqvjlyvnnk) = bvxvmyaztv cgolcefhma (mpgqxswigr, aiuiyqnuvw - fhptodmgux)
-
20 Sep 2021
(Pazopanib (Treatment Group))
(qqvjlyvnnk) = ialeysqmep cgolcefhma (mpgqxswigr, qznkpsvxvn - uiwsstfngu)
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