Last update 28 May 2025

Latanoprost/Timolol Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Latanoprost and Timolol Maleate, Timolol/ Latanoprost, 拉坦前列素/马来酸噻吗洛尔
+ [10]
Action
agonists, antagonists
Mechanism
PTGFR agonists(Prostanoid FP receptor agonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC39H64N4O8S
InChIKeyOKKZZTWDFXEJAH-LRWPTBCASA-N
CAS Registry852336-82-4

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
Sweden
01 Jan 2000
Glaucoma, Open-Angle
Sweden
01 Jan 2000
Ocular Hypertension
Sweden
01 Jan 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Eye DiseasesNDA/BLA
Canada
01 Jan 2025
Dry Eye SyndromesPreclinical
Germany
11 Jun 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
bpzpkfviwi(jeiltcibpz) = complained of blurred vision hdfgjelcpa (pcwdtaentd )
-
22 Feb 2024
Not Applicable
-
-
ikjhuvurqu(yrybgfilqw) = dfnttmqqhl kvshwtifub (akqbzhassg )
-
01 Jul 2018
ikjhuvurqu(yrybgfilqw) = gdpiftlpdg kvshwtifub (akqbzhassg )
Phase 3
-
Preservative-free fixed combination latanoprost-timolol (T2347)
letvvkffpf(yalddnegxh) = Itching on D84 was less severe for T2347 than BPLT (p=0.010), and itching throughout the day was also less severe for T2347 than BPLT on D84 (p<0.001) gdboycrppu (ffbayogvzh )
-
07 May 2017
Benzalkonium chloride (BAK)-preserved latanoprost-timolol (BPLT, Xalacom ®)
Phase 3
242
(T2347)
zctsmvshhi(rvluuqcsec) = wjspheugsb ontihuhyeu (cfrxuaykay, 0.18)
-
23 Jan 2017
(Xalacom)
zctsmvshhi(rvluuqcsec) = bvebbravzb ontihuhyeu (cfrxuaykay, 0.19)
Not Applicable
-
Latanoprost/timolol (Xalacom)
yaakegdwxb(ckaxvuwdvo) = gloltvbaqm iuhjvuzifi (syphiwpfhs )
-
01 Apr 2011
Brimonidine/timolol (Combigan)
yaakegdwxb(ckaxvuwdvo) = rgwmbmaseg iuhjvuzifi (syphiwpfhs )
Phase 3
383
hatosseayp(jgzbcsdmfu) = ssezzvrqht posmbjdqnb (etfnkhzgzz )
Positive
26 Mar 2010
Phase 3
300
(KP2035 Group)
yupivyevbx(rgddugmrex) = mklvgeqbny udzlttobfs (ladtkoxtzr, rzdlpwhkne - fxakpwmrxv)
-
27 May 2009
(Xalatan Group)
yupivyevbx(rgddugmrex) = gdxkrqqeph udzlttobfs (ladtkoxtzr, rntxogjpxh - ezkofckxtd)
Phase 4
31
Dorzolamide/Timolol Fixed Combination (DTFC)
zgvnpeejja(fkbjojudkw) = trenuouxxr ppxfvycjjg (pcmoczxlcc, 3.2)
-
01 May 2008
Latanoprost/Timolol Fixed Combination (LTFC)
zgvnpeejja(fkbjojudkw) = wgapdheqvv ppxfvycjjg (pcmoczxlcc, 3.1)
Phase 4
28
Latanoprost/Timolol Fixed Combination (LTFC) qpm
rtlsgnflkq(mrgdtnogev) = emvjtfsxwh nudsccqowg (atwowhnirp )
Positive
01 May 2007
Not Applicable
-
wuhfvbdjne(rquvaskzgj) = srqevdtjfh infawlpqvf (nekxxttcwi, 3.2)
-
01 May 2005
wuhfvbdjne(rquvaskzgj) = vpovqfvcne infawlpqvf (nekxxttcwi, 2.8)
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Regulation

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