An Open-Label Study to Evaluate the Effect of a Single Dose of Briakinumab on the Pharmacokinetics of Single Doses of Caffeine, Tolbutamide, Omeprazole, Metroprolol, and Midazolam in Subjects With Moderate to Severe Psoriasis

Phase 1, drug-drug interaction study to evaluate the effects of Briakinumab on hte pharmacokinetics of single doses of CYP substrate in subjects with moderate to severe psoriasis.

Start Date01 Apr 2011

Sponsor / Collaborator

Alere, Inc.

NCT00870948 / CompletedPhase 1

Phase 1 BA Study, Single Center With Healthy Volunteers

Single dose in healthy volunteers to assess bioavailability (amount of study drug in the system) between different formulations of ABT-874.

Start Date01 Jan 2009

Sponsor / Collaborator

Abbott Laboratories

NCT00710580 / CompletedPhase 3

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Efficacy and Safety of ABT-874 to Etanercept and Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis

Compare the efficacy of ABT-874 versus etanercept in subjects with moderate to severe plaque psoriasis

Start Date01 Jul 2008

Sponsor / Collaborator

AbbVie, Inc.

[+1]

100 Clinical Results associated with Briakinumab

100 Translational Medicine associated with Briakinumab

100 Patents (Medical) associated with Briakinumab

Literatures (Medical) associated with Briakinumab

01 Sep 2024·CLINICAL RHEUMATOLOGY

Prioritizing drug targets in systemic lupus erythematosus from a genetic perspective: a druggable genome-wide Mendelian randomization study

Article

Author: Wu, Haiyang ; Lin, Zikai ; Xie, Yingying ; Gao, Yuan ; Chen, Fengzhen ; Peng, Chusheng ; Zhou, Youtao

Abstract:

Objectives:

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with an unsatisfactory state of treatment. We aim to explore novel targets for SLE from a genetic standpoint.

Methods:

Cis-expression quantitative trait loci (eQTLs) for whole blood from 31,684 samples provided by the eQTLGen Consortium as well as two large SLE cohorts were utilized for screening and validating genes causally associated with SLE. Colocalization analysis was employed to further investigate whether changes in the expression of risk genes, as indicated by GWAS signals, influence the occurrence and development of SLE. Targets identified for drug development were evaluated for potential side effects using a phenome-wide association study (PheWAS). Based on the multiple databases, we explored the interactions between drugs and genes for drug prediction and the assessment of current medications.

Results:

The analysis comprised 5427 druggable genes in total. The two-sample Mendelian randomization (MR) in the discovery phase identified 20 genes causally associated with SLE and validated 8 genes in the replication phase. Colocalization analysis ultimately identified five genes (BLK, HIST1H3H, HSPA1A, IL12A, NEU1) with PPH4 > 0.8. PheWAS further indicated that drugs acting on BLK and IL12A are less likely to have potential side effects, while HSPA1A and NEU1 were associated with other traits. Four genes (BLK, HSPA1A, IL12A, NEU1) have been targeted for drug development in autoimmune diseases and other conditions.

Conclusions:

.This study identified five genes as therapeutic targets for SLE. Repurposing and developing drugs targeting these genes is anticipated to improve the existing treatment state for SLE. Key Points• We identified five gene targets of priority for the treatment of SLE, with BLK and IL12A indicating fewer side effects.• Among the existing drugs that target these candidate genes, Ustekinumab, Ebdarokimab, and Briakinumab (targeting the IL12 gene) and CD24FC (targeting HSPA1A) may potentially be repurposed for the treatment of SLE.

