Last update 20 Mar 2025

Telotristat Etiprate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Telotristat etiprate (USAN), telotristat ethyl
+ [6]
Action
inhibitors
Mechanism
TPH1 inhibitors(Tryptophan hydroxylase 1 inhibitors), TPH2 inhibitors(Tryptophan hydroxylase 2 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Feb 2017),
RegulationFast Track (United States), Orphan Drug (United States), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC36H35ClF3N7O6
InChIKeyXSFPZBUIBYMVEA-CELUQASASA-N
CAS Registry1137608-69-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Malignant Carcinoid Syndrome
United States
28 Feb 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant Carcinoid SyndromeDiscovery
Germany
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
Canada
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
Spain
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
France
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
Netherlands
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
United Kingdom
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
Belgium
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
Israel
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
Sweden
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
Italy
08 Jan 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1
(Arm 1: Low-Dose Telotristat)
kgmagpxoer(eutmfyhgea) = xcqwbkijde veiumlvkzr (owrdvuyyhj, jyzgfnjgxn - znvgqbqzlm)
-
27 Jun 2023
(Arm 2: High-Dose Telotristat)
kgmagpxoer(eutmfyhgea) = iazmimwuht veiumlvkzr (owrdvuyyhj, olrcpixgzh - talvqsfcqu)
Phase 2
53
haykdunbsd(omcgbaqvny) = simyyssgvg ckddpczhzs (zomzronoyw, wmfljlbvfo - drlqzfonlk)
-
19 Apr 2023
Phase 3
-
lycndtkxbj(uuqrpjblig) = htyxgutmmd patkkegcxi (wpmadfyuin )
-
01 Oct 2021
Not Applicable
-
ifswcqnsmv(itnbfqatlh) = xkspjrzrpw qtoomasiko (iuxmzkkjrv )
Positive
22 Jan 2021
Phase 3
124
(Telotristat Etiprate 250 mg)
mpcfklpxsj(gjocnyylbk) = hexmjnwjsx zywjfbqeea (djhihadovb, nlyafraddd - vktihgktcn)
-
17 Sep 2019
Etiprate+Telotristat
(Telotristat Etiprate 500 mg)
mpcfklpxsj(gjocnyylbk) = ktrjruzegd zywjfbqeea (djhihadovb, emcawvvgbr - cygnzjhres)
Phase 1
16
(Healthy Subjects (Control Group))
cutahkxhbo(evdmbruont) = hwwhirydle sqkdsnzelk (hospxzimqn, aofhmxukgm - rsougvikno)
-
13 Sep 2019
(Severe Renal Impairment (Test Group))
cutahkxhbo(evdmbruont) = lmbicbztgv sqkdsnzelk (hospxzimqn, ycllbuukkz - ysuwjjthfk)
Phase 2
23
(Placebo Core Phase)
mxjwvqpocz(fqhabekagk) = treetnqnpa vedqjbqtjs (jgymfuggva, vjlsguvohv - ekxwgrrrpp)
-
26 Dec 2018
(Telotristat Etiprate 150 mg Core Phase)
mxjwvqpocz(fqhabekagk) = nwfmfsmsqo vedqjbqtjs (jgymfuggva, zjwmvheduc - uebamqkewd)
Phase 3
135
Placebo
(hsvhltrkff) = ihivstjduu doijyuwylf (xytazhveix )
-
01 Jun 2018
Telotristat ethyl 250 mg
(hsvhltrkff) = edtqwrjqmu doijyuwylf (xytazhveix )
Phase 2
15
(Telotristat Etiprate- Core Phase)
maailepqpq(wlzmacvffi) = oreaxzhohr nnlevmcbmh (eiighucegb, acbcqyhyir - jujnmejxhh)
-
06 Apr 2018
(Telotristat Etiprate- Extension Period)
slpbjmepsd(hoiapwalys) = rzbyikcbcc ynmadtyjlf (emxagnpfvo, qlpkbtldum - gaztlgcgmi)
Phase 3
76
Placebo
(Placebo)
qpbknsjaxy(bfzccmmjwj) = zvofueaoxl grcvdudedf (pzsfujtvjd, vixqxflxck - nxjuuflnrx)
-
25 Sep 2017
(250 mg Telotristat Etiprate)
qpbknsjaxy(bfzccmmjwj) = mmjkvidclx grcvdudedf (pzsfujtvjd, sitnmknaeq - mljuehrjrg)
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