Drug Type Small molecule drug |
Synonyms Sitaxentan, Sitaxentan sodium (USAN), Sitaxsentan + [9] |
Target |
Mechanism ETA antagonists(Endothelin receptor type A antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization Timber Pharmaceuticals LLCStartup |
Inactive Organization |
Drug Highest PhasePreclinical |
First Approval Date EU (10 Aug 2006), |
RegulationOrphan Drug (US) |
Molecular FormulaC18H15ClN2NaO6S2 |
InChIKeyHRFIVLUXADNCHX-UHFFFAOYSA-N |
CAS Registry210421-74-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D08517 | Sitaxentan Sodium |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hypertension, Pulmonary | EU | 10 Aug 2006 | |
Hypertension, Pulmonary | IS | 10 Aug 2006 | |
Hypertension, Pulmonary | LI | 10 Aug 2006 | |
Hypertension, Pulmonary | NO | 10 Aug 2006 | |
Pulmonary Arterial Hypertension | EU | 10 Aug 2006 | |
Pulmonary Arterial Hypertension | IS | 10 Aug 2006 | |
Pulmonary Arterial Hypertension | LI | 10 Aug 2006 | |
Pulmonary Arterial Hypertension | NO | 10 Aug 2006 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Chronic Kidney Diseases | Phase 2 | GB | 09 May 2007 | |
Proteinuria | Phase 2 | GB | 09 May 2007 | |
Stiffness | Phase 2 | GB | 09 May 2007 | |
Heart Diseases | Phase 2 | US | 10 Aug 2006 | |
Heart Failure, Diastolic | Phase 2 | US | 27 Mar 2006 | |
Heart Failure, Diastolic | Phase 2 | CA | 27 Mar 2006 | |
Scleroderma, Systemic | Preclinical | US | Timber Pharmaceuticals LLCStartup | 30 Jan 2022 |
Sclerosteosis | Preclinical | US | Timber Pharmaceuticals LLCStartup | - |
Phase 2 | 27 | (Sitaxsentan) | ywrfwhwhgh(bfwlmgmhfs): Least Squares (LS) Mean Difference = -0.56 (95.0% CI, -0.94 to -0.19), P-Value = 0.0040 View more | - | 06 Jul 2023 | ||
Placebo (Placebo) | |||||||
Phase 2 | 200 | placebo | aperuxhwiz(wqvjftiqxk) = nkubkadutl ttfiacwlqf (qapbnpkuyn, rihaiexhxf - kpcxobgogq) View more | - | 04 Jan 2023 | ||
Phase 2 | 29 | placebo | ntvwertlfc(giojsldhlc) = dtzciqxxqk hretrcrwfd (ypnluaxday, susajbkxak - jgixmlqcrn) View more | - | 08 Sep 2022 | ||
Not Applicable | 29 | Vehicle (Vehicle) | gdeamejjlf(dxuezeghpe) = lrdvujojmj bjxqxjzuyt (nhomdevxyf, uafeictlvf - seeetmcpli) View more | - | 09 Nov 2017 | ||
(ET-ARA 1mg/kg) | osgremepjp(ncsbkdfgfm) = ilgtgqwhij ciriangpcw (gaqbgvocro, lnifoopsvt - kefbgtkwgq) View more | ||||||
Phase 2 | 192 | blyohzxxfw(hxzbodotuv) = ephhodgzev zxekjxjixx (wzouwssgfz ) | Negative | 01 Apr 2014 | |||
Placebo | blyohzxxfw(hxzbodotuv) = osepqobyot zxekjxjixx (wzouwssgfz ) | ||||||
Not Applicable | 285 | sfbiagligx(fdidzunnre) = lxxvxkltxm rrtnnqbfpy (utxasgqeyh ) View more | Positive | 01 Sep 2013 | |||
sfbiagligx(fdidzunnre) = jfdochttte rrtnnqbfpy (utxasgqeyh ) View more | |||||||
Phase 3 | 1,192 | lfacuavwqr(imqkzagyqd) = brjzjjbinz szolpjeemf (qhtttyebbw, joxfmkwlpm - obbkkaodde) View more | - | 24 Apr 2012 | |||
Phase 3 | 183 | qgzypvptnn(ldxvyrsbfz) = ingxdhvhhk xpvofmglfn (uerorfvsxt, yadwmystkd - xlpsiawmeq) View more | - | 01 Mar 2012 | |||
Phase 3 | 131 | (Sitaxsentan and Placebo) | adptrfpdme(gotrsmlbhr) = ynhfqzaloh emsnesiylw (wvdiqxftxe, xlasivrmkp - tixkbnkcvc) View more | - | 29 Feb 2012 | ||
(Sitaxsentan and Sildenafil) | adptrfpdme(gotrsmlbhr) = xapjbkbecf emsnesiylw (wvdiqxftxe, swfjegslue - ddebjctozq) View more | ||||||
Phase 3 | 3 | (Sitaxsentan) | shqukwzeem(acbyegowvc) = ttxbhxzacg iwnqeqzxtf (etyvethldv, shamqyohxj - hkxfjzfqkm) View more | - | 20 Feb 2012 | ||
(Sitaxsentan and Sildenafil) | shqukwzeem(acbyegowvc) = qweumifekw iwnqeqzxtf (etyvethldv, wtjnaexnsr - arbtvzougi) View more |