01 Jul 2023·Nature reviews. Gastroenterology & hepatology

IL-12 and IL-23 pathway inhibition in inflammatory bowel disease

Review

Author: Sandborn, William J. ; Panes, Julian ; Vande Casteele, Niels ; Verstockt, Bram ; Ma, Christopher ; Sands, Bruce E. ; Feagan, Brian G. ; Mehandru, Saurabh ; Veny, Marisol ; Eckmann, Lars ; Silverberg, Mark S. ; Abraham, Clara ; Vetrano, Stefania ; Vermeire, Severine ; Faubion, William A. ; Neurath, Markus F. ; Danese, Silvio ; D’Haens, Geert ; Leibovitzh, Haim ; Rieder, Florian ; Salas, Azucena ; Jairath, Vipul

Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in the pathogenesis of inflammatory bowel disease. Upon their secretion by antigen-presenting cells, they exert both pro-inflammatory and anti-inflammatory receptor-mediated effects. An increased understanding of these biological effects, particularly the pro-inflammatory effects mediated by IL-12 and IL-23, has led to the development of monoclonal antibodies that target a subunit common to IL-12 and IL-23 (p40; targeted by ustekinumab and briakinumab), or the IL-23-specific subunit (p19; targeted by risankizumab, guselkumab, brazikumab and mirikizumab). This Review provides a summary of the biology of the IL-12 family cytokines IL-12 and IL-23, discusses the role of these cytokines in intestinal homeostasis and inflammation, and highlights IL-12- and IL-23-directed drug development for the treatment of Crohn's disease and ulcerative colitis.

01 Sep 2021·American journal of clinical dermatologyQ2 · MEDICINE

Cardiovascular Safety of Biologics Targeting Interleukin (IL)-12 and/or IL-23: What Does the Evidence Say?

Q2 · MEDICINE

Review

Author: de Brito, Marianne ; Yiu, Zenas Z N

There is substantial evidence regarding the association between psoriasis and the elevated risk of cardiovascular (CV) disease. Many patients with psoriasis may also be concerned that their treatments may be associated with a further increase in the risk of CV disease. In this article, we summarize the data regarding the biological role of interleukin (IL)-12/23 in atherogenesis. We performed a literature search for currently known CV safety data from trials and observational studies of treatments targeting IL-12/23 in psoriasis, i.e. the p40 inhibitors ustekinumab and briakinumab, and the p19 inhibitors guselkumab, risankizumab, and tildrakizumab. On balance, extensive evidence supports the CV safety of ustekinumab, with over 14 years of follow-up data in multiple cohort studies and randomized controlled trials (RCTs). One self-controlled study concluded ustekinumab may precipitate short-term raised CV risk, but the study had limitations hindering interpretation. The safety evidence from RCTs on the p19 inhibitors are reassuring thus far, but these studies may not detect rare CV events in real-world patients. We concluded that the overall evidence does not show that ustekinumab is associated with an increase in the risk of CV disease in patients with psoriasis, but further data are awaited to assess the CV safety of p19 inhibitors for the treatment of psoriasis.

