Last update 08 May 2025

Dolutegravir Sodium/Lamivudine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dolutegravir/Lamivudine, Lamivudine/dolutegravir
+ [5]
Action
inhibitors
Mechanism
HIV-1 integrase inhibitors(HIV integrase inhibitors), RT inhibitors(Viral reverse transcriptase inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (08 Apr 2019),
Regulation-
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Structure/Sequence

Molecular FormulaC28H30F2N6NaO8S
InChIKeyYZPUFLUMGTVLTO-JQRDVGSASA-N
CAS Registry2446159-49-3

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
08 Apr 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV SeropositivityPreclinical
United States
18 Jan 2018
HIV SeropositivityPreclinical
Spain
18 Jan 2018
HIV SeropositivityPreclinical
Netherlands
18 Jan 2018
HIV SeropositivityPreclinical
United Kingdom
18 Jan 2018
HIV SeropositivityPreclinical
Australia
18 Jan 2018
HIV SeropositivityPreclinical
Belgium
18 Jan 2018
HIV SeropositivityPreclinical
France
18 Jan 2018
HIV SeropositivityPreclinical
Germany
18 Jan 2018
HIV SeropositivityPreclinical
Canada
18 Jan 2018
HIV SeropositivityPreclinical
Japan
18 Jan 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
222
ohsnvkyyxd(gweevppfne) = tuydalpbdc xkxmxjdbxf (cidpdnsmah, zxvixosnfx - nbnkjvzgeq)
-
17 Oct 2024
ohsnvkyyxd(gweevppfne) = almpdjvolv xkxmxjdbxf (cidpdnsmah, bcqpfmubpb - nzgdxlhtgq)
Phase 4
HIV Infections
Maintenance
-
(jsgiyohilt) = Dovato demonstrating non-inferior efficacy in maintaining viral suppression after 48 weeks of treatment compared to Biktarvy. urapfswjxo (sfrjgjvzge )
Met
Non-inferior
24 Jul 2024
Phase 3
362
(ngnkabixic) = brvsxckgjf qhrtawlbtc (iuyxaezzdz )
Positive
08 Apr 2024
Not Applicable
2,040
(xorjytqwck) = wffhbicgjv pynbwjwuoa (zbdgvzreyg )
Positive
01 Apr 2024
Continuing triple-drug antiretroviral regimens
(xorjytqwck) = leqbwvrfce pynbwjwuoa (zbdgvzreyg )
Phase 3
1,234
Switch to dolutegravir/lamivudine (DTG/3TC)
(wldqpaxlqu) = In the DTG/3TC group, incidence of adverse events (AEs) was similar across age groups. ebheagferp (zwtgwocowh )
Positive
21 Mar 2024
Continuing current antiretroviral regimen (CAR)
Phase 3
743
neypxjpboj(pusuppwfxr): adjusted odds ratio = 0.92
Positive
01 Jul 2023
Tenofovir Alafenamide-Based Regimens
Not Applicable
-
787
fmagxwsoyv(aijhecynhh) = bumhejobxn fqbdawwfgj (ggroestryv )
-
01 Jan 2022
fmagxwsoyv(aijhecynhh) = ggfznjtcuq fqbdawwfgj (ggroestryv )
Not Applicable
-
-
(oupayurlws) = lanwzwgyfo voahuxldtz (piwzlaezaj )
-
01 Jan 2022
(oupayurlws) = splhyencii voahuxldtz (piwzlaezaj )
Not Applicable
469
shsimduqbb(qpyuvoyeyc) = ytfjdzkyls ozigamfxuz (edxbilicnz )
-
01 Jan 2022
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Regulation

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