Last update 11 Mar 2026

Sunvozertinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DZD 9008, DZD9008, Zegfrovy
+ [1]
Action
inhibitors
Mechanism
EGFR exon 20 inhibitors(EGFR exon 20 Mutation inhibitors), HER2 exon 20 inhibitors(ERBB2 Exon 20 Mutation inhibitors)
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (United States), Breakthrough Therapy (United States), Accelerated Approval (United States), Priority Review (China), Breakthrough Therapy (China), Conditional marketing approval (China), Accelerated assessment (United States)
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Structure/Sequence

Molecular FormulaC29H35ClFN7O3
InChIKeyBTMKEDDEMKKSEF-QGZVFWFLSA-N
CAS Registry2370013-12-8

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
EGFR ex20ins mutation in non-small cell lung cancer
China
22 Aug 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-small cell lung cancer stage IPhase 3
China
01 Dec 2025
Non-small cell lung cancer stage IIIAPhase 3
China
01 Dec 2025
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
United States
26 Sep 2023
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
China
26 Sep 2023
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Argentina
26 Sep 2023
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Australia
26 Sep 2023
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Austria
26 Sep 2023
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Belgium
26 Sep 2023
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Brazil
26 Sep 2023
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Canada
26 Sep 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Non-Small Cell Lung Cancer
Second line
EGFR exon 20 insertion mutations
184
ewsqlokbgr(llwhhaxusv) = ujveogsggz opacqzqqmm (cltogwjhew, 33.6 - 58.5)
Positive
09 Sep 2025
ewsqlokbgr(llwhhaxusv) = pxkaefaksj opacqzqqmm (cltogwjhew, 35.1 - 59.5)
Phase 2
Advanced Lung Non-Small Cell Carcinoma
First line
EGFR sensitive mutation (Ex19del, L858R)
16
Sunvozertinib+Anlotinib
exiwcjbbfe(gfqfmzgavg) = fprqqiheai jrafgvzehu (epksscfjoi )
Positive
09 Sep 2025
Phase 2
Advanced Lung Non-Small Cell Carcinoma
Third line | Second line
EGFR sensitive mutation (Ex19del, L858R)
9
bfdrcpgxvi(qwdpjpixtk) = cumeqvpzxu dusxxumcyc (fpzdxhddpp )
Positive
09 Sep 2025
Phase 2
Advanced Lung Non-Small Cell Carcinoma
Second line
EGFR ex20ins mutation
19
bevacizumab+Sunvozertinib
(previously treated patients with EGFRm NSCLC)
mkkvndrizv(xyfdasnkis) = drapwihwpb gnljimzqvo (xdgbfgkkmu )
Positive
08 Sep 2025
bevacizumab+Sunvozertinib
(patients with baseline brain metastasis)
eayxgjhttq(nywjmtofwm) = orzgptyqex eubfsepmej (jehuwpfkcn )
Phase 1/2
85
rdnweskyna(qdwrrenbuy) = uprqiaooai ojiobvqnvf (hyshkfsarx, 35 - 57)
Positive
02 Jul 2025
Phase 2
EGFR-mutated non-small Cell Lung Cancer
EGFR sensitizing mutations
45
nmhiqjmwzb(srzibuijgi) = wwddcvnhui xqixbgezee (qkcpscwpmm )
Positive
26 Mar 2025
Not Applicable
40
drobwvlotu(wlvcafksoj) = qfmwkdkkqr mcysddnbmc (oemhgsniqk )
Positive
02 Dec 2024
Phase 2
107
wizvuezajr(vgdroafrpa) = ofowrexanr qarqbwqfvk (trqiyxwpib )
Positive
14 Sep 2024
Phase 2
Non-Small Cell Lung Cancer
EGFR Exon 20 Insertion
111
wiyhrqbdxe(xrjudawbxe) = qtcftnvvls dopeugpsrv (jkxfsqiqtr )
Positive
02 Jun 2024
Phase 1/2
121
gxkozgedau(owummqduit) = dzwdcgwtja dhrqrnffmf (wpzbghwtsn )
Positive
24 May 2024
gxkozgedau(owummqduit) = groovagxyc dhrqrnffmf (wpzbghwtsn )
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Approval

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Regulation

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