News (Medical) associated with Briakinumab

25 Oct 2021

·www.biospace.com

Janssen Scores Two Clinical Victories While ERYTECH Misses in Pancreatic Cancer

Monday morning’s press atmosphere produced a shower of announcements from ERYTECH and the Janssen Pharmaceutical Companies of Johnson & Johnson, as each reported the results of their respective research. Based in France, ERYTECH is a clinical-stage biopharmaceutical company focused on using its proprietary ERYCAPS platform to develop creative therapies for rare cancers and orphan diseases. Eryaspase, its chief therapeutic candidate, was recently studied in a Phase III clinical trial as a treatment for second-line advanced pancreatic cancer. While the trial ultimately did not meet its primary endpoint of overall survival, patients treated with eryaspase demonstrated better disease control than patients treated only with chemotherapy. Additionally, eryaspase’s safety pro consistent with the results of previous clinical trials and safety reviews. A subgroup of patients treated with eryaspase and an irinotecan-based chemotherapy showed a trend of small but noticeable survival benefit. However, patients being treated with gemcitabine and nabpaclitaxel did not exhibit any survival benefit from the addition of eryaspase, a contrast which ERYTECH noted might deserve further investigation. The company now plans to focus on its late-stage program in acute lymphoblastic leukemia (ALL) and continue to work toward approval in hypersensitive ALL based on the promising results of its Phase II trial. This is in accordance with the company’s original plan to submit a Biologics License Application before the end of 2021. Meanwhile, Janssen reported analyses in which STELARA® (ustekinumab), an interleukin (IL)-12 and IL-23 inhibitor, is showing promising results as a first-line therapy for Crohn’s Disease (CD) and Ulcerative Colitis (UC) in bio-naïve patients. This announcement referenced two different studies involving STELARA: the first as a treatment for UC, and the second as a treatment for CD. “These analyses in ulcerative colitis and Crohn’s disease expand the body of data for STELARA and give us insight into treatment sequencing and persistence rates, which are important when assessing biologic therapy options for patients. The data are informative because patients with inflammatory bowel disease can demonstrate a short-term clinical response and improvement with therapy and then lose response,” said Dr. Jan Wehkamp, M.D., vice president and gastroenterology disease area leader at Janssen Research & Development. The results of the UC study suggested that STELARA is more effective as a first-line advanced therapy than as a second or third-line therapy. This was reflected by the amount of time a patient spent in remission or response, as well as the postponing of surgery. When used as a first-line treatment, STELARA patients spent about 8.5 months in remission over one year, 23.1 months over three years and 32.2 months over five years. However, when used as a second-line treatment, STELARA patients only spent about 7.9 months in remission over one year, 14.5 months over three years and just 17.5 months over five years. The second study in CD suggested that a higher proportion of patients who started on STELARA were persistent on therapy than patients who started on adalimumab. This includes patients who were persistent on therapy and corticosteroid-free, as well as patients who were persistent and on monotherapy. Patients who started on STELARA rather than adalimumab had a 50% higher rate of persistence, a 17% higher rate of persistence and being corticosteroid-free and a 47% higher rate of persistence on monotherapy.

License out/in

09 Jul 2021

·www.biospace.com

Surrozen Presents New Data Demonstrating Superior Activity of SZN-1326 in Preclinical Inflammatory Bowel Disease Models at 16th Congress of the European Crohn’s and Colitis Organization

SOUTH SAN FRANCISCO, Calif., July 09, 2021 (GLOBE NEWSWIRE) -- Surrozen, Inc., a biotechnology company discovering and developing drug candidates to selectively modulate the Wnt pathway, announced today that new data from its inflammatory bowel disease (IBD) program, including preclinical studies of SZN-1326 showing superior activity compared to therapeutics currently used in treatment, were presented during the 16th Congress of the European Crohn’s and Colitis Organisation. Two poster presentations discussed data from studies of SZN-1326, a bi-specific full-length human antibody targeting Fzd5/8 and Lrp6 receptors in development for the treatment of IBD. A third poster presentation discussed expression profiling of Wnt pathway genes in colon biopsies from patients with ulcerative colitis (UC). Copies of posters will be available in the Investors & Media section of Surrozen’s website. “In both chronic and acute models presented at this congress, SZN-1326 demonstrated beneficial activity compared to other therapeutics currently used for the treatment of IBD that we believe could be meaningful for patients living with IBD,” said Craig Parker, President and Chief Executive Officer of Surrozen. “Combined with presented data about Wnt expression and our other studies of SZN-1326, we continue to be excited for this program and look forward to moving it into clinical investigation in 2022.” In a poster presentation titled, “SZN-1326, a Wnt agonist, improved epithelial healing and ameliorated colitis in a chronic DSS model, in stark contrast to anti-TNFa and anti-IL-12/23p40 antibodies,” findings from a chronic mouse IBD model showed SZN-1326 at various dosing regimens stimulated intestinal epithelial regeneration, induced mucosal healing and restored the epithelial barrier resulting in reduced inflammation, reduced serum cytokine levels, improved body weight and reduced disease activity. In contrast, treatment with anti-TNFa or anti-IL-12/23p40 antibodies led to reduction only in certain serum inflammatory cytokines but had no effect on disease activity or colon histology in this model. In a poster presentation titled, “SZN-1326, a Wnt signal activator, is more efficacious than cyclosporine A in an acute DSS model,” findings from an acute mouse IBD model showed SZN-1326 at various dosing regimens stimulated intestinal epithelial regeneration, induced mucosal healing and restored the epithelial barrier resulting in reduced inflammation, reduced serum cytokine and lipocalin-2 levels improved body weight and reduced disease activity. In comparison, Cyclosporine A showed only a mild effect on reducing disease activity and lipocalin-2. In a poster presentation titled, “Expression profiling of Wnt pathway genes in colon biopsies of patients with ulcerative colitis,” shows reduced expression of Wnt receptors, RSPOs and Wnt target genes indicated insufficient Wnt signal induction in the damaged colon epithelium of UC patients. The findings suggest that repair of the damaged epithelium by Wnt agonist treatment may constitute a new mechanism of action and benefit patients with UC. About Wnt Signaling Wnt signaling plays key roles in the control of development, homeostasis, and regeneration of many essential organs and tissues, including liver, intestine, lung, kidney, retina, central nervous system, cochlea, bone, and others. Modulation of Wnt signaling pathways has potential for treatment of degenerative diseases and tissue injuries. Surrozen’s platform and proprietary technologies have the potential to overcome the limitations in pursuing the Wnt pathway as a therapeutic strategy. About Surrozen Surrozen is a biotechnology company discovering and developing drug candidates to selectively modulate the Wnt pathway. Surrozen is developing tissue-specific antibodies designed to engage the body’s existing biological repair mechanisms with potential application across multiple disease areas, including inflammatory bowel disease, hepatitis, eye diseases, hearing loss, lung and airway diseases, and certain neurological disorders. For more information, please visit surrozen.com. Additional Information In connection with Surrozen’s recently announced business combination with Consonance-HFW Acquisition Corp. (“CHFW”), CHFW has filed with the U.S. Securities and Exchange Commission’s (“SEC”) a Registration Statement on Form S-4 (the “ Registration Statement ”), which includes a preliminary prospectus with respect to the securities of CHFW to be issued in connection with the business combination to Surrozen stockholders, and as well as a proxy statement with respect to the shareholder meeting of CHFW to vote on the business combination and related matters. CHFW will mail a definitive proxy statement/final prospectus and other relevant documents to its shareholders after the Registration Statement is declared effective by the SEC. This communication is not a substitute for the Registration Statement, the definitive proxy statement/final prospectus or any other document that CHFW will send to its shareholders in connection with the business combination. The definitive proxy statement/final prospectus will contain important information about CHFW, Surrozen and their respective business and related risks, the combined company, including pro forma financial information and the proposed business combination and related matters. Investors and security holders of CHFW are advised to read, when available, the proxy statement/prospectus in connection with CHFW’s solicitation of proxies for its extraordinary general meeting of shareholders to be held to approve the business combination (and related matters) because the proxy statement/prospectus will contain important information about the business combination and the parties to the business combination. Investors and security holders of Surrozen are advised to read, when available, the proxy statement/prospectus in connection with the written consent of Surrozen stockholders. The definitive proxy statement/final prospectus will be mailed to shareholders of CHFW as of a record date to be established for voting on the business combination. Shareholders will also be able to obtain copies of the proxy statement/prospectus, without charge, once available, at the SEC’s website at or by directing a request to: Consonance-HFW Acquisition Corp., 1 Palmer Square, Suite 305, Princeton, NJ. Participants in the Solicitation CHFW, Surrozen and their respective directors, executive officers, other members of management, and employees, under SEC rules, may be deemed to be participants in the solicitation of proxies of CHFW’s shareholders in connection with the business combination. Investors and security holders may obtain more detailed information regarding the names and interests in the business combination of CHFW’s directors and officers in CHFW’s filings with the SEC, including the Registration Statement filed with the SEC by CHFW, which includes the preliminary proxy statement of CHFW for the business combination, and such information and names of Surrozen’s directors and executive officers is also in the Registration Statement filed with the SEC by CHFW. Forward Looking Statements Certain statements made herein are not historical facts but are forward-looking statements for purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Forward-looking statements generally are accompanied by words such as “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “should,” “would,” “plan,” “predict,” “potential,” “seem,” “seek,” “future,” “outlook” and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding future events, the business combination between CHFW and Surrozen, the potential for, data regarding and benefits of the Wnt pathway and studies of SZN-043, including beliefs about recent data and plans and expected timeline for, and benefits resulting from, clinical trials, and potential market for the treatment of severe liver disease. These statements are based on the current expectations of Surrozen’s management and are not predictions of actual performance. These forward-looking statements are not intended to serve as, and must not be relied on, by any investor as a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and will differ from assumptions. Many actual events and circumstances are beyond the control of CHFW and Surrozen. These statements are subject to a number of risks and uncertainties regarding Surrozen’s and CHFW’s businesses and the business combination, and actual results may differ materially. These risks and uncertainties include, but are not limited to, the possibility that the Wnt platform may not meet expectations, general economic, political and business conditions; the inability of the parties to consummate the business combination or the occurrence of any event, change or other circumstances that could give rise to the termination of the business combination agreement; the outcome of any legal proceedings that may be instituted against the parties following the announcement of the business combination; the receipt of an unsolicited offer from another party for an alternative business transaction that could interfere with the business combination; the risk that the approval of the shareholders of CHFW or the stockholders of Surrozen for the potential transaction is not obtained; failure to realize the anticipated benefits of the business combination, including as a result of a delay in consummating the potential transaction or difficulty in integrating the businesses of CHFW and Surrozen; the risk that the business combination disrupts current plans and operations as a result of the announcement and consummation of the business combination; the ability of the combined company to grow and manage growth profitably and retain its key employees; the amount of redemption requests made by CHFW’s shareholders; the inability to obtain or maintain the listing of the post-acquisition company’s securities on Nasdaq following the business combination; costs related to the business combination; risks related to the matters set forth in the Staff Statement on Accounting and Reporting Considerations for Warrants Issued by Special Purpose Acquisition Companies, issued by the Division of Corporate Finance of the SEC on April 12, 2021; and those factors discussed in the Registration Statement and in CHFW’s annual report on Form 10-K for the year ended December 31, 2020 (as amended and restated), and subsequent filings with the SEC, including CHFW’s quarterly report on Form 10-Q for the quarter ended March 31, 2021 and the Registration Statement. There may be additional risks that neither CHFW nor Surrozen is presently aware or that CHFW or Surrozen currently believes are immaterial that could also cause actual results to differ from those contained in the forward-looking statements. In addition, forward-looking statements provide Surrozen’s expectations, plans or forecasts of future events and views as of the date of this communication. Surrozen and CHFW anticipate that subsequent events and developments may cause CHFW’s or Surrozen’s beliefs and assessments to change. However, while CHFW or Surrozen may elect to update these forward-looking statements at some point in the future, CHFW and Surrozen specifically disclaim any obligation to do so. These forward-looking statements should not be relied upon as representing CHFW’s or Surrozen’s beliefs, assessments or judgments as of any date subsequent to the date of this communication. Accordingly, undue reliance should not be placed upon the forward-looking statements. Disclaimer This communication is for informational purposes only and is neither a proxy statement, nor a solicitation of a proxy, consent or authorization with respect to any securities or in respect of the potential transaction, nor an offer to purchase, nor a solicitation of an offer to sell, subscribe for or buy any securities or the solicitation of any vote in any jurisdiction pursuant to the business combination or otherwise, nor shall there be any sale, issuance or transfer or securities in any jurisdiction in contravention of applicable law. No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act. Media Contact Ian Stone, Managing Director CanaleComm Tel.: (619) 518-3518 Email: ian.stone@canalecomm.com

AntibodyAcquisition

09 Jul 2021

·www.globenewswire.com

Surrozen Presents New Data Demonstrating Superior Activity of SZN-1326 in Preclinical Inflammatory Bowel Disease Models at 16th Congress of the European Crohn’s and Colitis Organisation (ECCO)

SOUTH SAN FRANCISCO, Calif., July 09, 2021 (GLOBE NEWSWIRE) -- Surrozen Inc., a biotechnology company discovering and developing drug candidates to selectively modulate the Wnt pathway, announced today that new data from its inflammatory bowel disease (IBD) program, including preclinical studies of SZN-1326 showing superior activity compared to therapeutics currently used in treatment, were presented during the 16th Congress of the European Crohn’s and Colitis Organisation. Two poster presentations discussed data from studies of SZN-1326, a bi-specific full-length human antibody targeting Fzd5/8 and Lrp6 receptors in development for the treatment of IBD. A third poster presentation discussed expression profiling of Wnt pathway genes in colon biopsies from patients with ulcerative colitis (UC). Copies of posters will be available in the Investors & Media section of Surrozen’s website. “In both chronic and acute models presented at this congress, SZN-1326 demonstrated beneficial activity compared to other therapeutics currently used for the treatment of IBD that we believe could be meaningful for patients living with IBD,” said Craig Parker, President and Chief Executive Officer of Surrozen. “Combined with presented data about Wnt expression and our other studies of SZN-1326, we continue to be excited for this program and look forward to moving it into clinical investigation in 2022.” In a poster presentation titled, “SZN-1326, a Wnt agonist, improved epithelial healing and ameliorated colitis in a chronic DSS model, in stark contrast to anti-TNFa and anti-IL-12/23p40 antibodies,” findings from a chronic mouse IBD model showed SZN-1326 at various dosing regimens stimulated intestinal epithelial regeneration, induced mucosal healing and restored the epithelial barrier resulting in reduced inflammation, reduced serum cytokine levels, improved body weight and reduced disease activity. In contrast, treatment with anti-TNFa or anti-IL-12/23p40 antibodies led to reduction only in certain serum inflammatory cytokines but had no effect on disease activity or colon histology in this model. In a poster presentation titled, “SZN-1326, a Wnt signal activator, is more efficacious than cyclosporine A in an acute DSS model,” findings from an acute mouse IBD model showed SZN-1326 at various dosing regimens stimulated intestinal epithelial regeneration, induced mucosal healing and restored the epithelial barrier resulting in reduced inflammation, reduced serum cytokine and lipocalin-2 levels improved body weight and reduced disease activity. In comparison, Cyclosporine A showed only a mild effect on reducing disease activity and lipocalin-2. In a poster presentation titled, “Expression profiling of Wnt pathway genes in colon biopsies of patients with ulcerative colitis,” shows reduced expression of Wnt receptors, RSPOs and Wnt target genes indicated insufficient Wnt signal induction in the damaged colon epithelium of UC patients. The findings suggest that repair of the damaged epithelium by Wnt agonist treatment may constitute a new mechanism of action and benefit patients with UC. About Wnt Signaling Wnt signaling plays key roles in the control of development, homeostasis, and regeneration of many essential organs and tissues, including liver, intestine, lung, kidney, retina, central nervous system, cochlea, bone, and others. Modulation of Wnt signaling pathways has potential for treatment of degenerative diseases and tissue injuries. Surrozen’s platform and proprietary technologies have the potential to overcome the limitations in pursuing the Wnt pathway as a therapeutic strategy. About Surrozen Surrozen is a biotechnology company discovering and developing drug candidates to selectively modulate the Wnt pathway. Surrozen is developing tissue-specific antibodies designed to engage the body’s existing biological repair mechanisms with potential application across multiple disease areas, including inflammatory bowel disease, hepatitis, eye diseases, hearing loss, lung and airway diseases, and certain neurological disorders. For more information, please visit surrozen.com. Additional Information In connection with Surrozen’s recently announced business combination with Consonance-HFW Acquisition Corp. (“CHFW”), CHFW has filed with the U.S. Securities and Exchange Commission’s (“SEC”) a Registration Statement on Form S-4 (the “Registration Statement”), which includes a preliminary prospectus with respect to the securities of CHFW to be issued in connection with the business combination to Surrozen stockholders, and as well as a proxy statement with respect to the shareholder meeting of CHFW to vote on the business combination and related matters. CHFW will mail a definitive proxy statement/final prospectus and other relevant documents to its shareholders after the Registration Statement is declared effective by the SEC. This communication is not a substitute for the Registration Statement, the definitive proxy statement/final prospectus or any other document that CHFW will send to its shareholders in connection with the business combination. The definitive proxy statement/final prospectus will contain important information about CHFW, Surrozen and their respective business and related risks, the combined company, including pro forma financial information and the proposed business combination and related matters. Investors and security holders of CHFW are advised to read, when available, the proxy statement/prospectus in connection with CHFW’s solicitation of proxies for its extraordinary general meeting of shareholders to be held to approve the business combination (and related matters) because the proxy statement/prospectus will contain important information about the business combination and the parties to the business combination. Investors and security holders of Surrozen are advised to read, when available, the proxy statement/prospectus in connection with the written consent of Surrozen stockholders. The definitive proxy statement/final prospectus will be mailed to shareholders of CHFW as of a record date to be established for voting on the business combination. Shareholders will also be able to obtain copies of the proxy statement/prospectus, without charge, once available, at the SEC’s website at or by directing a request to: Consonance-HFW Acquisition Corp., 1 Palmer Square, Suite 305, Princeton, NJ. Participants in the Solicitation CHFW, Surrozen and their respective directors, executive officers, other members of management, and employees, under SEC rules, may be deemed to be participants in the solicitation of proxies of CHFW’s shareholders in connection with the business combination. Investors and security holders may obtain more detailed information regarding the names and interests in the business combination of CHFW’s directors and officers in CHFW’s filings with the SEC, including the Registration Statement filed with the SEC by CHFW, which includes the preliminary proxy statement of CHFW for the business combination, and such information and names of Surrozen’s directors and executive officers is also in the Registration Statement filed with the SEC by CHFW. Forward Looking Statements Certain statements made herein are not historical facts but are forward-looking statements for purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Forward-looking statements generally are accompanied by words such as “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “should,” “would,” “plan,” “predict,” “potential,” “seem,” “seek,” “future,” “outlook” and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding future events, the business combination between CHFW and Surrozen, the potential for, data regarding and benefits of the Wnt pathway and studies of SZN-043, including beliefs about recent data and plans and expected timeline for, and benefits resulting from, clinical trials, and potential market for the treatment of severe liver disease. These statements are based on the current expectations of Surrozen’s management and are not predictions of actual performance. These forward-looking statements are not intended to serve as, and must not be relied on, by any investor as a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and will differ from assumptions. Many actual events and circumstances are beyond the control of CHFW and Surrozen. These statements are subject to a number of risks and uncertainties regarding Surrozen’s and CHFW’s businesses and the business combination, and actual results may differ materially. These risks and uncertainties include, but are not limited to, the possibility that the Wnt platform may not meet expectations, general economic, political and business conditions; the inability of the parties to consummate the business combination or the occurrence of any event, change or other circumstances that could give rise to the termination of the business combination agreement; the outcome of any legal proceedings that may be instituted against the parties following the announcement of the business combination; the receipt of an unsolicited offer from another party for an alternative business transaction that could interfere with the business combination; the risk that the approval of the shareholders of CHFW or the stockholders of Surrozen for the potential transaction is not obtained; failure to realize the anticipated benefits of the business combination, including as a result of a delay in consummating the potential transaction or difficulty in integrating the businesses of CHFW and Surrozen; the risk that the business combination disrupts current plans and operations as a result of the announcement and consummation of the business combination; the ability of the combined company to grow and manage growth profitably and retain its key employees; the amount of redemption requests made by CHFW’s shareholders; the inability to obtain or maintain the listing of the post-acquisition company’s securities on Nasdaq following the business combination; costs related to the business combination; risks related to the matters set forth in the Staff Statement on Accounting and Reporting Considerations for Warrants Issued by Special Purpose Acquisition Companies, issued by the Division of Corporate Finance of the SEC on April 12, 2021; and those factors discussed in the Registration Statement and in CHFW’s annual report on Form 10-K for the year ended December 31, 2020 (as amended and restated), and subsequent filings with the SEC, including CHFW’s quarterly report on Form 10-Q for the quarter ended March 31, 2021 and the Registration Statement. There may be additional risks that neither CHFW nor Surrozen is presently aware or that CHFW or Surrozen currently believes are immaterial that could also cause actual results to differ from those contained in the forward-looking statements. In addition, forward-looking statements provide Surrozen’s expectations, plans or forecasts of future events and views as of the date of this communication. Surrozen and CHFW anticipate that subsequent events and developments may cause CHFW’s or Surrozen’s beliefs and assessments to change. However, while CHFW or Surrozen may elect to update these forward-looking statements at some point in the future, CHFW and Surrozen specifically disclaim any obligation to do so. These forward-looking statements should not be relied upon as representing CHFW’s or Surrozen’s beliefs, assessments or judgments as of any date subsequent to the date of this communication. Accordingly, undue reliance should not be placed upon the forward-looking statements. Disclaimer This communication is for informational purposes only and is neither a proxy statement, nor a solicitation of a proxy, consent or authorization with respect to any securities or in respect of the potential transaction, nor an offer to purchase, nor a solicitation of an offer to sell, subscribe for or buy any securities or the solicitation of any vote in any jurisdiction pursuant to the business combination or otherwise, nor shall there be any sale, issuance or transfer or securities in any jurisdiction in contravention of applicable law. No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act. Media ContactIan Stone, Managing DirectorCanaleCommTel.: (619) 518-3518Email: ian.stone@canalecomm.com

CollaborateAntibodyAcquisition

100 Deals associated with Briakinumab

External Link

KEGG	Wiki	ATC	Drug Bank
D09588	Briakinumab	L04AC09	DB05459

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Plaque psoriasis	NDA/BLA	US	Abbott Laboratories	-
Plaque psoriasis	NDA/BLA	EU	Abbott Laboratories	-
Psoriasis	NDA/BLA	-	Abbott Laboratories	-
Psoriasis	NDA/BLA	-	Cambridge Antibody Technology	-
Crohn Disease	Phase 2	US	Abbott Laboratories	01 Nov 2007
Crohn Disease	Phase 2	AU	Abbott Laboratories	01 Nov 2007
Crohn Disease	Phase 2	AT	Abbott Laboratories	01 Nov 2007
Crohn Disease	Phase 2	BE	Abbott Laboratories	01 Nov 2007
Crohn Disease	Phase 2	CA	Abbott Laboratories	01 Nov 2007
Crohn Disease	Phase 2	DK	Abbott Laboratories	01 Nov 2007

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00679731 (Pubmed \| Br Dent J)	Phase 3	Psoriasis	317	Briakinumab	iikxyhtalq(rboqnlsoex) = gylaeqjdfg nzbgngnbkz (fyppsjdhoy )	Positive	27 Oct 2011
				Methotrexate	iikxyhtalq(rboqnlsoex) = scwquwxkbi nzbgngnbkz (fyppsjdhoy )
NCT00292396 (Pubmed) Manual	Phase 2	Plaque psoriasis	180	ABT-874 one 200-mg dose at week 0	lvjcruyntu(mmsszdhsyw) = xcvobucqho jvnjjfplku (xyuqymceyx )	Positive	01 Feb 2008
				ABT-874 100 mg every other week for 12 weeks	lvjcruyntu(mmsszdhsyw) = purmencjvx jvnjjfplku (xyuqymceyx )

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